Extra And Intracellular Calcium And Phosphate Regulation

Author : Felix Bronner,Meinrad Peterlik
Publisher : CRC Press
Page : 182 pages
File Size : 52,9 Mb
Release : 1992-02-21
Category : Medical
ISBN : 0849301882

Get Book

Extra- and Intracellular Calcium and Phosphate Regulation by Felix Bronner,Meinrad Peterlik Pdf

Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine presents thinking and front-line research addressing calcium and phosphate homeostasis and related clinical problems. Major topics include calcium and phosphate transport in the mammalian body and some of its defects; several aspects of hormonal control of calcium and phosphorus metabolism, including PTH-related peptide; and basic and clinical aspects of bone and bone diseases. Other topics include calcium entry and extrusion mechanisms, secondary osteoporosis, how bone cells translocate phosphate needed to bone mineral, and the culture of renal and intestinal cells capable of transporting calcium in vitro. The book also features two prize-winning contributions; one deals with the characterization of a major calcium transport protein, calbindin D-9K, while the other discusses how the osteoclast, the bone-resorbing cell, is feedback-regulated. Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine provides plenty of useful information for basic and clinical scientists alike, including biochemists, physiologists, cell biologists, pharmacologists, internists, orthopedic surgeons, dentists, and pathologists.

Author : Peter K.T. Pang
Publisher : Elsevier
Page : 382 pages
File Size : 45,9 Mb
Release : 2014-02-26
Category : Science
ISBN : 9780323162777

Get Book

Regulation of Calcium and Phosphate by Peter K.T. Pang Pdf

Regulation of Calcium and Phosphate

Author : Felix Bronner
Publisher : Wiley-Liss
Page : 504 pages
File Size : 50,5 Mb
Release : 1990-03
Category : Medical
ISBN : STANFORD:36105033129862

Get Book

Intracellular Calcium Regulation by Felix Bronner Pdf

Intracellular Calcium Regulation Editor Felix Bronner A notable development in biological research is the recent widespread interest in the role played by calcium in cellular metabolism. Calcium homeostasis has been studied intensively for many years and mechanisms by which calcium absorption, excretion and bone deposition are effected and regulated are beginning to be understood in detail. It now appears there may exist a parallel between the maintenance and regulation of intracellular and extracellular calcium. This volume presents up-to-date information on intracellular calcium regulation and thus provides a foundation for studies that aim to explore the relationship between intracellular and extracellular calcium metabolism. Intracellular Calcium Regulation examines in detail what happens to calcium inside the cell and offers authoritative discussions on such topics as: calcium fluxes: defining the role played by the plasma membrane in regulating the cellular calcium level, the application of tracer techniques to an analysis of the cellular calcium pool, the compartments making up the pool and the rates of exchange between compartments processes of calcium entry into the cell: describing entry into cells that do not fire action potentials, as well as three types of voltage-sensitive calcium channels, including their distribution, pharmacology, molecular properties and modulation organelles, such as the endoplasmic reticulum, the Golgi complex, lysosomes, or mitochondria and their role in regulating intracellular calcium levels the new, exciting field of calcium-binding or calcium modulated proteins, such as troponin-C, parvalbumin, S-100 proteins, calbindins, and calmodulin, as well as some novel calcium-binding proteins like the 42C and 42A proteins, calcyclin and caltractin calcium efflux: analyzing the role and function of the plasma membrane calcium pump and the Na+/Ca2+ exchanger, including the kinetics of ATP hydrolysis, how calcium transport and ATP hydrolysis are linked, the kinetics and properties of the sodium-calcium exchange, its regulation and role in such specialized cells as retinal rods and cardiac myocytes calcium transport as carried out by resting, stimulated and excitable cells with emphasis on activated phospholipase C, involvement of the G proteins and protein kinase C calcium transport as carried out by the specialized transport cells of intestine and kidney, entry via calcium channels, intracellular diffusion as facilitated by the calcium-binding proteins, and extrusion via the Ca-ATPase. Intracellular Calcium Regulation will be of interest to researchers and graduate students in the areas of biochemistry, biophysics, cell biology, nutrition, gastroenterology, nephrology and anatomy.

Author : Felix Bronner
Publisher : Elsevier
Page : 323 pages
File Size : 51,8 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323155915

Get Book

Calcium and Phosphate Transport Across Biomembranes by Felix Bronner Pdf

Calcium and Phosphate Transport Across Biomembranes is a collection of papers presented at the 1981 Calcium and Phosphate Transport Across Biomembranes international workshop held in Vienna, Austria. Contributors from a wide range of disciplines explore the intracellular role of calcium and phosphate and their transport into and out of the body through the intestine and the kidney. In particular, they describe calcium movement in the cell and across the plasma membrane, along with phosphate transport into the cell, particularly, at the brush border. Organized into 10 sections encompassing 53 chapters, this collection begins with an overview of the mechanisms underlying the net movements of calcium in the cell and plasma membrane. The discussion then shifts to the crystal structure of calmodulin, the phosphate transport in the mitochondria, the mechanisms for calcium extrusion, the calcium uptake by brush border membranes, and the possible role of the mitochondria in intracellular calcium regulation. The book also introduces the discussion on mitochondrial calcium transport protein, polypeptide and amine hormone regulation of calcium fluxes, mechanism of secretion by cultured pituitary cells, and regulation of the tubular transport of phosphate. A chapter that assesses the effects of vitamin D and insulin on phosphate transport in the differentiating chick small intestine concludes the book. This collection of papers will be of interest to scientists, neurochemists, physiologists, pharmacologists, biochemists, gastroenterologists, nutritionists, and pathophysiologists.

Author : Shaul Massry
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 41,9 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781461342175

Get Book

Phosphate Metabolism by Shaul Massry Pdf

We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.

Author : Anonim
Publisher : Academic Press
Page : 307 pages
File Size : 44,6 Mb
Release : 2013-07-24
Category : Science
ISBN : 9780124079380

Get Book

Store-Operated Calcium Channels by Anonim Pdf

Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject

Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 54,7 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051

Get Book

Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Author : Hirotoshi Morii
Publisher : Unknown
Page : 168 pages
File Size : 40,9 Mb
Release : 1991
Category : Bone and Bones
ISBN : 3805553722

Get Book

Calcium-regulating Hormones by Hirotoshi Morii Pdf

Author : Ellis D. Avner,William E. Harmon,Patrick Niaudet,Norishige Yoshikawa
Publisher : Springer Science & Business Media
Page : 2059 pages
File Size : 46,8 Mb
Release : 2009-08-20
Category : Medical
ISBN : 9783540763277

Get Book

Pediatric Nephrology by Ellis D. Avner,William E. Harmon,Patrick Niaudet,Norishige Yoshikawa Pdf

Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.

Author : J. Allgrove,N.J. Shaw
Publisher : Karger Medical and Scientific Publishers
Page : 434 pages
File Size : 50,9 Mb
Release : 2015-06-11
Category : Medical
ISBN : 9783318054675

Get Book

Calcium and Bone Disorders in Children and Adolescents by J. Allgrove,N.J. Shaw Pdf

There has been a rapid expansion of knowledge in the field of paediatric calcium and bone disorders over the past twenty years. Advances have been made in the underlying genetic basis for many conditions in conjunction with progress in bone density and geometry imaging and the development of new treatment options. The 2nd revised edition of ‘Calcium and Bone Disorders in Children and Adolescents’ presents up-to-date information on many aspects included in the 1st edition such as the physiology, pathology, diagnosis and management of numerous conditions including a chapter of case histories illustrating clinical aspects. New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. Providing a comprehensive update, this book is a useful clinical resource for paediatricians and specialists in endocrinology, metabolic bone disease, nephrology, rheumatology, radiology, orthopaedics and clinical genetics who may be faced with a child with a calcium and/or bone disorder.

Author : Carole Ichai,Hervé Quintard,Jean-Christophe Orban
Publisher : Springer
Page : 477 pages
File Size : 51,9 Mb
Release : 2017-12-30
Category : Medical
ISBN : 9783319640105

Get Book

Metabolic Disorders and Critically Ill Patients by Carole Ichai,Hervé Quintard,Jean-Christophe Orban Pdf

The purpose of this book is to bring together the latest findings on metabolic disorders that are strongly implicated in various critically ill patients. Since the beginning of the 20th century, maintaining the "milieu intérieur" has been a major challenge for intensivists. In addition to considerable technological developments in intensive care units, important advances in our understanding of metabolic disorders observed in critically ill patients have been made during the 10 last years. Today, the intensivit can’t ignore these disorders when selecting the most appropriate treatment for an illness. Cellular metabolic abnormalities are responsible for systems and organ failures, so the modern approach of organ dysfunctions now includes prevention or treatment of such disorders. This book is a comprehensive tool, allowing the physician to understand, diagnose and treat these metabolic disorders. Water, electrolyte, acid-base, glycemic and endocrinologic problems, as well as metabolic abnormalities observed in renal, cerebral and hepatic failure are presented in different chapters. The last part of the book is devoted to modern nutritional concepts, the consequences of energy modifications, mitochondrial dysfunction, hypothermia, oxidative stress and ischemia reperfusion, which open the way for new therapies.​

Author : A. Giustina,J.P. Bilezikian
Publisher : Karger Medical and Scientific Publishers
Page : 206 pages
File Size : 41,5 Mb
Release : 2018-03-29
Category : Medical
ISBN : 9783318063394

Get Book

Vitamin D in Clinical Medicine by A. Giustina,J.P. Bilezikian Pdf

Vitamin D deficiency is prevalent today not only among the elderly but pervasively throughout all ages of life.This is due, in part, to systemic diseases that affect vitamin D metabolism, to changes in lifestyle, such as insufficient exposure to sunlight, and to increased use of sunscreen. Apart from the obvious effects of vitamin D deficiency on skeletal metabolism, the problem is assuming even greater significance because observational and interventional studies have linked vitamin D deficiency to cardiovascular disease, cancer, and diabetes. This book addresses a variety of important issues that have emerged from this fast-moving area of clinical medicine. The topics include assays of vitamin D and its binding protein, effects on aging and associated complications, primary and secondary states of altered parathyroid hormone secretion, vitamin D in the growing years of children and adolescents, nutritional requirements, and vitamin D as it relates to systemic disorders such as diabetes mellitus. Vitamin D in Clinical Medicine aims to offer new insights, in an evidence-based way, on important issues related to vitamin D. It is written for general practitioners and internists, as well as for endocrinologists, nutritionists, pulmonologists, cardiologists, and oncologists.

Author : Benjamin Z. Leder,Marc N. Wein
Publisher : Springer Nature
Page : 518 pages
File Size : 52,7 Mb
Release : 2020-01-31
Category : Medical
ISBN : 9783319692876

Get Book

Osteoporosis by Benjamin Z. Leder,Marc N. Wein Pdf

Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies. Osteoporosis is a common disorder that is prevalent in over 20 million Americans over the age of 60. One and a half million osteoporotic fractures occur in the United States every year, including 300,000 hip fractures. Mortality rates after hip fracture approach 25%, with another 50% of patients experiencing a major decrease in their prior level of independence and quality of life. Despite the wide prevalence and severe consequences of osteoporosis, it remains a disorder that is severely under-diagnosed and treated. In this context, specialists and primary care physicians alike are having increasing difficulty keeping up with the rapid changes to the field and incorporating these advances to clinical care. In the years since the last edition of this book was published, the osteoporosis field has changed drastically. In addition to revising and updating existing chapters and removing a few that are no longer as relevant, new chapters discuss an advanced understanding of the cellular and molecular mechanisms underlying the disorder, the introduction of new diagnostic imaging techniques, a more nuanced appreciation of the risks and benefits of osteoporosis therapies, and the introduction of two new classes of osteoporosis medications. Following the format of the second edition, and including helpful key points at the opening of each chapter, this text will present a comprehensive overview of both the basic and clinical concepts relating to each topic, when appropriate. Chapter authors were chosen based on their high level of expertise and leadership in the field. Taken together, this text should thus be of great interest to physicians of multiple specialties, allied health professionals, as well as basic and clinical researchers.

Author : Shlomo Melmed,Ronald Koenig,Clifford J Rosen, MD,Richard J Auchus, MD PhD,Allison B Goldfine, MD
Publisher : Elsevier India
Page : 2250 pages
File Size : 40,9 Mb
Release : 2020-06-30
Category : Medical
ISBN : 9788131262160

Get Book

Williams Textbook of Endocrinology, 14 Edition: South Asia Edition, 2 Vol Set - E-Book by Shlomo Melmed,Ronald Koenig,Clifford J Rosen, MD,Richard J Auchus, MD PhD,Allison B Goldfine, MD Pdf

Williams Textbook of Endocrinology, 14 Edition: South Asia Edition, 2 Vol SET - E-Book

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1332 pages
File Size : 45,9 Mb
Release : 1992
Category : Medicine
ISBN : MINN:31951D01092868P

Get Book

National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf