Gapdh Biological Properties And Diversity

Author : Norbert W. Seidler
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 55,9 Mb
Release : 2012-07-31
Category : Medical
ISBN : 9789400747166

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GAPDH: Biological Properties and Diversity by Norbert W. Seidler Pdf

The book represents a comprehensive review and synthesis of the biomedical literature that spans over a half-century on a single protein called glyceraldehyde 3-phosphate dehydrogenase (or, GAPDH). Due to the protein’s involvement in a vast array of cellular activities, GAPDH is of interest to the cell biologist, immunologist, virologist, biochemist etc. The protein has a significant role in fertility, cancer and neurodegeneration, suggesting that this book can be a vital resource for drug development. GAPDH function may provide insight into anesthesia. Furthermore, GAPDH is highly conserved meaning that the protein found in microorganisms, such as pathogens, remained relatively unchanged in evolution. Pathogens use GAPDH as a virulence factor, offering a unique challenge in developing anti-microbial agents that target this protein. To the evolutionary biologist, a book on the multi-functionality of GAPDH provides a focal point for a cogent discussion on the very origin of life.

Author : Michael A. Sirover
Publisher : Academic Press
Page : 324 pages
File Size : 50,5 Mb
Release : 2017-05-22
Category : Science
ISBN : 9780128098981

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Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) by Michael A. Sirover Pdf

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein’s diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion. This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease. Contextualizes how GAPDH is utilized by cells in vivo Provides detailed insight into GAPDH post-translational modifications, including functional diversity and its subcellular localization Includes forward-thinking exposition on tough topics, such as the exploration of how GAPDG performs functions, how it decides where it should be present and requisite structural requirements

Author : Brian Henderson,Mario A. Fares,Andrew C. R. Martin
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 45,9 Mb
Release : 2016-12-12
Category : Science
ISBN : 9781118952092

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Protein Moonlighting in Biology and Medicine by Brian Henderson,Mario A. Fares,Andrew C. R. Martin Pdf

The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.

Author : Brian Henderson
Publisher : John Wiley & Sons
Page : 493 pages
File Size : 55,9 Mb
Release : 2017-04-17
Category : Science
ISBN : 9781118951118

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Moonlighting Proteins by Brian Henderson Pdf

Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science.

Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 48,9 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510

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Innovative Medicine by Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Pdf

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Author : Crystal Leigh Olson
Publisher : Unknown
Page : 294 pages
File Size : 49,9 Mb
Release : 2006
Category : Electronic
ISBN : UVA:X030008926

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The Design, Synthesis, and Biological Evaluation of Five Two-point Diversity "scaffolded" Libraries by Crystal Leigh Olson Pdf

Author : Shanmugasundaram Ganapathy-Kanniappan
Publisher : Springer
Page : 115 pages
File Size : 47,8 Mb
Release : 2018-01-16
Category : Science
ISBN : 9789811073427

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Advances in GAPDH Protein Analysis: A Functional and Biochemical Approach by Shanmugasundaram Ganapathy-Kanniappan Pdf

This book presents modern and classic analytical approaches that are crucial for the biochemical and functional characterization of the archetypal protein, glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The distinguishing feature of the book is that it covers, in addition to other methods, some of the uncommon but valuable techniques as well. For example, in-gel visualization of enzyme activity, immunoblotting protocols for native (non-denatured) proteins, and proteins resolved by pH-gradient [IEF-isoelectrofocusing], etc. These expedient methods are relevant and vital for the verification of biochemical properties of GAPDH, or similar protein of interest. This work outlines detailed protocols that are essential to investigate classical (cellular) and recently reported extracellular (secretory) isoforms of GAPDH. Precisely, the book covers techniques pertinent to enzymatic and non-enzymatic analysis of GAPDH that include, but not limited to, electrophoretic mobility shift assay (EMSA), two-dimensional (2D)-immunoblotting, immunofluorescence/confocal microscopy, mass spectrometry, ion-exchange and affinity chromatography. Readers will discover the importance of the experimental methods described in the book as they relate to the evaluation of the role and significance of GAPDH. Furthermore, majority of the methods described in the book have also been validated in the author’s laboratory, besides other research groups worldwide, underlining the repeatability and reproducibility of the protocols. Each method begins with an abstract and a brief background emphasizing its application and relevance. This will enable the readers to determine the choice of experimental design according to their research objectives. The book explains the methods systematically with ample illustrations to facilitate quick and easy comprehension of the practical knowledge. Although the book is focused on GAPDH, many of the protocols may be adopted to other proteins or enzymes with minimal modifications. Noteworthy, it is unequivocally established that GAPDH is a multifunctional protein involved in several cellular processes of health & disease conditions. Hence, this book will be a valuable practical guide for young researchers, scientists and clinician-scientists.

Author : Toshio Sekimura,H. Frederik Nijhout
Publisher : Springer
Page : 321 pages
File Size : 43,9 Mb
Release : 2017-08-29
Category : Science
ISBN : 9789811049569

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Diversity and Evolution of Butterfly Wing Patterns by Toshio Sekimura,H. Frederik Nijhout Pdf

This book facilitates an integrative understanding of the development, genetics and evolution of butterfly wing patterns. To develop a deep and realistic understanding of the diversity and evolution of butterfly wing patterns, it is essential and necessary to approach the problem from various kinds of key research fields such as “evo-devo,” “eco-devo,” ”developmental genetics,” “ecology and adaptation,” “food plants,” and “theoretical modeling.” The past decade-and-a-half has seen a veritable revolution in our understanding of the development, genetics and evolution of butterfly wing patterns. In addition, studies of how environmental and climatic factors affect the expression of color patterns has led to increasingly deeper understanding of the pervasiveness and underlying mechanisms of phenotypic plasticity. In recognition of the great progress in research on the biology, an international meeting titled “Integrative Approach to Understanding the Diversity of Butterfly Wing Patterns (IABP-2016)” was held at Chubu University, Japan in August 2016. This book consists of selected contributions from the meeting. Authors include main active researchers of new findings of corresponding genes as well as world leaders in both experimental and theoretical approaches to wing color patterns. The book provides excellent case studies for graduate and undergraduate classes in evolution, genetics/genomics, developmental biology, ecology, biochemistry, and also theoretical biology, opening the door to a new era in the integrative approach to the analysis of biological problems. This book is open access under a CC BY 4.0 license.

Author : Tadhg P. Begley
Publisher : Wiley-Blackwell
Page : 820 pages
File Size : 49,8 Mb
Release : 2009-02-03
Category : Science
ISBN : WISC:89101786226

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Wiley Encyclopedia of Chemical Biology, Volume 2 by Tadhg P. Begley Pdf

The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

Author : Armen M. Boldi
Publisher : CRC Press
Page : 354 pages
File Size : 49,9 Mb
Release : 2006-05-16
Category : Science
ISBN : 9781000612011

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Combinatorial Synthesis of Natural Product-Based Libraries by Armen M. Boldi Pdf

Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinato

Author : Anne-Marie Caminade,Cédric-Olivier Turrin,Jean-Pierre Majoral
Publisher : CRC Press
Page : 372 pages
File Size : 48,7 Mb
Release : 2018-05-03
Category : Medical
ISBN : 9781351617291

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Phosphorous Dendrimers in Biology and Nanomedicine by Anne-Marie Caminade,Cédric-Olivier Turrin,Jean-Pierre Majoral Pdf

Dendrimers, which are hyperbranched synthetic macromolecules, have attracted researchers’ increasing interest over the last three decades owing to their numerous properties, in particular, in the fields of biology and nanomedicine. This book is an up-to-date collection of the most recent achievements in the use of dendrimers in nanomedicine, exemplified by phosphorus-containing dendrimers. Starting with the synthesis and characterization of phosphorus dendrimers, the book discusses their use as biomaterials, carriers of biological entities, and anti-inflammatory drugs; in bioimaging; and against prion diseases, Alzheimer’s, HIV, and cancer. It compares phosphorus dendrimers with other types of dendrimers. Supplemented with numerous references and abundant illustrations, the book opens new perspectives for the researchers working on dendrimers.

Author : Joram PIATIGORSKY,Joram Piatigorsky
Publisher : Harvard University Press
Page : 337 pages
File Size : 54,9 Mb
Release : 2009-06-30
Category : Science
ISBN : 9780674042124

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Gene Sharing and Evolution by Joram PIATIGORSKY,Joram Piatigorsky Pdf

In Gene Sharing and Evolution Piatigorsky explores the generality and implications of gene sharing throughout evolution and argues that most if not all proteins perform a variety of functions in the same and in different species, and that this is a fundamental necessity for evolution.

Author : Anonim
Publisher : John Wiley & Sons
Page : 509 pages
File Size : 54,9 Mb
Release : 2011-11-30
Category : Science
ISBN : 9783527321049

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Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides by Anonim Pdf

This is the last of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides Volume 5 of this series presents a wealth of methods to analyze amino acids and peptides. Classical approaches are described, such as X-ray analysis, chromatographic methods, NMR, AFM, mass spectrometry and 2D-gel electrophoresis, as well as newer approaches, including Surface Plasmon Resonance and array technologies. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Author : Dusan Losic
Publisher : Royal Society of Chemistry
Page : 286 pages
File Size : 48,8 Mb
Release : 2018
Category : Science
ISBN : 9781782629320

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Diatom Nanotechnology by Dusan Losic Pdf

Diatoms are single cell algae composed of silica. They represent one of the most outstanding natural materials with exceptional structural, mechanical, optical, photonic and chemical properties optimized through millions of years of evolution. The unique nano and micro silica structures of the material combined with its availability as a low cost mineral from diatomaceous earth are attractive for solving many of today's environmental, energy and health problems. Diatom Nanotechnology provides a comprehensive overview of the material and its uses. The first part of the book looks at the distinctive porous silica structure of diatoms, the mechanism of their formation and their properties. Individual chapters then explore the broad range of their applications in nanotechnology including nanofabrication, optical biosensors, gas sensors, water purifications, photonics, drug delivery, batteries, solar cells, supercapacitors, new adsorbents and composite materials. With contributions from leading international experts, the book represents an important resource for academics, researchers, industry professionals, postgraduate and advanced level undergraduate students providing them with the latest developments on this emerging and dynamic field.

Author : Anonim
Publisher : Unknown
Page : 1798 pages
File Size : 51,9 Mb
Release : 1966
Category : Biochemistry
ISBN : UOM:39015012035674

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The Journal of Biological Chemistry by Anonim Pdf

Vols. 3-140 include the society's Proceedings, 1907-41