Forensic Practitioner S Guide To The Interpretation Of Complex Dna Profiles

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Forensic Practitioner's Guide to the Interpretation of Complex DNA Profiles

Peter Gill,Øyvind Bleka,Oskar Hansson,Corina Benschop,Hinda Haned
Forensic Practitioner s Guide to the Interpretation of Complex DNA Profiles Book PDF

Author : Peter Gill,Øyvind Bleka,Oskar Hansson,Corina Benschop,Hinda Haned
Publisher : Academic Press
Page : 532 pages
File Size : 53,8 Mb
Release : 2020-06-10
Category : Law
ISBN : 9780128205686

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Forensic Practitioner's Guide to the Interpretation of Complex DNA Profiles by Peter Gill,Øyvind Bleka,Oskar Hansson,Corina Benschop,Hinda Haned Pdf

Over the past twenty years, there’s been a gradual shift in the way forensic scientists approach the evaluation of DNA profiling evidence that is taken to court. Many laboratories are now adopting ‘probabilistic genotyping’ to interpret complex DNA mixtures. However, current practice is very diverse, where a whole range of technologies are used to interpret DNA profiles and the software approaches advocated are commonly used throughout the world. Forensic Practitioner’s Guide to the Interpretation of Complex DNA Profiles places the main concepts of DNA profiling into context and fills a niche that is unoccupied in current literature. The book begins with an introduction to basic forensic genetics, covering a brief historical description of the development and harmonization of STR markers and national DNA databases. The laws of statistics are described, along with the likelihood ratio based on Hardy-Weinberg equilibrium and alternative models considering sub-structuring and relatedness. The historical development of low template mixture analysis, theory and practice, is also described, so the reader has a full understanding of rationale and progression. Evaluation of evidence and statement writing is described in detail, along with common pitfalls and their avoidance. The authors have been at the forefront of the revolution, having made substantial contributions to theory and practice over the past two decades. All methods described are open-source and freely available, supported by sets of test-data and links to web-sites with further information. This book is written primarily for the biologist with little or no statistical training. However, sufficient information will also be provided for the experienced statistician. Consequently, the book appeals to a diverse audience Covers short tandem repeat (STR) analysis, including database searching and massive parallel sequencing (both STRs and SNPs) Encourages dissemination and understanding of probabilistic genotyping by including practical examples of varying complexity Written by authors intimately involved with software development, training at international workshops and reporting cases worldwide using the methods described in this book

Interpreting Complex Forensic DNA Evidence

Jane Moira Taupin
Interpreting Complex Forensic DNA Evidence Book PDF

Author : Jane Moira Taupin
Publisher : CRC Press
Page : 117 pages
File Size : 48,5 Mb
Release : 2019-11-14
Category : Law
ISBN : 9781351023764

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Interpreting Complex Forensic DNA Evidence by Jane Moira Taupin Pdf

Interpreting Complex Forensic DNA Evidence is a handy guide to recent advances—and emerging issues—in interpreting complex DNA evidence and profiles for use in criminal investigations. In certain cases, DNA cannot be connected to a specific biological material such as blood, semen or saliva. How or when the DNA was deposited may be an issue. The possibility of generating DNA profiles from touched objects, where there may not be a visible deposit, has expanded the scope and number of exhibits submitted for DNA analysis. With such advances, and increasing improvements in technological capabilities in testing samples, this means it is possible to detect ever smaller amounts of DNA. There are also many efforts underway to seek was to interpret DNA profiles that are sub-optimal—either relative to the amount required by the testing kit and, potentially, the quality of the obtained sample. Laboratories often use enhancements in order to obtain a readable DNA profile. The broad-reaching implications of improving DNA sensitivity have led to this next, emerging generation of more complex profiles. Examples partial profiles that do not faithfully reflect the proposed donor, or mixtures of partial DNA from multiple people. A complexity threshold has been proposed to limit interpretation of poor-quality data. Research is now addressing the interpretation of transfer of trace amounts of DNA. Complex issues are arising in trial that need to be reconciled as such complexity has added challenges to the interpretation of evidence and its introduction or dismissal in certain cases in the courts. Key Features: Addresses DNA transfer, from person-to-person as well as to objects Outlines each stage required to produce a DNA profile from an exhibit—including collection, handling, storage, and analysis Discusses ethics, subjectivity, and bias—including cognitive dissonance—as they relate specifically to complex DNA evidence Highlights current techniques and the latest advances in DNA analysis, including advances in familial DNA searches Interpreting Complex Forensic DNA Evidence provides tools to assist the criminal investigator, forensic expert, and legal professional when posed with a DNA result in a forensic report or testimony. The result—and any associated statistic—may not reveal any ambiguity, complexity, or the assumptions involved in deriving it. Questions from resolved criminal cases are posed, and the relevant forensic literature, provided for the reader to assess a DNA result and any associated statistic. Case studies throughout illustrate concepts and emphasize the need for conclusions in the forensic report that are supported by the data.

Weight-of-Evidence for Forensic DNA Profiles

David J. Balding,Christopher D. Steele
Weight of Evidence for Forensic DNA Profiles Book PDF

Author : David J. Balding,Christopher D. Steele
Publisher : John Wiley & Sons
Page : 232 pages
File Size : 42,5 Mb
Release : 2015-07-20
Category : Mathematics
ISBN : 9781118814550

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Weight-of-Evidence for Forensic DNA Profiles by David J. Balding,Christopher D. Steele Pdf

DNA evidence is widely used in the modern justice system. Statistical methodology plays a key role in ensuring that this evidence is collected, interpreted, analysed and presented correctly. This book is a guide to assessing DNA evidence and presenting that evidence in a courtroom setting. It offers practical guidance to forensic scientists with little dependence on mathematical ability, and provides the scientist with the understanding they require to apply the methods in their work. Since the publication of the first edition of this book in 2005 there have been many incremental changes, and one dramatic change which is the emergence of low template DNA (LTDNA) profiles. This second edition is edited and expanded to cover the basics of LTDNA technology. The author's own open-source R code likeLTD is described and used for worked examples in the book. Commercial and free software are also covered.

Weight-of-Evidence for Forensic DNA Profiles

David J. Balding
Weight of Evidence for Forensic DNA Profiles Book PDF

Author : David J. Balding
Publisher : John Wiley & Sons
Page : 198 pages
File Size : 46,5 Mb
Release : 2005-04-08
Category : Mathematics
ISBN : 9780470867662

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Weight-of-Evidence for Forensic DNA Profiles by David J. Balding Pdf

Assessing Weight-of-Evidence for DNA Profiles is an excellent introductory text to the use of statistical analysis for assessing DNA evidence. It offers practical guidance to forensic scientists with little dependence on mathematical ability as the book includes background information on statistics – including likelihood ratios – population genetics, and courtroom issues. The author, who is highly experienced in this field, has illustrated the book throughout with his own experiences as well as providing a theoretical underpinning to the subject. It is an ideal choice for forensic scientists and lawyers, as well as statisticians and population geneticists with an interest in forensic science and DNA.

A Guide to Forensic DNA Profiling

Scott Bader
A Guide to Forensic DNA Profiling Book PDF

Author : Scott Bader
Publisher : John Wiley & Sons
Page : 453 pages
File Size : 48,8 Mb
Release : 2016-03-21
Category : Law
ISBN : 9781118751527

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A Guide to Forensic DNA Profiling by Scott Bader Pdf

The increasingly arcane world of DNA profiling demands that those needing to understand at least some of it must find a source of reliable and understandable information. Combining material from the successful Wiley Encyclopedia of Forensic Science with newly commissioned and updated material, the Editors have used their own extensive experience in criminal casework across the world to compile an informative guide that will provide knowledge and thought-provoking articles of interest to anyone involved or interested in the use of DNA in the forensic context. Following extensive introductory chapters covering forensic DNA profiling and forensic genetics, this comprehensive volume presents a substantial breadth of material covering: Fundamental material – including sources of DNA, validation, and accreditation Analysis and interpretation – including, extraction, quantification, amplification and interpretation of electropherograms (epgs) Evaluation – including mixtures, low template, and transfer Applications – databases, paternity and kinship, mitochondrial-DNA, wildlife DNA, single-nucleotide polymorphism, phenotyping and familial searching Court - report writing, discovery, cross examination, and current controversies With contributions from leading experts across the whole gamut of forensic science, this volume is intended to be authoritative but not authoritarian, informative but comprehensible, and comprehensive but concise. It will prove to be a valuable addition, and useful resource, for scientists, lawyers, teachers, criminologists, and judges.

Forensic DNA Profiling

Jo-Anne Bright,Michael Coble
Forensic DNA Profiling Book PDF

Author : Jo-Anne Bright,Michael Coble
Publisher : CRC Press
Page : 132 pages
File Size : 55,9 Mb
Release : 2019-12-09
Category : Law
ISBN : 9780429671425

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Forensic DNA Profiling by Jo-Anne Bright,Michael Coble Pdf

DNA testing and its forensic analysis are recognized as the “gold standard” in forensic identification science methods. However, there is a great need for a hands-on step-by-step guide to teach the forensic DNA community how to interpret DNA mixtures, how to assign a likelihood ratio, and how to use the subsequent likelihood ratio when reporting interpretation conclusions. Forensic DNA Profiling: A Practical Guide to Assigning Likelihood Ratios will provide a roadmap for labs all over the world and the next generation of analysts who need this foundational understanding. The techniques used in forensic DNA analysis are based upon the accepted principles of molecular biology. The interpretation of a good-quality DNA profile generated from a crime scene stain from a single-source donor provides an unambiguous result when using the most modern forensic DNA methods. Unfortunately, many crime scene profiles are not single source. They are described as mixed since they contain DNA from two or more individuals. Interpretation of DNA mixtures represents one of the greatest challenges to the forensic DNA analyst. As such, the book introduces terms used to describe DNA profiles and profile interpretation. Chapters explain DNA extraction methods, the polymerase chain reaction (PCR), capillary electrophoresis (CE), likelihood ratios (LRs) and their interpretation, and population genetic models—including Mendelian inheritance and Hardy-Weinberg equilibrium. It is important that analysts understand how LRs are generated in a probabilistic framework, ideally with an appreciation of both semicontinuous and fully continuous probabilistic approaches. KEY FEATURES: • The first book to focus entirely on DNA mixtures and the complexities involved with interpreting the results • Takes a hands-on approach offering theory with worked examples and exercises to be easily understood and implementable by laboratory personnel • New methods, heretofore unpublished previously, provide a means to innovate deconvoluting a mixed DNA profile, assign an LR, and appropriately report the weight of evidence • Includes a chapter on assigning LRs for close relatives (i.e., “It’s not me, it was my brother”), and discusses strategies for the validation of probabilistic genotyping software Forensic DNA Profiling fills the void for labs unfamiliar with LRs, and moving to probabilistic solutions, and for labs already familiar with LRs, but wishing to understand how they are calculated in more detail. The book will be a welcome read for lab professionals and technicians, students, and legal professionals seeking to understand and apply the techniques covered.

Statistical DNA Forensics

Wing Kam Fung,Yue-Qing Hu
Statistical DNA Forensics Book PDF

Author : Wing Kam Fung,Yue-Qing Hu
Publisher : John Wiley & Sons
Page : 262 pages
File Size : 42,6 Mb
Release : 2008-04-15
Category : Mathematics
ISBN : 0470727039

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Statistical DNA Forensics by Wing Kam Fung,Yue-Qing Hu Pdf

Statistical methodology plays a key role in ensuring that DNA evidence is collected, interpreted, analyzed and presented correctly. With the recent advances in computer technology, this methodology is more complex than ever before. There are a growing number of books in the area but none are devoted to the computational analysis of evidence. This book presents the methodology of statistical DNA forensics with an emphasis on the use of computational techniques to analyze and interpret forensic evidence.

Fundamentals of Forensic DNA Typing

John M. Butler
Fundamentals of Forensic DNA Typing Book PDF

Author : John M. Butler
Publisher : Academic Press
Page : 519 pages
File Size : 47,5 Mb
Release : 2009-09-30
Category : Law
ISBN : 9780080961767

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Fundamentals of Forensic DNA Typing by John M. Butler Pdf

Fundamentals of Forensic DNA Typing is written with a broad viewpoint. It examines the methods of current forensic DNA typing, focusing on short tandem repeats (STRs). It encompasses current forensic DNA analysis methods, as well as biology, technology and genetic interpretation. This book reviews the methods of forensic DNA testing used in the first two decades since early 1980’s, and it offers perspectives on future trends in this field, including new genetic markers and new technologies. Furthermore, it explains the process of DNA testing from collection of samples through DNA extraction, DNA quantitation, DNA amplification, and statistical interpretation. The book also discusses DNA databases, which play an important role in law enforcement investigations. In addition, there is a discussion about ethical concerns in retaining DNA profiles and the issues involved when people use a database to search for close relatives. Students of forensic DNA analysis, forensic scientists, and members of the law enforcement and legal professions who want to know more about STR typing will find this book invaluable. Includes a glossary with over 400 terms for quick reference of unfamiliar terms as well as an acronym guide to decipher the DNA dialect Continues in the style of Forensic DNA Typing, 2e, with high-profile cases addressed in D.N.A.Boxes-- "Data, Notes & Applications" sections throughout Ancillaries include: instructor manual Web site, with tailored set of 1000+ PowerPoint slides (including figures), links to online training websites and a test bank with key

Forensic Analysis of Biological Evidence

J. Thomas McClintock
Forensic Analysis of Biological Evidence Book PDF

Author : J. Thomas McClintock
Publisher : CRC Press
Page : 176 pages
File Size : 46,7 Mb
Release : 2017-08-02
Category : Law
ISBN : 9781466504585

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Forensic Analysis of Biological Evidence by J. Thomas McClintock Pdf

A powerful tool in the identification of individuals, DNA typing has revolutionized criminal and paternity investigations. Widespread analysis is now conducted by public and private laboratories in the United States and abroad. Focusing on the basic techniques used in forensic DNA laboratories, Forensic Analysis of Biological Evidence: A Laboratory

Handbook of DNA Forensic Applications and Interpretation

Amit Kumar,G. K. Goswami,Edwin Huffine
Handbook of DNA Forensic Applications and Interpretation Book PDF

Author : Amit Kumar,G. K. Goswami,Edwin Huffine
Publisher : Springer Nature
Page : 190 pages
File Size : 45,6 Mb
Release : 2022-07-01
Category : Medical
ISBN : 9789811900433

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Handbook of DNA Forensic Applications and Interpretation by Amit Kumar,G. K. Goswami,Edwin Huffine Pdf

This handbook covers tested and proven DNA forensic testing methodologies, forensic bioinformatics techniques, case studies and current forensic legal framework for investigation of variety of crimes and provides a clinching evidence for speedy justice. DNA testing is widely used for forensic purposes and is changing the paradigm of (crime) investigation. The book contains chapters on usage of ultramodern DNA collection kits, presents era evidence collection and preservation, high-end DNA sample analysis in laboratory, DNA legislation, expert evidences, challenging and successful case studies, data generation and application of AI and IoT techniques for DNA data analysis, DNA databanks and training manpower to facilitate timely reporting to the requesting agencies. This handbook equips and enables police, investigators and crime analysis laboratories with knowhow of high-end tools, procedures and techniques to link or exclude a criminal to a crime. It is expected that this will be used by first responders, police, forensic analysts, judiciaries, evidence handlers and students and scholars of criminology and forensic sciences worldwide. The intention to write this handbook is to make DNA technology and its importance reach every common man and professional for correctly using it as a tool as and when required. This is quite evident that awareness of DNA technology has increased at a reasonable pace. Courts and investigating agencies are convinced and confident with its accuracy, reliability and unmatched peace delivered by various techniques of DNA fingerprinting and DNA profiling.

DNA

Lawrence Kobilinsky,Thomas Liotti,Jamel L. Oeser-Sweat
DNA Book PDF

Author : Lawrence Kobilinsky,Thomas Liotti,Jamel L. Oeser-Sweat
Publisher : Wiley-Interscience
Page : 375 pages
File Size : 44,5 Mb
Release : 2004-11-11
Category : Science
ISBN : 9780471681908

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DNA by Lawrence Kobilinsky,Thomas Liotti,Jamel L. Oeser-Sweat Pdf

Includes a Foreword by Dr. James D. Watson, the co-discoverer of the DNA double helix, and Dr. Jan A. Witkowski. "From the Foreword by Drs. Watson and Witkowski: 'DNA: Forensic and Legal Applications is a comprehensive and invaluable guide to the field, covering topics ranging from collecting samples in the field to presenting the complex results to a jury. We are sure that it will play its part in promoting this most powerful tool in the forensic scientist's armamentarium.'" DNA: Forensic and Legal Applications covers the technology and laws related to DNA, as well as the use of DNA evidence in the legal system. This combination of science and law makes it the first comprehensive title of its kind and an appropriate reference for those with both elementary and advanced knowledge of the topic. It draws together in one source information that would previously have required extensive research and reliance on experts to obtain, offering both breadth and depth in a clear style without s acrificing scholarly goals. With material from both scientific and legal areas, DNA: Forensic and Legal Applications covers the latest advances in technology. It provides an ideal text for forensic scientists and students of forensic science, analytical chemists, lawyers, judges, police officers, and detectives.

Misleading DNA Evidence

Peter Gill
Misleading DNA Evidence Book PDF

Author : Peter Gill
Publisher : Elsevier
Page : 195 pages
File Size : 53,5 Mb
Release : 2014-06-18
Category : Social Science
ISBN : 9780124172203

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Misleading DNA Evidence by Peter Gill Pdf

Misleading DNA Evidence: A Guide for Scientists, Judges, and Lawyers presents the reasons miscarriages of justice can occur when dealing with DNA, what the role of the forensic scientist is throughout the process, and how judges and lawyers can educate themselves about all of the possibilities to consider when dealing with cases that involve DNA evidence. DNA has become the gold standard by which a person can be placed at the scene of a crime, and the past decade has seen great advances in this powerful crime solving tool. But the statistics that analysts can attach to DNA evidence often vary, and in some cases the statistical weight assigned to that match, can vary enormously. The numbers provided to juries often overstate the evidence, and can result in a wrongful conviction. In addition to statistics, the way the evidence is collected, stored and analyzed can also result in a wrongful conviction due to contamination. This book reviews high-profile and somewhat contentious cases to illustrate these points, including the death of Meredith Kercher. It examines crucial topics such as characterization of errors and determination of error rates, reporting DNA profiles and the source and sub-source levels, and the essentials of statement writing. It is a concise, readable resource that will help not only scientists, but legal professionals with limited scientific backgrounds, to understand the intricacies of DNA use in the justice system. Ideal reference for scientists and for those without extensive scientific backgrounds Written by one of the pioneers in forensic DNA typing and interpretation of DNA profiling results Ideal format for travel, court environments, or wherever easy access to reference material is vital

Forensic DNA Evidence Interpretation

John S. Buckleton,Jo-Anne Bright,Duncan Taylor
Forensic DNA Evidence Interpretation Book PDF

Author : John S. Buckleton,Jo-Anne Bright,Duncan Taylor
Publisher : CRC Press
Page : 509 pages
File Size : 40,6 Mb
Release : 2018-09-03
Category : Law
ISBN : 9781315362434

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Forensic DNA Evidence Interpretation by John S. Buckleton,Jo-Anne Bright,Duncan Taylor Pdf

Now in its second edition, Forensic DNA Evidence Interpretation is the most comprehensive resource for DNA casework available today. Written by leaders in the fields of biology and statistics, including a contribution from Peter Gill, the father of DNA analysis, the book emphasizes the interpretation of test results and provides the necessary formulae in an easily accessible manner. This latest edition is fully updated and includes current and emerging techniques in this fast-moving field. The book begins by reviewing all pertinent biology, and then provides information on every aspect of DNA analysis. This includes modern interpretation methods and contemporary population genetic models available for estimating DNA frequencies or likelihood ratios. Following a chapter on procedures for validating databases, the text presents overviews and performance assessments of both modern sampling uncertainty methods and current paternity testing techniques, including new guidelines on paternity testing in alignment with the International Society for Forensic Genetics. Later chapters discuss the latest methods for mixture analysis, LCN (ultra trace) analysis and non-autosomal (mito, X, and Y) DNA analysis. The text concludes with an overview of procedures for disaster victim identification and information on DNA intelligence databases. Highlights of the second edition include: New information about PCR processes, heterozygote balance and back and forward stuttering New information on the interpretation of low template DNA, drop models and continuous models Additional coverage of lineage marker subpopulation effects, mixtures and combinations with autosomal markers This authoritative book provides a link among the biological, forensic, and interpretative domains of the DNA profiling field. It continues to serve as an invaluable resource that allows forensic scientists, technicians, molecular biologists and attorneys to use forensic DNA evidence to its greatest potential.

Forensic DNA Transfer

Jane Moira Taupin
Forensic DNA Transfer Book PDF

Author : Jane Moira Taupin
Publisher : CRC Press
Page : 298 pages
File Size : 41,7 Mb
Release : 2023-10-06
Category : Law
ISBN : 9781000970005

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Forensic DNA Transfer by Jane Moira Taupin Pdf

Forensic DNA Transfer provides a guide to the recognition and current understanding of DNA transfer in forensic criminal investigations. Increased improvements in technology mean that it is now routinely possible to obtain DNA profiles from non-visible deposits. How or when the DNA in question was deposited may be an issue in the context of the case, especially if the donor of the DNA is not in dispute. A DNA profile alone cannot reveal when or how that DNA was deposited at a crime scene, nor can it reveal the body matter from which it originated. Issues of transfer associated with activities may be debated – which the traditional discrimination purpose of DNA profiling cannot address. DNA may be everywhere and anywhere – in homes, at workplaces, during transport, and on personal items including clothing. DNA from a person may be on an object they have never contacted or in a room they have never entered. Concepts discussed in the book include non-self DNA on hands through day-to-day activities, the prevalence of background DNA in the environment and perhaps on the exhibit, the persistence of any DNA transferred, and that a DNA result will depend on these variables as well as recovery techniques. Since DNA may be transferred to an exhibit: (a) during the commission of a crime, (b) before the crime, and/or (c) after the crime through handling, examination, and testing, this book covers various transfer pathways and sources of DNA. Inadvertent issues of transfer of DNA resulting in wrongful convictions and the misleading of investigations are discussed, with an emphasis on contamination mitigation. Forensic DNA Transfer examines the additional complexity resulting from non-visible deposits of DNA that impact on sampling and testing regimes. The changing understanding of the composition of purported 'touch DNA' deposits from the skin, including extracellular DNA transported via body secretions is described. Further, the newer focus on interpreting DNA evidence – using activity level propositions and the rationale and associated issues – is also discussed.

An Introduction to Forensic Genetics

William Goodwin,Adrian Linacre,Sibte Hadi
An Introduction to Forensic Genetics Book PDF

Author : William Goodwin,Adrian Linacre,Sibte Hadi
Publisher : John Wiley & Sons
Page : 170 pages
File Size : 46,6 Mb
Release : 2007-11-27
Category : Science
ISBN : 9780470010259

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An Introduction to Forensic Genetics by William Goodwin,Adrian Linacre,Sibte Hadi Pdf

An Introduction to Forensic Genetics is a comprehensive introduction to this fast moving area from the collection of evidence at the scene of a crime to the presentation of that evidence in a legal context. The last few years have seen significant advances in the subject and the development and application of genetics has revolutionised forensic science. This book begins with the key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field, illustrated throughout with references to relevant casework. In addition to the technology involved in generating a DNA profile, the underlying population biology and statistical interpretation are also covered. The evaluation and presentation of DNA evidence in court is discussed as well with guidance on the evaluation process and how court reports and statements should be presented. An accessible introduction to Forensic Genetics from the collection of evidence to the presentation of that evidence in a legal context Includes case studies to enhance student understanding Includes the latest developments in the field focusing on the technology used today and that which is likely to be used in the future Accessible treatment of population biology and statistics associated with forensic evidence This book offers undergraduate students of Forensic Science an accessible approach to the subject that will have direct relevance to their courses. An Introduction to Forensic Genetics is also an invaluable resource for postgraduates and practising forensic scientists looking for a good introduction to the field.