Free Radicals In Biology

Author : Barry Halliwell,John M. C. Gutteridge
Publisher : Oxford University Press
Page : 961 pages
File Size : 47,5 Mb
Release : 2015
Category : Science
ISBN : 9780198717478

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Free Radicals in Biology and Medicine by Barry Halliwell,John M. C. Gutteridge Pdf

Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Author : Ismail Laher
Publisher : Springer
Page : 0 pages
File Size : 42,9 Mb
Release : 2014-06-16
Category : Medical
ISBN : 3642300170

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Systems Biology of Free Radicals and Antioxidants by Ismail Laher Pdf

The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.

Author : Barry Halliwell,John M. C. Gutteridge
Publisher : Oxford University Press, USA
Page : 568 pages
File Size : 47,6 Mb
Release : 1989
Category : Biochemistry
ISBN : UCSC:32106009290187

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Free Radicals in Biology and Medicine by Barry Halliwell,John M. C. Gutteridge Pdf

"This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet." "This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and medical sciences."--BOOK JACKET.

Author : A. Favier,J. Cadet,B. Kalyanaraman,M. Fontecave,J.L. Pierre
Publisher : Birkhäuser
Page : 314 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783034890748

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Analysis of Free Radicals in Biological Systems by A. Favier,J. Cadet,B. Kalyanaraman,M. Fontecave,J.L. Pierre Pdf

"Oxidative stress" is used as the generic term describing the involve ment of reactive oxygen species in various human diseases. The scope of such a topic is becoming increasingly wide. The recent interest in radicals such as nitric oxide and the discovery of new mechanisms such as the effect of free radicals on redox sensitive proteins and genes are enlarging our understanding of the physiological role of free radicals. Oxidative stress is involved in numerous pathological. processes such as ageing, respiratory or cardiovascular diseases, cancer, neurological pathologies such as dementia or Parkinson's disease. It still remains difficult, however, to demonstrate by chemical measurement the in vivo production of free radicals and even more to realise their speciation. Therefore, the development of new tools and indicators is engrossing many researchers working in this field. Reliable indicators are abso lutely necessary not only to monitor the evolution of oxidative stress in patients but also to evaluate the efficiency of new antioxidant treat ments. The French Free radical club of Grenoble, the CERLIB has been involved for many years in the organisation of international training programs on methodology, in order to provide both theoretical and practical help to researchers from various countries. Such training sessions have been highly successful and participants value the oppor tunity to learn reliable techniques. This positive echo explains why the researchers of CERLIB decided, with the help of Prof. Dr. B. Kalyanaraman, to publish selected techniques on free radical re search.

Author : William A. Pryor
Publisher : Unknown
Page : 0 pages
File Size : 53,5 Mb
Release : 1976
Category : Biochemistry
ISBN : 0125665016

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Free Radicals in Biology by William A. Pryor Pdf

Author : Gerald M. Rosen
Publisher : Oxford University Press, USA
Page : 506 pages
File Size : 48,9 Mb
Release : 1999-12-02
Category : Medical
ISBN : 0195095057

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Free Radicals by Gerald M. Rosen Pdf

Free radicals play key roles in physiologic regulation and in many degenerative and pathologic processes, making them a fertile area of research. This book focuses on spin trapping, a sophisticated technique for the identification of free radicals in biological systems. The method is complex, and this book offers an in-depth guide to all of the critical aspects needed for its application to free radicals in biology. This includes advice on interpreting results, trouble-shooting, and experimental designs.

Author : William A. Pryor
Publisher : Unknown
Page : 312 pages
File Size : 42,7 Mb
Release : 1976
Category : Science
ISBN : UOM:39015006046984

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Free Radicals in Biology by William A. Pryor Pdf

Free Radicals in Biology V5 ...

Author : Michael Simic
Publisher : Springer Science & Business Media
Page : 1064 pages
File Size : 53,6 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781468455687

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Oxygen Radicals in Biology and Medicine by Michael Simic Pdf

This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.

Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Page : 610 pages
File Size : 53,6 Mb
Release : 2016-04-11
Category : Science
ISBN : 9781118832486

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Oxidative Stress and Antioxidant Protection by Donald Armstrong,Robert D. Stratton Pdf

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Author : Kavindra Kumar Kesari,Niraj Kumar Jha
Publisher : Springer
Page : 392 pages
File Size : 52,7 Mb
Release : 2022-02-08
Category : Medical
ISBN : 303083445X

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Free Radical Biology and Environmental Toxicity by Kavindra Kumar Kesari,Niraj Kumar Jha Pdf

The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of free radical research and environmental toxicity. This book presents various state-of-the-art chapters of recent progress in the field of cellular toxicology and clinical manifestations of various disorders. Topics include cell signaling, various risk factors, the pathophysiology of disease instigation and distribution, mechanistic insights into metal and nanoparticle toxicity, neural toxicity, nongenotoxic carcinogenicity, immune and idiosyncratic toxicity, prevention, biomarkers related to disease progression and therapeutic strategies. In particular, this book provides valuable insight for researchers, pathologists, and clinicians with an interest in toxicological research and cellular impairments with special emphasis on therapeutic advancement.

Author : F. Minisci
Publisher : Springer Science & Business Media
Page : 496 pages
File Size : 51,7 Mb
Release : 2013-04-17
Category : Science
ISBN : 9789401716079

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Free Radicals in Biology and Environment by F. Minisci Pdf

Our understanding of the quantitative aspects of free radical chemistry and the involvement of radicals in such areas as biology, medicine, the environment, etc., has developed spectacularly over recent years, yet the various topics are commonly discussed separately, in specific meetings and specialised publications. Free Radicals in Biology and Environment draws together two important areas of free radical chemistry, using as a bridge the fundamental physical chemistry of free radicals (spectroscopic detection of free radicals, evaluation of absolute rate constants, elucidation of mechanisms of free radical reactions and catalysis, photochemical and radiation processes, etc.). The most relevant topics covered are the EPR detection of radicals in biochemical systems and in pollutant formation and degradation, oxidation processes in biology and in the troposphere, radiation and induced damage, and atmospheric pollutants arising from incomplete combustion. Also covered are the chemistry and biochemistry of nitric oxide and peroxynitrite, the chemistry and biochemistry of DNA radicals, the role of radicals in myeloperoxidase, lignineperoxidase, radicals and cardiovascular injury, radiation and the fragmentation of cells and tissues.

Author : Kenneth B. Storey
Publisher : John Wiley & Sons
Page : 640 pages
File Size : 45,9 Mb
Release : 2005-02-25
Category : Science
ISBN : 9780471675570

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Functional Metabolism by Kenneth B. Storey Pdf

Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosis and treatment of disease. It also takes a unique comparative approach in which human metabolism is a reference for metabolism in microorganisms and plant design, and presents novel coverage of development and aging, and human health and animal adaptation. The final chapter reviews the past and future promise of new genetic approaches to treatment and bioinformatics. This, the most exhaustive treatment of metabolism currently available, is a useful text for advanced undergraduates and graduates in biochemistry, cell/molecular biology, and biomedicine, as well as biochemistry instructors and investigators in related fields.

Author : Manfred Lamprecht
Publisher : CRC Press
Page : 304 pages
File Size : 52,8 Mb
Release : 2014-09-17
Category : Medical
ISBN : 9781466567573

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Antioxidants in Sport Nutrition by Manfred Lamprecht Pdf

The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Author : Toshikazu Yoshikawa
Publisher : Unknown
Page : 560 pages
File Size : 47,6 Mb
Release : 2000
Category : Antioxidants
ISBN : STANFORD:36105025027470

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Free Radicals in Chemistry, Biology and Medicine by Toshikazu Yoshikawa Pdf

Author : Anonim
Publisher : BoD – Books on Demand
Page : 132 pages
File Size : 48,7 Mb
Release : 2020-07-15
Category : Science
ISBN : 9781789851434

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Free Radical Medicine and Biology by Anonim Pdf

Although free radicals perform some useful immune functions, they can also damage healthy cells through a process called oxidation. Antioxidants reduce the effect of free radicals by binding together with these harmful molecules, decreasing their destructive power. This book highlights various issues of free radical biology from the perspective of antioxidant defense mechanisms. It also provides useful information on gene modulation, radiation-generated reactive oxygen species-induced apoptosis in cancer, and environmental aspects associated with free radicals’ exposure on living systems.