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Author : Ramon Latorre,Juan Carlos Saez
Publisher : Unknown
Page : 536 pages
File Size : 52,7 Mb
Release : 2014-09-01
Category : Electronic
ISBN : 1489917969
Author : Ramón Latorre,Juan Carlos Sáez
Publisher : Springer Science & Business Media
Page : 515 pages
File Size : 43,8 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781489917959
Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and, in this regard, they put us in contact with the external world. These ion channels are protein molecules located in the cell membrane. In complex organisms, cells need to communicate in order to know about their metabolic status and to act in a coordinate manner. The latter is also accomplished by a class of ion channels able to pierce the lipid bilayer membranes of two adjacent cells. These intercellular channels are the functional subunits of gap junctions. Accordingly, the book is divided in two parts: the first part is dedicated to ion channels that look to the external world, and the second part is dedicated to gap junctions found at cell interfaces. This book is based on a series of symposia for a meeting on ion channels and gap junctions held in Santiago, Chile, on November 28-30, 1995. The book should be useful to graduate students taking the first steps in this field as well as a reference for the aficionado. The aim of the meeting was mainly to show the impact of various modern techniques, including cell biology, molecular biology, biophysics, and molecular genetics techniques in the study of these ubiquitous intrinsic membrane proteins. Molecular-genetics techniques paved the road to the manipulation of the channel forming molecules.
Author : Francisco Sepulveda,Francisco Bezanilla
Publisher : Springer Science & Business Media
Page : 175 pages
File Size : 52,6 Mb
Release : 2006-03-30
Category : Science
ISBN : 9780387274249
This book is a compilation of articles based on some of the talks given at the Centro de Estudios Cientificos (CECS) in Valdivia during the course of a celebration to th mark the 60 birthdays of Ramon Latorre and Enrico Stefani. Ramon Latorre is one of the most outstanding figures in channel Biophysics today. The first surprise is that he trained as a Biochemist! He soon, however, became a biophysicist through his work with Guayo (Eduardo) Rojas who guided him during his Ph. D thesis in the Laboratorio de Fisiologia Celular in Montemar. His work at N.I.H with Gerald Eherenstein and Harold Lecar constitutes one of the milestones of single ion channel Biophysics. This classical work, done in planar bilayers, set the basis for understanding voltage-dependent conductances with single channel studies and predates, by many years, later studies using patch clamping techniques. Ramon was one of the firsts to find and recognize the importance of calci- activated potassium channels and to begin a detailed study of channel properties. He pioneered the ideas of voltage and calcium modulation of the open probability and he added detailed studies of gating and its modulation by other ions. Ramon is also interested in permeation and selectivity and he produced classical studies on the number of water molecules in the channel and sites occupied by barium. Results and concepts that have recently taken front page as the structure of KcSa has been described.
Author : Anonim
Publisher : Academic Press
Page : 514 pages
File Size : 50,9 Mb
Release : 2018-09-20
Category : Science
ISBN : 9780128154571
Cell Volume Regulation and Fluid Secretion, Volume 81, the latest release in the Current Topics in Membranes series highlights new advances in the field, with this new volume presenting interesting chapters on General principles of cell volume regulation, Cell volume maintenance: water and salt homeostasis, The search for ubiquitous cell volume sensor: the role of plasma membrane and cytoplasmic hydrogel, More than membranes, Cellular and membrane biomechanics of CVR response, Molecular identities of volume-regulatory anion channels, Molecular biology and physiology of volume-regulated anion channel (VRAC), the Role of WNKs in the modulation of intracellular chloride, amongst other topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on Cell Volume Regulation
Author : H. Richard Leuchtag
Publisher : Springer Science & Business Media
Page : 545 pages
File Size : 55,5 Mb
Release : 2008-12-21
Category : Science
ISBN : 9781402055256
Voltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Despite decades of intensive research under the traditional approach of gated structural pores, the relation between the structure of these molecules and their function remains enigmatic. This book examines physically oriented approaches not covered in other ion-channel books, and it develops a new physics-based approach to the problem of molecular excitability.
Author : Gabor L. Hornyak,H.F. Tibbals,Joydeep Dutta,John J. Moore
Publisher : CRC Press
Page : 1791 pages
File Size : 51,5 Mb
Release : 2008-12-22
Category : Science
ISBN : 9781439889954
The maturation of nanotechnology has revealed it to be a unique and distinct discipline rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry, physics, or engineering text focused on nano. It must be an integrated, multidisciplinary, and specifically nano textbook. The archetype of the modern nano textbook
Author : Dale J. Benos,Camillo Peracchia
Publisher : Gulf Professional Publishing
Page : 692 pages
File Size : 48,9 Mb
Release : 1999-12-14
Category : Medical
ISBN : 0125506457
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot-Marie-Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas disease.
Author : Gabor L. Hornyak,Joydeep Dutta,H.F. Tibbals,Anil Rao
Publisher : CRC Press
Page : 852 pages
File Size : 46,7 Mb
Release : 2008-05-15
Category : Science
ISBN : 9781420048063
Tomorrow's nanoscientist will have a truly interdisciplinary and nano-centric education, rather than, for example, a degree in chemistry with a specialization in nanoscience. For this to happen, the field needs a truly focused and dedicated textbook. This full-color masterwork is such a textbook. It introduces the nanoscale along with the societal
Author : Andres Gomberoff,Donald Marolf
Publisher : Springer Science & Business Media
Page : 350 pages
File Size : 52,9 Mb
Release : 2006-05-30
Category : Science
ISBN : 9780387249926
The 2002 Pan-American Advanced Studies Institute School on Quantum Gravity was held at the Centro de Estudios Cientificos (CECS),Valdivia, Chile, January 4-14, 2002. The school featured lectures by ten speakers, and was attended by nearly 70 students from over 14 countries. A primary goal was to foster interaction and communication between participants from different cultures, both in the layman’s sense of the term and in terms of approaches to quantum gravity. We hope that the links formed by students and the school will persist throughout their professional lives, continuing to promote interaction and the essential exchange of ideas that drives research forward. This volume contains improved and updated versions of the lectures given at the School. It has been prepared both as a reminder for the participants, and so that these pedagogical introductions can be made available to others who were unable to attend. We expect them to serve students of all ages well.
Author : Daniel M. Hardy,D. L. Garbers
Publisher : Elsevier
Page : 446 pages
File Size : 49,5 Mb
Release : 2001-12-12
Category : Medical
ISBN : 9780080531649
Fertilization provides in-depth reviews of individual research topics, while emphasizing key concepts and the significance of findings within other fields. The author identifies essential questions to be answered by future research. Fertilization broadly covers the many molecular and cellular events of animal fertilization and includes a section on unique problems and potential applications of fertilization research. Provides in-depth reviews of individual research topics Emphasizes key concepts and significance of findings to other fields Broadly covers the many molecular and cellular events of animal fertilization Includes a section on unique problems and potential applications of fertilization research Identifies essential questions to be answered by future research
Author : Anonim
Publisher : Academic Press
Page : 414 pages
File Size : 53,7 Mb
Release : 2019-06-05
Category : Science
ISBN : 9780128177655
Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders, Volume 83, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this volume presenting chapters from recognized experts on topics such as cardiotonic steroids, Na+, K+ pumps and vascular fibrosis, purinergic signaling in the lung, structural models of a2-subunit N-termini and binding interfaces, ubiquitous and cell type-specific transcriptomic changes triggered by dissipation of monovalent cation gradients, the Na, K-ATPase alpha2 isoform in cardiovascular pathologies, the role of cell swelling and volume-sensitive ion channels in stroke pathology, structure-function relationships in the renal NaCl cotransporter, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on membrane ion transporters
Author : Nicholas Sperelakis
Publisher : Elsevier
Page : 1262 pages
File Size : 45,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080574554
This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
Author : David J. Aidley,Peter R. Stanfield
Publisher : Cambridge University Press
Page : 324 pages
File Size : 41,6 Mb
Release : 1996-08-13
Category : Medical
ISBN : 0521498821
Ion channels are crucial components of living cells. Situated in the cell's membranes. they allow particular ions to pass from one side of the membrane to the other. In recent years the patch clamp technique has allowed the activity of individual channels to be measured, and recombinant DNA technology has led to fascinating detail on their structure. Together, these technical advances have produced a great flowering of knowledge and understanding about the subject, itself leading to further breakthroughs in science and medicine. Ion Channels provides an introduction to this scientific endeavour. It emphasises the molecular structure of channels as determined by gene cloning technology. This knowledge illuminates discussions of the permeability and selectivity of channels, their gating and modulation, their responses to drugs and toxins and the human diseases caused when they do not function properly.
Author : Gino Casassa,Francisco V. Sepúlveda,Rolf M. Sinclair
Publisher : Springer Science & Business Media
Page : 202 pages
File Size : 52,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461506454
The majesty of the icefields is beyond description. He who has been fortunate to be there once, remains bound forever. To a theoretical physicist working on black holes the icefields produce a familiar vertigo, the instinctive certainty of being confronted with something so simple and beautifully extreme that it must be of importance. The meeting whose proceedings are contained in this volume was conducted onboard of a vessel that went to the icefields, and the participants could literally set foot on them. It was expected that, for those who had not been there before, this would constitute a ritual of initiation. And so it did. For this reason we like to refer to the meeting as an expedition because, although it did not have the hardship, it had the spirit. After this foundational expedition there have been two others, this time both with spirit and hardship, one from Chile and one from Argentina. At the moment of this writing, a fourth, full-fledged airborne expedition to the icefields is about to depart from Valdivia. Many of the people of many nations who were on board of the Aquiles will take part in it. We look forward to its results, and to an ongoing exciting scientific adventure. Claudio Teitelboim Director, Centro de Estudios Cientfficos Valdivia, September 2001 v ACKNOWLEDGMENTS This volume is the result of the effort and generosity of many people and institutions.
Author : E. Bruce Goldstein
Publisher : John Wiley & Sons
Page : 800 pages
File Size : 47,8 Mb
Release : 2008-04-15
Category : Psychology
ISBN : 9780470751992
This state-of-the-art handbook provides an authoritative overview of the field of perception, with special emphasis on new developments and trends. Surveys the entire field of perception, including vision, hearing, taste, olfaction, and cutaneous sensibility. Ideal for researchers and teachers looking for succinct, state-of-the-art overviews of areas outside their speciality, and for anyone wanting to know about current research and future trends. Uses a tutorial approach that results in a balanced description of topics. A 'Selected Readings' section points to general references that provide more detailed treatments of each topic; 'Additional Topics' provide references to important topics. Written by noted authorities in the field. Now available in full text online via xreferplus, the award-winning reference library on the web from xrefer. For more information, visit www.xreferplus.com
