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Author : Anonim
Publisher : Academic Press
Page : 667 pages
File Size : 45,8 Mb
Release : 1992-02-03
Category : Science
ISBN : 008085933X
Functional Organization of The Nucleus
Author : Ronald Berezney,Kwang W. Jeon
Publisher : Elsevier
Page : 1096 pages
File Size : 54,8 Mb
Release : 1995
Category : Medical
ISBN : 012384620X
Research on the nuclear matrix has grown enormously since Bereney and Coffey first reported its isolation and initial characterization in 1974. Since then, more than 1000 papers have been published on the subject by numerous workers around the world. This is the first book devoted to reviewing the major developments in this growing field. Key Features * The chapters cover a variety of topics, including: * Isolation of the nuclear matrix * Nuclear structure morphology in situ * Structural domains of the nuclear matrix and its components * Biochemistry and molecular biology of the matrix proteins and associated DNA and RNA * Functional properties associated with the nuclear matrix * DNA replication * Transcription * RNA splicing * Transcription regulation * Intranuclear and nucleocytoplasmic transport and targeting * Cell cycle regulation
Author : Iris Meier
Publisher : Springer Science & Business Media
Page : 199 pages
File Size : 53,7 Mb
Release : 2008-12-16
Category : Science
ISBN : 9783540710585
In a presentation to the Linnean Society of London in November 1831, the Scottish botanist Robert Brown (perhaps better known for his discovery of Brownian motion) mentioned almost as an afterthought that in orchid epidermal cells, a single “circular areola” could be seen, a “nucleus of the cell as perhaps it might be termed.” Thus, the term “nucleus” (from Latin nucleus or nuculeus, “little nut” or kernel) was born for the compartment of the eukaryotic cell that contains the maj- ity of genetic information. One hundred and seventy-seven years later, we know that the nucleus is the site where genetic information is stored in the form of DNA, and where it is protected from damage, duplicated, divided, recombined, repaired, and “expressed.” For the latter, the genetic information is faithfully transcribed from DNA to RNA, then released from the nucleus into the surrounding cytoplasm. Most likely translated into polypeptide chains, the information re-enters the nucleus in the form of diverse proteins that function in the processes listed above.
Author : Ana Pombo,Martin W. Hetzer,Tom Misteli
Publisher : Unknown
Page : 300 pages
File Size : 48,8 Mb
Release : 2021-09
Category : Cell nuclei
ISBN : 162182389X
The nucleus is the most prominent structure in eukaryotic cells. It houses the cell's DNA and is the hub for DNA replication, transcription, and RNA processing. Despite its prominence and importance, our understanding of how the nucleus and its DNA are organized in space and time--and the implications of that organization for proper function--has lagged behind that of other cellular structures. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers recent advances in our understanding of nuclear organization and function. The contributors discuss the 3D organization of chromatin, the various nuclear bodies and compartments that have been identified, and the roles of RNA and actin in shaping nuclear organization, as well as how these structures interact with each other and with peripheral features (e.g., the nuclear pore complex and inner nuclear membrane proteins) to carry out the work of the nucleus. Insights into DNA replication timing and RNA processing dynamics based on new technologies aimed at examining chromatin and other intranuclear structures at high resolution are also included. Multiple chapters are devoted to physiological and disease processes involving disruption of nuclear structure and function (e.g., viral infection). This volume is therefore essential reading for all cell and molecular biologists, as well as pathologists interested in the role of nuclear architecture in disease.
Author : Iris Meier
Publisher : Springer
Page : 192 pages
File Size : 46,7 Mb
Release : 2009-08-29
Category : Science
ISBN : 3540867473
In a presentation to the Linnean Society of London in November 1831, the Scottish botanist Robert Brown (perhaps better known for his discovery of Brownian motion) mentioned almost as an afterthought that in orchid epidermal cells, a single “circular areola” could be seen, a “nucleus of the cell as perhaps it might be termed.” Thus, the term “nucleus” (from Latin nucleus or nuculeus, “little nut” or kernel) was born for the compartment of the eukaryotic cell that contains the maj- ity of genetic information. One hundred and seventy-seven years later, we know that the nucleus is the site where genetic information is stored in the form of DNA, and where it is protected from damage, duplicated, divided, recombined, repaired, and “expressed.” For the latter, the genetic information is faithfully transcribed from DNA to RNA, then released from the nucleus into the surrounding cytoplasm. Most likely translated into polypeptide chains, the information re-enters the nucleus in the form of diverse proteins that function in the processes listed above.
Author : Oriol Bachs,Neus Agell
Publisher : Springer Science & Business Media
Page : 145 pages
File Size : 54,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783662216866
This book is about the role of calcium and calmodulin in the cell nucleus. Calcium, which is an important second messenger of signal transduction pathways, can also operate in the cell nucleus. Different calcium binding proteins, which are the targets of cellular calcium, have been identified in the nucleus of many different cell types. Prominent among these calcium binding proteins is calmodulin, which appears to be involved in the regulation of major nuclear functions such as gene expression and DNA replication.
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 53,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Karsten Rippe
Publisher : John Wiley & Sons
Page : 597 pages
File Size : 40,9 Mb
Release : 2011-12-19
Category : Science
ISBN : 9783527326983
By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.
Author : David P. Bazett-Jones,Graham Dellaire
Publisher : Springer
Page : 513 pages
File Size : 48,8 Mb
Release : 2016-10-17
Category : Science
ISBN : 9783319388823
This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.
Author : Joseph Eisenman,S. Landgren,Donald Novin
Publisher : Unknown
Page : 52 pages
File Size : 42,9 Mb
Release : 1963
Category : Cats
ISBN : CUB:U183044461531
Author : J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Publisher : Unknown
Page : 0 pages
File Size : 43,6 Mb
Release : 2013-04-25
Category : Electronic
ISBN : 1947172808
Author : Ricardo Gattass,Juliana G.M. Soares,Bruss Lima
Publisher : Springer
Page : 66 pages
File Size : 47,5 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9783319700465
This book discusses the hypothesis that the primate pulvinar contains an original scaffold which is derived from cytoarchitectural markers and specific protein distributions. Thereafter, along primate evolution, different selective pressures acted in order to shape and fine-tune the connectivity of the pulvinar with specific regions of the neocortex. This divergence created, among other things, the different sets of retinotopic map representations in the pulvinar nucleus depending on functional and behavioral requirements of each species. The pulvinar, the largest nucleus of the primate thalamus, has extensive and reciprocal connections with several areas of the neocortex. These input-output loops suggest that the pulvinar may regulate the flow of information within and between cortical areas in a highly dynamic fashion. Therefore, understanding the anatomical subdivisions within the pulvinar, and its connectivity with the cortex, is paramount to understanding pulvinar physiological function. However, there is a stark contrast regarding the way that the pulvinar is subdivided depending on the technique employed. Cytoarchitectural and immunohistochemical methods reveal a very similar pattern of pulvinar subdivision across Old- and New-World monkeys. On the other hand, electrophysiological and connectivity studies expose clear discrepancies in pulvinar organization across primate evolution.
Author : Ainsley Iggo
Publisher : Springer Science & Business Media
Page : 861 pages
File Size : 50,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642654381
The waterproof sensory sheet covering the mammalian body has a rich afferent innervation which provides an abundance of complex information for use by the central nervous system often in conjunction with information from receptors in the joints. This book is an attempt to provide a systematic account of the way in which this somatosensory system works. The properties of the peripheral receptors have been debated in scientific terms for about a century and the resolu tion of the conflict in favour of the existence of 'specific' receptors for mechanical, thermal and noxious stimuli is reported and discussed in the opening chapters of the book. An awareness of this specificity has forced a re-consideration of the ways in which the central nervous system de-codes the information which is showered upon it. Advances in knowledge of the fine structure of the central nervous system have raised functional questions about the operation and organisation of the sensory systems in the spinal cord and brain. Fresh insight into the morphological complexity of the dorsal horn and higher levels of the nervous system gives the physiologist a clearer idea of the units with which he works. Progress has been made in understanding the function of sensory relay nuclei in general and indivi dual tracts in particular and is fully decomented.
Author : James F. Bosma
Publisher : Unknown
Page : 380 pages
File Size : 48,5 Mb
Release : 1973
Category : Children
ISBN : UOM:39015072148482
Author : Antoine Depaulis,Richard Bandler
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461533023
This book constitutes the proceedings of a NATO Advanced Research Workshop held at Chateau de Bonas (France) from 10-15 July 1990 on the Midbrain Periaqueductal Gray Matter (PAG). The aim of this meeting was to review and integrate our knowledge about the functional, anatomical and neuro chemical organization of the PAG. The PAG has been the subject of many investi gations during the last decade usually on different topics (e.g., pain modulation, defensive and sexual behavior) and generally there has been little interchange between the different research areas. The main purpose of this meeting was to bring together, for the first time, scientists who have worked on the PAG from different perspectives. This book does not pretend to present an exhaustive review of the data collected during the last 20 years of research on the PAG. The contributors to this book have been selected because their data provide key elements in the search to understand both the organization of the PAG and the role of this structure in the integration of behavior. We believe that this book will provide clues that will assist in unraveling the organization of the PAG in the coming years.
