Biomedical Applications Of Extracellular Vesicles

Author : Zhenhua Li,Xing-Jie Liang,Ke Cheng
Publisher : John Wiley & Sons
Page : 213 pages
File Size : 50,5 Mb
Release : 2023-11-29
Category : Science
ISBN : 9783527352128

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Biomedical Applications of Extracellular Vesicles by Zhenhua Li,Xing-Jie Liang,Ke Cheng Pdf

Biomedical Applications of Extracellular Vesicles Unique resource focusing on biomedical applications and clinical translation of extracellular vesicles in science and medicine Focusing on key points to better understand extracellular vesicles (EVs) and their development, Biomedical Applications of Extracellular Vesicles describes in detail the biogenesis of EVs, the mechanism of intercellular communication, and the treatment of various diseases of EVs and the EV-based drug delivery platforms. An application-oriented resource, the work presents rapidly newer biomedical and clinical applications of natural and engineered EVs such as drug delivery, diagnosis, prognosis monitoring, immunotherapy, and more. The first part of this book provides a basic background on EVs. Next, the book introduces the excellent therapeutic effects of EVs themselves and the underlying mechanisms, followed by how EVs from different sources were used to construct drug delivery platforms. The latest research on EVs from leading groups around the world is presented. Sample topics covered in Biomedical Applications of Extracellular Vesicles include: Biogenesis of various EVs Pros and cons of the different instrumental and methodological developments for analytical strategies applied to EVs EVs in treatment of major diseases, such as cancer, cardiovascular and respiratory diseases Current methods of engineering EVs, and a comparison of the advantages and disadvantages of each method Biomaterials, such as hydrogels, scaffolds, and microneedles, that have been developed to further enhance the therapeutic efficacy of EVs Key challenges, such as quality control, scalability, and biosafety, that limit the clinical and industrial translation of EVs Explaining in detail how extracellular vesicles are produced and engineered, along with potential applications and commercial developments of EVs in science and industry, Biomedical Applications of Extracellular Vesicles is an essential resource on the subject for chemists, cell biologists, and molecular physicists.

Author : Wojciech Chrzanowski,Chwee Teck Lim,Sally Yunsun Kim
Publisher : Royal Society of Chemistry
Page : 358 pages
File Size : 46,7 Mb
Release : 2021-10-20
Category : Technology & Engineering
ISBN : 9781839164569

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Extracellular Vesicles by Wojciech Chrzanowski,Chwee Teck Lim,Sally Yunsun Kim Pdf

Extracellular and biofluids vesicles (EVs) are highly specialised yet ubiquitous nanoscale messengers secreted by cells. With the development of stem cell engineering, EVs promise to deliver next generation tools in regenerative medicine and tissue engineering, as well as in diagnostics. A vibrant and promising field, this book provides the first resource to the field. Covering basic cell biology, including EV production and intracellular communication, this book will provide material scientists and engineers with a foundation to the necessary biology. The reader will then learn about the isolation of extracellular vesicles their physicochemical characterisation and therapeutic application of EVs in regenerative medicine as well as their potential as biomarkers in medical diagnostic. This book will also discuss the regulatory landscape of EVs. Bridging cell biology, biomaterials, biophysics and biomedical engineering the content of this book is written with a broad interdisciplinary audience in mind. Researchers, new and established will find this a must-have on their shelf.

Author : Zhenhua Li,Xing-Jie Liang,Ke Cheng
Publisher : John Wiley & Sons
Page : 213 pages
File Size : 46,5 Mb
Release : 2023-11-30
Category : Science
ISBN : 9783527842148

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Biomedical Applications of Extracellular Vesicles by Zhenhua Li,Xing-Jie Liang,Ke Cheng Pdf

Biomedical Applications of Extracellular Vesicles Unique resource focusing on biomedical applications and clinical translation of extracellular vesicles in science and medicine Focusing on key points to better understand extracellular vesicles (EVs) and their development, Biomedical Applications of Extracellular Vesicles describes in detail the biogenesis of EVs, the mechanism of intercellular communication, and the treatment of various diseases of EVs and the EV-based drug delivery platforms. An application-oriented resource, the work presents rapidly newer biomedical and clinical applications of natural and engineered EVs such as drug delivery, diagnosis, prognosis monitoring, immunotherapy, and more. The first part of this book provides a basic background on EVs. Next, the book introduces the excellent therapeutic effects of EVs themselves and the underlying mechanisms, followed by how EVs from different sources were used to construct drug delivery platforms. The latest research on EVs from leading groups around the world is presented. Sample topics covered in Biomedical Applications of Extracellular Vesicles include: Biogenesis of various EVs Pros and cons of the different instrumental and methodological developments for analytical strategies applied to EVs EVs in treatment of major diseases, such as cancer, cardiovascular and respiratory diseases Current methods of engineering EVs, and a comparison of the advantages and disadvantages of each method Biomaterials, such as hydrogels, scaffolds, and microneedles, that have been developed to further enhance the therapeutic efficacy of EVs Key challenges, such as quality control, scalability, and biosafety, that limit the clinical and industrial translation of EVs Explaining in detail how extracellular vesicles are produced and engineered, along with potential applications and commercial developments of EVs in science and industry, Biomedical Applications of Extracellular Vesicles is an essential resource on the subject for chemists, cell biologists, and molecular physicists.

Author : Qihui Zhou,Brandon W. Peterson,Yong Liu,Huihua Yuan
Publisher : Frontiers Media SA
Page : 188 pages
File Size : 54,8 Mb
Release : 2023-05-11
Category : Science
ISBN : 9782832519004

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Biomaterials with the regulation of reactive oxygen/nitrogen species for biomedical applications by Qihui Zhou,Brandon W. Peterson,Yong Liu,Huihua Yuan Pdf

Author : Marcio Rodrigues,Guilhem Janbon
Publisher : Springer Nature
Page : 193 pages
File Size : 54,5 Mb
Release : 2022-01-01
Category : Science
ISBN : 9783030833916

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Fungal Extracellular Vesicles by Marcio Rodrigues,Guilhem Janbon Pdf

This book provides an in-depth overview on the manifold functions of fungal extracellular vesicles (EV) which span from cell-to-cell communication, pathogenicity and stimulation of host’s immunity to export of hundreds of biomolecules. The book summarizes the present knowledge on the impact of extracellular vesicles on fungal biology. Extracellular vesicles participate in fundamental biological processes in all living cells but only during the last 15 years the production and functions of EVs were identified and studied in fungal species too. Up to date more than 50 independent studies have shown that extracellular vesicles are produced by at least 20 fungal species. The book addresses researchers and advanced students in Microbiology, Mycology and Biotechnology.

Author : Ana Gil De Bona,Jose Antonio Reales-Calderon
Publisher : BoD – Books on Demand
Page : 172 pages
File Size : 41,7 Mb
Release : 2020-03-04
Category : Science
ISBN : 9781789239430

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Extracellular Vesicles and Their Importance in Human Health by Ana Gil De Bona,Jose Antonio Reales-Calderon Pdf

Extracellular vesicle is a wide term that involves many different types of vesicles. Almost all the cell types studied secrete vesicles to the extracellular environment related to cell - cell communication. Extracellular vesicles have been found in different biological fluids, such as blood, milk, saliva, tears, urine, and cerebrospinal fluid. These vesicles transport different molecules, including mRNA, proteins, and lipids, some of them cell type specific that make them ideal biomarkers in both health and disease conditions. However, their contribution to different conditions is not well understood. The aim of this book is to provide an overview of the extracellular vesicles in the human body, how they are internalized, and their participation in several diseases.

Author : Paul Harrison,Chris Gardiner,Ian L. Sargent
Publisher : CRC Press
Page : 484 pages
File Size : 43,6 Mb
Release : 2014-05-02
Category : Medical
ISBN : 9789814411981

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Extracellular Vesicles in Health and Disease by Paul Harrison,Chris Gardiner,Ian L. Sargent Pdf

Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly. It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling. Moreover, they are significantly elevated in a number of diseases. This raises the question of their direct role in pathogenesis as well as their possible use as biomarkers. This book stems from the first international meeting on "Microvesicles and Nanovesicles in Health and Disease" held at Magdalen College, Oxford, in 2010. The purpose of the meeting was to bring together, for the first time, a range of experts from around the world to discuss the latest advances in this field. Key to the study of these vesicles is the availability of methodologies for their measurement in biological fluids. A major section of the meeting focused on a range of exciting new technologies which have been developed for this purpose. The presentations at this meeting form the basis of this book, which will appeal to basic scientists, clinicians, and those developing technology for the measurement of extracellular vesicles.

Author : Anonim
Publisher : Academic Press
Page : 314 pages
File Size : 48,9 Mb
Release : 2020-11-08
Category : Science
ISBN : 9780128206621

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Extracellular Vesicles by Anonim Pdf

Extracellular Vesicles, Volume 645 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Genetic labeling of extracellular vesicle exosomes for studying biogenesis and uptake in living mammalian cells, Fluorescent Labeling of Extracellular Vesicles, Isolation of extracellular vesicles from lymph, Transgenic rats for tracking body fluid/tissue-derived extracellular vesicles, Isolation of amniotic extracellular vesicles, Urinary extracellular vesicle isolation, Immunocapture-based ELISA to Characterize and Quantify Extracellular Vesicles in Both Cell Culture Supernatants and Body Fluids, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series

Author : Faisal A. Alzahrani,Islam M. Saadeldin
Publisher : Springer Nature
Page : 373 pages
File Size : 43,8 Mb
Release : 2020-11-20
Category : Medical
ISBN : 9789811565991

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Role of Exosomes in Biological Communication Systems by Faisal A. Alzahrani,Islam M. Saadeldin Pdf

This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.

Author : Mariusz Z. Ratajczak
Publisher : Springer Nature
Page : 410 pages
File Size : 48,9 Mb
Release : 2020-01-02
Category : Science
ISBN : 9783030312060

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Stem Cells by Mariusz Z. Ratajczak Pdf

Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.

Author : Sharmilla Fagoonee
Publisher : Unknown
Page : 48 pages
File Size : 41,6 Mb
Release : 2022
Category : Medical
ISBN : 8855321226

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Stem Cell-derived Extracellular Vesicles for Therapy of Human Diseases by Sharmilla Fagoonee Pdf

Author : S.N. Chatterjee,Keya Chaudhuri
Publisher : Springer Science & Business Media
Page : 165 pages
File Size : 40,5 Mb
Release : 2012-08-01
Category : Medical
ISBN : 9783642305269

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Outer Membrane Vesicles of Bacteria by S.N. Chatterjee,Keya Chaudhuri Pdf

This book provides a detailed account of the physico-chemical properties and biological functions of the outer membrane vesicles (OMVs) of different pathogenic and non-pathogenic Gram-negative bacteria. It also includes an authentic record of the first systematic study that discovered the mechanism of OMV formation by a pathogen, Vibrio cholerae, and proposed that the process represented a novel secretory activity of bacteria. Furthermore, the authors present clinical and laboratory data on the use of OMVs as immunogens, as effective and licensed vaccines against Neisseria meningitidis serogroup B infections and on the development of more effective vaccines against other human and animal pathogens including Vibrio cholerae. This volume thus bears witness to the emerging revolution in the field of vaccines against pathogens and closes with a discussion of open questions and future research on OMVs.

Author : Yaoliang Tang,Buddhadeb Dawn
Publisher : Academic Press
Page : 288 pages
File Size : 55,8 Mb
Release : 2015-09-02
Category : Medical
ISBN : 9780128004975

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Mesenchymal Stem Cell Derived Exosomes by Yaoliang Tang,Buddhadeb Dawn Pdf

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Author : Zoraida Aguilar
Publisher : Newnes
Page : 481 pages
File Size : 42,8 Mb
Release : 2012-10-10
Category : Medical
ISBN : 9780123850898

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Nanomaterials for Medical Applications by Zoraida Aguilar Pdf

Structurally the work is demarcated into the six most popular areas of research: (1) biocompatibility of nanomaterials with living organisms in their various manifestations (2) nanobiosensors for clinical diagnostics, detecting biomolecules which are useful in the clinical diagnosis of genetic, metabolically acquired, induced or infectious disease (3) targeted drug delivery for nanomaterials in their various modifications (4) nanomedical devices and structures which are used in the development of implantable medical devices and structures such as nanorobots (5) nanopharmacology, as novel nanoparticles are increasingly engineered to diagnose conditions and recognize pathogens, identify ideal pharmaceutical agents to treat the condition or pathogens, fuel high-yield production of matched pharmaceuticals (potentially in vivo), locate, attach or enter target tissue,

Author : Jin Yan,Sen Hou,Long Wu
Publisher : Frontiers Media SA
Page : 135 pages
File Size : 51,6 Mb
Release : 2023-07-04
Category : Science
ISBN : 9782832529157

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Self-assembly Biomaterials as Theragnostic for Injury and Disease by Jin Yan,Sen Hou,Long Wu Pdf