Intracellular Calcium Regulation

Author : Felix Bronner
Publisher : Wiley-Liss
Page : 504 pages
File Size : 41,7 Mb
Release : 1990-03
Category : Medical
ISBN : STANFORD:36105033129862

Get Book

Intracellular Calcium Regulation by Felix Bronner Pdf

Intracellular Calcium Regulation Editor Felix Bronner A notable development in biological research is the recent widespread interest in the role played by calcium in cellular metabolism. Calcium homeostasis has been studied intensively for many years and mechanisms by which calcium absorption, excretion and bone deposition are effected and regulated are beginning to be understood in detail. It now appears there may exist a parallel between the maintenance and regulation of intracellular and extracellular calcium. This volume presents up-to-date information on intracellular calcium regulation and thus provides a foundation for studies that aim to explore the relationship between intracellular and extracellular calcium metabolism. Intracellular Calcium Regulation examines in detail what happens to calcium inside the cell and offers authoritative discussions on such topics as: calcium fluxes: defining the role played by the plasma membrane in regulating the cellular calcium level, the application of tracer techniques to an analysis of the cellular calcium pool, the compartments making up the pool and the rates of exchange between compartments processes of calcium entry into the cell: describing entry into cells that do not fire action potentials, as well as three types of voltage-sensitive calcium channels, including their distribution, pharmacology, molecular properties and modulation organelles, such as the endoplasmic reticulum, the Golgi complex, lysosomes, or mitochondria and their role in regulating intracellular calcium levels the new, exciting field of calcium-binding or calcium modulated proteins, such as troponin-C, parvalbumin, S-100 proteins, calbindins, and calmodulin, as well as some novel calcium-binding proteins like the 42C and 42A proteins, calcyclin and caltractin calcium efflux: analyzing the role and function of the plasma membrane calcium pump and the Na+/Ca2+ exchanger, including the kinetics of ATP hydrolysis, how calcium transport and ATP hydrolysis are linked, the kinetics and properties of the sodium-calcium exchange, its regulation and role in such specialized cells as retinal rods and cardiac myocytes calcium transport as carried out by resting, stimulated and excitable cells with emphasis on activated phospholipase C, involvement of the G proteins and protein kinase C calcium transport as carried out by the specialized transport cells of intestine and kidney, entry via calcium channels, intracellular diffusion as facilitated by the calcium-binding proteins, and extrusion via the Ca-ATPase. Intracellular Calcium Regulation will be of interest to researchers and graduate students in the areas of biochemistry, biophysics, cell biology, nutrition, gastroenterology, nephrology and anatomy.

Author : Hermann Bader
Publisher : Manchester University Press
Page : 504 pages
File Size : 46,5 Mb
Release : 1986
Category : Calcium
ISBN : 0719018358

Get Book

Intracellular Calcium Regulation by Hermann Bader Pdf

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Page : 309 pages
File Size : 47,5 Mb
Release : 2011
Category : Science
ISBN : 9781615041237

Get Book

The Endothelium by Michel Félétou Pdf

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Author : Danielle Pansu,Felix Bronner
Publisher : Springer Science & Business Media
Page : 435 pages
File Size : 52,7 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642839771

Get Book

Calcium Transport and Intracellular Calcium Homeostasis by Danielle Pansu,Felix Bronner Pdf

The crucial role played by calcium as a cellular messenger has become increasingly evident, as has the recognition that cells spend much energy in maintaining the cytosolic concentration of this cation both constant and low. It is thought they do this to avoid precipitating phosphate, needed as a source of bond energy and to modulate protein structure. Moreover, since calcium that does enter the cell must be disposed with, processes that utilize calcium have evolved, e.g. secretion, contraction, signaling, to name just some. New knowledge concerning the processes of cellular calcium entry, extrusion and the fate of intracellular calcium has accumulated in recent years. Much has also been learned about calcium transport by and across epithelial cells. It seems logical to think that the processes of calcium entry, extrusion and intracellular handling are similar in all cells. We have therefore assembled in one volume overviews and research reports of transport and cellular calcium regulation so as to explore similarities and differences between cells that utilize calcium for metabolic purposes and those whose primary function is transport.

Author : Anthony R. Means
Publisher : Lippincott Williams & Wilkins
Page : 404 pages
File Size : 50,9 Mb
Release : 1995
Category : Science
ISBN : 078170233X

Get Book

Calcium Regulation of Cellular Function by Anthony R. Means Pdf

Calcium-dependent regulation of protein synthesis/regulation of calcium channels in the heart/intracellular calcium waves

Author : Juliusz Ashot Kozak,James W. Putney, Jr.
Publisher : CRC Press
Page : 343 pages
File Size : 40,8 Mb
Release : 2017-07-14
Category : Science
ISBN : 9781498752732

Get Book

Calcium Entry Channels in Non-Excitable Cells by Juliusz Ashot Kozak,James W. Putney, Jr. Pdf

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Author : E. Carafoli,J. Krebs
Publisher : Springer Science & Business Media
Page : 192 pages
File Size : 52,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642583063

Get Book

Calcium Homeostasis by E. Carafoli,J. Krebs Pdf

With contributions by numerous experts

Author : Ernesto Carafoli,Claude B. Klee
Publisher : Oxford University Press, USA
Page : 664 pages
File Size : 42,7 Mb
Release : 1999
Category : Calcium
ISBN : 0195094212

Get Book

Calcium as a Cellular Regulator by Ernesto Carafoli,Claude B. Klee Pdf

Encompassing all aspects of calcium signalling, from methods of measuring calcium in cells to the molecular mechanisms for decoding its information, this comprehensive book balances historical aspects and state of the art developments.

Author : Anonim
Publisher : Academic Press
Page : 307 pages
File Size : 54,8 Mb
Release : 2013-07-24
Category : Science
ISBN : 9780124079380

Get Book

Store-Operated Calcium Channels by Anonim Pdf

Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject

Author : Oriol Bachs,Neus Agell
Publisher : Springer Science & Business Media
Page : 173 pages
File Size : 50,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783662216866

Get Book

Calcium and Calmodulin Function in the Cell Nucleus by Oriol Bachs,Neus Agell Pdf

This book is about the role of calcium and calmodulin in the cell nucleus. Calcium, which is an important second messenger of signal transduction pathways, can also operate in the cell nucleus. Different calcium binding proteins, which are the targets of cellular calcium, have been identified in the nucleus of many different cell types. Prominent among these calcium binding proteins is calmodulin, which appears to be involved in the regulation of major nuclear functions such as gene expression and DNA replication.

Author : Jonathan Soboloff,Dietmar J. Kappes
Publisher : CRC Press
Page : 258 pages
File Size : 47,7 Mb
Release : 2017-03-27
Category : Medical
ISBN : 9781498705097

Get Book

Signaling Mechanisms Regulating T Cell Diversity and Function by Jonathan Soboloff,Dietmar J. Kappes Pdf

T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Author : Wai Yiu Cheung
Publisher : Unknown
Page : 536 pages
File Size : 52,9 Mb
Release : 1980
Category : Medical
ISBN : UCSD:31822026060319

Get Book

Calcium and Cell Function by Wai Yiu Cheung Pdf

Author : J.J. Lemasters,C.R. Hackenbrock,R.G. Thurman,H.V. Westerhoff
Publisher : Springer Science & Business Media
Page : 647 pages
File Size : 54,9 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781489925510

Get Book

Integration of Mitochondrial Function by J.J. Lemasters,C.R. Hackenbrock,R.G. Thurman,H.V. Westerhoff Pdf

In aerobic tissues such as heart, brain, kidney, liver and brown fat, mitochon dria account for more than 20% of cell protein and play an essential role in res piration, ATP formation, ketogenesis, gluconeogenesis, amino acid metabolism, ureagenesis, thermogenesis and a variety of other metabolic activities. The mecha nisms by which these activities are integrated and regulated within the overall context of cellular physiology is of much current research interest. In order to bring together scientists examining the various diverse aspects of this overall pro blem, an International Conference on INTEGRATION OF MITOCHONDRIAL FUNC TION was held June 4-7, 1987 at the Hanes Art Center on the campus of the Uni versity of North Carolina at Chapel Hill. The chapters of this volume derive from presentations made at this conference. The focus of INTEGRATION OF MITOCHONDRIAL FUNCTION is on signifi cant new experimental and theoretical advances concerning integration of mito chondrial function at the organelle, cell, tissue and whole organism levels of organization.

Author : Lucia Banci
Publisher : Springer Science & Business Media
Page : 642 pages
File Size : 55,7 Mb
Release : 2013-04-18
Category : Science
ISBN : 9789400755611

Get Book

Metallomics and the Cell by Lucia Banci Pdf

Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 40,5 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051

Get Book

Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.