Focus On Leukemia Research

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Biology and Treatment of Leukemia and Bone Marrow Neoplasms

Vinod Pullarkat,Guido Marcucci
Biology and Treatment of Leukemia and Bone Marrow Neoplasms Book PDF

Author : Vinod Pullarkat,Guido Marcucci
Publisher : Springer Nature
Page : 200 pages
File Size : 51,7 Mb
Release : 2021-10-09
Category : Medical
ISBN : 9783030783112

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Biology and Treatment of Leukemia and Bone Marrow Neoplasms by Vinod Pullarkat,Guido Marcucci Pdf

This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.

Chronic Lymphocytic Leukemia Research Focus

Chadi Nabhan
Chronic Lymphocytic Leukemia Research Focus Book PDF

Author : Chadi Nabhan
Publisher : Nova Publishers
Page : 242 pages
File Size : 42,5 Mb
Release : 2007
Category : Age factors in disease
ISBN : 1600215262

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Chronic Lymphocytic Leukemia Research Focus by Chadi Nabhan Pdf

Chronic lymphocytic leukaemia (or "chronic lymphoid leukaemia"), known for short as CLL, is a type of leukaemia in which too many lymphocytes are produced. Although the malignant lymphocytes in CLL may look normal and mature, they are not and these cells may not cope effectively with infection. CLL is the most common form of leukaemia in adults. Men are twice as likely to develop CLL as women. However, the key risk factor is age. Over 75% of new cases are diagnosed in patients over age 50. This book presents important research from around the world in this field.

Focus on Leukemia Research

Rafael M. Romero
Focus on Leukemia Research Book PDF

Author : Rafael M. Romero
Publisher : Nova Publishers
Page : 206 pages
File Size : 44,8 Mb
Release : 2004
Category : Leukemia
ISBN : 1594540934

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Focus on Leukemia Research by Rafael M. Romero Pdf

This new book brings together leading research from around the globe. Leukaemia is cancer that begins in blood cells. In people with leukaemia, the bone marrow produces abnormal white blood cells. The abnormal cells are leukaemia cells. At first, leukaemia cells function almost normally. In time, they may crowd out normal white blood cells, red blood cells, and platelets. The scope of the book includes the four common types of leukaemia: chronic lymphocytic leukaemia (chronic lymphoblastic leukaemia, CLL) - most often affecting people over age 55; chronic myeloid leukaemia (chronic myelogenous leukaemia, CML) - affects mainly adults; acute lymphocytic leukaemia (acute lymphoblastic leukaemia, ALL) - the most common type of leukaemia in young children; and acute myeloid leukaemia (acute myelogenous leukaemia, AML) - which occurs in both adults and children. New advances in diagnosis, pathogenesis and therapy are also presented.

Childhood Acute Lymphoblastic Leukemia

Ajay Vora
Childhood Acute Lymphoblastic Leukemia Book PDF

Author : Ajay Vora
Publisher : Springer
Page : 342 pages
File Size : 43,8 Mb
Release : 2017-04-21
Category : Medical
ISBN : 9783319397085

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Childhood Acute Lymphoblastic Leukemia by Ajay Vora Pdf

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Tumors in Adolescents and Young Adults

Daniel P. Stark,Gilles Vassal
Tumors in Adolescents and Young Adults Book PDF

Author : Daniel P. Stark,Gilles Vassal
Publisher : Karger Medical Scientific
Page : 0 pages
File Size : 44,9 Mb
Release : 2016
Category : Cancer in children
ISBN : 3318059110

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Tumors in Adolescents and Young Adults by Daniel P. Stark,Gilles Vassal Pdf

The field of adolescents and young adult (AYA) oncology is experiencing a very challenging time. This book is a guide to the key issues for any clinician and health professional managing AYA with cancer in Europe. Emphasis is on collaboration between adult and pediatric specialists. Authors present their perception of the current state of the most prominent primary issues in AYA oncology. Chapters cover cross-cutting issues such as disease epidemiology, systems of care, access to innovative therapy and late effects of treatment and survivorship for AYA-onset cancers. There are discussions of the latest developments and the most important cancer types for AYA, including the shared perspectives of adult and pediatric specialists. Throughout the book recurrent challenges to the AYA community are exposed and solutions proposed. Tumors in Adolescents and Young Adults is highly recommended to any oncologist or haematologist treating patients aged 15 to 39 diagnosed with cancer. It will also be of interest to other members of the multidisciplinary teams involved with this patient group.

Allogeneic Stem Cell Transplantation

Hillard M. Lazarus,Mary J. Laughlin
Allogeneic Stem Cell Transplantation Book PDF

Author : Hillard M. Lazarus,Mary J. Laughlin
Publisher : Springer Science & Business Media
Page : 881 pages
File Size : 44,6 Mb
Release : 2010-03-02
Category : Medical
ISBN : 9781597454780

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Allogeneic Stem Cell Transplantation by Hillard M. Lazarus,Mary J. Laughlin Pdf

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

The Leukemias: Etiology, Pathophysiology, and Treatment

John W. Rebuck,Frank H. Bethell,Raymond W. Monto
The Leukemias Etiology Pathophysiology and Treatment Book PDF

Author : John W. Rebuck,Frank H. Bethell,Raymond W. Monto
Publisher : Elsevier
Page : 730 pages
File Size : 55,9 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483263755

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The Leukemias: Etiology, Pathophysiology, and Treatment by John W. Rebuck,Frank H. Bethell,Raymond W. Monto Pdf

The Leukemias: Etiology, Pathophysiology, and Treatment documents the proceedings of an International Symposium on The Leukemias: Etiology and Pathophysiology, held at Henry Ford Hospital, Detroit, Michigan, 8-10 March 1956. This volume gives the present complex position of leukemic etiology and pathophysiologic disturbance, a much needed knowledge of detailed leukocytic functions and comprehensive thought on the therapy of the leukemias. It also establishes a basis of comparison with the earlier works of Downey and Forkner in this field in the late thirties and thus makes it possible to see with some clarity the extent of progress made. The volume contains 39 papers organized into nine parts. The papers in Part I focus on the leukemic cell, its structure, and antigenicity. Part II presents studies on genetic and environmental factors in the transmission of leukemia. Part III examines the radiation biology of leukocytes. Part IV focuses on the leukemias and the malignant lymphomas while Part V deals with leukocytic physiology. Part VI covers the metabolism of amino and nucleic acids in the leukemias. Part VII takes up further biochemical considerations in the leukemias. Part VIII contains papers that examine nucleic acids as the target for chemotherapy. Part IX presents a round-table discussion on therapy.

Trends in Brain Cancer Research

Andrew V. Yang
Trends in Brain Cancer Research Book PDF

Author : Andrew V. Yang
Publisher : Nova Publishers
Page : 358 pages
File Size : 43,5 Mb
Release : 2006
Category : Brain
ISBN : 1594549729

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Trends in Brain Cancer Research by Andrew V. Yang Pdf

There are two types of brain tumours: primary brain tumours that originate in the brain and metastatic (secondary) brain tumours that originate from cancer cells that have migrated from other parts of the body. Primary brain cancer rarely spreads beyond the central nervous system, and death results from uncontrolled tumour growth within the limited space of the skull. Metastatic brain cancer indicates advanced disease and has a poor prognosis. Primary brain tumours can be cancerous or non-cancerous. Both types take up space in the brain and may cause serious symptoms (e.g., vision or hearing loss) and complications (e.g., stroke). All cancerous brain tumours are life threatening (malignant) because they have an aggressive and invasive nature. A non-cancerous primary brain tumour is life threatening when it compromises vital structures (e.g., an artery). This book brings together the leading research in this dynamic area of research.

Analysis of Cancer Risks in Populations Near Nuclear Facilities

National Research Council,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilitiesâ¬"Phase I
Analysis of Cancer Risks in Populations Near Nuclear Facilities Book PDF

Author : National Research Council,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilitiesâ¬"Phase I
Publisher : National Academies Press
Page : 424 pages
File Size : 43,6 Mb
Release : 2012-06-29
Category : Medical
ISBN : 9780309255714

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Analysis of Cancer Risks in Populations Near Nuclear Facilities by National Research Council,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilitiesâ¬"Phase I Pdf

In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.

Leading Edge Cancer Research

Glenn V. Sizemore
Leading Edge Cancer Research Book PDF

Author : Glenn V. Sizemore
Publisher : Nova Publishers
Page : 182 pages
File Size : 55,9 Mb
Release : 2007
Category : Cancer
ISBN : 1600211976

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Leading Edge Cancer Research by Glenn V. Sizemore Pdf

Cancer is a group of different diseases (over 100) characterised by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. If a cancer spreads (metastasizes), the new tumour bears the same name as the original (primary) tumour. Significant progress has been made in recent years in the battle against cancer and in understanding its underlying biological mechanisms. This research progress has resulted in many experimental treatments and cures which establish hope for wide-spread cures. This book brings together important research from around the world in this frontal field.

Trends in Thyroid Cancer Research

Carl A. Milton
Trends in Thyroid Cancer Research Book PDF

Author : Carl A. Milton
Publisher : Nova Publishers
Page : 388 pages
File Size : 47,5 Mb
Release : 2007
Category : Thyroid gland
ISBN : 1594546274

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Trends in Thyroid Cancer Research by Carl A. Milton Pdf

Thyroid cancer is cancer of the thyroid gland. These may be of many types including papillary, follicular, Hurthle cell (aka oxyphilic or oncocytic), or medullary cancers. Surgery plays an important role in treating these cancers. The thyroid concentrates iodine and so is extremely sensitive to the effects of various radioactive isotopes of iodine produced by nuclear fission. These radioactive isotopes increase the chances of developing cancer, though thyroid cancer can develop even without any exposure to radioactivity. Some evidence suggests that insufficient or excessive dietary iodine may also increase the risk for thyroid cancer. This book presents the latest research in this field.

New Topics in Cancer Research

Fredrick G. Drabell
New Topics in Cancer Research Book PDF

Author : Fredrick G. Drabell
Publisher : Nova Publishers
Page : 304 pages
File Size : 52,7 Mb
Release : 2006
Category : Cancer
ISBN : 1600211550

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New Topics in Cancer Research by Fredrick G. Drabell Pdf

Cancer is a group of different diseases (more than 100) characterised by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. If a cancer spreads (metastasizes), the new tumour bears the same name as the original (primary) tumour. Significant progress has been made in recent years in the battle against cancer and in understanding its underlying biological mechanisms. This research progress has resulted in many experimental treatments and cures which establish hope for wide-spread cures. This book brings together important research from around the world in this frontal field.

Adult Acute Lymphocytic Leukemia

Anjali S. Advani,Hillard M. Lazarus
Adult Acute Lymphocytic Leukemia Book PDF

Author : Anjali S. Advani,Hillard M. Lazarus
Publisher : Springer Science & Business Media
Page : 388 pages
File Size : 49,5 Mb
Release : 2010-11-18
Category : Medical
ISBN : 9781607617075

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Adult Acute Lymphocytic Leukemia by Anjali S. Advani,Hillard M. Lazarus Pdf

The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments. Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. This is the first book to focus exclusively on the adult ALL patient. It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population.

Walking with a Shadow

Nanci A. Sullivan
Walking with a Shadow Book PDF

Author : Nanci A. Sullivan
Publisher : Bloomsbury Publishing USA
Page : 312 pages
File Size : 48,8 Mb
Release : 2004-09-30
Category : Health & Fitness
ISBN : 9780313051395

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Walking with a Shadow by Nanci A. Sullivan Pdf

Childhood cancer, particularly leukemia, is on the rise. Leukemia strikes one child in every 25,000, and most often does so between the ages of 3 and 7. Annually, more than 2,700 children are diagnosed with leukemia in the United States. Due to advances in biotechnology and medicine, survival rates for this once-deadly disease now stand at 80%. But the psychological effects of diagnosis, removal from school, treatment, and remission or cure, linger. Here nine long-term survivors of childhood leukemia share their vivid memories and give us insight into the physiological changes, psychosocial and educational difficulties that became a constant shadow in their lives. Author Nanci Sullivan provides recommendations for ways teachers, counselors and other professionals may better help young students with leukemia cope.

The First Cell

Azra Raza
The First Cell Book PDF

Author : Azra Raza
Publisher : Basic Books
Page : 368 pages
File Size : 55,5 Mb
Release : 2019-10-15
Category : Health & Fitness
ISBN : 9781541699502

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The First Cell by Azra Raza Pdf

With the fascinating scholarship of The Emperor of All Maladies and the deeply personal experience of When Breath Becomes Air, a world-class oncologist examines the current state of cancer and its devastating impact on the individuals it affects -- including herself. In The First Cell, Azra Raza offers a searing account of how both medicine and our society (mis)treats cancer, how we can do better, and why we must. A lyrical journey from hope to despair and back again, The First Cell explores cancer from every angle: medical, scientific, cultural, and personal. Indeed, Raza describes how she bore the terrible burden of being her own husband's oncologist as he succumbed to leukemia. Like When Breath Becomes Air, The First Cell is no ordinary book of medicine, but a book of wisdom and grace by an author who has devoted her life to making the unbearable easier to bear.