Essential Metals In Medicine Therapeutic Use And Toxicity Of Metal Ions In The Clinic

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Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Peggy L. Carver
Essential Metals in Medicine Therapeutic Use and Toxicity of Metal Ions in the Clinic Book PDF

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 455 pages
File Size : 53,9 Mb
Release : 2019-01-14
Category : Science
ISBN : 9783110527872

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Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by Peggy L. Carver Pdf

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Chelation Therapy in the Treatment of Metal Intoxication

Jan Aaseth,Guido Crisponi,Ole Anderson
Chelation Therapy in the Treatment of Metal Intoxication Book PDF

Author : Jan Aaseth,Guido Crisponi,Ole Anderson
Publisher : Academic Press
Page : 388 pages
File Size : 54,9 Mb
Release : 2016-04-18
Category : Medical
ISBN : 9780128030738

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Chelation Therapy in the Treatment of Metal Intoxication by Jan Aaseth,Guido Crisponi,Ole Anderson Pdf

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Metal Ions in Bio-Imaging Techniques

Astrid Sigel,Eva Freisinger,Roland K.O. Sigel
Metal Ions in Bio Imaging Techniques Book PDF

Author : Astrid Sigel,Eva Freisinger,Roland K.O. Sigel
Publisher : Walter de Gruyter GmbH & Co KG
Page : 547 pages
File Size : 54,9 Mb
Release : 2021-03-08
Category : Science
ISBN : 9783110685701

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Metal Ions in Bio-Imaging Techniques by Astrid Sigel,Eva Freisinger,Roland K.O. Sigel Pdf

Volume 22, entitled Metal Ions in Bio-Imaging Techniques, of the series Metal Ions in Life Sciences deals with metal ions as tools in imaging. This dates back to the first half of the past century, when barium sulfate was orally given to patients undergoing X-ray examination. The use of contrast agents has since developed into a large interdisciplinary field encompassing not only medicine, but also chemistry, material sciences, physics, biology, engineering, and computer sciences. MILS-22 provides deep and current insights in 17 stimulating chapters on the new research frontiers of this fast growing field on bio-imaging ... and beyond. For example, adding bio-sensing yields theranostic agents, meaning diagnosis and therapy linked in the same molecule; ions of Gd, Mn, Fe, Co, Ir, 99mTc, etc., are involved. Other important topics are, e.g., metal complexes in paramagnetic Chemical Exchange Transfer (paraCEST), radiometals for Positron Emission Tomography (PET) imaging, or paramagnetic metal ion probes for 19F magnetic resonance imaging. MILS-22 is written by 57 internationally recognized experts from 12 countries, that is, from the US via Europe to China. The impact of this vibrant research area is manifested by more than 2300 references and nearly 120 figures, mostly in color, and several informative tables. To conclude, Metal Ions in Bio-Imaging Techniques is an essential resource for scientists working in the wide range from material sciences, enzymology, analytic, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that also excellent information for teaching is provided.

Metal Ions in Biology and Medicine

Maria Agnes Cser
Metal Ions in Biology and Medicine Book PDF

Author : Maria Agnes Cser
Publisher : John Libbey Eurotext
Page : 718 pages
File Size : 45,9 Mb
Release : 2004
Category : Ions
ISBN : 2742005226

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Metal Ions in Biology and Medicine by Maria Agnes Cser Pdf

8th International Congress on Metal Ions in Biology and Medicine, Budapest, Hungary 18 to 22 May 2004. Every two years, the world's leading specialists meet exchange information on the most recent advances in understanding metals and the part they play in treating some diseases. This book aims to help advance our knowledge of the role of metal ions in a number of fields in biology and medicine.

Transition Metals and Sulfur – A Strong Relationship for Life

Martha Sosa Torres,Peter Kroneck
Transition Metals and Sulfur A Strong Relationship for Life Book PDF

Author : Martha Sosa Torres,Peter Kroneck
Publisher : Walter de Gruyter GmbH & Co KG
Page : 610 pages
File Size : 43,5 Mb
Release : 2020-04-06
Category : Science
ISBN : 9783110588941

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Transition Metals and Sulfur – A Strong Relationship for Life by Martha Sosa Torres,Peter Kroneck Pdf

Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes; in fact, it is an old wisdom that metals are indispensable for life. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in numerous interconnecting research fields.

Metals, Microbes, and Minerals - The Biogeochemical Side of Life

Peter Kroneck,Martha Sosa Torres
Metals Microbes and Minerals The Biogeochemical Side of Life Book PDF

Author : Peter Kroneck,Martha Sosa Torres
Publisher : Walter de Gruyter GmbH & Co KG
Page : 386 pages
File Size : 49,7 Mb
Release : 2021-01-18
Category : Science
ISBN : 9783110589771

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Metals, Microbes, and Minerals - The Biogeochemical Side of Life by Peter Kroneck,Martha Sosa Torres Pdf

One of the biggest questions in today's biochemistry is how biological molecules became essential for the processes that occur within living cells. This new book from outstanding Metal Ions in Life Science series gives an overview about biochemical evolution of organic molecules and metabolic pathways in living systems and outlines the vital biochemical processes in microbial cells in which metals are involved.

Metal Ions in Biological Systems

Helmut Sigel
Metal Ions in Biological Systems Book PDF

Author : Helmut Sigel
Publisher : CRC Press
Page : 390 pages
File Size : 49,6 Mb
Release : 1982-02-26
Category : Science
ISBN : 0824715691

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Metal Ions in Biological Systems by Helmut Sigel Pdf

This book describes drug metal-ion interactions in the gut and deals with the deficiency of zinc and iron and their pharmacological use. It covers anti-inflammatory activities of copper and gold complexes and considers the role of metal ions and chelating agents in anti-viral chemotherapy.

Metal Toxicology Handbook

Debasis Bagchi,Manashi Bagchi
Metal Toxicology Handbook Book PDF

Author : Debasis Bagchi,Manashi Bagchi
Publisher : CRC Press
Page : 511 pages
File Size : 55,7 Mb
Release : 2020-11-19
Category : Health & Fitness
ISBN : 9780429795749

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Metal Toxicology Handbook by Debasis Bagchi,Manashi Bagchi Pdf

Heavy metals and metalloids, singly or in combination, induce toxic manifestations either through acute or chronic pathology. In particular, long-term chronic exposure to diverse heavy metals and metalloids to humans and animals can lead to numerous physical, muscular, neurological, nephrological, and diverse degenerative diseases and dysfunctions, including multiple sclerosis, muscular dystrophy, Parkinson’s and Alzheimer’s diseases, cardiovascular disorders, and several others. Recognized heavy metals such as lead, mercury, arsenic, cadmium, thallium, and hexavalent chromium are known for enormous toxicity. The immediate vital signs of acute heavy metal exposure include nausea, vomiting, diarrhea, and acute abdominal pain. Mercury has been identified as the most toxic heavy metal, and mercury poisoning is known as acrodynia or pink disease. Similarly, lead, another toxic heavy metal, was at one time an integral part of painting. Metal Toxicology Handbook further explains and discusses the varying attributes of metals, discussing toxicity, safety, and proper human utilization of metals. Beginning with a broad overview of metals, metalloids, redox biology, and neurodegeneration and going further into the roles, benefits, and toxicity of metals with each section, the text contains 28 chapters from eminent researchers and scientists in their respective fields and is a must-have for anyone researching the potential toxicity in metals. Key Features Discusses the pathology of metal toxicity Highlights the benefits of metals Explains the mechanism and salient features of restoring metabolic homeostasis Highlights dose-dependent beneficial and adverse effects of vanadium safety and toxicity The initial introductory section provides a broad overview of metals, metalloids, redox biology, and neurodegeneration. The second section discusses the pathology of metal toxicity in two chapters, while the third section highlights the mechanism and salient features of restoring metabolic homeostasis in two chapters. The fourth section demonstrates the aspect of radionuclides toxicity. In a change of pace, the fifth section discusses the benefits of metals in four chapters. The sixth section, titled "Toxic Manifestations by Diverse Heavy Metals and Metalloids," provides fourteen chapters that discuss the toxicological mechanism and manifestation of individual metals. The editors have crafted a commentary titled "A Treatise on Metal Toxicity" and summarized a vivid scenario of metal toxicity and its consequences.

Metallo-Drugs: Development and Action of Anticancer Agents

Astrid Sigel,Helmut Sigel,Eva Freisinger,Roland K.O. Sigel
Metallo Drugs Development and Action of Anticancer Agents Book PDF

Author : Astrid Sigel,Helmut Sigel,Eva Freisinger,Roland K.O. Sigel
Publisher : Walter de Gruyter GmbH & Co KG
Page : 588 pages
File Size : 47,8 Mb
Release : 2018-02-05
Category : Science
ISBN : 9783110469905

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Metallo-Drugs: Development and Action of Anticancer Agents by Astrid Sigel,Helmut Sigel,Eva Freisinger,Roland K.O. Sigel Pdf

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Toxicology

Vinood B. Patel,Victor R Preedy
Toxicology Book PDF

Author : Vinood B. Patel,Victor R Preedy
Publisher : Academic Press
Page : 596 pages
File Size : 46,6 Mb
Release : 2020-11-17
Category : Medical
ISBN : 9780128190937

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Toxicology by Vinood B. Patel,Victor R Preedy Pdf

Toxicology: Oxidative Stress and Dietary Antioxidants examines the nature of oxidative stress as a consequence of exposure to toxins and how antioxidant approaches can mitigate the impact of toxicant exposures. Sections covers the basic biology of oxidative stress, from molecular biology, to physiological pathology, mechanisms of action of specific toxicants, metals and other chemicals/drugs, and antioxidant approaches and therapies for toxic exposures. With contributions from an international group of experts, useful summary sections, a dictionary of terms, and applications to other areas of toxicology, this book is an informative, consolidated reference that helps bridge the interrelationship between toxicology, oxidative stress and antioxidants. Provides a novel collection of information linking both sides of redox biology (oxidants and antioxidants) and toxicology Explores the role of free radical mediated damage and toxicology Contains contributions from experts on toxicological science surrounding oxidative stress and on antioxidant approaches for reducing the impact of toxicant exposures

The Toxicology of Essential and Nonessential Metals

Nichole Coleman, PhD,Aisha Castrejon,Christopher Blaine,Tojo Chemmachel
The Toxicology of Essential and Nonessential Metals Book PDF

Author : Nichole Coleman, PhD,Aisha Castrejon,Christopher Blaine,Tojo Chemmachel
Publisher : Lulu.com
Page : 198 pages
File Size : 44,8 Mb
Release : 2017-05-11
Category : Science
ISBN : 9781483469089

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The Toxicology of Essential and Nonessential Metals by Nichole Coleman, PhD,Aisha Castrejon,Christopher Blaine,Tojo Chemmachel Pdf

No matter how careful we are at using metals in industrial processes, some level of human exposure is unavoidable. Countless metals are obtained through mining and smelting activities that amplify their distribution throughout the environment. Applications of metals in industry, medicine, and agriculture have increased our exposure. These metals are not merely an occupational hazard for those working with them-they affect consumers and anyone exposed through environmental contamination. Even worse, they cannot be destroyed and are thus non-biodegradable. The blades we use, the pots and pans we cook with, children's face paint, and facial makeup contain toxic metals. Toxic heavy metals are also found in cigarettes, gourmet foods such as seasonings, fish, and chocolates. When you sprinkle a dish with Himalayan sea salt, you may end up ingesting toxic metals such as arsenic, cadmium and lead.

Bioinorganic Chemistry

Rosette M. Roat-Malone
Bioinorganic Chemistry Book PDF

Author : Rosette M. Roat-Malone
Publisher : John Wiley & Sons
Page : 350 pages
File Size : 48,8 Mb
Release : 2020-03-17
Category : Science
ISBN : 9781119535218

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Bioinorganic Chemistry by Rosette M. Roat-Malone Pdf

Introduces students to the basics of bioinorganic chemistry This book provides the fundamentals for inorganic chemistry and biochemistry relevant to understanding bioinorganic topics. It provides essential background material, followed by detailed information on selected topics, to give readers the background, tools, and skills they need to research and study bioinorganic topics of interest to them. To reflect current practices and needs, instrumental methods and techniques are referred to and mixed in throughout the book. Bioinorganic Chemistry: A Short Course, Third Edition begins with a chapter on Inorganic Chemistry and Biochemistry Essentials. It then continues with chapters on: Computer Hardware, Software, and Computational Chemistry Methods; Important Metal Centers in Proteins; Myoglobins, Hemoglobins, Superoxide Dismutases, Nitrogenases, Hydrogenases, Carbonic Anhydrases, and Nitrogen Cycle Enzymes. The book concludes with chapters on Nanobioinorganic Chemistry and Metals in Medicine. Readers are also offered end-of-section summaries, conclusions, and thought problems. Reduces size of the text from previous edition to match the first, keeping it appropriate for a one-semester course Offers primers and background materials to help students feel comfortable with research-level bioinorganic chemistry Emphasizes select and diverse topics using extensive references from current scientific literature, with more emphasis on molecular biology in the biochemistry section, leading to a discussion of CRISPR technology Adds new chapters on hydrogenases, carbonic anhydrases, and nitrogen cycle enzymes, along with a separate chapter on nanobioinorganic chemistry Features expanded coverage of computer hardware and software, metalloenzymes, and metals in medicines Supplemented with a companion website for students and instructors featuring Powerpoint and JPEG figures and tables, arranged by chapter Appropriate for one-semester bioinorganic chemistry courses, Bioinorganic Chemistry: A Short Course, Third Edition is ideal for upper-level undergraduate and beginning graduate students. It is also a valuable reference for practitioners and researchers in need of a general introduction to the subject, as well as chemists requiring an accessible reference.

Analysis and Characterisation of Metal-Based Nanomaterials

Anonim
Analysis and Characterisation of Metal Based Nanomaterials Book PDF

Author : Anonim
Publisher : Elsevier
Page : 454 pages
File Size : 44,5 Mb
Release : 2021-05-28
Category : Science
ISBN : 9780323853064

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Analysis and Characterisation of Metal-Based Nanomaterials by Anonim Pdf

Analysis and Characterisation of Metal-Based Nanomaterials, Volume 93 in the Comprehensive Analytical Chemistry series, introduces recent developments in analytical methodologies for detection, characterization and quantification of metal-based nanomaterials and their applications to a variety of complex environmental, biological and food samples as well as different consumer products. Single-particle inductively coupled plasma mass spectrometry is highlighted as a powerful analytical tool for number-based concentration and size distribution, also from the metrological viewpoint. An emerging approach for the measurement of multi-metal nanoparticles by single-particle inductively coupled plasma time-of-flight mass spectrometry is discussed. Imaging of metal-based nanoparticles by hyphenated inductively coupled plasma-based techniques is also introduced. The potential of different liquid chromatography and field flow fractionation separation techniques hyphenated to inductively coupled plasma mass spectrometry is emphasized as a powerful tool in particular for complex matrices and small particles sizes. The use of different microscopic techniques for the characterization of metal-based nanoparticles and characterization of metal-based nanoparticles as contrast agents for magnetic resonance imaging are presented. Moreover, occurrence, behaviour and fate of inorganic nanoparticles in the environment is overviewed. Finally, the need for quality control standards and reference nano-materials is emphasized throughout. Presents recent developments in analytical methodologies based on mass spectrometry, light scattering and microscopic techniques for detection, characterization and quantification of metal-based nanomaterials Describes applications of the nanoparticle analysis in a variety of complex environmental, biological and food samples as well as different consumer products Provides the metrological aspects for the analysis of metal-based nanoparticles when using emerging techniques such as single-particle inductively coupled plasma mass spectrometry

Metal Ions in Biology and Medicine

Lylia Khassanova
Metal Ions in Biology and Medicine Book PDF

Author : Lylia Khassanova
Publisher : John Libbey Eurotext
Page : 692 pages
File Size : 54,8 Mb
Release : 1990-05
Category : Medical
ISBN : 2742004297

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Metal Ions in Biology and Medicine by Lylia Khassanova Pdf

Proceedings of the Seventh International Symposium on Metal Ions in Biology & Medicine held in Saint Petersburg State University, Saint Petersburg, Russia, on 5-9 May 2002.

Schiff Base in Organic, Inorganic and Physical Chemistry

Takashiro Akitsu
Schiff Base in Organic Inorganic and Physical Chemistry Book PDF

Author : Takashiro Akitsu
Publisher : BoD – Books on Demand
Page : 210 pages
File Size : 55,6 Mb
Release : 2023-03-08
Category : Science
ISBN : 9781803556789

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Schiff Base in Organic, Inorganic and Physical Chemistry by Takashiro Akitsu Pdf

A Schiff base (imine -N=CH-) is a part of a popular group of organic compounds prepared form primary amines and aldehyde. Many studies have been carried out on Schiff bases not only as organic compounds but also as ligands for metal complexes. In this context, this book provides a comprehensive, interdisciplinary review of Schiff base compounds, with an emphasis on the latest advances. It compiles research results, commentary, reviews, and more dealing with preparation, spectroscopy, crystallography, (asymmetric) synthetic roles, physical properties (magnets, optics, etc.), computational chemistry, and theoretical chemistry. The book focuses on Schiff base and its strong connection to organic chemistry, biochemistry, and polymer materials chemistry. It covers three topics: Schiff base of organic chemistry, Schiff base of inorganic chemistry, and Schiff base of functional or biological materials.