Gene And Cellular Immunotherapy For Cancer

Author : Armin Ghobadi,John F. DiPersio
Publisher : Springer Nature
Page : 371 pages
File Size : 50,6 Mb
Release : 2022-01-01
Category : Medical
ISBN : 9783030878498

Get Book

Gene and Cellular Immunotherapy for Cancer by Armin Ghobadi,John F. DiPersio Pdf

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

Author : Robert E Hawkins
Publisher : World Scientific
Page : 212 pages
File Size : 51,9 Mb
Release : 2014-05-05
Category : Medical
ISBN : 9789814618533

Get Book

Cellular Therapy Of Cancer: Development Of Gene Therapy Based Approaches by Robert E Hawkins Pdf

Cancer research has progressed enormously in recent years. This review volume will address recent findings in the area of T-cell therapy for cancer, including use of tumour infiltrating lymphocytes (TILs) as a therapy for melanoma, choice of target antigens, advances in engineered receptors, methods of gene transfer to T cells, review of cell processing methods and clinical trial design. Written by leadings scientists in the field, this up-to-date review on cancer research will be an important reference source to the researchers and healthcare professionals in the field.

Author : George Morstyn,William Sheridan
Publisher : Cambridge University Press
Page : 656 pages
File Size : 50,5 Mb
Release : 1996-03-29
Category : Medical
ISBN : 0521473152

Get Book

Cell Therapy by George Morstyn,William Sheridan Pdf

Cell therapy is a rapidly developing area, drawing on cell biology, molecular biology, virology, immunology, cell quantitation techniques and biomedical engineering. It has potential in many clinical settings, in the treatment of cancer and other diseases. This volume in the series Cancer: Clinical Science in Practice examines the current state and future prospects of cell therapy, which seems likely to have an even more profound impact on health care than did the production of proteins by recombinant DNA technology. The coverage is broad, including the scientific principles of haematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy, and the principles and practice of cellular immunotherapy. Up-to-date and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.

Author : Stanton L. Gerson,Edmund C. Lattime
Publisher : Elsevier
Page : 534 pages
File Size : 40,5 Mb
Release : 2002-04-04
Category : Science
ISBN : 0080491367

Get Book

Gene Therapy of Cancer by Stanton L. Gerson,Edmund C. Lattime Pdf

The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Key Features * Provides in-depth description of targeted systems and treatment strategies * Explains the underlying cancer biology necessary for understanding a given therapeutic approach * Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses * Presents translational focus with emphasis on requirements for clinical implementation * Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Author : Daniel W. Lee,Nirali N. Shah
Publisher : Elsevier Health Sciences
Page : 246 pages
File Size : 55,5 Mb
Release : 2019-11-30
Category : Medical
ISBN : 9780323755979

Get Book

Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book by Daniel W. Lee,Nirali N. Shah Pdf

From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

Author : Asha B. Pillai,Rizwan Romee
Publisher : Frontiers Media SA
Page : 132 pages
File Size : 47,8 Mb
Release : 2023-09-13
Category : Science
ISBN : 9782832534908

Get Book

Innate Immune Cell Therapy of Cancer by Asha B. Pillai,Rizwan Romee Pdf

Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.

Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 47,6 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9781597452229

Get Book

Gene Therapy for Cancer by Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher Pdf

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Author : H. C. Stevenson
Publisher : CRC Press
Page : 272 pages
File Size : 52,5 Mb
Release : 1989-07-17
Category : Medical
ISBN : 0824781112

Get Book

Adoptive Cellular Immunotherapy of Cancer by H. C. Stevenson Pdf

This volume presents the most complicated and powerful cancer biotherapies developed. It provides an overview of human immune system function and the mechanisms by which adoptive cellular immunotherapies (ACI) harnesses the activity. The volume provides a vision on the developments in ACI.

Author : Paolo A. Ascierto,David F. Stroncek,Ena Wang
Publisher : Humana Press
Page : 305 pages
File Size : 50,8 Mb
Release : 2015-11-26
Category : Medical
ISBN : 9783319211671

Get Book

Developments in T Cell Based Cancer Immunotherapies by Paolo A. Ascierto,David F. Stroncek,Ena Wang Pdf

This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.

Author : Katy Rezvani,Rohtesh S. Mehta
Publisher : Frontiers Media SA
Page : 182 pages
File Size : 54,6 Mb
Release : 2020-01-16
Category : Electronic
ISBN : 9782889633784

Get Book

Cellular Therapies in Cancer by Katy Rezvani,Rohtesh S. Mehta Pdf

Author : Robert L. Truitt
Publisher : John Wiley & Sons
Page : 494 pages
File Size : 51,8 Mb
Release : 1987-09-01
Category : Electronic
ISBN : 0471635413

Get Book

Cellular Immunotherapy of Cancer by Robert L. Truitt Pdf

Author : Jack A. Roth
Publisher : Springer Science & Business Media
Page : 282 pages
File Size : 44,6 Mb
Release : 2010-07-28
Category : Medical
ISBN : 9781441961020

Get Book

Gene-Based Therapies for Cancer by Jack A. Roth Pdf

Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area.

Author : Jeffrey Medin,Daniel Fowler
Publisher : Springer Science & Business Media
Page : 442 pages
File Size : 55,6 Mb
Release : 2010-12-03
Category : Medical
ISBN : 9781607619802

Get Book

Experimental and Applied Immunotherapy by Jeffrey Medin,Daniel Fowler Pdf

Immunotherapy is now recognized as an essential component of treatment for a wide variety of cancers. It is an interdisciplinary field that is critically dependent upon an improved understanding of a vast network of cross-regulatory cellular populations and a diversity of molecular effectors; it is a leading example of translational medicine with a favorable concept-to-clinical-trial timeframe of just a few years. There are many established immunotherapies already in existence, but there are exciting new cancer immunotherapies just on the horizon, which are likely to be more potent, less toxic and more cost effective than many therapies currently in use. Experimental and Applied Immunotherapy is a state-of-the-art text offering a roadmap leading to the creation of these future cancer-fighting immunotherapies. It includes essays by leading researchers that cover a wide variety of topics including T cell and non-T cell therapy, monoclonal antibody therapy, dendritic cell-based cancer vaccines, mesenchymal stromal cells, negative regulators in cancer immunology and immunotherapy, non-cellular aspects of cancer immunotherapy, the combining of cancer vaccines with conventional therapies, the combining of oncolytic viruses with cancer immunotherapy, transplantation, and more. The field of immunotherapy holds great promise that will soon come to fruition if creative investigators can bridge seemingly disparate disciplines, such as T cell therapy, gene therapy, and transplantation therapy. This text is a vital tool in the building of that bridge.

Author : Biaoru Li, Alan Larson,Shen Li
Publisher : Bentham Science Publishers
Page : 283 pages
File Size : 48,9 Mb
Release : 2020-11-03
Category : Medical
ISBN : 9789811482731

Get Book

Personalized Immunotherapy for Tumor Diseases and Beyond by Biaoru Li, Alan Larson,Shen Li Pdf

This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology. Key Features: - Introduces readers to basic concepts in personalized medicine and immunotherapy - Presents current information about immunological assays used in research - Presents an overview of T cell immunotherapy and cloning techniques - Presents an overview of tumor cell bioinformatics and its role in immunotherapy - Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling) - Includes a section on biobanking - Presents information in an easy-to-read format for a wide range of readers - Brings contributions from experts with over 30 years of experience in personalized immunotherapy Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided.

Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Page : 550 pages
File Size : 48,8 Mb
Release : 2021-08-18
Category : Business & Economics
ISBN : 9780128236376

Get Book

Cancer Immunology and Immunotherapy by Mansoor M. Amiji,Lara Scheherazade Milane Pdf

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO