The Functional Nucleus

Author : David P. Bazett-Jones,Graham Dellaire
Publisher : Springer
Page : 513 pages
File Size : 48,5 Mb
Release : 2016-10-17
Category : Science
ISBN : 9783319388823

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The Functional Nucleus by David P. Bazett-Jones,Graham Dellaire Pdf

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

Author : Karsten Rippe
Publisher : John Wiley & Sons
Page : 597 pages
File Size : 48,9 Mb
Release : 2011-12-19
Category : Science
ISBN : 9783527326983

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Genome Organization And Function In The Cell Nucleus by Karsten Rippe Pdf

By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Mark O. J. Olson
Publisher : Springer Science & Business Media
Page : 434 pages
File Size : 45,9 Mb
Release : 2011-09-15
Category : Science
ISBN : 9781461405146

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The Nucleolus by Mark O. J. Olson Pdf

Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.

Author : Iris Meier
Publisher : Springer
Page : 0 pages
File Size : 55,5 Mb
Release : 2010-11-23
Category : Science
ISBN : 3642090109

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Functional Organization of the Plant Nucleus by Iris Meier Pdf

In a presentation to the Linnean Society of London in November 1831, the Scottish botanist Robert Brown (perhaps better known for his discovery of Brownian motion) mentioned almost as an afterthought that in orchid epidermal cells, a single “circular areola” could be seen, a “nucleus of the cell as perhaps it might be termed.” Thus, the term “nucleus” (from Latin nucleus or nuculeus, “little nut” or kernel) was born for the compartment of the eukaryotic cell that contains the maj- ity of genetic information. One hundred and seventy-seven years later, we know that the nucleus is the site where genetic information is stored in the form of DNA, and where it is protected from damage, duplicated, divided, recombined, repaired, and “expressed.” For the latter, the genetic information is faithfully transcribed from DNA to RNA, then released from the nucleus into the surrounding cytoplasm. Most likely translated into polypeptide chains, the information re-enters the nucleus in the form of diverse proteins that function in the processes listed above.

Author : Oriol Bachs,Neus Agell
Publisher : Springer Science & Business Media
Page : 145 pages
File Size : 42,5 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783662216866

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Calcium and Calmodulin Function in the Cell Nucleus by Oriol Bachs,Neus Agell Pdf

This book is about the role of calcium and calmodulin in the cell nucleus. Calcium, which is an important second messenger of signal transduction pathways, can also operate in the cell nucleus. Different calcium binding proteins, which are the targets of cellular calcium, have been identified in the nucleus of many different cell types. Prominent among these calcium binding proteins is calmodulin, which appears to be involved in the regulation of major nuclear functions such as gene expression and DNA replication.

Author : Terence Allen,Graham Cowling
Publisher : OUP Oxford
Page : 160 pages
File Size : 42,6 Mb
Release : 2011-09-29
Category : Science
ISBN : 9780191620263

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The Cell: A Very Short Introduction by Terence Allen,Graham Cowling Pdf

All living things on Earth are composed of cells. A cell is the simplest unit of a self-contained living organism, and the vast majority of life on Earth consists of single-celled microbes, mostly bacteria. These consist of a simple 'prokaryotic' cell, with no nucleus. The bodies of more complex plants and animals consist of billions of 'eukaryotic' cells, of varying kinds, adapted to fill different roles - red blood cells, muscle cells, branched neurons. Each cell is an astonishingly complex chemical factory, the activities of which we have only begun to unravel in the past fifty years or so through modern techniques of microscopy, biochemistry, and molecular biology. In this Very Short Introduction, Terence Allen and Graham Cowling describe the nature of cells - their basic structure, their varying forms, their division, their differentiation from initially highly flexible stem cells, their signalling, and programmed death. Cells are the basic constituent of life, and understanding cells and how they work is central to all biology and medicine. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Author : Ana Pombo,Martin W. Hetzer,Tom Misteli
Publisher : Unknown
Page : 300 pages
File Size : 54,6 Mb
Release : 2021-09
Category : Cell nuclei
ISBN : 162182389X

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The Nucleus, Second Edition by Ana Pombo,Martin W. Hetzer,Tom Misteli Pdf

The nucleus is the most prominent structure in eukaryotic cells. It houses the cell's DNA and is the hub for DNA replication, transcription, and RNA processing. Despite its prominence and importance, our understanding of how the nucleus and its DNA are organized in space and time--and the implications of that organization for proper function--has lagged behind that of other cellular structures. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers recent advances in our understanding of nuclear organization and function. The contributors discuss the 3D organization of chromatin, the various nuclear bodies and compartments that have been identified, and the roles of RNA and actin in shaping nuclear organization, as well as how these structures interact with each other and with peripheral features (e.g., the nuclear pore complex and inner nuclear membrane proteins) to carry out the work of the nucleus. Insights into DNA replication timing and RNA processing dynamics based on new technologies aimed at examining chromatin and other intranuclear structures at high resolution are also included. Multiple chapters are devoted to physiological and disease processes involving disruption of nuclear structure and function (e.g., viral infection). This volume is therefore essential reading for all cell and molecular biologists, as well as pathologists interested in the role of nuclear architecture in disease.

Author : Anonim
Publisher : Academic Press
Page : 667 pages
File Size : 43,8 Mb
Release : 1992-02-03
Category : Science
ISBN : 008085933X

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Functional Organization of The Nucleus by Anonim Pdf

Functional Organization of The Nucleus

Author : Anders Rehfeld,Malin Nylander,Kirstine Karnov
Publisher : Springer
Page : 670 pages
File Size : 53,5 Mb
Release : 2017-09-07
Category : Medical
ISBN : 9783319418735

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Compendium of Histology by Anders Rehfeld,Malin Nylander,Kirstine Karnov Pdf

This book has been designed to help medical students succeed with their histology classes, while using less time on studying the curriculum. The book can both be used on its own or as a supplement to the classical full-curriculum textbooks normally used by the students for their histology classes. Covering the same curriculum as the classical textbooks, from basic tissue histology to the histology of specific organs, this book is formatted and organized in a much simpler and intuitive way. Almost all text is formatted in bullets or put into structured tables. This makes it quick and easy to digest, helping the student get a good overview of the curriculum. It is easy to locate specific information in the text, such as the size of cellular structures etc. Additionally, each chapter includes simplified illustrations of various histological features. The aim of the book is to be used to quickly brush up on the curriculum, e.g. before a class or an exam. Additionally, the book includes guides to distinguish between the different histological tissues and organs that can be presented to students microscopically, e.g. during a histology spot test. This guide lists the specific characteristics of the different histological specimens and also describes how to distinguish a specimen from other similar specimens. For each histological specimen, a simplified drawing and a photomicrograph of the specimen, is presented to help the student recognize the important characteristics in the microscope. Lastly, the book contains multiple “memo boxes” in which parts of the curriculum are presented as easy-to-remember mnemonics.

Author : Ivan Cameron
Publisher : Elsevier
Page : 363 pages
File Size : 45,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323154123

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Acidic Proteins of the Nucleus by Ivan Cameron Pdf

Acidic Proteins of the Nucleus focuses on the functional role of acidic nuclear proteins in differential gene expression. Historically, these proteins are referred to as acidic in nature because they are insoluble in dilute mineral acids and their amino acid composition shows a preponderance of acidic over basic amino acid residues. After an introduction to DNA-binding proteins and transcriptional control in prokaryotic and eukaryotic systems, the subsequent chapters describe various approaches for isolating, separating, and characterizing acidic nuclear proteins. The core chapters specifically cover the isolation, fractionation, and characterization of acidic nuclear phosphoproteins, and the role of these proteins in cell proliferation, cell differentiation, and cell cycle. The last two chapters address the role of acidic nuclear protein in binding steroid hormones and in gene regulation. Each chapter contains some previously unpublished work and provides recommendations for future research. This book will be a good reference background for researchers of acidic nuclear proteins.

Author : P. R. Cook
Publisher : Wiley-Liss
Page : 376 pages
File Size : 41,7 Mb
Release : 2001-04-24
Category : Science
ISBN : UOM:39015050548513

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Principles of Nuclear Structure and Function by P. R. Cook Pdf

The nucleus guides the life processes of the cell by directing cellular reproduction, differentiation during development, and metabolism. The study of the structure and function of the nucleus along with its genetic material serves as the foundation for the science of genetics. Principles of Nuclear Structure and Function provides a comprehensive overview of the cell nucleus by illustrating the connection between function and the architecture of the nucleus. Richly illustrated throughout, each chapter includes an overview, detailed examples, summary points, references, and callout boxes highlighting methods and cutting-edge technology. The appendix provides a useful list of related Web sites. Some of the subjects reviewed within Principles of Nuclear Structure and Function include: * Nuclear structure, replication, damage, and repair * Regulation of gene expression * The cell cycle * Meiosis and recombination This timely volume presents functional studies within their proper structural context and is an informative profile of the cell and molecular biology in nuclei and chromatin. For those studying cell biology, along with molecular and cell biologists, geneticists, and reproductive biologists, Principles of Nuclear Structure and Function is a definitive resource. Visit www.wiley.com/cook for supplementary information, including additional Web resources, downloadable figures, and discussion questions.

Author : Lisa Bartee,Walter Shiner,Catherine Creech
Publisher : Unknown
Page : 128 pages
File Size : 47,8 Mb
Release : 2017
Category : Electronic
ISBN : 1636350410

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Principles of Biology by Lisa Bartee,Walter Shiner,Catherine Creech Pdf

The Principles of Biology sequence (BI 211, 212 and 213) introduces biology as a scientific discipline for students planning to major in biology and other science disciplines. Laboratories and classroom activities introduce techniques used to study biological processes and provide opportunities for students to develop their ability to conduct research.

Author : M. A. Preston
Publisher : CRC Press
Page : 447 pages
File Size : 43,9 Mb
Release : 2018-03-14
Category : Science
ISBN : 9780429972645

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Structure Of The Nucleus by M. A. Preston Pdf

A graduate-level one-volume textbook and reference work on the structure and physics of atomic nuclei. Throughout this book the underlying emphasis is on how a nucleus is constituted through the interaction between the nucleons. The book is structured into three parts: the first part contains a detailed treatment of the two-nucleon force and of basic model-independent nuclear properties the second part discusses the experimental results of nuclear models and their bases in fundamental theory the third part deals in some detail with alpha-decay and fission.

Author : Samantha Fowler,Rebecca Roush,James Wise
Publisher : Unknown
Page : 618 pages
File Size : 41,5 Mb
Release : 2018-01-07
Category : Science
ISBN : 9888407457

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Concepts of Biology by Samantha Fowler,Rebecca Roush,James Wise Pdf

Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.