Fundamentals Of Molecular Structural Biology

Author : Subrata Pal
Publisher : Academic Press
Page : 518 pages
File Size : 52,8 Mb
Release : 2019-08-13
Category : Science
ISBN : 9780128148563

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Fundamentals of Molecular Structural Biology by Subrata Pal Pdf

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease

Author : Jayanta K. Pal,Saroj S. Ghaskadbi
Publisher : Oxford University Press, USA
Page : 0 pages
File Size : 41,8 Mb
Release : 2009
Category : Fundamentals
ISBN : 0195697812

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Fundamentals of Molecular Biology by Jayanta K. Pal,Saroj S. Ghaskadbi Pdf

Fundamentals of Molecular Biology is designed to serve as a syllabus-oriented textbook for undergraduate students of Biotechnology from JNTU, Anna University, BITS Pilani, WBUT etc. The focus is on explaining the basic concepts and techniques in molecular biology and their applications thereof. Starting with the definition and role of molecular biology, the book provides complete coverage of topics such as micro and macromolecule, DNA enzymes, the concept of genomes and various techniques used through its study and an overview of recombinant DNA technology and its applications. The book delves deeper into the subject by providing discussions on DNA replication, its damage, repair and recombination, transcription machinery in prokaryotes and eukaryotes, translation, protein folding, modifications and degradations, finally concluding with a detailed discussion on Genomics and Proteomics. The book is written in simple language aimed at helping students assimilate complex theories with ease. The text is complemented by a large number of diagrams, colour illustrations, and end-chapter questions. Key terms are highlighted in the text for students to grasp concepts quickly. Exhaustive references for further reading are provided at the end of every chapter for the interested reader.

Author : Leonard J. Banaszak
Publisher : Elsevier
Page : 168 pages
File Size : 47,5 Mb
Release : 2000-02-08
Category : Science
ISBN : 0080521843

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Foundations of Structural Biology by Leonard J. Banaszak Pdf

Imagine trying to understand an engine without visualizing its moving parts. Biological processes involve far more complex chemical reactions and components than any engine. Furthermore, the parts work together to do many more functions than an engine which sole task is to turn a shaft. Understanding the implications of the three-dimensional coordinates for a molecule with several thousand atoms requires an understanding of, and practice with, 3D imaging. For many biologists, this means acquiring a whole new set of skills. Foundations of Structural Biology is aimed at helping the reader develop visualization skills for protein or DNA segments, while also describing the fundamental principles underlying the organization and interaction between these complex molecules. Key Features * Explains how to use coordinate databases and atomic coordinates of biological macromolecules * Teaches the skills of stereoviewing * Contains computer-generated stereographics * Describes the principles of symmetry and handedness in proteins and DNA * Introduces metal and lipid binding proteins and DNA-protein interactions * Explains the principles involved in understanding secondary and quaternary structure * Includes coverage of protein-metal, protein-nucleic acid, and protein-lipid interactions

Author : Gordon S. Rule,T. Kevin Hitchens
Publisher : Springer Science & Business Media
Page : 543 pages
File Size : 44,7 Mb
Release : 2005-10-28
Category : Science
ISBN : 9781402034992

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Fundamentals of Protein NMR Spectroscopy by Gordon S. Rule,T. Kevin Hitchens Pdf

NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding and developing novel pulse programs. This text not only covers topics from chemical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offer students a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular systems, but will also be a useful reference for the experienced investigator.

Author : Donald Voet,Judith G. Voet,Charlotte W. Pratt
Publisher : John Wiley & Sons
Page : 1187 pages
File Size : 40,8 Mb
Release : 2016-02-29
Category : Science
ISBN : 9781118918401

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Fundamentals of Biochemistry by Donald Voet,Judith G. Voet,Charlotte W. Pratt Pdf

Voet, Voet and Pratt's Fundamentals of Biochemistry, 5th Edition addresses the enormous advances in biochemistry, particularly in the areas of structural biology and Bioinformatics, by providing a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future. While continuing in its tradition of presenting complete and balanced coverage that is clearly written and relevant to human health and disease, Fundamentals of Biochemistry, 5e includes new pedagogy and enhanced visuals that provide a pathway for student learning.

Author : Bruce R. Donald
Publisher : MIT Press
Page : 497 pages
File Size : 41,5 Mb
Release : 2023-08-15
Category : Science
ISBN : 9780262548793

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Algorithms in Structural Molecular Biology by Bruce R. Donald Pdf

An overview of algorithms important to computational structural biology that addresses such topics as NMR and design and analysis of proteins.Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules. Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility. The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field.

Author : Alasdair Steven,Wolfgang Baumeister,Louise N. Johnson,Richard N. Perham
Publisher : Garland Science
Page : 881 pages
File Size : 51,6 Mb
Release : 2016-02-18
Category : Medical
ISBN : 9781000064902

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Molecular Biology of Assemblies and Machines by Alasdair Steven,Wolfgang Baumeister,Louise N. Johnson,Richard N. Perham Pdf

Molecular Biology of Assemblies and Machines provides a comprehensive narrative of the ways in which macromolecular structures assemble and how they interact with other complexes and organelles in the cell. Richly illustrated in full color, the text is written for advanced undergraduates, graduate students, and researchers in biochemistry, molecular biology, biophysics, cell biology, chemistry, structural biology, immunology, microbiology, and medicine.

Author : Subrata Pal
Publisher : Elsevier
Page : 311 pages
File Size : 44,7 Mb
Release : 2022-11-19
Category : Science
ISBN : 9780323906630

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Mathematical Approaches to Molecular Structural Biology by Subrata Pal Pdf

Mathematical Approaches to Molecular Structural Biology offers a comprehensive overview of the mathematical foundations behind the study of biomolecular structure. Initial chapters provide an introduction to the mathematics associated with the study of molecular structure, such as vector spaces and matrices, linear systems, matrix decomposition, vector calculus, probability and statistics. The book then moves on to more advanced areas of molecular structural biology based on the mathematical concepts discussed in earlier chapters. Here, key methods such as X-ray crystallography and cryo-electron microscopy are explored, in addition to biomolecular structure dynamics within the context of mathematics and physics. This book equips readers with an understanding of the fundamental principles behind structural biology, providing researchers with a strong groundwork for further investigation in both this and related fields. Includes a detailed introduction to key mathematical principles and their application to molecular structural biology Explores the mathematical underpinnings behind advanced techniques such as X-ray crystallography and Cryo-electron microscopy Features step-by-step protocols that illustrate mathematical and statistical principles for studying molecular structure and dynamics Provides a basis for further investigation into the field of computational molecular biology Includes figures and graphs throughout to visually demonstrate the concepts discussed

Author : Anders Liljas
Publisher : World Scientific
Page : 581 pages
File Size : 44,6 Mb
Release : 2009
Category : Science
ISBN : 9789812772077

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Textbook of Structural Biology by Anders Liljas Pdf

A textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. It covers various aspects of proteins, nucleic acids and lipids, including the rise and fall of proteins, membranes and gradients, the structural biology of cells, and evolution - the comparative structural biology.

Author : Zandra Edmonds
Publisher : Unknown
Page : 236 pages
File Size : 49,7 Mb
Release : 2019-06-12
Category : Electronic
ISBN : 1641160772

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Principles and Applications of Structural Biology by Zandra Edmonds Pdf

Structural biology is the scientific study of the molecular structure of important macromolecules like amino acids, proteins and nucleic acids. It comes under the domain of molecular biology, but builds on the technological tools of biophysics like spectrometry, crystallography, proteolysis, scattering, etc. It also uses the principles of biochemistry to study, design, alteration and evolution of macromolecules. This book discusses the modern approaches of structural biology. It also elucidates the principles and applications of structural biology in a multidisciplinary manner. Experts and students in biotechnology, biophysics, biochemistry, structural biology and bioinformatics will be assisted by this book.

Author : Stephen Neidle
Publisher : Springer
Page : 228 pages
File Size : 41,6 Mb
Release : 1981-06-18
Category : Science
ISBN : 9781349046911

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Topics in Nucleic Acid Structure by Stephen Neidle Pdf

Author : Phoebe A. Rice,Carl C. Correll
Publisher : Royal Society of Chemistry
Page : 417 pages
File Size : 55,8 Mb
Release : 2008-05-22
Category : Science
ISBN : 9780854042722

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Protein-Nucleic Acid Interactions by Phoebe A. Rice,Carl C. Correll Pdf

This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include: - the role of ions and hydration in protein-nucleic acid interactions - transcription factors and combinatorial specificity - indirect readout of DNA sequence - single-stranded nucleic acid binding proteins - nucleic acid junctions and proteins, - RNA protein recognition - recognition of DNA damage. It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.

Author : Chang-Hui Shen
Publisher : Elsevier
Page : 590 pages
File Size : 47,5 Mb
Release : 2023-06-29
Category : Science
ISBN : 9780323986090

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Diagnostic Molecular Biology by Chang-Hui Shen Pdf

Diagnostic Molecular Biology, Second Edition describes the fundamentals of molecular biology in a clear, concise manner with each technique explained within its conceptual framework and current applications of clinical laboratory techniques comprehensively covered. This targeted approach covers the principles of molecular biology, including basic knowledge of nucleic acids, proteins and chromosomes; the basic techniques and instrumentations commonly used in the field of molecular biology, including detailed procedures and explanations; and the applications of the principles and techniques currently employed in the clinical laboratory. Topics such as whole exome sequencing, whole genome sequencing, RNA-seq, and ChIP-seq round out the discussion. Fully updated, this new edition adds recent advances in the detection of respiratory virus infections in humans, like influenza, RSV, hAdV, hRV but also corona. This book expands the discussion on NGS application and its role in future precision medicine. Provides explanations on how techniques are used to diagnosis at the molecular level Explains how to use information technology to communicate and assess results in the lab Enhances our understanding of fundamental molecular biology and places techniques in context Places protocols into context with practical applications Includes extra chapters on respiratory viruses (Corona)

Author : Rossen Donev
Publisher : Academic Press
Page : 215 pages
File Size : 52,7 Mb
Release : 2011-08-29
Category : Science
ISBN : 9780123864833

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Advances in Protein Chemistry and Structural Biology by Rossen Donev Pdf

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Protein Aggregation. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Author : S.K. Malhotra
Publisher : Elsevier Science
Page : 350 pages
File Size : 49,7 Mb
Release : 1993-05-15
Category : Science
ISBN : 1559385847

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Advances in Structural Biology by S.K. Malhotra Pdf