Exploring New Findings On Amyloidosis

Author : Ana Maria Fernandez-Escamilla
Publisher : BoD – Books on Demand
Page : 348 pages
File Size : 43,8 Mb
Release : 2016-08-24
Category : Medical
ISBN : 9789535126188

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Exploring New Findings on Amyloidosis by Ana Maria Fernandez-Escamilla Pdf

Amyloid protein aggregates are involved in ''protein-misfolding diseases'' of enormous social and economic impact, still with no effective therapies. The most prevalent amyloid pathologies are related to neurodegenerative diseases, but amyloidosis also affects other organs. The majority of the studies includes serious health connotations on amyloids. However, not all amyloid fibers play a detrimental role in host. An increasing number of studies shows an important beneficial role as ''functional amyloids''. This book opens an exciting door to provide up-to-date information about the function and the mechanisms of the amyloid formation process from the structural, biophysical, biomedical, and nanotechnological perspective, combining the new findings on toxic and functional amyloids studies using theoretical and experimental approaches to fight against amyloid-based diseases.

Author : Morie A. Gertz,S. Vincent Rajkumar
Publisher : Springer Science & Business Media
Page : 243 pages
File Size : 54,5 Mb
Release : 2010-06-14
Category : Medical
ISBN : 9781607616313

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Amyloidosis by Morie A. Gertz,S. Vincent Rajkumar Pdf

An up-to-date reference on this fascinating set of complex disorders, this book features the most comprehensive strategies for diagnosing, classifying, imaging, treating, and managing amyloidosis in multiple organ systems. Beneficial to the spectrum of practitioners from residents to sub-specialists, this book is a succinct authoritative text written by leaders in the field. The authors provide instruction on all forms of amyloidosis - including primary amyloidosis (AL), secondary amyloidosis (AA), and familial amyloidosis. With essential treatment algorithms, Amyloidosis: Diagnosis and Treatment is the gold-standard for all hematologists, oncologists, and internists caring for patients with this complex disease.

Author : Aldostefano Porcari,Gianfranco Sinagra,Julian Gillmore,Claudio Rapezzi
Publisher : Frontiers Media SA
Page : 107 pages
File Size : 49,5 Mb
Release : 2023-08-02
Category : Medical
ISBN : 9782832531242

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Proceedings and Predictions in Cardiac Amyloidosis: Unsolved mysteries and challenges for the future by Aldostefano Porcari,Gianfranco Sinagra,Julian Gillmore,Claudio Rapezzi Pdf

Author : Josefine Hirschfeld,Iain L. C. Chapple
Publisher : Quintessenz Verlag
Page : 502 pages
File Size : 51,8 Mb
Release : 2021-04-19
Category : Medical
ISBN : 9783868675573

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Periodontitis and Systemic Diseases by Josefine Hirschfeld,Iain L. C. Chapple Pdf

The association between periodontitis and systemic diseases has become a hot topic in recent years. This comprehensive book reviews the clinical evidence and biological plausibility of the many systemic diseases that have been linked to periodontitis. Edited by Dr Josefine Hirschfeld and Prof Iain L.C. Chapple, experts in each field discuss the mechanisms at work, citing the available key literature and clearly summarising current knowledge and understanding of the associations between periodontitis and diabetes mellitus, cardiovascular diseases, chronic kidney disease, inflammatory bowel diseases, rheumatoid arthritis, respiratory diseases, pregnancy and fertility, malignancy, neurodegenerative diseases, stress and depression, and autoimmunity. Each chapter critically appraises the existing evidence, providing comprehensive, contemporary and well-considered insights into the clinical evidence and biological plausibility of each condition, as well as the limitations of existing studies and how these can be overcome in the future. Periodontitis and Systemic Diseases: Clinical Evidence and Biological Plausibility is an indispensable reference for both clinicians and researchers.

Author : Dmitry Kurouski
Publisher : BoD – Books on Demand
Page : 244 pages
File Size : 46,8 Mb
Release : 2019-08-07
Category : Medical
ISBN : 9781789853810

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Amyloid Diseases by Dmitry Kurouski Pdf

Neurodegenerative diseases are severe, rapidly developing, and currently incurable conditions that result in progressive degeneration and the death of neurons. This causes dementia, movement problems, and essentially loss of personal identity. Amyloids attempts to answer the following questions: (1) why do we develop these severe neurodegenerative diseases? (2) what histological and physiological changes are observed upon development and progression of these diseases? and (3) how can we treat amyloid-associated diseases?

Author : Ray Griffiths
Publisher : Singing Dragon
Page : 338 pages
File Size : 43,9 Mb
Release : 2018-04-19
Category : Health & Fitness
ISBN : 9780857012883

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Mitochondria in Health and Disease by Ray Griffiths Pdf

What are the functions of mitochondria in the human body? Why might they stop working properly and what can happen as a result? How can personalized nutrition help to optimize mitochondrial function and prevent or address chronic conditions? This innovative book explores the incredibly complex biochemical roles of mitochondria in health and disease. When healthy, mitochondria provide us with ninety percent of our body's energy. When unhealthy, this can lead to many chronic and degenerative conditions including cancer and Alzheimer's disease. This guide helps practitioners to identify the mitochondrial dysfunction underlying a wide range of health complaints, and provides inspiration about relevant and emerging mitochondria-supportive dietary regimes and nutrients to explore within the model of personalized nutrition.

Author : Maria M. Picken,Guillermo A. Herrera,Ahmet Dogan
Publisher : Humana Press
Page : 542 pages
File Size : 42,5 Mb
Release : 2015-08-17
Category : Medical
ISBN : 9783319192949

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Amyloid and Related Disorders by Maria M. Picken,Guillermo A. Herrera,Ahmet Dogan Pdf

The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered. Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.

Author : Cassandra Jones
Publisher : Unknown
Page : 0 pages
File Size : 41,8 Mb
Release : 2015-02-10
Category : Electronic
ISBN : 1632421275

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Encyclopedia of Amyloidosis by Cassandra Jones Pdf

This book combines a basic understanding of amyloidosis with a discussion of the advancements in treatment strategies of this disease. Amyloidosis is a gradually progressive condition characterized by the occurrence of extracellular fibrillar proteins in many organs and tissues. It has systemic and locally confined forms, and both these forms have been a point of interest for many experts. There have been a large number of case studies regarding amyloidosis in the last few years. This book intends to help students and even experts in comprehending the topic thoroughly and accomplish their respective researches.

Author : Ramasamy Paulmurugan,Tarik F. Massoud
Publisher : Academic Press
Page : 832 pages
File Size : 48,6 Mb
Release : 2021-06-25
Category : Science
ISBN : 9780128215685

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Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies by Ramasamy Paulmurugan,Tarik F. Massoud Pdf

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

Author : Brian J. Hall,Cary Chisholm,Travis Vandergriff,Chad Jessup
Publisher : Elsevier Health Sciences
Page : 765 pages
File Size : 40,8 Mb
Release : 2016-10-20
Category : Medical
ISBN : 9780323443111

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Diagnostic Pathology: Nonneoplastic Dermatopathology E-Book by Brian J. Hall,Cary Chisholm,Travis Vandergriff,Chad Jessup Pdf

Part of the highly regarded Diagnostic Pathology series, Diagnostic Pathology: Nonneoplastic Dermatopathology, Second Edition is designed to improve patient care by breaking down the subject of inflammatory dermatopathology into digestible chapters, equipping physicians with the knowledge necessary to reach a confident diagnosis. Classic histologic images highlighting the most important findings are also included, making this a perfect visual aid for residents and practicing pathologists alike. Includes clinical images of nearly all 275 diagnoses discussed in the book, ensuring a better understanding of the clinical appearance of these lesions correlated with their major histologic and clinical differential diagnoses Features 103 new diagnoses with an emphasis on rare but important diseases Provides practical and accessible clinical references for many lesions not often seen or taught outside of a specific clinical rotation in dermatology or dermatopathology Includes two brand new sections on spirochetal diseases and disorders of pigmentation

Author : Thimmaiah Govindaraju
Publisher : Royal Society of Chemistry
Page : 695 pages
File Size : 46,6 Mb
Release : 2022-01-04
Category : Medical
ISBN : 9781839162749

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Alzheimer's Disease by Thimmaiah Govindaraju Pdf

Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.

Author : Jolanta Dorszewska,Wojciech Kozubski
Publisher : BoD – Books on Demand
Page : 164 pages
File Size : 50,9 Mb
Release : 2018-07-18
Category : Medical
ISBN : 9781789234626

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Alzheimer's Disease by Jolanta Dorszewska,Wojciech Kozubski Pdf

Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.

Author : G.A. Herrera
Publisher : Karger Medical and Scientific Publishers
Page : 381 pages
File Size : 41,5 Mb
Release : 2011-01-14
Category : Medical
ISBN : 9783805595384

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Experimental Models for Renal Diseases by G.A. Herrera Pdf

Our understanding of the pathogenesis of renal diseases and the ability to accurately classify and diagnose them has improved considerably over the last two decades. Until now, however, this information has not been available in a single, up-to-date and succinct yet comprehensive source. The publication at hand aims at filling this gap, condensing a vast amount of information into easily accessible chapters.After a discussion of basic concepts and principles of renal tissue reactions to injurious agents using a specific cell/compartment approach, a multitude of disorders are looked at, including renal interstitial fibrosis, glomerulosclerosis, various forms of glomerulonephritis and nephropathy, amyloidosis and renal Fanconi syndrome. Some of the chapters address controversial subjects, reporting the current situation and showing areas of future potential research interest. At the end of many of the contributions, a summary is provided, often in the form of a chart to facilitate the understanding of the information and to make it most useful for didactic purposes.This book is intended for students of various disciplines, as well as clinicians and investigators and all those trying to correlate basic research information with clinical issues.

Author : Gilles Grateau,Robert A. Kyle,Martha Skinner
Publisher : CRC Press
Page : 576 pages
File Size : 47,9 Mb
Release : 2004-11-29
Category : Medical
ISBN : 9781420037494

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Amyloid and Amyloidosis by Gilles Grateau,Robert A. Kyle,Martha Skinner Pdf

This authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins, protein folding disorders, and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techniques; biological functions; genetics; disorders, diagnosis, and treatments, incl

Author : Jesus Jimenez-Barbero,F. Javier Canada,Sonsoles Martin-Santamaria
Publisher : Royal Society of Chemistry
Page : 320 pages
File Size : 55,6 Mb
Release : 2015-03-30
Category : Science
ISBN : 9781849739993

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Carbohydrates in Drug Design and Discovery by Jesus Jimenez-Barbero,F. Javier Canada,Sonsoles Martin-Santamaria Pdf

In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery. Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.