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Author : Zénon M. Bacq
Publisher : Unknown
Page : 659 pages
File Size : 51,8 Mb
Release : 1979
Category : Electronic
ISBN : OCLC:749446299
Author : Z. M. Bacq
Publisher : Elsevier
Page : 694 pages
File Size : 53,5 Mb
Release : 2014-05-17
Category : Medical
ISBN : 9781483181622
Fundamentals of Biochemical Pharmacology explains the molecular aspects of drugs and the changes in bio-chemical systems. The cellular movements that result from such changes are also evaluated. Biochemical lesion is extensively defined in the book. A discussion on electromagnetic radiation is also provided. A chapter of the book is devoted to the principles of electronic and nuclear magnetic resonance. The principles and applications of mass spectrometry and combined gas chromatography are then discussed. The scientific advances made with the use of immunological methods are the focus of a section of the book. Another section provides an introduction to the kinetic properties of reactions made by enzymes. The process called homogenization is clearly explained along with a discussion on the use of electron microscopy. Autoradiography shows the distribution of compounds at the subcellular level. The theoretical background of molecular spectroscopy is presented completely. The book is intended for chemists, biochemists, physicists, micro-biologists, zoologists, and botanists .
Author : Michael Palmer
Publisher : John Wiley & Sons
Page : 436 pages
File Size : 54,7 Mb
Release : 2012-03-27
Category : Medical
ISBN : 9780470174456
"Biochemical abnormalities play a key role in human illness. To pinpoint effective curative solutions, biochemical pharmacologists use drugs to discover new information about biosynthetic pathways and their kinetics. Using a more chemistry- and mechanism-oriented approach than standard pharmacology books, Introduction to Biochemical Pharmacology is a one-stop reference that focuses on how a drug interacts with a target receptor or enzyme at the molecular level. Learning is reinforced through the use of end-of-chapter exercises, PowerPoint slides, and a problem-and-solutions manual"--Provided by publisher.
Author : H.S. Ackermann,Bernard B. Brodie,James R. Gillette
Publisher : Springer Science & Business Media
Page : 486 pages
File Size : 41,8 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9783642650529
This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bioche mical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. BYRON CLARKE, Director of the Pharmacology-Toxicology Program at the National Insti tutes of Health, whose support made possible much of the work described in this volume. Contents Section One: Routes of Drug Administration Chapter 1: Biological Membranes and Their Passage by Drugs. C. A. M. HOGBEN 1 References. . . . . . . . . . . . . . . . . . . . . . . . . . 8 Chapter 2: Absorption of Drugs from the Gastrointestinal Tract. L. S. SCHANKER. With 5 Figures. 9 I. Introduction. . . . . . . . . . . . . . . . . . . . . . . 9 II. Methods of Study. . . . . . . . . . . . . . . . . . . . . 9 III. Absorption from the Stomach . . . . . . . . . . . . . . . 11 IV. Intestinal Absorption of Non-Electrolytes and Weak Electrolytes 15 V. Absorption of Weak Electrolytes from the Colon and Rectum 18 VI. Intestinal Absorption of Organic Ions. . . . . . . . . . 19 VII. Intestinal Absorption of Macromolecules . . . . . . . . . . 19 VIII. Active Transport across the Intestinal Epithelium . . . . . 20 IX. Effect of EDTA on Drug Absorption from the Intestine . . . . . . .
Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 52,9 Mb
Release : 1959
Category : Electronic
ISBN : OCLC:252486964
Author : Bernard B. Brodie,James R. Gillette
Publisher : Springer Science & Business Media
Page : 797 pages
File Size : 48,6 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9783642651779
This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bio chemical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. Byron Clark, Director of the Pharmacology-Toxicology Program at the National Institutes of Health whose support made possible much of the work described in this volume. Contents Section Four: Methods 01 Stooging the MetoholiBm 01 Drugs Subsection A. Assay 01 Drugs and Their M etoholites Chapter 22 : Basic Principles in Development of Methods for Drug Assay. B. B. BRODIE. With 2 Figures 1 1 A. Introduction . . . . . . . . . . B. Principles of Developing a Method. . . . . . 1 I. Section of Method of Assay . . . . . . 1 II. Choice of Solvent for Extraction of Drug 2 III. Adsorption of Drugs by Glass Surfaces . . . . . . . . . . . . . . 3 IV. Recoveries of Known Amounts of Compound from Biological Material. 4 V. Assessment of Sensitivity 5 VI. Assessment of Specificity 5 References. . . . . . . . . . .
Author : Bernard Beryl Brodie
Publisher : Unknown
Page : 128 pages
File Size : 55,9 Mb
Release : 1977
Category : Electronic
ISBN : OCLC:1110788374
Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 54,7 Mb
Release : 2024-07-03
Category : Electronic
ISBN : OCLC:714207818
Author : Anonim
Publisher : Unknown
Page : 27 pages
File Size : 50,5 Mb
Release : 1975
Category : Electronic
ISBN : OCLC:251398289
Author : Michael Palmer,Alice Chan,Thorsten Dieckmann,John Honek
Publisher : John Wiley & Sons
Page : 388 pages
File Size : 55,7 Mb
Release : 2013-08-08
Category : Science
ISBN : 9781118819982
This book contains lecture notes intended for teaching biochemical pharmacology. The content is based on and best understood as an ancillary with the authors' textbook Biochemical Pharmacology (Wiley, 2012). Most of the figures have been adapted, with enhancements and occasional corrections, whereas the text is new and more condensed -- making it easier to cover most or all of the content in a single term. The focus is on principles, not on comprehensive coverage or clinical relevance. It uses a simple layout, presenting lecture slides in sequence, augmented with the explanatory text below each. This is an ideal format for ebook reading, yielding easier on-screen reading than a traditional book layout.
Author : Bernard B. Brodie,James R. Gillette,Jerry R. Mitchell,Helen S. Ackerman
Publisher : Unknown
Page : 496 pages
File Size : 54,8 Mb
Release : 1971
Category : Biochemistry
ISBN : NWU:35558001446281
Author : P.S. Randall,James R. Gillette,J.R. Mitchell
Publisher : Springer Science & Business Media
Page : 509 pages
File Size : 55,5 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9783642463143
Part 3 of the Handbook of Experimental Pharmacology (Concepts in Biochem ical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man. Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmaco kinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader. Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, entero hepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.
Author : G. Siest,C. Heusghem
Publisher : Unknown
Page : 128 pages
File Size : 41,8 Mb
Release : 1977
Category : Electronic
ISBN : OCLC:637678573
Author : Bernard B. Brodie,Jerry R. Mitchell,James R. Gillette,Helen S. Ackerman
Publisher : Unknown
Page : 128 pages
File Size : 52,9 Mb
Release : 1971
Category : Drugs
ISBN : LCCN:79135957
Author : Anonim
Publisher : Unknown
Page : 480 pages
File Size : 54,9 Mb
Release : 1975
Category : Pharmacology
ISBN : OCLC:15666823