Gene Therapy Of Cancer

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Gene Therapy of Cancer

Stanton L. Gerson,Edmund C. Lattime
Gene Therapy of Cancer Book PDF

Author : Stanton L. Gerson,Edmund C. Lattime
Publisher : Elsevier
Page : 534 pages
File Size : 44,9 Mb
Release : 2002-04-04
Category : Science
ISBN : 0080491367

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Gene Therapy of Cancer by Stanton L. Gerson,Edmund C. Lattime Pdf

The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Key Features * Provides in-depth description of targeted systems and treatment strategies * Explains the underlying cancer biology necessary for understanding a given therapeutic approach * Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses * Presents translational focus with emphasis on requirements for clinical implementation * Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Gene Therapy for Cancer

Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Gene Therapy for Cancer Book PDF

Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 42,8 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9781597452229

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Gene Therapy for Cancer by Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher Pdf

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Cancer Gene Therapy

David T. Curiel,Joanne T. Douglas
Cancer Gene Therapy Book PDF

Author : David T. Curiel,Joanne T. Douglas
Publisher : Springer Science & Business Media
Page : 490 pages
File Size : 43,5 Mb
Release : 2007-11-03
Category : Medical
ISBN : 9781592597857

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Cancer Gene Therapy by David T. Curiel,Joanne T. Douglas Pdf

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Gene Therapy of Cancer

Wolfgang Walther,Ulrike Stein
Gene Therapy of Cancer Book PDF

Author : Wolfgang Walther,Ulrike Stein
Publisher : Springer Science & Business Media
Page : 633 pages
File Size : 48,5 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592590865

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Gene Therapy of Cancer by Wolfgang Walther,Ulrike Stein Pdf

Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized by aberrant gene expression, cancer has been a target of gene therapy research since the inception of this treatment modality. Numerous cancer gene therapy strategies are currently being investigated, including gene replacement therapy, the regulation of gene expression to modulate immu- logical responses to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes have been extensively st- ied. All these strategies aim for the selective destruction of human malignant disease while circumventing the destruction of nonmalignant cells and tissues thereby minimizing toxicity to the patient.

Gene-Based Therapies for Cancer

Jack A. Roth
Gene Based Therapies for Cancer Book PDF

Author : Jack A. Roth
Publisher : Springer Science & Business Media
Page : 282 pages
File Size : 41,6 Mb
Release : 2010-07-28
Category : Medical
ISBN : 9781441961020

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Gene-Based Therapies for Cancer by Jack A. Roth Pdf

Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area.

Gene Therapy in Cancer

Grace W. Redberry
Gene Therapy in Cancer Book PDF

Author : Grace W. Redberry
Publisher : Nova Publishers
Page : 244 pages
File Size : 51,7 Mb
Release : 2005
Category : Cancer
ISBN : 1594542880

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Gene Therapy in Cancer by Grace W. Redberry Pdf

Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This new book offers the latest research in a field bursting with new developments, hope and expectations.

Gene Therapy and Cancer Research Focus

Rebecca N. Campbell
Gene Therapy and Cancer Research Focus Book PDF

Author : Rebecca N. Campbell
Publisher : Nova Publishers
Page : 354 pages
File Size : 47,8 Mb
Release : 2008
Category : Cancer
ISBN : 1600219705

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Gene Therapy and Cancer Research Focus by Rebecca N. Campbell Pdf

Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. The volume presents significant new research results in this promising field.

Handbook of Research on Advancements in Cancer Therapeutics

Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh
Handbook of Research on Advancements in Cancer Therapeutics Book PDF

Author : Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh
Publisher : IGI Global
Page : 913 pages
File Size : 54,9 Mb
Release : 2020-11-27
Category : Medical
ISBN : 9781799865315

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Handbook of Research on Advancements in Cancer Therapeutics by Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh Pdf

The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.

Gene and Cellular Immunotherapy for Cancer

Armin Ghobadi,John F. DiPersio
Gene and Cellular Immunotherapy for Cancer Book PDF

Author : Armin Ghobadi,John F. DiPersio
Publisher : Springer Nature
Page : 371 pages
File Size : 54,7 Mb
Release : 2022-01-01
Category : Medical
ISBN : 9783030878498

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Gene and Cellular Immunotherapy for Cancer by Armin Ghobadi,John F. DiPersio Pdf

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

Cancer Gene Therapy

Nagy Habib
Cancer Gene Therapy Book PDF

Author : Nagy Habib
Publisher : Springer Science & Business Media
Page : 496 pages
File Size : 48,6 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306468179

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Cancer Gene Therapy by Nagy Habib Pdf

With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very exciting times. Today we have at our disposal the technology to diagnose abnormalities in our cancer genes and the means to correct the deficit and very soon we will have the complete sequence of the human genome. With the use of gene chip technology the way doctors will be able to assess patients will change completely. Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes. In this book various authors have highlighted specific genes that could be expressed, overexpressed, neutralised or h- nessed to achieve cancer control. The problem of transferring the therapeutic gene into the cancer cell has been partly addressed with major developments in the field of naked plasmid DNA, adenovirus, retrovirus and adeno-associated viruses. However, further improvements are yet to be made to achieve significant gene transfer. Gene expression, in particular specificity of gene transfer, is obviously an important issue and one which is highlighted in this book by the use of specific promoter.

Gene Therapy of Cancer

Edmund C. Lattime,Stanton L. Gerson
Gene Therapy of Cancer Book PDF

Author : Edmund C. Lattime,Stanton L. Gerson
Publisher : Academic Press
Page : 554 pages
File Size : 44,5 Mb
Release : 2013-08-28
Category : Science
ISBN : 9780123946324

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Gene Therapy of Cancer by Edmund C. Lattime,Stanton L. Gerson Pdf

Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategies Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

Gene Therapy and Cancer Research Progress

Jessica L. Lewis
Gene Therapy and Cancer Research Progress Book PDF

Author : Jessica L. Lewis
Publisher : Nova Publishers
Page : 240 pages
File Size : 47,7 Mb
Release : 2008
Category : Cancer
ISBN : 1600218113

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Gene Therapy and Cancer Research Progress by Jessica L. Lewis Pdf

Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This new book presents the latest research in the field from around the world.

Gene Therapy of Cancer

Peter Walden,Uwe Trefzer,Wolfram Sterry,Farzin Farzaneh
Gene Therapy of Cancer Book PDF

Author : Peter Walden,Uwe Trefzer,Wolfram Sterry,Farzin Farzaneh
Publisher : Springer Science & Business Media
Page : 547 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461553571

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Gene Therapy of Cancer by Peter Walden,Uwe Trefzer,Wolfram Sterry,Farzin Farzaneh Pdf

The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.

New Gene Therapy and Cancer Research

Wilma B. Gustafsson
New Gene Therapy and Cancer Research Book PDF

Author : Wilma B. Gustafsson
Publisher : Nova Publishers
Page : 332 pages
File Size : 47,6 Mb
Release : 2008
Category : Cancer
ISBN : 1600219691

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New Gene Therapy and Cancer Research by Wilma B. Gustafsson Pdf

Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This book offers research from around the globe dedicated to this subject.

Cancer Gene Therapy by Viral and Non-viral Vectors

Malcolm Brenner,Mien-Chie Hung
Cancer Gene Therapy by Viral and Non viral Vectors Book PDF

Author : Malcolm Brenner,Mien-Chie Hung
Publisher : John Wiley & Sons
Page : 176 pages
File Size : 52,7 Mb
Release : 2014-02-25
Category : Medical
ISBN : 9781118501658

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Cancer Gene Therapy by Viral and Non-viral Vectors by Malcolm Brenner,Mien-Chie Hung Pdf

Provides expert, state-of-the-art insight into the currentprogress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era ofpersonalized or precision medicine. No longer a one-size-fits-allapproach, the treatment of cancer is now based on an understandingof underlying biologic mechanisms and is increasingly beingtailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinentmolecular discoveries in the cancer field and explains how theseare being used for gene-based cancer therapies. Designed as avolume in the Translational Oncology book series, Cancer GeneTherapy by Viral and Non-viral Vectors deals with the practiceof gene-therapy, with reference to vectors for gene expression andgene transfer, as well as viral therapy. It covers the history andcurrent and future applications of gene transfer in cancer, andprovides expert insight on the progress of viral and non-viral genetherapy with regard to delivery system, vector design, potentialtherapeutic genes, and principles and regulations for cancer genetherapy. Presented in three parts, Cancer Gene Therapy by Viral andNon-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viraland Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy ofCancer • Cancer Therapy with RNAi delivered by Non-viralMembrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific andCancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectorsand Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in GeneTherapy • Remaining Obstacles to the Success of Cancer GeneTherapy Focusing on speeding the process in clinical cancer care bybringing therapies as quickly as possible from bench to bedside,Cancer Gene Therapy by Viral and Non-viral Vectors is anabsolutely vital book for physicians, clinicians, researchers, andstudents involved in this area of medicine.