Flow And Microreactor Technology In Medicinal Chemistry

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Flow and Microreactor Technology in Medicinal Chemistry

Esther Alza
Flow and Microreactor Technology in Medicinal Chemistry Book PDF

Author : Esther Alza
Publisher : John Wiley & Sons
Page : 372 pages
File Size : 55,6 Mb
Release : 2022-06-20
Category : Science
ISBN : 9783527346899

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Flow and Microreactor Technology in Medicinal Chemistry by Esther Alza Pdf

Learn to master a powerful technology to enable a faster drug discovery workflow The ultimate dream for medicinal chemists is the ability to synthesize new drug-like compounds with the push of a button. The key to synthesizing chemical compounds more quickly and accurately lies in computer-controlled technologies that can be optimized by machine learning. Recent developments in computer-controlled automated syntheses that rely on miniature flow reactors—with integrated analysis of the resulting products—provide a workable technology for synthesizing new chemical substances very quickly and with minimal effort. In Flow and Microreactor Technology in Medicinal Chemistry, early adopters of this ground-breaking technology describe its current and potential uses in medicinal chemistry. Based on successful examples of the use of flow and microreactor synthesis for drug-like compounds, the book introduces current as well as emerging uses for automated synthesis in a drug discovery context. Flow and Microreactor Technology in Medicinal Chemistry readers will also find: Numerous case studies that address the most common applications of this technology in the day-to-day work of medicinal chemists How to integrate flow synthesis with drug discovery How to perform enantioselective reactions under continuous flow conditions Flow and Microreactor Technology in Medicinal Chemistry is a valuable practical reference for medicinal chemists, organic chemists, and natural products chemists, whether they are working in academia or in the pharmaceutical industry.

Flow Chemistry in Drug Discovery

Jesus Alcazar,Antonio de la Hoz,Angel Díaz-Ortiz
Flow Chemistry in Drug Discovery Book PDF

Author : Jesus Alcazar,Antonio de la Hoz,Angel Díaz-Ortiz
Publisher : Springer Nature
Page : 501 pages
File Size : 53,9 Mb
Release : 2021-12-08
Category : Science
ISBN : 9783030855925

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Flow Chemistry in Drug Discovery by Jesus Alcazar,Antonio de la Hoz,Angel Díaz-Ortiz Pdf

This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental methodologies and reactions, such as the application of catalysis, especially biocatalysis and organocatalysis; and non-conventional activation techniques, from photochemistry to electrochemistry; but also the development of new process windows, processes and reactions in drug synthesis. Particular attention is given to automatization and library synthesis, which are of great importance in the pharmaceutical industry. Readers will also find coverage on selected topics of general interest, such as how flow chemistry is contributing to drug discovery R&D in developing countries, and the green character of this enabling technology, for example in the production of raw materials for the pharmaceutical industry from waste. Given its scope, the book appeals to medicinal chemistry researchers working in academia and industry alike, as well as professionals involved in scale-up and drug development.

Flow and Microreactor Technology in Medicinal Chemistry

Esther Alza
Flow and Microreactor Technology in Medicinal Chemistry Book PDF

Author : Esther Alza
Publisher : John Wiley & Sons
Page : 372 pages
File Size : 51,5 Mb
Release : 2022-06-13
Category : Science
ISBN : 9783527824618

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Flow and Microreactor Technology in Medicinal Chemistry by Esther Alza Pdf

Learn to master a powerful technology to enable a faster drug discovery workflow The ultimate dream for medicinal chemists is the ability to synthesize new drug-like compounds with the push of a button. The key to synthesizing chemical compounds more quickly and accurately lies in computer-controlled technologies that can be optimized by machine learning. Recent developments in computer-controlled automated syntheses that rely on miniature flow reactors—with integrated analysis of the resulting products—provide a workable technology for synthesizing new chemical substances very quickly and with minimal effort. In Flow and Microreactor Technology in Medicinal Chemistry, early adopters of this ground-breaking technology describe its current and potential uses in medicinal chemistry. Based on successful examples of the use of flow and microreactor synthesis for drug-like compounds, the book introduces current as well as emerging uses for automated synthesis in a drug discovery context. Flow and Microreactor Technology in Medicinal Chemistry readers will also find: Numerous case studies that address the most common applications of this technology in the day-to-day work of medicinal chemists How to integrate flow synthesis with drug discovery How to perform enantioselective reactions under continuous flow conditions Flow and Microreactor Technology in Medicinal Chemistry is a valuable practical reference for medicinal chemists, organic chemists, and natural products chemists, whether they are working in academia or in the pharmaceutical industry.

Flow Chemistry in Drug Discovery

Jesus Alcazar,Antonio de la Hoz,Angel Díaz-Ortiz
Flow Chemistry in Drug Discovery Book PDF

Author : Jesus Alcazar,Antonio de la Hoz,Angel Díaz-Ortiz
Publisher : Unknown
Page : 0 pages
File Size : 53,8 Mb
Release : 2021
Category : Electronic
ISBN : 3030855937

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Flow Chemistry in Drug Discovery by Jesus Alcazar,Antonio de la Hoz,Angel Díaz-Ortiz Pdf

This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental methodologies and reactions, such as the application of catalysis, especially biocatalysis and organocatalysis; and non-conventional activation techniques, from photochemistry to electrochemistry; but also the development of new process windows, processes and reactions in drug synthesis. Particular attention is given to automatization and library synthesis, which are of great importance in the pharmaceutical industry. Readers will also find coverage on selected topics of general interest, such as how flow chemistry is contributing to drug discovery R&D in developing countries, and the green character of this enabling technology, for example in the production of raw materials for the pharmaceutical industry from waste. Given its scope, the book appeals to medicinal chemistry researchers working in academia and industry alike, as well as professionals involved in scale-up and drug development.

Basics of Flow Microreactor Synthesis

Jun-ichi Yoshida
Basics of Flow Microreactor Synthesis Book PDF

Author : Jun-ichi Yoshida
Publisher : Springer
Page : 108 pages
File Size : 55,9 Mb
Release : 2015-05-08
Category : Science
ISBN : 9784431555131

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Basics of Flow Microreactor Synthesis by Jun-ichi Yoshida Pdf

This book provides in a concise form the principles and applications of flow microreactors in organic and polymer synthesis. Recently, it became possible to conduct chemical reactions in a flow reactor in laboratory synthesis. The flow microreactor enables reactions that cannot be done in batch, opening a new possibility of chemical synthesis. Extremely fast mass and heat transfer and high-resolution residence time control are responsible for the remarkable features of that process. The book is not an exhaustive compilation of all known examples of flow microreactor synthesis. Rather, it is a sampling of sufficient variety to illustrate the concept, the scope, and the current state of flow microreactor synthesis. Researchers both in academia and in industry will be interested in this book because the topics encompassed by the book are vigorously studied in many university and company laboratories today.

Green Techniques for Organic Synthesis and Medicinal Chemistry

Wei Zhang,Berkeley W. Cue
Green Techniques for Organic Synthesis and Medicinal Chemistry Book PDF

Author : Wei Zhang,Berkeley W. Cue
Publisher : John Wiley & Sons
Page : 769 pages
File Size : 48,6 Mb
Release : 2012-07-23
Category : Medical
ISBN : 9780470711514

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Green Techniques for Organic Synthesis and Medicinal Chemistry by Wei Zhang,Berkeley W. Cue Pdf

Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts: Introduction: Introduces the reader to the toxicology of organic chemicals,their environmental impact, and the concept of green chemistry. Green Catalysis: Covers a variety of green catalytic techniques including organocatalysis, supported catalysis, biocatalysis, fluorous catalysis, and catalytic direct C-H bond activation reactions. Green Synthetic Techniques: Presents a series of new techniques, assessing the green chemistry aspects and limitations (i.e. cost, equipment, expertise). Techniques include reactions in alternative solvents, atom economic multicomponent reactions, microwave and ultrasonic reactions, solid-supported synthesis, fluorous and ionic liquid-based recycling techniques, and flow reactors. Green Techniques in Pharmaceutical Industry: Covers applications of green chemistry concepts and special techniques for medicinal chemistry, including synthesis, analysis, separation, formulation, , and drug delivery. Process and business case studies are included to illustrate the applications in the pharmaceutical industry. Green Techniques for Organic Synthesis and Medicinal Chemistry is an essential resource on green chemistry technologies for academic researchers, R&D professionals and students working in organic chemistry and medicinal chemistry.

Flash Chemistry

Jun-ichi Yoshida
Flash Chemistry Book PDF

Author : Jun-ichi Yoshida
Publisher : John Wiley & Sons
Page : 244 pages
File Size : 41,7 Mb
Release : 2008-10-13
Category : Science
ISBN : 9780470723418

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Flash Chemistry by Jun-ichi Yoshida Pdf

Have you ever wished you could speed up your organic syntheses without losing control of the reaction? Flash Chemistry is a new concept which offers an integrated scheme for fast, controlled organic synthesis. It brings together the generation of highly reactive species and their reactions in Microsystems to enable highly controlled organic syntheses on a preparative scale in timescales of a few seconds or less. Flash Chemistry: Fast Organic Synthesis in microsystems is the first book to describe this exciting new technique, with chapters covering: an introduction to flash chemistry reaction dynamics: how fast is the act of chemical transformation, what is the rate of reaction, and what determines the selectivity of a reaction? examples of why flash chemistry is needed: the rapid construction of chemical libraries, rapid synthesis of radioactive PET probes, and on-demand rapid synthesis in industry the generation of highly reactive species through thermal, microwave, chemical, photochemical, and electrochemical activation microsystems: What are microsystems and how are they made? Why is size so important? What are the characteristic features of microsystems? conduction and control of extremely fast reactions using microsystems applications of flash chemistry in organic synthesis polymer synthesis based on flash chemistry industrial applications of flash chemistry Flash Chemistry: Fast Organic Synthesis in Microsystems is an essential introduction to anyone working in organic synthesis, process chemistry, chemical engineering and physical organic chemistry concerned with fundamental aspects of chemical reactions an d synthesis and the production of organic compounds.

Continuous-Flow Chemistry in the Research Laboratory

Toma Glasnov
Continuous Flow Chemistry in the Research Laboratory Book PDF

Author : Toma Glasnov
Publisher : Springer
Page : 119 pages
File Size : 52,8 Mb
Release : 2016-06-01
Category : Science
ISBN : 9783319321967

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Continuous-Flow Chemistry in the Research Laboratory by Toma Glasnov Pdf

This book presents a short introduction to the historical background to the field, the state of the art and a brief survey of the available instrumentation and the processing techniques used. The following major areas of interest in synthetic, organic and medicinal chemistry are elaborated on: transition-metal catalyzed reactions, organocatalytic transformations, heterocyclic synthesis, and photochemical reactions. Finally, selected applications in industry are also discussed. With its ample presentation of examples from recent literature, this is an essential and reliable source of information for both experienced researchers and postgraduate newcomers to the field.

Microreaction Technology

M. Matlosz,W. Ehrfeld,J.P. Baselt
Microreaction Technology Book PDF

Author : M. Matlosz,W. Ehrfeld,J.P. Baselt
Publisher : Springer Science & Business Media
Page : 584 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642567636

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Microreaction Technology by M. Matlosz,W. Ehrfeld,J.P. Baselt Pdf

IMRET 5 featured more than 80 oral and poster communications, covering the entire interdisciplinary field from design, production, modeling and characterization of microreactor devices to application of microstructured systems for production, energy and transportation, including many analytical and biological applications. A particularly strong topic was the investigation of the potential of microstructuring of reactors and systems components for process intensification. Perspectives of combining local, in situ, data acquisition with appropriate microstructuring of actuators and components within chemical and biological devices were explored in order to enhance process performance and facilitate process control.

Microreactors in Preparative Chemistry

Wladimir Reschetilowski
Microreactors in Preparative Chemistry Book PDF

Author : Wladimir Reschetilowski
Publisher : John Wiley & Sons
Page : 352 pages
File Size : 46,8 Mb
Release : 2013-09-13
Category : Science
ISBN : 9783527652914

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Microreactors in Preparative Chemistry by Wladimir Reschetilowski Pdf

This is the first book in the field to focus on these aspects, providing extremely valuable information unavailable elsewhere for anyone seeking the practical application of microreactor technology in preparative chemistry. The topics covered branch out in three different directions. To begin with, the knowledge necessary for the preparative chemistry concerning the influence of the so-called microeffects on the reaction procedure and on mass and heat transfer as well as the surface phenomena are provided in detail. Next, practical aspects of the synthesis of various basic chemicals and fine chemicals, polymers, bioproducts and nanoparticles are discussed, including important advice for both the researcher and industrial chemist. Finally, reaction examples in microreactors whose reaction guidance are best understood are given together with universally applicable correlations as well as modeling approaches and transfer potential on related reaction systems. With its specific instructions, tips and experimental procedures for product syntheses as well as the inclusion of both the technical and theoretical background this is a must-have for beginners and experts alike working in this emerging field.

Design and Engineering of Microreactor and Smart-Scaled Flow Processes

Volker Hessel
Design and Engineering of Microreactor and Smart Scaled Flow Processes Book PDF

Author : Volker Hessel
Publisher : MDPI
Page : 250 pages
File Size : 43,8 Mb
Release : 2018-10-08
Category : Technology & Engineering
ISBN : 9783038420385

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Design and Engineering of Microreactor and Smart-Scaled Flow Processes by Volker Hessel Pdf

This book is a printed edition of the Special Issue "Design and Engineering of Microreactor and Smart-Scaled Flow Processes" that was published in Processes

Science of Synthesis: Flow Chemistry in Organic Synthesis

T.F. Jamison,G. Koch
Science of Synthesis Flow Chemistry in Organic Synthesis Book PDF

Author : T.F. Jamison,G. Koch
Publisher : Thieme
Page : 932 pages
File Size : 45,9 Mb
Release : 2018-12-12
Category : Science
ISBN : 9783132423343

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Science of Synthesis: Flow Chemistry in Organic Synthesis by T.F. Jamison,G. Koch Pdf

The aim of this work is to convey the practice, power, and potential of flow chemistry to a larger audience. An emerging and strengthening trend is that flow chemistry is much more than the adaption of batch processes to flow systems. Rather, flow chemistry offers a new paradigm in the way we think about chemical synthesis. This volume demonstrates the enabling power of continuous flow to access new reaction types and different chemistry space and, to this end, it has been compiled by a team of pioneers and leaders, who present both the practical and conceptual aspects of this rapidly growing field. Included are the principles of reactor design, automation, and separations/purifications in flow systems, applications in photochemistry, electrochemistry, gaseous systems, immobilized reagents and catalysts, and multistep processes. The synthesis of peptides, carbohydrates, and pharmaceuticals is covered and several chapters give insight into the use of flow in an industrial context.

Continuous Pharmaceutical Processing and Process Analytical Technology

Ajit S. Narang,Atul Dubey
Continuous Pharmaceutical Processing and Process Analytical Technology Book PDF

Author : Ajit S. Narang,Atul Dubey
Publisher : CRC Press
Page : 723 pages
File Size : 43,6 Mb
Release : 2023-03-01
Category : Medical
ISBN : 9781000804492

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Continuous Pharmaceutical Processing and Process Analytical Technology by Ajit S. Narang,Atul Dubey Pdf

Continuous manufacturing of pharmaceuticals, including aspects of modern process development is highlighted in this book with both the ‘why’ and the ‘how’, emphasizing process modeling and process analytical technologies. Presenting specific case studies and drawing upon extensive experience from industry and academic opinion leaders, this book focuses on the practical aspects of continuous manufacturing. It gives the readers the strategic perspective and technical depth needed to adopt and implement these technologies, where appropriate, in order to gain the competitive edge in speed, agility, and reliability. Features: Discusses scientific solutions and process analytical technology to enable continuous manufacturing in the development of new drugs Includes short stories about how some companies have adopted CM and what their drivers were and what benefits were realized Addresses economic and practical considerations, unlike many other technical books Emphasizes the practical aspects to give the reader the strategic imperative and technological depth to adopt and implement these technologies Highlights the "why" and the "how", focusing on the need analysis and process modeling and process analytical technologies

Flow Chemistry for Pharmaceuticals

Rodrigo Octavio Mendonca Alves de Souza
Flow Chemistry for Pharmaceuticals Book PDF

Author : Rodrigo Octavio Mendonca Alves de Souza
Publisher : Unknown
Page : 310 pages
File Size : 41,6 Mb
Release : 2022-11-13
Category : Electronic
ISBN : 3110646250

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Flow Chemistry for Pharmaceuticals by Rodrigo Octavio Mendonca Alves de Souza Pdf

Flow chemistry offers several advantages for a change to more sustainability and flexibility in the production of pharmaceuticals. This book explains the basic concepts of flow chemistry and describes various examples for continuous synthesis and crystallization of active pharmaceutical ingredients. Recently developed techniques but also protocols already applied in industry offer a useful source for researchers in academia and professionals.

Open Access Databases and Datasets for Drug Discovery

Antoine Daina,Michael T Przewosny,Vincent Zoete
Open Access Databases and Datasets for Drug Discovery Book PDF

Author : Antoine Daina,Michael T Przewosny,Vincent Zoete
Publisher : John Wiley & Sons
Page : 357 pages
File Size : 49,8 Mb
Release : 2023-12-26
Category : Medical
ISBN : 9783527348398

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Open Access Databases and Datasets for Drug Discovery by Antoine Daina,Michael T Przewosny,Vincent Zoete Pdf

Open Access Databases and Datasets for Drug Discovery Timely resource discussing the future of data-driven drug discovery and the growing number of open-source databases With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process. Contributed to and edited by experts with long-time experience in the field, Open Access Databases and Datasets for Drug Discovery includes information on: An extensive listing of open access databases and datasets for computer-aided drug design PubChem as a chemical database for drug discovery, DrugBank Online, and bioisosteric replacement for drug discovery supported by the SwissBioisostere database The Protein Data Bank (PDB) and macromolecular structure data supporting computer-aided drug design, and the SWISS-MODEL repository of 3D protein structures and models PDB-REDO in computational aided drug design (CADD), and using Pharos/TCRD for discovering druggable targets Unmatched in scope and thoroughly reviewing small and large open data sources relevant for rational drug design, Open Access Databases and Datasets for Drug Discovery is an essential reference for medicinal and pharmaceutical chemists, and any scientists involved in the drug discovery and drug development.