Experimental And Clinical Evidence Of The Neuropathology Of Parkinson S Disease

Author : Ahmed Draoui,Omar El Hiba,Arumugam R. Jayakumar
Publisher : Medical Information Science Reference
Page : 0 pages
File Size : 53,8 Mb
Release : 2023-06-30
Category : Electronic
ISBN : 1668451565

Get Book

Experimental and Clinical Evidence of the Neuropathology of Parkinson's Disease by Ahmed Draoui,Omar El Hiba,Arumugam R. Jayakumar Pdf

Parkinson's disease is the second most common neurodegenerative disorder in the world after Alzheimer's disease. Thanks to the pioneering works of Arvid Carlson in the 20th century identifying dopamine as the main neurochemical agent involved in Parkinson's disease's onset and progress, our understanding of the neuropathology has increased. The elaboration of L-Dopa as the first pharmacological treatment approach has brought new hope for curing or at least slowing the neurodegenerative progress and the decline of motor and cognitive functions in Parkinson's disease patients. To date, imaging techniques along with genetic and biochemical tools have allowed scientists and clinicians to predict and diagnose the disease several years prior to the motor disorder's appearance. Experimental and Clinical Evidence of the Neuropathology of Parkinson's Disease sheds light on the history of Parkinson's disease as well as the recent literature on the epidemiological data worldwide including the prevalence of the disease, the morbimortality rates, and the sex dimorphism and aging components. It addresses the current neuropathological evidence of Parkinson's disease, including the latest discoveries in terms of neuropathology and treatments available or under clinical trials with the efficacy and limitations of each. Covering topics such as epidemiology, stem cells, and neuropathology, this premier reference source is an excellent resource for clinicians, physicians, epidemiologists, neuroscientists, microbiologists, biochemists, pharmacologists, toxicologists, medical professionals, nurses, medical students and educators, librarians, researchers, and academicians.

Author : Jonas H. Ellenberg,William C. Koller,James William Langston
Publisher : CRC Press
Page : 600 pages
File Size : 49,7 Mb
Release : 1995-03-01
Category : Medical
ISBN : 0824788230

Get Book

Etiology of Parkinson's Disease by Jonas H. Ellenberg,William C. Koller,James William Langston Pdf

This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Author : Martina Mancini,John G. Nutt,Fay B. Horak
Publisher : Academic Press
Page : 226 pages
File Size : 47,7 Mb
Release : 2019-09-14
Category : Medical
ISBN : 9780128138755

Get Book

Balance Dysfunction in Parkinson’s Disease by Martina Mancini,John G. Nutt,Fay B. Horak Pdf

Balance Dysfunction in Parkinson’s Disease: Basic Mechanisms to Clinical Management presents the most updated information on a variety of topics. Sections help clinicians evaluate the types of balance control issues, dynamic balance dysfunction during turning, and the effects of medication, deep brain stimulation, and rehabilitation intervention on balance control. This book is the first to review the four main postural control systems and how they are affected, including balance during quiet stance, reactive postural adjustments to external perturbations, anticipatory postural adjustments in preparation for voluntary movements, and dynamic balance control during walking and turning. In addition, the book's authors summarize the effects of levodopa, deep brain stimulation, and rehabilitation intervention for each balance domain. This book is recommended for anyone interested in how and why balance control is affected by PD. Provides the first comprehensive review of research to date on balance dysfunctions in Parkinson's disease Discusses how to translate current neuroscience research into practice regarding neural control of balance Provides evidence on the effects of current interventions on balance control

Author : Frank Clifford Rose
Publisher : Demos Medical Publishing
Page : 232 pages
File Size : 53,9 Mb
Release : 1987
Category : Parkinson's disease
ISBN : UCSD:31822003947520

Get Book

Parkinson's Disease by Frank Clifford Rose Pdf

This volume surveys advances that have occured in the last five years. The increased understanding in the neuropathology and neurophysiology of the disease are discussed as well as its history, new drug therapy and the possibility that transplantation of brain cells will prove an effective remedy.

Author : Draoui, Ahmed,El Hiba, Omar,Jayakumar, Arumugam R.
Publisher : IGI Global
Page : 475 pages
File Size : 44,9 Mb
Release : 2023-08-04
Category : Medical
ISBN : 9781668451571

Get Book

Experimental and Clinical Evidence of the Neuropathology of Parkinson’s Disease by Draoui, Ahmed,El Hiba, Omar,Jayakumar, Arumugam R. Pdf

Parkinson’s disease is the second most common neurodegenerative disorder in the world after Alzheimer’s disease. Thanks to the pioneering works of Arvid Carlson in the 20th century identifying dopamine as the main neurochemical agent involved in Parkinson’s disease’s onset and progress, our understanding of the neuropathology has increased. The elaboration of L-Dopa as the first pharmacological treatment approach has brought new hope for curing or at least slowing the neurodegenerative progress and the decline of motor and cognitive functions in Parkinson’s disease patients. To date, imaging techniques along with genetic and biochemical tools have allowed scientists and clinicians to predict and diagnose the disease several years prior to the motor disorder’s appearance. Experimental and Clinical Evidence of the Neuropathology of Parkinson’s Disease sheds light on the history of Parkinson’s disease as well as the recent literature on the epidemiological data worldwide including the prevalence of the disease, the morbimortality rates, and the sex dimorphism and aging components. It addresses the current neuropathological evidence of Parkinson’s disease, including the latest discoveries in terms of neuropathology and treatments available or under clinical trials with the efficacy and limitations of each. Covering topics such as epidemiology, stem cells, and neuropathology, this premier reference source is an excellent resource for clinicians, physicians, epidemiologists, neuroscientists, microbiologists, biochemists, pharmacologists, toxicologists, medical professionals, nurses, medical students and educators, librarians, researchers, and academicians.

Author : Anonim
Publisher : Elsevier
Page : 368 pages
File Size : 43,5 Mb
Release : 2010-10-13
Category : Science
ISBN : 0444537511

Get Book

Recent Advances in Parkinsons Disease by Anonim Pdf

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author : Peter Riederer,Heinz Reichmann,Moussa B. H. Youdim,Manfred Gerlach
Publisher : Springer Science & Business Media
Page : 484 pages
File Size : 50,5 Mb
Release : 2006-11-23
Category : Medical
ISBN : 9783211452950

Get Book

Parkinson's Disease and Related Disorders by Peter Riederer,Heinz Reichmann,Moussa B. H. Youdim,Manfred Gerlach Pdf

This book gives a comprehensive overview on current clinical and basic research issues related to Parkinson’s disease and its related disorders. The book is the result of the 16th International Congress of Parkinson’s Disease and Related disorders congress 2005. Its contents are suitable for neurologists, psychiatrists, neurosurgeons, basic researchers, geneticians and patients as well as their relatives.

Author : John Mitrofanis
Publisher : Morgan & Claypool Publishers
Page : 172 pages
File Size : 49,7 Mb
Release : 2019-08-05
Category : Science
ISBN : 9781643277202

Get Book

Run in the Light by John Mitrofanis Pdf

Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity. In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (λ=600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful "dynamic duo", offering a most effective neuroprotective treatment option to patients.

Author : Cristian Falup-Pecurariu,Peter Jenner
Publisher : Academic Press
Page : 314 pages
File Size : 55,8 Mb
Release : 2021-09-28
Category : Technology & Engineering
ISBN : 9780323851237

Get Book

Autonomic Dysfunction in Parkinson's Disease by Cristian Falup-Pecurariu,Peter Jenner Pdf

Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson’s disease. Autonomic Dysfunction in Parkinson's Disease provides up to date information on this important topic, which affects quality of life of these patients. This include a large number of domains: orthostatic hypotension, excessive sweating, dry eyes, constipation, weight loss, increased sensitivity to heat and cold, sexual dysfunction. Provides comprehensive reviews on different topics of autonomic dysfunction in Parkinson’s disease Each chapter covers a specific autonomic symptom: classification, assessment, treatment Presents the newest information on each autonomic symptom in Parkinson’s disease

Author : K. Ray Chaudhuri,Eduardo Tolosa,Anthony H. V. Schapira,Werner Poewe
Publisher : Oxford University Press, USA
Page : 517 pages
File Size : 50,7 Mb
Release : 2014
Category : Medical
ISBN : 9780199684243

Get Book

Non-Motor Symptoms of Parkinson's Disease by K. Ray Chaudhuri,Eduardo Tolosa,Anthony H. V. Schapira,Werner Poewe Pdf

Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.

Author : Dennis Dickson,Roy O. Weller
Publisher : John Wiley & Sons
Page : 497 pages
File Size : 40,6 Mb
Release : 2011-09-09
Category : Medical
ISBN : 9781444341232

Get Book

Neurodegeneration by Dennis Dickson,Roy O. Weller Pdf

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Author : Dr. Stewart A. Factor, DO,Dr. William Weiner, MD
Publisher : Demos Medical Publishing
Page : 1024 pages
File Size : 45,5 Mb
Release : 2007-12-15
Category : Medical
ISBN : 1934559873

Get Book

Parkinson's Disease by Dr. Stewart A. Factor, DO,Dr. William Weiner, MD Pdf

Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Still the only major text on the subject, the completely revised and updated second edition of Parkinson's Disease: Diagnosis and Clinical Management comes at a time when specialists have made important advances in our understanding of the etiology, pathogenesis, investigation, and management of Parkinson's disease. The book includes 23 completely new chapters, and has updated information on: Genetics Pathology Biomarkers Pathogenesis Impulse control disorders in Parkinson's disease Updated outcome measures Complementary and alternative medicine for the treatment of Parkinson's disease Together the chapters form a comprehensive review of the many issues facing PD physicians today. Lucid and easily readable from beginning to end, each chapter may also stand on its own as a scholarly review of the individual subject. Each one is concisely written and heavily referenced for this purpose. The second edition of Parkinson's Disease: Diagnosis and Clinical Management provides a state-of-the-art review of where we've been, where we are now, and where we are going in treating this disease.

Author : Carol Brayne,Professor of Public Health Medicine and Director of the Cambridge University Department of Public Health Carol Brayne,Director National Institute for Stroke and Applied Neuroscience (Nisan) Valery Feigin,Valery Feigin,Lenore Launer,Giancarlo Logroscino
Publisher : Oxford University Press, USA
Page : 513 pages
File Size : 43,8 Mb
Release : 2020-11-02
Category : Medical
ISBN : 9780198749493

Get Book

Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology by Carol Brayne,Professor of Public Health Medicine and Director of the Cambridge University Department of Public Health Carol Brayne,Director National Institute for Stroke and Applied Neuroscience (Nisan) Valery Feigin,Valery Feigin,Lenore Launer,Giancarlo Logroscino Pdf

The Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology focuses on the overlaps between neuro-epidemiological disorders. Harmonising cohort studies to determine causes related to rarer disorders, this key work is an invaluable reference to current neuro-epidemiological methods.

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
Page : 319 pages
File Size : 50,5 Mb
Release : 2015
Category : Medical
ISBN : 9781107442429

Get Book

Neuropathology of Neurodegenerative Diseases Book and Online by Gabor G. Kovacs Pdf

This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.

Author : David Crosiers,Patrick Santens,K. Ray Chaudhuri
Publisher : Frontiers Media SA
Page : 90 pages
File Size : 40,9 Mb
Release : 2021-02-17
Category : Medical
ISBN : 9782889664894

Get Book

Prodromal Parkinson’s Disease by David Crosiers,Patrick Santens,K. Ray Chaudhuri Pdf