Extracellular Vesicles

Author : Wojciech Chrzanowski,Chwee Teck Lim,Sally Yunsun Kim
Publisher : Royal Society of Chemistry
Page : 358 pages
File Size : 48,7 Mb
Release : 2021-10-20
Category : Technology & Engineering
ISBN : 9781839164569

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Extracellular Vesicles by Wojciech Chrzanowski,Chwee Teck Lim,Sally Yunsun Kim Pdf

Extracellular and biofluids vesicles (EVs) are highly specialised yet ubiquitous nanoscale messengers secreted by cells. With the development of stem cell engineering, EVs promise to deliver next generation tools in regenerative medicine and tissue engineering, as well as in diagnostics. A vibrant and promising field, this book provides the first resource to the field. Covering basic cell biology, including EV production and intracellular communication, this book will provide material scientists and engineers with a foundation to the necessary biology. The reader will then learn about the isolation of extracellular vesicles their physicochemical characterisation and therapeutic application of EVs in regenerative medicine as well as their potential as biomarkers in medical diagnostic. This book will also discuss the regulatory landscape of EVs. Bridging cell biology, biomaterials, biophysics and biomedical engineering the content of this book is written with a broad interdisciplinary audience in mind. Researchers, new and established will find this a must-have on their shelf.

Author : Paul Harrison,Chris Gardiner,Ian L. Sargent
Publisher : CRC Press
Page : 474 pages
File Size : 53,7 Mb
Release : 2014-05-02
Category : Medical
ISBN : 9789814411998

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Extracellular Vesicles in Health and Disease by Paul Harrison,Chris Gardiner,Ian L. Sargent Pdf

Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly. It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling. Moreover, they are significantly elevated in a number of diseases. This raises the question of their direct role

Author : Ana Gil De Bona,Jose Antonio Reales-Calderon
Publisher : BoD – Books on Demand
Page : 172 pages
File Size : 46,7 Mb
Release : 2020-03-04
Category : Science
ISBN : 9781789239430

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Extracellular Vesicles and Their Importance in Human Health by Ana Gil De Bona,Jose Antonio Reales-Calderon Pdf

Extracellular vesicle is a wide term that involves many different types of vesicles. Almost all the cell types studied secrete vesicles to the extracellular environment related to cell - cell communication. Extracellular vesicles have been found in different biological fluids, such as blood, milk, saliva, tears, urine, and cerebrospinal fluid. These vesicles transport different molecules, including mRNA, proteins, and lipids, some of them cell type specific that make them ideal biomarkers in both health and disease conditions. However, their contribution to different conditions is not well understood. The aim of this book is to provide an overview of the extracellular vesicles in the human body, how they are internalized, and their participation in several diseases.

Author : Irwin M. Arias,Harvey J. Alter,James L. Boyer,David E. Cohen,David A. Shafritz,Snorri S. Thorgeirsson,Allan W. Wolkoff
Publisher : John Wiley & Sons
Page : 1156 pages
File Size : 53,8 Mb
Release : 2020-03-09
Category : Medical
ISBN : 9781119436829

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The Liver by Irwin M. Arias,Harvey J. Alter,James L. Boyer,David E. Cohen,David A. Shafritz,Snorri S. Thorgeirsson,Allan W. Wolkoff Pdf

Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Author : Anonim
Publisher : Academic Press
Page : 316 pages
File Size : 47,9 Mb
Release : 2020-10-24
Category : Science
ISBN : 9780128206638

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Extracellular Vesicles by Anonim Pdf

Extracellular Vesicles, Volume 645 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Genetic labeling of extracellular vesicle exosomes for studying biogenesis and uptake in living mammalian cells, Fluorescent Labeling of Extracellular Vesicles, Isolation of extracellular vesicles from lymph, Transgenic rats for tracking body fluid/tissue-derived extracellular vesicles, Isolation of amniotic extracellular vesicles, Urinary extracellular vesicle isolation, Immunocapture-based ELISA to Characterize and Quantify Extracellular Vesicles in Both Cell Culture Supernatants and Body Fluids, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series

Author : Qian Wang
Publisher : Springer Nature
Page : 586 pages
File Size : 53,7 Mb
Release : 2024-07-01
Category : Electronic
ISBN : 9789819983650

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Extracellular Vesicles by Qian Wang Pdf

Author : Anonim
Publisher : BoD – Books on Demand
Page : 340 pages
File Size : 52,8 Mb
Release : 2022-07-20
Category : Science
ISBN : 9781803550541

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Extracellular Vesicles by Anonim Pdf

Extracellular vesicles (EVs) are nanoscale vesicles secreted by cells that mediate horizontal cargo transport from donor to recipient cell, thereby establishing cell-cell communication and signaling. This book provides critical information on the fundamentals of EVs, their roles in diseases like cancer, and their use in disease management. The chapters emphasize the emerging data confirming the role of EVs in the pathogenesis of diseases and discuss the scientific advances that have made it feasible to characterize and engineer EVs, leading to their use as tools in biomarker discovery and disease diagnosis, prognosis, therapeutic application, and theranostics. This volume is a valuable resource for basic biologists, translational scientists, and clinicians.

Author : Suresh Mathivanan,Pamali Fonseka,Christina Nedeva,Ishara Atukorala
Publisher : Springer Nature
Page : 539 pages
File Size : 42,8 Mb
Release : 2021-03-29
Category : Science
ISBN : 9783030671716

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New Frontiers: Extracellular Vesicles by Suresh Mathivanan,Pamali Fonseka,Christina Nedeva,Ishara Atukorala Pdf

The field of extracellular vesicles (EVs) has progressed immensely in recent times with evidences highlighting their importance in physiology and pathology. This book entails extensive reflective literature on many subtypes of EVs including exosomes, exomeres, ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The book further discusses the biogenesis and secretion of these EVs, detailing the biological pathways and proteins involved. Research investigating the biological functions of EVs is rapidly increasing and the current knowledge around their role in progression of diseases such as cancer, neurodegeneration and metabolic disorders is discussed in multiple chapters. The implications of EVs in intercellular communication and the significance of biologically active cargo carried within these EVs are further examined. Moreover, the numerous applications of EVs in diagnostics and treatment of diseases are reviewed in detail, particularly their potential as biomarkers and drug delivery vehicles. Taken together, this book is a compilation of the key implications of EVs that are secreted by virtually all cell types. Readers will gain a perspective into the biology, functions and applications of EVs and their constantly evolving knowledge base.

Author : Zhenhua Li,Xing-Jie Liang,Ke Cheng
Publisher : John Wiley & Sons
Page : 213 pages
File Size : 54,7 Mb
Release : 2023-11-29
Category : Science
ISBN : 9783527352128

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Biomedical Applications of Extracellular Vesicles by Zhenhua Li,Xing-Jie Liang,Ke Cheng Pdf

Biomedical Applications of Extracellular Vesicles Unique resource focusing on biomedical applications and clinical translation of extracellular vesicles in science and medicine Focusing on key points to better understand extracellular vesicles (EVs) and their development, Biomedical Applications of Extracellular Vesicles describes in detail the biogenesis of EVs, the mechanism of intercellular communication, and the treatment of various diseases of EVs and the EV-based drug delivery platforms. An application-oriented resource, the work presents rapidly newer biomedical and clinical applications of natural and engineered EVs such as drug delivery, diagnosis, prognosis monitoring, immunotherapy, and more. The first part of this book provides a basic background on EVs. Next, the book introduces the excellent therapeutic effects of EVs themselves and the underlying mechanisms, followed by how EVs from different sources were used to construct drug delivery platforms. The latest research on EVs from leading groups around the world is presented. Sample topics covered in Biomedical Applications of Extracellular Vesicles include: Biogenesis of various EVs Pros and cons of the different instrumental and methodological developments for analytical strategies applied to EVs EVs in treatment of major diseases, such as cancer, cardiovascular and respiratory diseases Current methods of engineering EVs, and a comparison of the advantages and disadvantages of each method Biomaterials, such as hydrogels, scaffolds, and microneedles, that have been developed to further enhance the therapeutic efficacy of EVs Key challenges, such as quality control, scalability, and biosafety, that limit the clinical and industrial translation of EVs Explaining in detail how extracellular vesicles are produced and engineered, along with potential applications and commercial developments of EVs in science and industry, Biomedical Applications of Extracellular Vesicles is an essential resource on the subject for chemists, cell biologists, and molecular physicists.

Author : Dr Wojciech Chrzanowski,Professor Chwee Teck Lim,Dr Sally Yunsun Kim
Publisher : Royal Society of Chemistry
Page : 358 pages
File Size : 55,5 Mb
Release : 2021-10-29
Category : Technology & Engineering
ISBN : 9781788018944

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Extracellular Vesicles by Dr Wojciech Chrzanowski,Professor Chwee Teck Lim,Dr Sally Yunsun Kim Pdf

Extracellular and biofluids vesicles (EVs) are highly specialised yet ubiquitous nanoscale messengers secreted by cells. With the development of stem cell engineering, EVs promise to deliver next generation tools in regenerative medicine and tissue engineering, as well as in diagnostics. A vibrant and promising field, this book provides the first resource to the field. Covering basic cell biology, including EV production and intracellular communication, this book will provide material scientists and engineers with a foundation to the necessary biology. The reader will then learn about the isolation of extracellular vesicles their physicochemical characterisation and therapeutic application of EVs in regenerative medicine as well as their potential as biomarkers in medical diagnostic. This book will also discuss the regulatory landscape of EVs. Bridging cell biology, biomaterials, biophysics and biomedical engineering the content of this book is written with a broad interdisciplinary audience in mind. Researchers, new and established will find this a must-have on their shelf.

Author : Winston Patrick Kuo,Shidong Jia
Publisher : Humana
Page : 0 pages
File Size : 47,6 Mb
Release : 2018-08-03
Category : Science
ISBN : 1493984314

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Extracellular Vesicles by Winston Patrick Kuo,Shidong Jia Pdf

This volume examines established methods and protocols to isolate and characterize extracellular vesicles (EVs) and their composition, among other techniques including purification, imaging, biofluid-specific and cell-specific isolation and downstream genomic and proteomic profiling. The international group of expert scientists who have contributed to this collection provide a variety of different techniques related to the growing assortment of EV applications, given that at times using only one technique or two is insufficient to address the question at hand. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Extracellular Vesicles: Methods and Protocols serves as an ideal guide for researchers seeking to expand our knowledge of EV functions and applications.

Author : Paul J. Harrison,I. L. Sargent
Publisher : Unknown
Page : 464 pages
File Size : 54,8 Mb
Release : 2014
Category : Electronic
ISBN : OCLC:1065704921

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Extracellular Vesicles in Health and Diseases by Paul J. Harrison,I. L. Sargent Pdf

Author : Andrew F Hill
Publisher : Humana
Page : 0 pages
File Size : 40,5 Mb
Release : 2016-12-10
Category : Science
ISBN : 1493967266

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Exosomes and Microvesicles by Andrew F Hill Pdf

This volume covers methods for the analysis of extracellular vesicles (EV) that can be applied to isolated EVs from a wide variety of sources. This includes the use of electron microscopy, tunable resistance pulse sensing, and nanoparticle tracking analysis. The chapters in this book discuss EV cargoes containing proteins and genomic materials using a number of different approaches, and isolating EVs from platelets and neuronal cells and tissues. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and comprehensive, Exosomes and Microvesicles: Methods and Protocols is a valuable resource containing methodologies for anyone interested in researching EVs.

Author : Ivan K. H. Poon,Christopher D. Gregory,Maria Kaparakis-Liaskos
Publisher : Frontiers Media SA
Page : 141 pages
File Size : 46,7 Mb
Release : 2019-02-11
Category : Electronic
ISBN : 9782889457540

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The Immunomodulatory Properties of Extracellular Vesicles from Pathogens, Immune Cells and Non-Immune Cells by Ivan K. H. Poon,Christopher D. Gregory,Maria Kaparakis-Liaskos Pdf

Author : Shulamit Michaeli,Neta Regev-Rudzki,Ana Claudia Torrecilhas
Publisher : Frontiers Media SA
Page : 221 pages
File Size : 46,5 Mb
Release : 2021-07-22
Category : Science
ISBN : 9782889710775

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Extracellular Vesicles in Infectious Diseases by Shulamit Michaeli,Neta Regev-Rudzki,Ana Claudia Torrecilhas Pdf