Extrasynaptic Gabaa Receptors

Extrasynaptic Gabaa Receptors Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Extrasynaptic Gabaa Receptors book. This book definitely worth reading, it is an incredibly well-written.

Extrasynaptic GABAA Receptors

Adam C. Errington,Giuseppe Di Giovanni,Vincenzo Crunelli
Extrasynaptic GABAA Receptors Book PDF

Author : Adam C. Errington,Giuseppe Di Giovanni,Vincenzo Crunelli
Publisher : Springer
Page : 301 pages
File Size : 52,8 Mb
Release : 2014-09-22
Category : Medical
ISBN : 9781493914265

Get Book

Extrasynaptic GABAA Receptors by Adam C. Errington,Giuseppe Di Giovanni,Vincenzo Crunelli Pdf

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Jasper's Basic Mechanisms of the Epilepsies

Jeffrey L. Noebels,Massimo Avoli
Jasper s Basic Mechanisms of the Epilepsies Book PDF

Author : Jeffrey L. Noebels,Massimo Avoli
Publisher : OUP USA
Page : 1258 pages
File Size : 51,8 Mb
Release : 2012-06-29
Category : Medical
ISBN : 9780199746545

Get Book

Jasper's Basic Mechanisms of the Epilepsies by Jeffrey L. Noebels,Massimo Avoli Pdf

Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

The GABA Receptors

Salvatore J. Enna,Hanns Möhler
The GABA Receptors Book PDF

Author : Salvatore J. Enna,Hanns Möhler
Publisher : Humana Press
Page : 325 pages
File Size : 50,6 Mb
Release : 2007-07-19
Category : Medical
ISBN : 1588298132

Get Book

The GABA Receptors by Salvatore J. Enna,Hanns Möhler Pdf

The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors. Emphasis is placed on exploring cutting-edge findings on the structureal properties of receptor sites, mechanisms of receptor expression, chemical agents that differentiate receptor subtypes, and phenotypes displayed by GABA receptor null mice. Chapters in this updated and expanded edition examine such topics as GABA receptor subypes, trafficking postsynaptic GABA receptors, GABA receptor mutations associated with idiopathic generalized epilepsies and febrile seizures, and GABA receptors as a potential therapeutic target.

Inhibitory Regulation of Excitatory Neurotransmission

Mark G. Darlison
Inhibitory Regulation of Excitatory Neurotransmission Book PDF

Author : Mark G. Darlison
Publisher : Springer
Page : 0 pages
File Size : 47,5 Mb
Release : 2010-11-22
Category : Science
ISBN : 3642091628

Get Book

Inhibitory Regulation of Excitatory Neurotransmission by Mark G. Darlison Pdf

Darlison’s excellent work reviews aspects of GABA-A receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABA-C receptors and G-protein coupled receptors including neuropeptides. Glycine receptors and potassium channels are covered too. The consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are also discussed.

GABA And Glutamate

Janko Samardzic
GABA And Glutamate Book PDF

Author : Janko Samardzic
Publisher : BoD – Books on Demand
Page : 139 pages
File Size : 44,7 Mb
Release : 2018-03-21
Category : Medical
ISBN : 9789535138211

Get Book

GABA And Glutamate by Janko Samardzic Pdf

This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.

Recent Advances in Epilepsy Research

Devin K. Binder,Helen E. Scharfman
Recent Advances in Epilepsy Research Book PDF

Author : Devin K. Binder,Helen E. Scharfman
Publisher : Springer Science & Business Media
Page : 274 pages
File Size : 53,9 Mb
Release : 2004-06-24
Category : Medical
ISBN : 0306478609

Get Book

Recent Advances in Epilepsy Research by Devin K. Binder,Helen E. Scharfman Pdf

Epilepsy research has entered an exciting phase as advances in molecular analysis have supplemented in vitro and in vivo electrophysiologic and phenotypic characterization. Recent Advances in Epilepsy Research sets forth a series of chapter reviews by researchers involved in these advances. This volume is a composite profile of some exciting recent investigations in select areas of enquiry. Key features: neurogenetics of seizure disorders, new developments in cellular and molecular neurobiology of seizure disorders, the role of growth factors in seizures, new advances in the roles of metabotropic glutamate receptors and GABA receptors and transporters, gap junctions, neuroimmunology of epilepsy, malformations of cortical development, neurogenesis, new animal models of epilepsy and the use of brain stimulation to treat epilepsy. This book should be of interest to a wide variety of audiences, including graduate students in neurobiology and related disciplines, neuroscientists, medical students, neurologists, neurosurgeons, and industry including pharmaceutical companies and medical device companies. There are many ideas in this book that will lead ingenious innovators in academia and industry to develop new and better therapies.

Pharmacology of Ionic Channel Function: Activators and Inhibitors

M. Endo,Y. Kurachi,M. Mishina
Pharmacology of Ionic Channel Function Activators and Inhibitors Book PDF

Author : M. Endo,Y. Kurachi,M. Mishina
Publisher : Springer Science & Business Media
Page : 674 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642570834

Get Book

Pharmacology of Ionic Channel Function: Activators and Inhibitors by M. Endo,Y. Kurachi,M. Mishina Pdf

Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.

Glutamate and GABA Receptors and Transporters

Jan Egebjerg,Arne Schousboe,Povl Krogsgaard-Larsen
Glutamate and GABA Receptors and Transporters Book PDF

Author : Jan Egebjerg,Arne Schousboe,Povl Krogsgaard-Larsen
Publisher : CRC Press
Page : 456 pages
File Size : 40,9 Mb
Release : 2001-10-04
Category : Science
ISBN : 0748408819

Get Book

Glutamate and GABA Receptors and Transporters by Jan Egebjerg,Arne Schousboe,Povl Krogsgaard-Larsen Pdf

The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover, continuous development of novel and selective drugs has revealed detailed information on the mechanism of receptor activation and regulation. However, the rapid development of different aspects of glutamate and GABA receptor research makes it increasingly difficult to establish a general view of the field. Studies of the receptors are a multi-disciplinary task employing many specialised techniques. This book conveys recent discoveries in a framework of the basic concepts in the field of glutamate and GABA receptor research. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology is suitable for postgraduate students studying ligand gated channels but also beneficial for industrial and academic research scientists in both the glutamate and GABA field. Universities offering programs in neuroscience, molecular pharmacology or medicinal chemistry will find this a valuable reference.

Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A

Anonim
Diversity and Functions of GABA Receptors A Tribute to Hanns M hler Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 282 pages
File Size : 47,8 Mb
Release : 2015-01-12
Category : Medical
ISBN : 9780128026922

Get Book

Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A by Anonim Pdf

This new volume of Advances in Pharmacology presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists

GABA Receptors—Advances in Research and Application: 2012 Edition

Anonim
GABA Receptors Advances in Research and Application 2012 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 190 pages
File Size : 46,7 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781464998874

Get Book

GABA Receptors—Advances in Research and Application: 2012 Edition by Anonim Pdf

GABA Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about GABA Receptors. The editors have built GABA Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about GABA Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of GABA Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Dynamic-Clamp

Alain Destexhe,Thierry Bal
Dynamic Clamp Book PDF

Author : Alain Destexhe,Thierry Bal
Publisher : Springer Science & Business Media
Page : 428 pages
File Size : 53,9 Mb
Release : 2009-03-11
Category : Medical
ISBN : 9780387892795

Get Book

Dynamic-Clamp by Alain Destexhe,Thierry Bal Pdf

Dynamic-clamp is a fascinating electrophysiology technique that consists of merging living neurons with computational models. The dynamic-clamp (also called “conductance injection”) allows experimentalists and theoreticians to challenge neurons (or any other type of cell) with complex conductance stimuli generated by a computer. The technique can be implemented from neural simulation environments and a variety of custom-made or commercial systems. The real-time interaction between the computer and cell also enables the design of recording paradigms with unprecedented accuracy via a computational model of the electrode. Dynamic-Clamp: From Principles to Applications contains contributions from leading researchers in the field, who investigate these paradigms at the cellular or network level, in vivo and in vitro, and in different brain regions and cardiac cells. Topics discussed include the addition of artificially-generated synaptic activity to neurons; adding, amplifying or neutralizing voltage-dependent conductances; creating hybrid networks with real and artificial cells; attaching simulated dendritic tree structures to the living cell; and connecting different neurons. This book will be of interest to experimental biophysicists, neurophysiologists, and cardiac physiologists, as well as theoreticians, engineers, and computational neuroscientists. Graduate and undergraduate students will also find up-to-date coverage of physiological problems and how they are investigated.

Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler

Anonim
Diversity and Functions of GABA Receptors A Tribute to Hanns M hler Book PDF

Author : Anonim
Publisher : Academic Press
Page : 284 pages
File Size : 41,9 Mb
Release : 2015-01-27
Category : Medical
ISBN : 9780128026915

Get Book

Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler by Anonim Pdf

Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part B, a new volume of Advances in Pharmacology, presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years, which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists

Essentials of Cerebellum and Cerebellar Disorders

Donna L. Gruol,Noriyuki Koibuchi,Mario Manto,Marco Molinari,Jeremy D. Schmahmann,Ying Shen
Essentials of Cerebellum and Cerebellar Disorders Book PDF

Author : Donna L. Gruol,Noriyuki Koibuchi,Mario Manto,Marco Molinari,Jeremy D. Schmahmann,Ying Shen
Publisher : Springer
Page : 656 pages
File Size : 53,8 Mb
Release : 2016-11-22
Category : Medical
ISBN : 9783319245515

Get Book

Essentials of Cerebellum and Cerebellar Disorders by Donna L. Gruol,Noriyuki Koibuchi,Mario Manto,Marco Molinari,Jeremy D. Schmahmann,Ying Shen Pdf

Essentials of the Cerebellum and Cerebellar Disorders is the first book of its kind written specifically for graduate students and clinicians. It is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. This monograph makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from ataxia clinics and cerebellar laboratories throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.

The Neurobiological Basis of Suicide

Yogesh Dwivedi
The Neurobiological Basis of Suicide Book PDF

Author : Yogesh Dwivedi
Publisher : CRC Press
Page : 485 pages
File Size : 53,5 Mb
Release : 2012-06-25
Category : Medical
ISBN : 9781439838815

Get Book

The Neurobiological Basis of Suicide by Yogesh Dwivedi Pdf

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 74 pages
File Size : 43,9 Mb
Release : 2011-08-05
Category : Medical
ISBN : 9780309212212

Get Book

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.