Chelation Therapy In The Treatment Of Metal Intoxication

Author : Jan Aaseth,Guido Crisponi,Ole Anderson
Publisher : Academic Press
Page : 388 pages
File Size : 52,6 Mb
Release : 2016-04-18
Category : Medical
ISBN : 9780128030738

Get Book

Chelation Therapy in the Treatment of Metal Intoxication by Jan Aaseth,Guido Crisponi,Ole Anderson Pdf

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Author : Dr. Eleonore Blaurock-Busch, PhD,Dr. Swaran J.S. Flora, PhD,Dr. Ebrahim Sulaiman, MD
Publisher : BoD – Books on Demand
Page : 122 pages
File Size : 53,8 Mb
Release : 2020-06-02
Category : Medical
ISBN : 9783750428676

Get Book

Evidence-Based Clinical Chelation by Dr. Eleonore Blaurock-Busch, PhD,Dr. Swaran J.S. Flora, PhD,Dr. Ebrahim Sulaiman, MD Pdf

This is an easy-to-read manual about chelation therapy. It contains specific protocols for the treatment of chronic metal overexposure, all of which are evidence-based, aiding the inexperienced and the experienced therapist in selecting the optimal chelating agent for the metal(s) in question. Expert chemists and chelation therapists have contributed invaluable knowledge and experience to this book. Most importantly, this is not a book promoting personal views or preferences. In fact, the information presents and explains different approaches, and allows the reader to draw his own conclusion. All the protocols listed have been modified for the treatment of chronic metal intoxication, included are oral and intravenous treatment plans. The authors explain in simple terms how a chelating agent ́s bioavailability affects metal binding and how various protocols such as the Cutler Protocol affect the detoxification process, why DMPS binds mercury and which chelators are useful for the detoxification of certain organ system. Also discussed is the importance and effect of treatment pauses. Diagnostic tests are discussed, and which are useful under certain conditions. Shown are tables comparing the average metal binding ability of the various EDTAs, DMPS, DMSA and other chelating agents. Detailed information explains which chelator binds which metal and why, all of which aids the therapist in finding optimal treatment schedules. Novel chelating agents are presented such as MIADMSA, a new oral chelator specifically designed for arsenic intoxication, or how natural Pectin may be used an alternative for gadolinium intoxication, which metals are bound by lipoic acid and why a slightly alkaline environment supports metal binding, even preventing the often-feared metal redistribution. All in all, this evidence-based chelation "cookbook" should be in medical libraries and on the bookshelf of every physician treating environmental disease.

Author : Robert R Crichton,Roberta J Ward,Robert C Hider
Publisher : Royal Society of Chemistry
Page : 322 pages
File Size : 55,6 Mb
Release : 2016-10-18
Category : Science
ISBN : 9781782623892

Get Book

Metal Chelation in Medicine by Robert R Crichton,Roberta J Ward,Robert C Hider Pdf

Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

Author : Chaim Hershko
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 40,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461505938

Get Book

Iron Chelation Therapy by Chaim Hershko Pdf

Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 640 pages
File Size : 53,7 Mb
Release : 2019-01-14
Category : Science
ISBN : 9783110526981

Get Book

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by Peggy L. Carver Pdf

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Page : 848 pages
File Size : 43,6 Mb
Release : 1999
Category : Medical
ISBN : 0781719526

Get Book

Hepatotoxicity by Hyman J. Zimmerman Pdf

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Author : Swaran Jeet Singh Flora
Publisher : Academic Press
Page : 752 pages
File Size : 51,7 Mb
Release : 2014-12-26
Category : Medical
ISBN : 9780124199552

Get Book

Handbook of Arsenic Toxicology by Swaran Jeet Singh Flora Pdf

Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. Brings together current findings on the effects of arsenic on the environment and human health Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms Provides all the information needed for effective risk assessment, prevention and countermeasure

Author : Herman Richard Casdorph,Morton Walker
Publisher : Penguin
Page : 436 pages
File Size : 46,9 Mb
Release : 1995
Category : Fiction
ISBN : 0895296497

Get Book

Toxic Metal Syndrome by Herman Richard Casdorph,Morton Walker Pdf

"Toxic Metal Syndrome" exposes the root causes of the wastes that cause debilitating conditions and pollute the environment and explodes the myth that nothing can be done to avoid or treat them.

Author : Sarah E. Royce
Publisher : Unknown
Page : 60 pages
File Size : 47,7 Mb
Release : 2000
Category : Lead
ISBN : UOM:39015051606617

Get Book

Lead Toxicity by Sarah E. Royce Pdf

Author : Gerard Marshall Raj,Ramasamy Raveendran
Publisher : Springer Nature
Page : 410 pages
File Size : 55,9 Mb
Release : 2019-11-16
Category : Medical
ISBN : 9789813297791

Get Book

Introduction to Basics of Pharmacology and Toxicology by Gerard Marshall Raj,Ramasamy Raveendran Pdf

This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.

Author : Prem Chhatwani
Publisher : Speedy Publishing LLC
Page : 49 pages
File Size : 53,5 Mb
Release : 2013-10-06
Category : Health & Fitness
ISBN : 9781631876516

Get Book

EDTA by Prem Chhatwani Pdf

A must read book for Men and women. Do not miss the important message for the Ladies in chapter 9. See what others are saying. * The finest book I have read in a long time. * Helpful read backed with facts & case studies * Low cost life saving technology. *EDTA Chelation: Common Therapy for Metal Toxicity with Unexpected Benefits! * A GREAT BOOK ON METAL DETOXIFICATION An effective and life saving alternative therapy, using EDTA Chelation, for restoring blood circulation in patients affected by blocked arteries. Completely non-invasive painless treatment done in an outpatient setting. Equally effective to heal patients suffering from Cancer, Diabetes, High Blood Pressure and other diseases of Aging. TABLE OF CONTENTS 1.Introduction 2.Actual Case Studies 3.History Of Chelation 4.How Chelation Works 5.Mercury in your blood-how we get it and how to get rid of it? 6.Oral Chelation Vs IV Chelation 7.How to Find a Trained Practitioner where you are! 8.Latest Medical Tests Worth Your Investigation 9.Important Message for the Ladies! 10. Resources

Author : Carlo Colosimo,Antonio Gil-Nagel,Nils Erik Gilhus,Alan M. Rapoport,Olajide Williams
Publisher : Oxford University Press, USA
Page : 481 pages
File Size : 51,8 Mb
Release : 2015
Category : Medical
ISBN : 9780199862924

Get Book

Handbook of Neurological Therapy by Carlo Colosimo,Antonio Gil-Nagel,Nils Erik Gilhus,Alan M. Rapoport,Olajide Williams Pdf

This is a practical book on neurological therapy. It is aimed at giving concise and updated answers to busy practicing clinicians in the clinic, ward, or emergency department. An evidence-based approach is used, but when there is no evidence or the data are inconclusive, an expert opinion is always given in order to meet the expectations of the reader. All neurological conditions, common and less common, are discussed; each chapter has a similar format, and contains an initial brief introduction on the epidemiology and clinical features of each disease. The therapy is then discussed, including pharmacological and non-pharmacological, with wide use of Tables & Figures. Flowcharts are also included in most of the chapters.

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on the Toxicological Effects of Methylmercury
Publisher : National Academies Press
Page : 364 pages
File Size : 48,5 Mb
Release : 2000-09-27
Category : Nature
ISBN : 9780309171717

Get Book

Toxicological Effects of Methylmercury by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on the Toxicological Effects of Methylmercury Pdf

Mercury is widespread in our environment. Methylmercury, one organic form of mercury, can accumulate up the aquatic food chain and lead to high concentrations in predatory fish. When consumed by humans, contaminated fish represent a public health risk. Combustion processes, especially coal-fired power plants, are major sources of mercury contamination in the environment. The U.S. Environmental Protection Agency (EPA) is considering regulating mercury emissions from those plants. Toxicological Effects of Methylmercury reviews the health effects of methylmercury and discusses the estimation of mercury exposure from measured biomarkers, how differences between individuals affect mercury toxicity, and appropriate statistical methods for analysis of the data and thoroughly compares the epidemiological studies available on methylmercury. Included are discussions of current mercury levels on public health and a delineation of the scientific aspects and policy decisions involved in the regulation of mercury. This report is a valuable resource for individuals interested in the public health effects and regulation of mercury. The report also provides an excellent example of the implications of decisions in the risk assessment process for a larger audience.

Author : Richard Eugene Frye,Michael Berk
Publisher : Springer
Page : 394 pages
File Size : 45,5 Mb
Release : 2018-09-20
Category : Medical
ISBN : 9789811053115

Get Book

The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine by Richard Eugene Frye,Michael Berk Pdf

Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.

Author : Institute of Medicine,Committee on Curriculum Development in Environmental Medicine
Publisher : National Academies Press
Page : 988 pages
File Size : 41,9 Mb
Release : 1995-05-28
Category : Medical
ISBN : 9780309051408

Get Book

Environmental Medicine by Institute of Medicine,Committee on Curriculum Development in Environmental Medicine Pdf

People are increasingly concerned about potential environmental health hazards and often ask their physicians questions such as: "Is the tap water safe to drink?" "Is it safe to live near power lines?" Unfortunately, physicians often lack the information and training related to environmental health risks needed to answer such questions. This book discusses six competency based learning objectives for all medical school students, discusses the relevance of environmental health to specific courses and clerkships, and demonstrates how to integrate environmental health into the curriculum through published case studies, some of which are included in one of the book's three appendices. Also included is a guide on where to obtain additional information for treatment, referral, and follow-up for diseases with possible environmental and/or occupational origins.