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Author : Aldostefano Porcari,Gianfranco Sinagra,Julian Gillmore,Claudio Rapezzi
Publisher : Frontiers Media SA
Page : 107 pages
File Size : 42,5 Mb
Release : 2023-08-02
Category : Medical
ISBN : 9782832531242
Author : Junjie Xiao
Publisher : Springer
Page : 426 pages
File Size : 54,8 Mb
Release : 2021-04-28
Category : Science
ISBN : 9811516731
This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.
Author : Perry Elliott,Professor of Cardiovascular Medicine University College London Head of the Ucl Centre for Heart Muscle Disease and Lead of the Inherited Cardiovascular Disease Unit Perry Elliott,Pier D. Lambiase,Dhavendra Kumar,Visiting Professor at the Genomic Policy Unit the University of South Wales and Consultant in Clinical Genetics Dhavendra Kumar
Publisher : Oxford University Press, USA
Page : 433 pages
File Size : 47,9 Mb
Release : 2020-11-11
Category : Medical
ISBN : 9780198829126
Fully updated to reflect advances in molecular genetic technologies and national guidelines on inherited cardiac diseases in families, this second edition provides a comprehensive summary of the aetiology, presentation, and management of genetic disorders of the cardiovascular system.
Author : Anonim
Publisher : Bbva-Open Mind
Page : 408 pages
File Size : 43,9 Mb
Release : 2017-03
Category : Science
ISBN : 8416714452
The Next Step: Exponential Life presents essays on the potential of what are known as "exponential technologies"--those whose development is accelerating rapidly, such as robotics, artificial intelligence or industrial biology--considering their economic, social, environmental, ethical and even ontological implications. This book's premise is that humanity is at the beginning of a technological revolution that is evolving at a much faster pace than earlier ones--a revolution is so far-reaching it is destined to generate transformations we can only begin to imagine. Contributors include Aubrey D.N.J. de Grey, Jonathan Rossiter, Joseph A. Paradiso, Kevin Warwick, Huma Shah, Ramón López de Mántaras, Helen Papagiannis, Jay David Bolter, Maria Engberg, Robin Hanson, Stuart Russell, Darrell M. West, Francisco González, Chris Skinner, Steven Monroe Lipkin, S. Matthew Liao, James Giordano, Luciano Floridi, Seán Ó Héigeartaigh and Martin Rees.
Author : Linda B. Nilson
Publisher : John Wiley & Sons
Page : 401 pages
File Size : 41,9 Mb
Release : 2010-04-20
Category : Education
ISBN : 9780470612361
Teaching at Its Best This third edition of the best-selling handbook offers faculty at all levels an essential toolbox of hundreds of practical teaching techniques, formats, classroom activities, and exercises, all of which can be implemented immediately. This thoroughly revised edition includes the newest portrait of the Millennial student; current research from cognitive psychology; a focus on outcomes maps; the latest legal options on copyright issues; and how to best use new technology including wikis, blogs, podcasts, vodcasts, and clickers. Entirely new chapters include subjects such as matching teaching methods with learning outcomes, inquiry-guided learning, and using visuals to teach, and new sections address Felder and Silverman's Index of Learning Styles, SCALE-UP classrooms, multiple true-false test items, and much more. Praise for the Third Edition of Teaching at Its BestEveryone veterans as well as novices will profit from reading Teaching at Its Best, for it provides both theory and practical suggestions for handling all of the problems one encounters in teaching classes varying in size, ability, and motivation." Wilbert McKeachie, Department of Psychology, University of Michigan, and coauthor, McKeachie's Teaching TipsThis new edition of Dr. Nilson's book, with its completely updated material and several new topics, is an even more powerful collection of ideas and tools than the last. What a great resource, especially for beginning teachers but also for us veterans!" L. Dee Fink, author, Creating Significant Learning ExperiencesThis third edition of Teaching at Its Best is successful at weaving the latest research on teaching and learning into what was already a thorough exploration of each topic. New information on how we learn, how students develop, and innovations in instructional strategies complement the solid foundation established in the first two editions." Marilla D. Svinicki, Department of Psychology, The University of Texas, Austin, and coauthor, McKeachie's Teaching Tips
Author : National Research Council,Division on Engineering and Physical Sciences,Board on Physics and Astronomy,Solid State Sciences Committee,Committee on Opportunities in High Magnetic Field Science
Publisher : National Academies Press
Page : 189 pages
File Size : 42,5 Mb
Release : 2005-08-26
Category : Science
ISBN : 9780309095822
High-field magnetsâ€"those that operate at the limits of the mechanical and/or electromagnetic properties of their structural materialsâ€"are used as research tools in a variety of scientific disciplines. The study of high magnetic fields themselves is also important in many areas such as astrophysics. Because of their importance in scientific research and the possibility of new breakthroughs, the National Science Foundation asked the National Research Council to assess the current state of and future prospects for high-field science and technology in the United States. This report presents the results of that assessment. It focuses on scientific and technological challenges and opportunities, and not on specific program activities. The report provides findings and recommendations about important research directions, the relative strength of U.S. efforts compared to other countries, and ways in which the program can operate more effectively.
Author : Ambrose S. Kibos,Bradley P. Knight,Vidal Essebag,Steven B. Fishberger,Mark Slevin,Ion C. Țintoiu
Publisher : Springer
Page : 0 pages
File Size : 40,5 Mb
Release : 2016-09-27
Category : Medical
ISBN : 1447170156
This book covers all the major aspects associated with pathophysiological development of cardiac arrhythmias (covering enhanced or suppressed automaticity, triggered activity, or re-entry), from basic concepts through disease association, limitations of current pharmacotherapy and implant therapies and on-going trials and analysis of new biomarkers based on current knowledge of cellular interaction and signalling. The book describes novel and state-of-the-art methods for differentiating between the major types of arrhythmia, structural abnormalities and current practice guidelines and determination of risk stratification associated with sudden cardiac death. A particular focus is on arrhythmias associated with atrial fibrillation and includes details of associations with cardiac disease, current detection, analysis and imaging and future perspectives.
Author : Y. Hirabayashi,Y. Igarashi,A.H. Jr. Merrill
Publisher : Springer Science & Business Media
Page : 528 pages
File Size : 49,5 Mb
Release : 2007-12-31
Category : Science
ISBN : 9784431342007
Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.
Author : Hans-Curt Flemming,Dr Thomas R. Neu,Dr Jost Wingender
Publisher : IWA Publishing
Page : 336 pages
File Size : 53,8 Mb
Release : 2016-09-15
Category : Science
ISBN : 9781780407418
The Perfect Slime presents the latest state of knowledge and all aspects of the Extracellular Polymeric Substances, (EPS) matrix – from the ecological and health to the antifouling perspectives. The book brings together all the current material in order to expand our understanding of the functions, properties and characteristics of the matrix as well as the possibilities to strengthen or weaken it. The EPS matrix represents the immediate environment in which biofilm organisms live. From their point of view, this matrix has paramount advantages. It allows them to stay together for extended periods and form synergistic microconsortia, it retains extracellular enzymes and turns the matrix into an external digestion system and it is a universal recycling yard, it protects them against desiccation, it allows for intense communication and represents a huge genetic archive. They can remodel their matrix, break free and eventually, they can use it as a nutrient source. The EPS matrix can be considered as one of the emergent properties of biofilms and are a major reason for the success of this form of life. Nevertheless, they have been termed the “black matter of biofilms” for good reasons. First of all: the isolation methods define the results. In most cases, only water soluble EPS components are investigated; insoluble ones such as cellulose or amyloids are much less included. In particular in environmental biofilms with many species, it is difficult to impossible isolate, separate the various EPS molecules they are encased in and to define which species produced which EPS. The regulation and the factors which trigger or inhibit EPS production are still very poorly understood. Furthermore: bacteria are not the only microorganisms to produce EPS. Archaea, Fungi and algae can also form EPS. This book investigates the questions, What is their composition, function, dynamics and regulation? What do they all have in common?
Author : Sherwin B. Nuland
Publisher : Vintage
Page : 547 pages
File Size : 52,7 Mb
Release : 2011-10-19
Category : Biography & Autobiography
ISBN : 9780307807892
From the author of How We Die, the extraordinary story of the development of modern medicine, told through the lives of the physician-scientists who paved the way. How does medical science advance? Popular historians would have us believe that a few heroic individuals, possessing superhuman talents, lead an unselfish quest to better the human condition. But as renowned Yale surgeon and medical historian Sherwin B. Nuland shows in this brilliant collection of linked life portraits, the theory bears little resemblance to the truth. Through the centuries, the men and women who have shaped the world of medicine have been not only very human, but also very much the products of their own times and places. Presenting compelling studies of great medical innovators and pioneers, Doctors gives us a fascinating history of modern medicine. Ranging from the legendary Father of Medicine, Hippocrates, to Andreas Vesalius, whose Renaissance masterwork on anatomy offered invaluable new insight into the human body, to Helen Taussig, founder of pediatric cardiology and co-inventor of the original "blue baby" operation, here is a volume filled with the spirit of ideas and the thrill of discovery.
Author : Bruce S. McEwen,Harold Marshall Schmeck (Jr.)
Publisher : Rockefeller Univ. Press
Page : 336 pages
File Size : 42,5 Mb
Release : 1994
Category : Medical
ISBN : 0874700566
Author : Ruggero Caputo,Gianluca Tadini
Publisher : CRC Press
Page : 448 pages
File Size : 40,5 Mb
Release : 2005-12-12
Category : Medical
ISBN : 9781841842516
A lavishly illustrated guide to almost 200 inherited diseases of the skin, hair, and nails. Each entry includes synonyms, age of onset, clinical findings, complications, course, laboratory findings, diagnosis, therapy, and key references, adding up to far more than just a collection of photographs. In addition to being a clinical primer, this is also a work of scientific research and contains the first printed description of two new syndromes. The fast-moving world of genetic research means that the latest genetic correlations, included here, render previous texts out of date. All specialists in Dermatology and Pediatrics should find this an invaluable front-line resource in the clinic.
Author : Dr. Euan Angus Ashley
Publisher : Celadon Books
Page : 221 pages
File Size : 48,5 Mb
Release : 2021-02-23
Category : Science
ISBN : 9781250234971
In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease. Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human. In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome. These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.
Author : Yaoliang Tang,Buddhadeb Dawn
Publisher : Academic Press
Page : 288 pages
File Size : 49,8 Mb
Release : 2015-09-02
Category : Medical
ISBN : 9780128004975
Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Author : Philip J. Hashkes,Ronald M. Laxer,Anna Simon
Publisher : Springer
Page : 820 pages
File Size : 54,6 Mb
Release : 2019-02-13
Category : Medical
ISBN : 9783319986050
This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.
