Epitranscriptomics

Author : Stefan Jurga,Jan Barciszewski
Publisher : Springer Nature
Page : 632 pages
File Size : 48,5 Mb
Release : 2021-07-28
Category : Science
ISBN : 9783030716127

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Epitranscriptomics by Stefan Jurga,Jan Barciszewski Pdf

This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.

Author : Xiao Han,Jia Meng,Giovanni Nigita
Publisher : Frontiers Media SA
Page : 387 pages
File Size : 54,9 Mb
Release : 2022-05-05
Category : Science
ISBN : 9782889761067

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RNA Modifications and Epitranscriptomics by Xiao Han,Jia Meng,Giovanni Nigita Pdf

Author : Mattia Pelizzola,Pavel V. Baranov,Erik Dassi
Publisher : Frontiers Media SA
Page : 155 pages
File Size : 55,5 Mb
Release : 2021-02-02
Category : Science
ISBN : 9782889664405

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Computational Epitranscriptomics: Bioinformatic Approaches for the Analysis of RNA Modifications by Mattia Pelizzola,Pavel V. Baranov,Erik Dassi Pdf

Author : Pedro H. Oliveira
Publisher : Springer Nature
Page : 267 pages
File Size : 54,8 Mb
Release : 2023-02-01
Category : Science
ISBN : 9781071629628

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Computational Epigenomics and Epitranscriptomics by Pedro H. Oliveira Pdf

This volume details state-of-the-art computational methods designed to manage, analyze, and generally leverage epigenomic and epitranscriptomic data. Chapters guide readers through fine-mapping and quantification of modifications, visual analytics, imputation methods, supervised analysis, and integrative approaches for single-cell data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Computational Epigenomics and Epitranscriptomics aims to provide an overview of epiomic protocols, making it easier for researchers to extract impactful biological insight from their data.

Author : Giovanni Nigita,Mario Acunzo,William Chi Shing Cho,Carlo Maria Croce
Publisher : Frontiers Media SA
Page : 127 pages
File Size : 42,5 Mb
Release : 2019-01-31
Category : Electronic
ISBN : 9782889457410

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Epitranscriptomics: The Novel RNA Frontier by Giovanni Nigita,Mario Acunzo,William Chi Shing Cho,Carlo Maria Croce Pdf

Following the formulation of the central dogma of molecular biology and the later discovery of classes of non-coding RNAs, the primary focus of Genetics was essentially on variation of DNA aiming at elucidating biological pathways perturbed in diseases. Recently, extensive attention has shifted towards the study of posttranscriptional RNA modifications occurring in both protein-coding as well as non-coding RNAs, revealing a novel and finer layer of complexity in gene regulation. This, in turn, has led to the birth of the novel field of ‘Epitranscriptomics’. The recent increase of applications of high-throughput sequencing technology (HTS) has allowed the unprecedented opportunity to identify on a transcriptome-wide scale, millions of RNA modifications in human genes, counting today more than 140 distinct types such as: methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe) methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe), pseudourylation (?), deamination (e.g. A-to-I RNA editing). The scope of this Research Topic was to collect both reviews and research articles addressing the wet lab approaches and bioinformatics methodologies necessary to aid in the identification of novel RNA modifications and characterization of their biological functions. Among the articles embracing the aim of the Research Topic, we have collected four original research and methods articles, five reviews, and a technology article.

Author : Giovanni Nigita,Xiao Han,Ernesto Picardi,Kunqi Chen
Publisher : Frontiers Media SA
Page : 208 pages
File Size : 45,7 Mb
Release : 2023-06-30
Category : Science
ISBN : 9782832527771

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RNA modifications and epitranscriptomics - volume II by Giovanni Nigita,Xiao Han,Ernesto Picardi,Kunqi Chen Pdf

Author : Narendra Wajapeyee,Romi Gupta
Publisher : Unknown
Page : 298 pages
File Size : 53,8 Mb
Release : 2018
Category : Transcription factors
ISBN : 1493988085

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Epitranscriptomics by Narendra Wajapeyee,Romi Gupta Pdf

Author : Gurbachan Singh Miglani
Publisher : I K International Pvt Ltd
Page : 710 pages
File Size : 50,7 Mb
Release : 2023-06-13
Category : Medical
ISBN : 9789390620722

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Epigenomics by Gurbachan Singh Miglani Pdf

Epigenomics deals in detail with the concepts, principles, procedures, developments, limitations, advantages, applications and future prospects of different areas of epigenomics in a comprehensive manner. It provides concise yet complete knowledge on the many aspects of the basic and most recent methods and applications in epigenomics, a branch of epigenetics that deals with the mechanisms such as DNA modifications, histone modifications, RNA modifications, small and long non-coding RNAs, chromatin remodeling, which are involved in epigenetic control of gene expression without involving variations in DNA sequences. These regulatory mechanisms lead to phenotypic variations. These epigenetic mechanisms can be exploited for crop improvement and cure of human diseases. Epigenomics strives to understand the role of epigenetic marks (chemical tags) in the development of phenotype. This understanding provides epigeneticists to apply epigenomics in medicine and agriculture. Self-explanatory adequately labelled figures have been the special emphasis throughout. This book is primarily designed for senior undergraduate and graduate level (M.Sc. and Ph.D.) students studying epigenetics in conventional, agricultural and medicinal universities. This book will be a useful reference text for teachers and researcher in any discipline of life sciences, agricultural sciences, medicine, and biotechnology.

Author : Yujing Li,Xuekun Li,Zhao-Qian Teng,Shunliang Xu
Publisher : Frontiers Media SA
Page : 190 pages
File Size : 46,6 Mb
Release : 2023-04-05
Category : Science
ISBN : 9782832518175

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Epigenomic and Epitranscriptomic Basis of Development and Human Disease by Yujing Li,Xuekun Li,Zhao-Qian Teng,Shunliang Xu Pdf

Author : Xing Niu,Xiang Xue,Min Sun
Publisher : Frontiers Media SA
Page : 253 pages
File Size : 42,6 Mb
Release : 2023-12-29
Category : Science
ISBN : 9782832542057

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Epitranscriptomic RNA modification in non-apoptotic forms of regulated cell death by Xing Niu,Xiang Xue,Min Sun Pdf

Author : Liang Zhou,William K. K. Wu,Xiaoxing Li,Yanquan Zhang,Xichen Bao
Publisher : Frontiers Media SA
Page : 125 pages
File Size : 53,8 Mb
Release : 2023-11-02
Category : Science
ISBN : 9782832538203

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Protein-RNA Interplay-Regulated Signaling in Stem Cells and Cancer by Liang Zhou,William K. K. Wu,Xiaoxing Li,Yanquan Zhang,Xichen Bao Pdf

Author : Debmalya Barh,Vasco Ariston De Car Azevedo
Publisher : Academic Press
Page : 464 pages
File Size : 48,7 Mb
Release : 2022-12-01
Category : Medical
ISBN : 9780323986212

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Omics Approaches and Technologies in COVID-19 by Debmalya Barh,Vasco Ariston De Car Azevedo Pdf

The COVID-19 pandemic has affected the entire world in an unprecedented way since 2019. However, novel and innovative applications of various omics, computational, and smart technologies have helped manage the pandemic of the 21st century in a very effective manner. Omics approaches and technologies in COVID-19 presents up-to-date knowledge on omics, genetic engineering, mathematical and computational approaches, and advanced technologies in the diagnosis, prevention, monitoring, and management of COVID-19. This book contains 26 chapters written by academic and industry experts from more than 15 countries. Split into three sections (Omics; Artificial Intelligence and Bioinformatics; and Smart and Emerging Technologies), it brings an overview of novel technologies under omics such as, genomic, metagenomic, pangenomic, metabolomics and proteomics in COVID-19. In addition, it discusses hostpathogen interactions and interactomics, management options, application of genetic engineering, mathematical modeling andsimulations, systems biology, and bioinformatics approaches in COVID-19 drug discovery and vaccine development. This is a valuable resource for students, biotechnologists, bioinformaticians, virologists, clinicians, and pharmaceutical, biomedical, and healthcare industry people who want to understand the promising omics and other technologies used in combating COVID-19 from various aspects. Provides novel technologies for rapid diagnostics, drug discovery, vaccine development, monitoring, prediction of future waves, etc. Describes various omics applications including genomics, metagenomics, epigenomics, nutrigenomics, transcriptomics,miRNAomics, proteomics, metabolomics, phenomics, multiomics, etc., in COVID-19 Presents applications of genetic engineering, CRISPR, artificial intelligence, mathematical and in silico modeling, systems biology,and other computational approaches in COVID-19 Discusses emerging, digital, and smart technologies for the monitoring and management of COVID-19

Author : Mary McMahon
Publisher : Humana
Page : 427 pages
File Size : 53,9 Mb
Release : 2022-06-18
Category : Science
ISBN : 1071613766

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RNA Modifications by Mary McMahon Pdf

This detailed book describes some of the most recent advances and up-to-date methodologies to detect, quantify, analyze, and elucidate the biological function of different types of RNA modifications. Importantly, the methodologies and tools described herein can be applied to a wide variety of organisms and can be used to address biological and clinical questions. Beginning with a section on bioinformatics tools, the collection continues with sections on detecting RNA modifications using Nanopore direct RNA sequencing, next-generation sequencing approaches, qPCR- and molecular biology-based methods, mass spectrometry- and NMR-based methods, as well as approaches to assess kinetics, determinants, and functions of RNA modifications. Written for the highly successful Methods in Molecular Biology series style, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, RNA Modifications: Methods and Protocols serves as an ideal guide for those working directly in the fields of epitranscriptomics and post-transcriptional gene regulation, as well as for scientists and clinicians interested in bioinformatic tools to study RNA modifications and techniques to dissect their roles in physiology and disease. /divChapter 20 is available open access under a CC BY 4.0 license.

Author : Steven Gray
Publisher : Elsevier
Page : 773 pages
File Size : 54,7 Mb
Release : 2023-05-03
Category : Medical
ISBN : 9780323917155

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Epigenetic Cancer Therapy by Steven Gray Pdf

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering. Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, thus demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs Provides a fully updated resource on new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution Features chapter contributions from leading experts in the field

Author : Hongbao Cao,Michela Candini,Jurgen Germann,Katherine Kuhl-Meltzoff Stavropoulos,Prathibha Karanth,Julia Dallman,Flavia Venetucci Gouveia,Edward Quadros,Tongtong Ge,Xingyin Liu
Publisher : Frontiers Media SA
Page : 174 pages
File Size : 52,8 Mb
Release : 2023-10-03
Category : Science
ISBN : 9782832535523

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New Insights into Neurodevelopmental Biology and Autistic Spectrum Disorders by Hongbao Cao,Michela Candini,Jurgen Germann,Katherine Kuhl-Meltzoff Stavropoulos,Prathibha Karanth,Julia Dallman,Flavia Venetucci Gouveia,Edward Quadros,Tongtong Ge,Xingyin Liu Pdf