Free Radical Biology And Environmental Toxicity

Author : Kavindra Kumar Kesari,Niraj Kumar Jha
Publisher : Springer Nature
Page : 392 pages
File Size : 48,7 Mb
Release : 2022-03-11
Category : Medical
ISBN : 9783030834463

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Free Radical Biology and Environmental Toxicity by Kavindra Kumar Kesari,Niraj Kumar Jha Pdf

The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of free radical research and environmental toxicity. This book presents various state-of-the-art chapters of recent progress in the field of cellular toxicology and clinical manifestations of various disorders. Topics include cell signaling, various risk factors, the pathophysiology of disease instigation and distribution, mechanistic insights into metal and nanoparticle toxicity, neural toxicity, nongenotoxic carcinogenicity, immune and idiosyncratic toxicity, prevention, biomarkers related to disease progression and therapeutic strategies. In particular, this book provides valuable insight for researchers, pathologists, and clinicians with an interest in toxicological research and cellular impairments with special emphasis on therapeutic advancement.

Author : Chris J Rhodes
Publisher : CRC Press
Page : 514 pages
File Size : 55,5 Mb
Release : 2000-02-24
Category : Science
ISBN : 0748409165

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Toxicology of the Human Environment by Chris J Rhodes Pdf

The environment in which human beings live is complex and we may encounter many different potentially toxic chemical substances during the course of our lives. These xenobiotic agents may invade the living system in the form of environmental pollutants, in the diet, as pharmaceutically administered compounds or even as chemical weapons and it is becoming widely recognised that free radicals are often involved in this toxicity. The book covers all aspects of toxic agents in the environment from their detection to their effects. Final year undergraduates and postgraduates studying toxicology, biochemistry, cell biology or environmental science will find this book valuable reading, whilst researchers in academia, the pharmaceutical industry, and public health laboratories will appreciate it as a comprehensive reference.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 132 pages
File Size : 42,7 Mb
Release : 2020-07-15
Category : Science
ISBN : 9781789851434

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Free Radical Medicine and Biology by Anonim Pdf

Although free radicals perform some useful immune functions, they can also damage healthy cells through a process called oxidation. Antioxidants reduce the effect of free radicals by binding together with these harmful molecules, decreasing their destructive power. This book highlights various issues of free radical biology from the perspective of antioxidant defense mechanisms. It also provides useful information on gene modulation, radiation-generated reactive oxygen species-induced apoptosis in cancer, and environmental aspects associated with free radicals’ exposure on living systems.

Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Page : 600 pages
File Size : 43,6 Mb
Release : 2016-01-14
Category : Science
ISBN : 9781118832400

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Oxidative Stress and Antioxidant Protection by Donald Armstrong,Robert D. Stratton Pdf

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Author : Vinood B. Patel,Victor R Preedy
Publisher : Academic Press
Page : 596 pages
File Size : 41,8 Mb
Release : 2020-11-17
Category : Medical
ISBN : 9780128190937

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Toxicology by Vinood B. Patel,Victor R Preedy Pdf

Toxicology: Oxidative Stress and Dietary Antioxidants examines the nature of oxidative stress as a consequence of exposure to toxins and how antioxidant approaches can mitigate the impact of toxicant exposures. Sections covers the basic biology of oxidative stress, from molecular biology, to physiological pathology, mechanisms of action of specific toxicants, metals and other chemicals/drugs, and antioxidant approaches and therapies for toxic exposures. With contributions from an international group of experts, useful summary sections, a dictionary of terms, and applications to other areas of toxicology, this book is an informative, consolidated reference that helps bridge the interrelationship between toxicology, oxidative stress and antioxidants. Provides a novel collection of information linking both sides of redox biology (oxidants and antioxidants) and toxicology Explores the role of free radical mediated damage and toxicology Contains contributions from experts on toxicological science surrounding oxidative stress and on antioxidant approaches for reducing the impact of toxicant exposures

Author : Irena Kruk
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 49,7 Mb
Release : 1997-11-06
Category : Nature
ISBN : 3540619836

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Environmental Toxicology and Chemistry of Oxygen Species by Irena Kruk Pdf

Properties, sources of formation, reactions, and detection of oxygen species form the first part of this volume. Biochemical, toxicological and environmental aspects are dealt with in detail in the following chapters. This information provides the basis for a state-of-the-art understanding of the role of oxygen species in environmental pollution and as a health hazard.

Author : Toshikazu Yoshikawa
Publisher : Unknown
Page : 560 pages
File Size : 48,5 Mb
Release : 2000
Category : Antioxidants
ISBN : STANFORD:36105025027470

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Free Radicals in Chemistry, Biology and Medicine by Toshikazu Yoshikawa Pdf

Author : F. Minisci
Publisher : Springer Science & Business Media
Page : 496 pages
File Size : 43,9 Mb
Release : 2013-04-17
Category : Science
ISBN : 9789401716079

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Free Radicals in Biology and Environment by F. Minisci Pdf

Our understanding of the quantitative aspects of free radical chemistry and the involvement of radicals in such areas as biology, medicine, the environment, etc., has developed spectacularly over recent years, yet the various topics are commonly discussed separately, in specific meetings and specialised publications. Free Radicals in Biology and Environment draws together two important areas of free radical chemistry, using as a bridge the fundamental physical chemistry of free radicals (spectroscopic detection of free radicals, evaluation of absolute rate constants, elucidation of mechanisms of free radical reactions and catalysis, photochemical and radiation processes, etc.). The most relevant topics covered are the EPR detection of radicals in biochemical systems and in pollutant formation and degradation, oxidation processes in biology and in the troposphere, radiation and induced damage, and atmospheric pollutants arising from incomplete combustion. Also covered are the chemistry and biochemistry of nitric oxide and peroxynitrite, the chemistry and biochemistry of DNA radicals, the role of radicals in myeloperoxidase, lignineperoxidase, radicals and cardiovascular injury, radiation and the fragmentation of cells and tissues.

Author : Barry Halliwell,John M. C. Gutteridge
Publisher : OUP Oxford
Page : 896 pages
File Size : 55,6 Mb
Release : 2015-08-21
Category : Science
ISBN : 9780191026980

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Free Radicals in Biology and Medicine by Barry Halliwell,John M. C. Gutteridge Pdf

Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Author : Doris Abele,Jose Pablo Vazquez-Medina,Tania Zenteno-Savin
Publisher : John Wiley & Sons
Page : 818 pages
File Size : 41,7 Mb
Release : 2011-11-03
Category : Science
ISBN : 9781444345964

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Oxidative Stress in Aquatic Ecosystems by Doris Abele,Jose Pablo Vazquez-Medina,Tania Zenteno-Savin Pdf

Reactive oxygen species (ROS) are increasingly appreciated as down-stream effectors of cellular damage and dysfunction under natural and anthropogenic stress scenarios in aquatic systems. This comprehensive volume describes oxidative stress phenomena in different climatic zones and groups of organisms, taking into account specific habitat conditions and how they affect susceptibility to ROS damage. A comprehensive and detailed methods section is included which supplies complete protocols for analyzing ROS production, oxidative damage, and antioxidant systems. Methods are also evaluated with respect to applicability and constraints for different types of research. The authors are all internationally recognized experts in particular fields of oxidative stress research. This comprehensive reference volume is essential for students, researchers, and technicians in the field of ROS research, and also contains information useful for veterinarians, environmental health professionals, and decision makers.

Author : William Pryor
Publisher : Elsevier
Page : 304 pages
File Size : 49,8 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323156820

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Free Radicals in Biology V1 by William Pryor Pdf

Free Radicals in Biology, Volume 1, provides an introduction to some of the basic concepts of free radical biology. The book emerged from the President's Symposium of the American Society for Experimental Pathology held in Atlantic City in April 1970. The book's opening chapter introduces a mechanistic view of free radical reactions using examples from biological systems. This is followed by a discussion of autoxidative damage to lipids in membranes. Some of the special chemistry of lipid oxidation are presented, and a number of novel ideas are suggested. The third chapter deals with the uses of electron-spin resonance in biology. Spin labeling is also discussed, which is one of the most useful methods of probing the chemical and physical environment of molecules in cells. The remaining chapters cover free radicals which occur in photosynthesis and the importance of the enzyme, superoxide dismutase. The study of the occurrence and reactions of this enzyme provides an important and extensive body of data clearly pointing to the significance of free radicals in cellular chemistry.

Author : Helen Wiseman,Peter Goldfarb,Tim Ridgway,Alan Wiseman
Publisher : Wiley
Page : 0 pages
File Size : 51,8 Mb
Release : 2000-11-17
Category : Science
ISBN : 0471490768

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Biomolecular Free Radical Toxicity by Helen Wiseman,Peter Goldfarb,Tim Ridgway,Alan Wiseman Pdf

Biomolecular Free Radical Toxicity: Causes and Prevention provides a comprehensive overview of biomolecular injury. By discussing recent research and providing interpretations of the available data, this unique and timely book explores the causes of biomolecular injury and the possible routes to its prevention. Split into three sections, the book covers: * macromolecular mechanisms of injury and the role of antioxidants; * gene expression and cell mediated mechanisms of toxicity expression; and, * human and environmental health effects. Written by experts in the field, Biomolecular Free Radical Toxicity: Causes and Prevention will be invaluable to researchers specialising in food and nutrition-based toxicology, biomolecular sciences, biochemistry, genetics, environmental biomonitoring, drug metabolism and carcinogenesis.

Author : Donald Armstrong,Robert D. Stratton
Publisher : Wiley
Page : 600 pages
File Size : 41,9 Mb
Release : 2016-03-28
Category : Science
ISBN : 1118832442

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Oxidative Stress and Antioxidant Protection by Donald Armstrong,Robert D. Stratton Pdf

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease provides an overview of the basic principles of free radical formation. The text delves into free radical formation in molecular biology and its effect on subcellular damage, as well as the role of antioxidant reserves as a protective mechanism. Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Author : Jelte Rozema,J.A.C. Verkleij
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400905993

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Ecological responses to environment stresses by Jelte Rozema,J.A.C. Verkleij Pdf

September 1987, the Faculty Biology of the Vrije Universiteit, Amsterdam commemorated the fact that Prof. Dr. Wilfried Hans Otto Ernst had been active as a scientist for 25 years. This period of 25 years of scientific research started at the Institut flir Angewandte Botanik (Institute of Applied Botany) of the University of Munster, FRG. In 1965 he completed his Ph. D. thesis, entitled "Untersuchungen der Schwermetallpflanzengesellschaften Mitteleuropas unter Einschluss der Alpen. " He was appointed full Professor at the Department of Ecology of the Vrije Universiteit, Amsterdam in 1973. On the occasion of his 25th anniversary as a scientist, a promise was made, though in covert terms, which we could not redeem at that time. The promise held to offer Prof. Ernst a book, in which his former and present staffmembers, Ph. D. students and colle ages should write a review about their specialism concerning a central theme. Now, at the beginning of 1990 we consider the chapters of "Ecological Responses to Environmental Stresses" to be completed. The book reflects the wide range of research approaches that has been initiated and organized by Wilfried Ernst. The editors hope to have attained the primary aim of the production of the book of friends, that is to gather relevant papers of staff-members and colleagues of Wilfried Ernst. The title of the book "Ecological Responses to Environmental Stresses" covers the majority of the chapters included.

Author : Thomas Dziubla,D Allan Butterfield
Publisher : Academic Press
Page : 404 pages
File Size : 43,9 Mb
Release : 2016-05-31
Category : Technology & Engineering
ISBN : 9780128032701

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Oxidative Stress and Biomaterials by Thomas Dziubla,D Allan Butterfield Pdf

Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility