Error Tolerant Biochemical Sample Preparation With Microfluidic Lab On Chip

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Error-Tolerant Biochemical Sample Preparation with Microfluidic Lab-on-Chip

Sudip Poddar,Bhargab B. Bhattacharya
Error Tolerant Biochemical Sample Preparation with Microfluidic Lab on Chip Book PDF

Author : Sudip Poddar,Bhargab B. Bhattacharya
Publisher : CRC Press
Page : 240 pages
File Size : 47,5 Mb
Release : 2022-07-27
Category : Technology & Engineering
ISBN : 9781000612738

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Error-Tolerant Biochemical Sample Preparation with Microfluidic Lab-on-Chip by Sudip Poddar,Bhargab B. Bhattacharya Pdf

Microfluidic biochips have gained prominence due to their versatile applications to biochemistry and health-care domains such as point-of-care clinical diagnosis of tropical and cardiovascular diseases, cancer, diabetes, toxicity analysis, and for the mitigation of the global HIV crisis, among others. Microfluidic Lab-on-Chips (LoCs) offer a convenient platform for emulating various fluidic operations in an automated fashion. However, because of the inherent uncertainty of fluidic operations, the outcome of biochemical experiments performed on-chip can be erroneous even if the chip is tested a priori and deemed to be defect-free. This book focuses on the issues encountered in reliable sample preparation with digital microfluidic biochips (DMFBs), particularly in an error-prone environment. It presents state-of-the-art error management techniques and underlying algorithmic challenges along with their comparative discussions. Describes a comprehensive framework for designing a robust and error-tolerant biomedical system which will help in migrating from cumbersome medical laboratory tasks to small-sized LOC-based systems Presents a comparative study on current error-tolerant strategies for robust sample preparation using DMFBs and reports on efficient algorithms for error-tolerant sample dilution using these devices Illustrates how algorithmic engineering, cyber-physical tools, and software techniques are helpful in implementing fault tolerance Covers the challenges associated with design automation for biochemical sample preparation Teaches how to implement biochemical protocols using software-controlled microfluidic biochips Interdisciplinary in its coverage, this reference is written for practitioners and researchers in biochemical, biomedical, electrical, computer, and mechanical engineering, especially those involved in LOC or bio-MEMS design.

Algorithms for Sample Preparation with Microfluidic Lab-on-Chip

Sukanta Bhattacharjee,Bhargab B. Bhattacharya,Krishnendu Chakrabarty
Algorithms for Sample Preparation with Microfluidic Lab on Chip Book PDF

Author : Sukanta Bhattacharjee,Bhargab B. Bhattacharya,Krishnendu Chakrabarty
Publisher : CRC Press
Page : 179 pages
File Size : 52,9 Mb
Release : 2022-09-01
Category : Technology & Engineering
ISBN : 9781000795783

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Algorithms for Sample Preparation with Microfluidic Lab-on-Chip by Sukanta Bhattacharjee,Bhargab B. Bhattacharya,Krishnendu Chakrabarty Pdf

Recent microfluidic technologies have brought a complete paradigm shift in automating biochemical processing on a tiny lab-on-chip (a.k.a. biochip) that replaces expensive and bulky instruments traditionally used in implementing bench-top laboratory protocols. Biochips have already made a profound impact on various application domains such as clinical diagnostics, DNA analysis, genetic engineering, and drug discovery, among others. They are capable of precisely manipulating micro-/pico-liter quantities of fluids, and provide integrated support for mixing, storage, transportation, and sensing, on-chip. In almost all bioprotocols, sample preparation plays an important role, which includes dilution and mixing of several fluids satisfying certain volumetric ratios. However, designing algorithms that minimize reactant-cost and sample-preparation time suited for microfluidic chips poses a great challenge from the perspective of protocol mapping, scheduling, and physical design. Algorithms for Sample Preparation with Microfluidic Lab-on-Chip attempts to bridge the widening gap between biologists and engineers by introducing, from the fundamentals, several state-of-the-art computer-aided-design (CAD) algorithms for sample preparation with digital and flow-based microfluidic biochips. Technical topics discussed in the book include: Basics of digital and flow-based microfluidic lab-on-chipComprehensive review of state-of-the-art sample preparation algorithmsSample-preparation algorithms for digital microfluidic lab-on-chipSample-preparation algorithms for flow-based microfluidic lab-on-chip

Fault-Tolerant Digital Microfluidic Biochips

Paul Pop,Mirela Alistar,Elena Stuart,Jan Madsen
Fault Tolerant Digital Microfluidic Biochips Book PDF

Author : Paul Pop,Mirela Alistar,Elena Stuart,Jan Madsen
Publisher : Springer
Page : 234 pages
File Size : 40,8 Mb
Release : 2015-09-07
Category : Technology & Engineering
ISBN : 9783319230726

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Fault-Tolerant Digital Microfluidic Biochips by Paul Pop,Mirela Alistar,Elena Stuart,Jan Madsen Pdf

This book describes for researchers in the fields of compiler technology, design and test, and electronic design automation the new area of digital microfluidic biochips (DMBs), and thus offers a new application area for their methods. The authors present a routing-based model of operation execution, along with several associated compilation approaches, which progressively relax the assumption that operations execute inside fixed rectangular modules. Since operations can experience transient faults during the execution of a bioassay, the authors show how to use both offline (design time) and online (runtime) recovery strategies. The book also presents methods for the synthesis of fault-tolerant application-specific DMB architectures. · Presents the current models used for the research on compilation and synthesis techniques of DMBs in a tutorial fashion; · Includes a set of “benchmarks”, which are presented in great detail and includes the source code of most of the techniques presented, including solutions to the basic compilation and synthesis problems; · Discusses several new research problems in detail, using numerous examples.

Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery

Paul C.H. Li
Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery Book PDF

Author : Paul C.H. Li
Publisher : CRC Press
Page : 420 pages
File Size : 41,5 Mb
Release : 2010-02-24
Category : Medical
ISBN : 9781439882177

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Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery by Paul C.H. Li Pdf

Lab-on-a-chip technology permits us to make many important discoveries that can only be observed at the microscale or the nanoscale. Using this technology, biological and biochemical analyses translate into greater sensitivity, more accurate results, and more valuable findings. Authored by one of the field's pioneering researchers, Fundamentals of

Emerging Electronic Devices, Circuits and Systems

Chandan Giri,Takahiro Iizuka,Hafizur Rahaman,Bhargab B. Bhattacharya
Emerging Electronic Devices Circuits and Systems Book PDF

Author : Chandan Giri,Takahiro Iizuka,Hafizur Rahaman,Bhargab B. Bhattacharya
Publisher : Springer Nature
Page : 465 pages
File Size : 45,8 Mb
Release : 2023-06-01
Category : Technology & Engineering
ISBN : 9789819900558

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Emerging Electronic Devices, Circuits and Systems by Chandan Giri,Takahiro Iizuka,Hafizur Rahaman,Bhargab B. Bhattacharya Pdf

The book constitutes peer-reviewed proceedings of a workshop on Emerging Electronics Devices, Circuits, and Systems (EEDCS) held in conjunction with International Symposium on Devices, Circuits, and Systems (ISDCS 2022). The book focuses on the recent development in devices, circuits, and systems. It also discusses innovations, trends, practical challenges, and solutions adopted in device design, modeling, fabrication, characterization, and their circuit implementation with pertinent system applications. It will be useful for researchers, developers, engineers, academicians, and students.

Advanced Materials for Wastewater Treatment and Desalination

Ahmad Fauzi Ismail,Pei Sean Goh,Hasrinah Hasbullah,Farhana Aziz
Advanced Materials for Wastewater Treatment and Desalination Book PDF

Author : Ahmad Fauzi Ismail,Pei Sean Goh,Hasrinah Hasbullah,Farhana Aziz
Publisher : CRC Press
Page : 378 pages
File Size : 41,8 Mb
Release : 2022-08-19
Category : Technology & Engineering
ISBN : 9781000638448

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Advanced Materials for Wastewater Treatment and Desalination by Ahmad Fauzi Ismail,Pei Sean Goh,Hasrinah Hasbullah,Farhana Aziz Pdf

Advanced Materials for Wastewater Treatment and Desalination: Fundamentals to Applications offers a comprehensive overview of current progress in the development of advanced materials used in wastewater treatment and desalination. The book is divided into two major sections, covering both fundamentals and applications. This book: Describes the synthesis and modification of advanced materials, including metal oxides, carbonaceous materials, perovskite-based materials, polymer-based materials, and advanced nanocomposites Examines relevant synthesis routes and mechanisms as well as correlates materials' properties with their characterization Details new fabrication techniques including green synthesis, solvent-free, and energy-saving synthesis approaches Highlights various applications, such as removal of organic contaminants, discoloration of dye wastewater, petrochemical wastewater treatment, and electrochemically-enhanced water treatment With chapters written by leading researchers from around the world, this book will be of interest to chemical, materials, and environmental engineers working on progressing materials applications to improve water treatment technologies.

Biosensors

Sibel A. Ozkan,Bengi Uslu,Mustafa Kemal Sezgintürk
Biosensors Book PDF

Author : Sibel A. Ozkan,Bengi Uslu,Mustafa Kemal Sezgintürk
Publisher : CRC Press
Page : 395 pages
File Size : 43,6 Mb
Release : 2022-07-11
Category : Medical
ISBN : 9781000612622

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Biosensors by Sibel A. Ozkan,Bengi Uslu,Mustafa Kemal Sezgintürk Pdf

Biosensors: Fundamentals, Emerging Technologies, and Applications provides insight into the sensing applications of different types of biosensors relating to environmental pollutants, microbiological analysis, and healthcare. It describes state-of-the-art research in biosensors, point of care testing, potential applications, as well as future prospects for biosensors. This book: Presents the essentials that readers need to know to make full use of biosensor technology Discusses recent perspectives on optical and electrochemical biosensors Details biosensor types for medical applications Teaches how to use enzymes for biological recognition in biomarker assays Proposes innovations in wearable and smart biosensors This book is aimed at advanced students, researchers, and academics across a broad interdisciplinary field including biochemical, pharmaceutical, and environmental engineering as well as materials science, analytical chemistry, and biosciences.

Hybrid Polymeric Nanocomposites from Agricultural Waste

Sefiu Adekunle Bello
Hybrid Polymeric Nanocomposites from Agricultural Waste Book PDF

Author : Sefiu Adekunle Bello
Publisher : CRC Press
Page : 284 pages
File Size : 41,5 Mb
Release : 2022-10-17
Category : Technology & Engineering
ISBN : 9781000736380

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Hybrid Polymeric Nanocomposites from Agricultural Waste by Sefiu Adekunle Bello Pdf

Hybrid Polymeric Nanocomposites from Agricultural Waste examines the use of agricultural by-products for green production of new materials. It covers nanoparticle synthesis from agricultural wastes and nanocomposite development with a focus on polyethylene, polylactic acid, polymethylmethacrylate, and epoxy resins, and considers possible biomedical and engineering applications. Showcases agricultural waste as polymer reinforcements to replace expensive synthetic fibres that discourage wide polymeric nanocomposite applications Discusses green synthesis and characterisation of hybrid nanocomposites from polylactic acid, polymethylmethacrylate, recycled/new polyethylene, and epoxy resins Contrasts hybrid nanocomposites properties with standard nanocomposites, using automotive case studies The book is aimed at researchers, advanced students, and industrial professionals in materials, polymer, and mechanical engineering and related areas interested in the development and application of sustainable materials.

Polymer Nanocomposites in Supercapacitors

Soney C George,Sam John,Sreelakshmi Rajeevan
Polymer Nanocomposites in Supercapacitors Book PDF

Author : Soney C George,Sam John,Sreelakshmi Rajeevan
Publisher : CRC Press
Page : 284 pages
File Size : 44,9 Mb
Release : 2022-10-17
Category : Technology & Engineering
ISBN : 9781000718478

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Polymer Nanocomposites in Supercapacitors by Soney C George,Sam John,Sreelakshmi Rajeevan Pdf

Supercapacitors are energy storing devices, gaining great scientific attention due to their excellent cycling life, charge-discharge stability, energy, and power density. The central theme of this book is to review the multiple applications of polymer nanocomposites in supercapacitors in a comprehensive manner, including discussions pertaining to various unresolved issues and new challenges in the subject area. It illustrates polymer nanocomposite preparation and working mechanisms as electrodes, binders, separators, and electrolytes. This edited volume also explains different components of supercapacitors, including theory, modelling, and simulation aspects. Features: Covers the synthesis and properties of polymer nanocomposites for varied usage. Explains roles of different types of nanofillers in polymeric systems for developing supercapacitors. Highlights theory, modelling, and simulation of polymeric supercapacitors. Gives an illustrative overview of the multiple applications of polymers and their nanocomposites. Includes graphene, CNT, nanoparticle, carbon, and nano-cellulose-based supercapacitors. This book is aimed at graduate students and researchers in materials science, polymer science, polymer physics, electrochemistry, electronic materials, energy management, electronic engineering, polymer engineers, and chemical engineering.

Nanomaterials in Manufacturing Processes

Dhiraj Sud,Anil Kumar Singla,Munish Kumar Gupta
Nanomaterials in Manufacturing Processes Book PDF

Author : Dhiraj Sud,Anil Kumar Singla,Munish Kumar Gupta
Publisher : CRC Press
Page : 311 pages
File Size : 53,5 Mb
Release : 2022-08-02
Category : Technology & Engineering
ISBN : 9781000630114

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Nanomaterials in Manufacturing Processes by Dhiraj Sud,Anil Kumar Singla,Munish Kumar Gupta Pdf

In the manufacturing sector, nanomaterials offer promising outcomes for cost reduction in production, quality improvement, and minimization of environmental hazards. This book focuses on the application of nanomaterials across a wide range of manufacturing areas, including in paint and coatings, petroleum refining, textile and leather industries, electronics, energy storage devices, electrochemical sensors, as well as in industrial waste treatment. This book: Examines nanofluids and nanocoatings in manufacturing and their characterization. Discusses nanomaterial applications in fabricating lightweight structural components, oil refining, smart leather processing and textile industries, and the construction industry. Highlights the role of 3D printing in realizing the full potential of nanotechnology. Considers synthetic strategies with a focus on greener protocols for the fabrication of nanostructured materials with enhanced properties and better control, including these materials' characterization and significant properties for ensuring smart outputs. Offers a unique perspective on applications in industrial waste recycling and treatment, along with challenges in terms of safety, economics, and sustainability in industrial processes. This work is written for researchers and industry professionals across a variety of engineering disciplines, including materials, manufacturing, process, and industrial engineering.

Green Synthesized Iron-based Nanomaterials

Piyal Mondal,Mihir Kumar Purkait
Green Synthesized Iron based Nanomaterials Book PDF

Author : Piyal Mondal,Mihir Kumar Purkait
Publisher : CRC Press
Page : 171 pages
File Size : 41,5 Mb
Release : 2022-09-08
Category : Technology & Engineering
ISBN : 9781000645224

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Green Synthesized Iron-based Nanomaterials by Piyal Mondal,Mihir Kumar Purkait Pdf

This book covers different green approaches used for the preparation of iron-based nanoparticles and their environmental remediation applications. It investi-gates various environmental applications such as antimicrobial studies, dye and heavy metal removal, and wastewater pollutant degradation by various green syn-thesized iron nanomaterials. Critical analysis of different routes and the sepa-ration techniques of iron-based nanomaterials along with the potential impacts of iron nanoparticles on human health and the atmosphere are also discussed. Overall, the authors: Summarize all the basic aspects of synthesis and application of iron-based green nanomaterials Explain morphological parameters of the prepared nanomaterials obtained from different routes and their specific applications Include different separation techniques from an industrial point of view Exclusively cover specific environmental remediation applications Discuss the future scope and challenges of green processes This book is aimed at researchers and professionals in chemical and environmental engineering, materials science, and nanotechnology.

Geopolymers as Sustainable Surface Concrete Repair Materials

Ghasan Fahim Huseien,Abdul Rahman Mohd Sam,Mahmood Md. Tahir
Geopolymers as Sustainable Surface Concrete Repair Materials Book PDF

Author : Ghasan Fahim Huseien,Abdul Rahman Mohd Sam,Mahmood Md. Tahir
Publisher : CRC Press
Page : 220 pages
File Size : 50,9 Mb
Release : 2022-08-11
Category : Technology & Engineering
ISBN : 9781000619591

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Geopolymers as Sustainable Surface Concrete Repair Materials by Ghasan Fahim Huseien,Abdul Rahman Mohd Sam,Mahmood Md. Tahir Pdf

The progressive deterioration of concrete surface structures is a major concern in construction engineering that requires precise repairing. While a number of repair materials have been developed, geopolymer mortars have been identified as potentially superior and environmentally friendly high-performance construction materials, as they are synthesized by selectively combining waste materials containing alumina and silica compounds which are further activated by a strong alkaline solution. Geopolymers as Sustainable Surface Concrete Repair Materials offers readers insights into the synthesis, properties, benefits and applications of geopolymer-based materials for concrete repair. • Discusses manufacturing and design methods of geopolymer-based materials • Assesses mechanical strength and durability of geopolymer-based materials under different aggressive environmental conditions • Characterizes the microstructure of these materials using XRD, SEM, EDX, TGA, DTG and FTIR measurements • Describes application of geopolymer-based materials as surface repair materials • Compares environmental and cost benefits against those of traditional OPC and commercial repair materials This book is written for researchers and professional engineers working with concrete materials, including civil and materials engineers.

Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms

Mohamed Ibrahim,Krishnendu Chakrabarty
Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms Book PDF

Author : Mohamed Ibrahim,Krishnendu Chakrabarty
Publisher : CRC Press
Page : 335 pages
File Size : 41,6 Mb
Release : 2020-05-31
Category : Technology & Engineering
ISBN : 9781000082708

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Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms by Mohamed Ibrahim,Krishnendu Chakrabarty Pdf

A microfluidic biochip is an engineered fluidic device that controls the flow of analytes, thereby enabling a variety of useful applications. According to recent studies, the fields that are best set to benefit from the microfluidics technology, also known as lab-on-chip technology, include forensic identification, clinical chemistry, point-of-care (PoC) diagnostics, and drug discovery. The growth in such fields has significantly amplified the impact of microfluidics technology, whose market value is forecast to grow from $4 billion in 2017 to $13.2 billion by 2023. The rapid evolution of lab-on-chip technologies opens up opportunities for new biological or chemical science areas that can be directly facilitated by sensor-based microfluidics control. For example, the digital microfluidics-based ePlex system from GenMarkDx enables automated disease diagnosis and can bring syndromic testing near patients everywhere. However, as the applications of molecular biology grow, the adoption of microfluidics in many applications has not grown at the same pace, despite the concerted effort of microfluidic systems engineers. Recent studies suggest that state-of-the-art design techniques for microfluidics have two major drawbacks that need to be addressed appropriately: (1) current lab-on-chip systems were only optimized as auxiliary components and are only suitable for sample-limited analyses; therefore, their capabilities may not cope with the requirements of contemporary molecular biology applications; (2) the integrity of these automated lab-on-chip systems and their biochemical operations are still an open question since no protection schemes were developed against adversarial contamination or result-manipulation attacks. Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms provides solutions to these challenges by introducing a new design flow based on the realistic modeling of contemporary molecular biology protocols. It also presents a microfluidic security flow that provides a high-level of confidence in the integrity of such protocols. In summary, this book creates a new research field as it bridges the technical skills gap between microfluidic systems and molecular biology protocols but it is viewed from the perspective of an electronic/systems engineer.

Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery

Paul C.H. Li
Microfluidic Lab on a Chip for Chemical and Biological Analysis and Discovery Book PDF

Author : Paul C.H. Li
Publisher : CRC Press
Page : 528 pages
File Size : 45,8 Mb
Release : 2005-11-01
Category : Science
ISBN : 1574445723

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Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery by Paul C.H. Li Pdf

The microfluidic lab-on-a-chip allows scientists to conduct chemical and biochemical analysis in a miniaturized format so small that properties and effects are successfully enhanced, and processes seamlessly integrated. This microscale advantage translates into greater sensitivity, more accurate results, and better information. Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery focuses on all aspects of the microfluidic lab-on-a-chip technologies and offers an overview of the available technology, its limitations, and its breakthroughs over the years. It emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays and enzymatic assays. Originally conceived as a single chapter published in Ewing's Analytical Instrumentation, this book is a gateway to the vast literature and conference proceedings on the topic. Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery expands upon its roots to present a comprehensive treatment of microfluidic lab-on-a-chip methods and applications for novices and advanced researchers alike.

Digital Microfluidic Biochips

Krishnendu Chakrabarty,Fei Su
Digital Microfluidic Biochips Book PDF

Author : Krishnendu Chakrabarty,Fei Su
Publisher : CRC Press
Page : 216 pages
File Size : 41,6 Mb
Release : 2018-10-03
Category : Technology & Engineering
ISBN : 9781351837538

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Digital Microfluidic Biochips by Krishnendu Chakrabarty,Fei Su Pdf

Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips. Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.