Gene Mapping Discovery And Expression

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Gene Mapping, Discovery, and Expression

Minou Bina
Gene Mapping Discovery and Expression Book PDF

Author : Minou Bina
Publisher : Springer Science & Business Media
Page : 335 pages
File Size : 48,7 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781597450973

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Gene Mapping, Discovery, and Expression by Minou Bina Pdf

Completion of the sequence of the human genome represents an unpar- leled achievement in the history of biology. The project has produced nearly complete, highly accurate, and comprehensive sequences of genomes of s- eral organisms including human, mouse, drosophila, and yeast. Furthermore, the development of high-throughput technologies has led to an explosion of projects to sequence the genomes of additional organisms including rat, chimp, dog, bee, chicken, and the list is expanding. The nearly completed draft of genomic sequences from numerous species has opened a new era of research in biology and in biomedical sciences. In keeping with the interdisciplinary nature of the new scientific era, the chapters in Gene Mapping, Discovery, and Expression: Methods and Protocols recapitulate the necessity of integration of experimental and computational tools for solving - portant research problems. The general underlying theme of this volume is DNA sequence-based technologies. At one level, the book highlights the importance of databases, genome-browsers, and web-based tools for data access and ana- sis. More specifically, sequencing projects routinely deposit their data in p- licly available databases including GenBank, at the National Center of Biotechnology (NCBI) in the United States; EMBL, maintained by the European Bioinformatics Institute; and DDBJ, the DNA Data Bank of Japan. Currently, several browsers offer facile access to numerous genomic DNA sequences for gene mapping and data retrieval.

Gene Mapping, Discovery, and Expression

Minou Bina
Gene Mapping Discovery and Expression Book PDF

Author : Minou Bina
Publisher : Unknown
Page : 128 pages
File Size : 53,7 Mb
Release : 2006
Category : Electronic
ISBN : OCLC:748540371

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Gene Mapping, Discovery, and Expression by Minou Bina Pdf

The general underlying theme of "Gene Mapping, Discovery, and Expression" is DNA-sequence-based technologies. At one level, the book highlights the importance of databases, genome-browsers, and web-based tools for data access and analysis. This volume also provides a computational protocol for identifying and mapping recent segmental and gene duplications, as well as step-by-step procedures for identifying paralogous genes, using the genome browser at UCSC. Lastly, several chapters in this volume offer non-invasive technologies for the isolation of transcription factor complexes formed with specific DNA sequences used as bait. These methods can lead to the discovery of novel transcription factors with important roles in the control of gene expression.

Gene Discovery for Disease Models

Weikuan Gu,Yongjun Wang
Gene Discovery for Disease Models Book PDF

Author : Weikuan Gu,Yongjun Wang
Publisher : John Wiley & Sons
Page : 642 pages
File Size : 42,9 Mb
Release : 2011-03-03
Category : Science
ISBN : 9781118002179

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Gene Discovery for Disease Models by Weikuan Gu,Yongjun Wang Pdf

This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that “The availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decades-old mouse mutants will be understood precisely at the DNA level in the near future.” The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the post-genome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL).

Gene Mapping, Discovery, and Expression

Minou Bina
Gene Mapping Discovery and Expression Book PDF

Author : Minou Bina
Publisher : Humana Press
Page : 334 pages
File Size : 51,7 Mb
Release : 2006-04-01
Category : Science
ISBN : 1588295753

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Gene Mapping, Discovery, and Expression by Minou Bina Pdf

Completion of the sequence of the human genome represents an unpar- leled achievement in the history of biology. The project has produced nearly complete, highly accurate, and comprehensive sequences of genomes of s- eral organisms including human, mouse, drosophila, and yeast. Furthermore, the development of high-throughput technologies has led to an explosion of projects to sequence the genomes of additional organisms including rat, chimp, dog, bee, chicken, and the list is expanding. The nearly completed draft of genomic sequences from numerous species has opened a new era of research in biology and in biomedical sciences. In keeping with the interdisciplinary nature of the new scientific era, the chapters in Gene Mapping, Discovery, and Expression: Methods and Protocols recapitulate the necessity of integration of experimental and computational tools for solving - portant research problems. The general underlying theme of this volume is DNA sequence-based technologies. At one level, the book highlights the importance of databases, genome-browsers, and web-based tools for data access and ana- sis. More specifically, sequencing projects routinely deposit their data in p- licly available databases including GenBank, at the National Center of Biotechnology (NCBI) in the United States; EMBL, maintained by the European Bioinformatics Institute; and DDBJ, the DNA Data Bank of Japan. Currently, several browsers offer facile access to numerous genomic DNA sequences for gene mapping and data retrieval.

Advances in Genomic Sequence Analysis and Pattern Discovery

Laura Elnitski,Helen Piontkivska,Lonnie R. Welch
Advances in Genomic Sequence Analysis and Pattern Discovery Book PDF

Author : Laura Elnitski,Helen Piontkivska,Lonnie R. Welch
Publisher : World Scientific
Page : 236 pages
File Size : 46,7 Mb
Release : 2011
Category : Science
ISBN : 9789814327725

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Advances in Genomic Sequence Analysis and Pattern Discovery by Laura Elnitski,Helen Piontkivska,Lonnie R. Welch Pdf

Mapping the genomic landscapes is one of the most exciting frontiers of science. We have the opportunity to reverse engineer the blueprints and the control systems of living organisms. Computational tools are key enablers in the deciphering process. This book provides an in-depth presentation of some of the important computational biology approaches to genomic sequence analysis. The first section of the book discusses methods for discovering patterns in DNA and RNA. This is followed by the second section that reflects on methods in various ways, including performance, usage and paradigms.

Mapping and Sequencing the Human Genome

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Mapping and Sequencing the Human Genome Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Publisher : National Academies Press
Page : 128 pages
File Size : 45,5 Mb
Release : 1988-01-01
Category : Science
ISBN : 9780309038409

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Mapping and Sequencing the Human Genome by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome Pdf

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Genome Mapping and Genomics in Domestic Animals

Noelle E. Cockett,Chittaranjan Kole
Genome Mapping and Genomics in Domestic Animals Book PDF

Author : Noelle E. Cockett,Chittaranjan Kole
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 40,8 Mb
Release : 2008-10-31
Category : Science
ISBN : 9783540738350

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Genome Mapping and Genomics in Domestic Animals by Noelle E. Cockett,Chittaranjan Kole Pdf

Genomics research on animals has generated huge databases and several new concepts and strategies, which are used to elucidate origin, evolution and phylogeny of species. Genetic and physical maps of genomes give details on chromosomal location, function, expression and regulation of genes. The series Genome Mapping and Genomics in Animals provides comprehensive and up-to-date reviews on genomic research on selected animal systems contributed by leading scientists from around the world. This volume offers information on gene mapping and genomics research in domesticated and farmed animals including cattle, water buffalo, sheep, deer, poultry, turkeys, rabbits, dogs and pigs. While the genome maps for some species are very limited, full genome sequences are available for cattle, chickens and dogs. Genomic research contributes to the identification of genetic regions that control the functionality and well-being of animals. Several farmed species are also used as models for biomedical studies.

Reproductive Biotechnology in Finfish Aquaculture

C.-S. Lee,E.M. Donaldson
Reproductive Biotechnology in Finfish Aquaculture Book PDF

Author : C.-S. Lee,E.M. Donaldson
Publisher : Elsevier
Page : 328 pages
File Size : 53,5 Mb
Release : 2012-12-02
Category : Technology & Engineering
ISBN : 9780080929866

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Reproductive Biotechnology in Finfish Aquaculture by C.-S. Lee,E.M. Donaldson Pdf

The successful reproduction of cultured brood stock is essential to the sustainable aquaculture of aquatic organisms. This book describes recent advances in the field of finfish reproductive biotechnology. The chapters in this volume are written by eminent scientists who review the progress and assess the status of biotechnology research that is applicable to the reproduction of finfish species for aquaculture. A wide range of topics is included starting with broodstock technologies such as broodstock genetics, broodstock nutrition, environmental control of maturation and impacts of stress on broodstock, gametes and progeny. The volume includes technologies for induction of ovulation and spermiation using synthetic hypothalamic peptides. Gamete technologies which are described include cryopreservation, chromosome set manipulation, disease prevention and control for gametes and embryos and the development of transgenic fish with enhanced production characteristics. Genetic and endocrine technologies for the production of monosex male and female fish stocks are also described. The closing chapter summarizes the discussion of each topic at the workshop, provides recommendations to industry and describes priorities of research and development. Researchers as well as teaching faculty in the aquaculture field will find this volume of great value.

New Technologies in Aquaculture

Gavin Burnell,Geoff Allan
New Technologies in Aquaculture Book PDF

Author : Gavin Burnell,Geoff Allan
Publisher : Elsevier
Page : 1224 pages
File Size : 45,8 Mb
Release : 2009-07-30
Category : Technology & Engineering
ISBN : 9781845696474

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New Technologies in Aquaculture by Gavin Burnell,Geoff Allan Pdf

With wild stocks declining due to over-fishing, aquaculture will have a more significant role to play in meeting future demand for fresh fish. Developments in research continue to lead to improvements in aquaculture production systems, resulting in increased production efficiency, higher product quality for consumers and a more sustainable industry. New technologies in aquaculture reviews essential advances in these areas. Part one focuses on the genetic improvement of farmed species and control of reproduction, with chapters on genome-based technologies in aquaculture research, selective breeding and the production of single sex and sterile populations, among other topics. Parts two and three review key issues in health, diet and husbandry, such as the control of viral and parasitic diseases, diet and husbandry techniques to improve disease resistance, advances in diets for particular fish species and the impact of harmful algal bloom on shellfisheries aquaculture. Chapters in Parts three and four then examine the design of different aquaculture production systems, including offshore technologies, tank-based recirculating systems and ponds, and key environmental issues, such as the prediction and assessment of the impact of aquaculture. Concluding chapters focus on farming new species. With its well-known editors and distinguished international team of contributors, New technologies in aquaculture is an essential purchase for professionals and researchers in the aquaculture industry. Reviews recent advances in improvements in aquaculture production Focuses on the genetic improvement and reproduction of farmed species, including genome-based technologies Discusses key health issues, including advances in disease diagnosis, vaccine development and other emerging methods to control pathogens in aquaculture

From Molecular Genetics to Genomics

Jean-Paul Gaudillière,Hans-Jörg Rheinberger
From Molecular Genetics to Genomics Book PDF

Author : Jean-Paul Gaudillière,Hans-Jörg Rheinberger
Publisher : Routledge
Page : 241 pages
File Size : 53,7 Mb
Release : 2004-10-07
Category : History
ISBN : 9781134334087

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From Molecular Genetics to Genomics by Jean-Paul Gaudillière,Hans-Jörg Rheinberger Pdf

With the rise of genomics, the life sciences have entered a new era. This book provides a comprehensive history of molecular genetics and genomics.

Genetic Analysis of Complex Disease

Jonathan L. Haines,Margaret A. Pericak-Vance
Genetic Analysis of Complex Disease Book PDF

Author : Jonathan L. Haines,Margaret A. Pericak-Vance
Publisher : John Wiley & Sons
Page : 507 pages
File Size : 44,6 Mb
Release : 2007-02-26
Category : Science
ISBN : 9780471781134

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Genetic Analysis of Complex Disease by Jonathan L. Haines,Margaret A. Pericak-Vance Pdf

Second Edition features the latest tools for uncovering thegenetic basis of human disease The Second Edition of this landmark publication bringstogether a team of leading experts in the field to thoroughlyupdate the publication. Readers will discover the tremendousadvances made in human genetics in the seven years that haveelapsed since the First Edition. Once again, the editorshave assembled a comprehensive introduction to the strategies,designs, and methods of analysis for the discovery of genes incommon and genetically complex traits. The growing social, legal,and ethical issues surrounding the field are thoroughly examined aswell. Rather than focusing on technical details or particularmethodologies, the editors take a broader approach that emphasizesconcepts and experimental design. Readers familiar with theFirst Edition will find new and cutting-edge materialincorporated into the text: Updated presentations of bioinformatics, multiple comparisons,sample size requirements, parametric linkage analysis, case-controland family-based approaches, and genomic screening New methods for analysis of gene-gene and gene-environmentinteractions A completely rewritten and updated chapter on determininggenetic components of disease New chapters covering molecular genomic approaches such asmicroarray and SAGE analyses using single nucleotide polymorphism(SNP) and cDNA expression data, as well as quantitative trait loci(QTL) mapping The editors, two of the world's leading genetic epidemiologists,have ensured that each chapter adheres to a consistent and highstandard. Each one includes all-new discussion questions andpractical examples. Chapter summaries highlight key points, and alist of references for each chapter opens the door to furtherinvestigation of specific topics. Molecular biologists, human geneticists, geneticepidemiologists, and clinical and pharmaceutical researchers willfind the Second Edition a helpful guide to understanding thegenetic basis of human disease, with its new tools for detectingrisk factors and discovering treatment strategies.

Self-Incompatibility in Flowering Plants

Vernonica E. Franklin-Tong
Self Incompatibility in Flowering Plants Book PDF

Author : Vernonica E. Franklin-Tong
Publisher : Springer Science & Business Media
Page : 341 pages
File Size : 54,8 Mb
Release : 2008-07-30
Category : Science
ISBN : 9783540684862

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Self-Incompatibility in Flowering Plants by Vernonica E. Franklin-Tong Pdf

Great progress has been made in our understanding of pollen-pistil interactions and self-incompatibility (SI) in flowering plants in the last few decades. This book covers a broad spectrum of research into SI, with accounts by internationally renowned scientists. It comprises two sections: Evolution and Population Genetics of SI, Molecular and Cell Biology of SI Systems. The reader will gain an insight into the diversity and complexity of these polymorphic cell-cell recognition and rejection systems. Heteromorphic and homomorphic SI systems and our current understanding of the evolution and phylogeny of these systems, based on the most recent molecular sequence data, are covered. Further, the book presents major advances in our knowledge of the pistil and pollen S-determinants and other unlinked components involved in SI, as well as the apparently diverse cellular regulatory mechanisms utilised to ensure inhibition of “self” pollen.

OMICS Applications in Crop Science

Debmalya Barh
OMICS Applications in Crop Science Book PDF

Author : Debmalya Barh
Publisher : CRC Press
Page : 719 pages
File Size : 48,8 Mb
Release : 2013-12-16
Category : Medical
ISBN : 9781466585317

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OMICS Applications in Crop Science by Debmalya Barh Pdf

Merging topical data from recently published review and research articles, as well as the knowledge and insight of industry experts, Omics Applications in Crop Science delves into plant science, and various technologies that use omics in agriculture. This book concentrates on crop breeding and environmental applications, and examines the applicatio

High Content Screening

D. Lansing Taylor
High Content Screening Book PDF

Author : D. Lansing Taylor
Publisher : Springer Science & Business Media
Page : 437 pages
File Size : 41,6 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781597452175

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High Content Screening by D. Lansing Taylor Pdf

There has always been some tension between proponents of hypothesis-driven and discovery-driven research in the broad field of life sciences. Academic research has been primarily focused on hypothesis-driven research. However, the success of the human genome project, a discovery-driven research approach, has opened the door to adding other types of discovery-driven research to a continuum of research approaches. In contrast, drug discovery research in the pharmaceutical industry has embraced discovery-driven research for many years. A good example has been the discovery of active compounds from large chemical libraries, through screening campaigns. The success of the human genome project has also demonstrated the need for both academic researchers and industrial researchers to now understand the functions of genes and gene products. The cell is the basic unit of life and it has been at the cellular level where function can be demonstrated most cost-effectively and rapidly. High content screening (HCS) was developed by Cellomics Inc. in the mid-1990s to address the need for a platform that could be used in the discovery-driven research and development required to understand the functions of genes and gene products at the level of the cell.

Genome Mapping and Genomics in Fishes and Aquatic Animals

Thomas D. Kocher,Chittaranjan Kole
Genome Mapping and Genomics in Fishes and Aquatic Animals Book PDF

Author : Thomas D. Kocher,Chittaranjan Kole
Publisher : Springer Science & Business Media
Page : 180 pages
File Size : 51,9 Mb
Release : 2008-06-07
Category : Science
ISBN : 9783540738374

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Genome Mapping and Genomics in Fishes and Aquatic Animals by Thomas D. Kocher,Chittaranjan Kole Pdf

Mapping of animal genomes has generated huge databases and several new concepts and strategies, which are useful to elucidate origin, evolution and phylogeny. Genetic and physical maps of genomes further provide precise details on chromosomal location, function, expression and regulation of academically and economically important genes. The series Genome Mapping and Genomics in Animals provides comprehensive and up-to-date reviews on genomic research on a large variety of selected animal systems, contributed by leading scientists from around the world. This volume summarizes the first era of genomic studies of aquaculture species, in which the tools and resources necessary to support whole-genome sequencing were developed. These tools will enhance efforts toward selective breeding of aquaculture species. Included in this volume are summaries of work on salmonids, cyprinids, catfish, tilapias, European sea bass, Japanese flounder, shrimps and oysters.