Gene Vaccination Theory And Practice

Author : Eyal Raz
Publisher : Springer Science & Business Media
Page : 182 pages
File Size : 54,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642468674

Get Book

Gene Vaccination: Theory and Practice by Eyal Raz Pdf

Vaccination has been established as an efficient procedure to prevent infections. Over the past few years, a new method of subunit vaccination has attracted the attention of immunologists. Despite its popularity, it is only recently that the basic mechanisms that drive the immune response to the encoded antigen have begun to unfold. The multidisciplinary approach of this book outlines the basic characteristics of gene (DNA) vaccination, the role of APCs or bone marrow derived cells in the induction of the immune response. It points out the potential applications for various infectious and allergic diseases and describes the multifaceted properties of DNA in initiating and determining the subsequent immune responses to the encoded antigen.

Author : Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee
Publisher : National Academies Press
Page : 152 pages
File Size : 46,5 Mb
Release : 2002-07-02
Category : Medical
ISBN : 9780309169882

Get Book

Immunization Safety Review by Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee Pdf

By two years of age, healthy infants in the United States can receive up to 20 vaccinations to protect against 11 diseases. Although most people know that vaccines effectively protect against serious infectious diseases, approximately one-quarter of parents in a recent survey believe that infants get more vaccines than are good for them, and that too many immunizations could overwhelm an infant's immune system. The Immunization Safety Review Committee reviewed the evidence regarding the hypothesis that multiple immunizations increase the risk for immune dysfunction. Specifically, the committee looked at evidence of potential biological mechanisms and at epidemiological evidence for or against causality related to risk for infections, the autoimmune disease type 1 diabetes, and allergic disorders.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Board on Health Sciences Policy,Committee on Equitable Allocation of Vaccine for the Novel Coronavirus
Publisher : National Academies Press
Page : 273 pages
File Size : 49,5 Mb
Release : 2020-11-30
Category : Medical
ISBN : 9780309682244

Get Book

Framework for Equitable Allocation of COVID-19 Vaccine by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Board on Health Sciences Policy,Committee on Equitable Allocation of Vaccine for the Novel Coronavirus Pdf

In response to the coronavirus disease 2019 (COVID-19) pandemic and the societal disruption it has brought, national governments and the international community have invested billions of dollars and immense amounts of human resources to develop a safe and effective vaccine in an unprecedented time frame. Vaccination against this novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), offers the possibility of significantly reducing severe morbidity and mortality and transmission when deployed alongside other public health strategies and improved therapies. Health equity is intertwined with the impact of COVID-19 and there are certain populations that are at increased risk of severe illness or death from COVID-19. In the United States and worldwide, the pandemic is having a disproportionate impact on people who are already disadvantaged by virtue of their race and ethnicity, age, health status, residence, occupation, socioeconomic condition, or other contributing factors. Framework for Equitable Allocation of COVID-19 Vaccine offers an overarching framework for vaccine allocation to assist policy makers in the domestic and global health communities. Built on widely accepted foundational principles and recognizing the distinctive characteristics of COVID-19, this report's recommendations address the commitments needed to implement equitable allocation policies for COVID-19 vaccine.

Author : PhD Miriam Jumba
Publisher : Strategic Book Publishing
Page : 211 pages
File Size : 40,5 Mb
Release : 2010
Category : Science
ISBN : 9781609110819

Get Book

Genetically Modified Organisms the Mystery Unraveled by PhD Miriam Jumba Pdf

Products of gene modification have vast implications. Creating public awareness and disseminating information on the subject seeks to demystify some of the widely held falsehoods regarding genetically modified products. This an informative, thorough and easy-to-understand guide book that aims to enlighten and debunk some of the commonly held misconceptions on products of gene modification and to give the reader a better understanding of the role genetic modification will play. The review sheds light on the safety, and application of these products in medicine, the food industry and other areas, especially those where genetic modification may represent a cheap, faster, credible and viable alternative in achieving sustainable development amongst resource-poor communities.

Author : Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee
Publisher : National Academies Press
Page : 118 pages
File Size : 47,8 Mb
Release : 2003-12-26
Category : Medical
ISBN : 9780309086103

Get Book

Immunization Safety Review by Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee Pdf

The Immunization Safety Review Committee was established by the Institute of Medicine (IOM) to evaluate the evidence on possible causal associations between immunizations and certain adverse outcomes, and to then present conclusions and recommendations. The committee's mandate also includes assessing the broader societal significance of these immunization safety issues. While all the committee members share the view that immunization is generally beneficial, none of them has a vested interest in the specific immunization safety issues that come before the group. The committee reviews three immunization safety review topics each year, addressing each one at a time. In this fifth report in a series, the committee examines the hypothesis that exposure to polio vaccine contaminated with simian virus 40 (SV40), a virus that causes inapparent infection in some monkeys, can cause certain types of cancer.

Author : Andrés Fraguela-Collar
Publisher : Bentham Science Publishers
Page : 583 pages
File Size : 54,5 Mb
Release : 2022-09-05
Category : Medical
ISBN : 9789815051919

Get Book

Moving From COVID-19 Mathematical Models to Vaccine Design: Theory, Practice and Experiences by Andrés Fraguela-Collar Pdf

This compendium represents a set of guides to understanding the challenging scientific, epidemiological, clinical, social, and economic phenomenon that is represented by the COVID-19 pandemic. The book explains the mathematical modeling of COVID-19 infection, with emphasis on traditional epidemiological principles. It represents a rigorous, comprehensive and multidisciplinary approach to a complex phenomenon. The chapters take into account the knowledge arising from different disciplines (epidemiology, pathophysiology, immunology, medicine, biology, vaccine development, etc.). It also covers COVID-19 data analysis, giving the reader a perspective of statistics and data science, and includes a discussion about social and economic issues of the pandemic. Each chapter is devoted to a specific topic, and is contributed by experts in epidemiology. Because of its multidisciplinary nature, this book is intended as a reference on mathematical models and basic immunotherapy for COVID-19 for a broad community of readers, from scholars who have scientific training, to general readers who have an interest in the disease.

Author : Anonim
Publisher : Unknown
Page : 188 pages
File Size : 47,8 Mb
Release : 2001
Category : Electronic journals
ISBN : UCLA:L0083739359

Get Book

Social Theory and Practice by Anonim Pdf

Author : Christopher A. Shaw
Publisher : Simon and Schuster
Page : 584 pages
File Size : 54,6 Mb
Release : 2021-08-31
Category : Health & Fitness
ISBN : 9781510758513

Get Book

Dispatches from the Vaccine Wars by Christopher A. Shaw Pdf

Enter the trenches of the bloodiest battles you've never heard of: the Vaccine Wars. Professor Christopher A Shaw discovered, after a deep-dive literature search on aluminum impacts on humans and animals, that aluminum hydroxide, an adjuvant in the anthrax vaccine, had a significantly negative impact on motor functions and reflexes of patients in the literature. After that finding, he did what scientists are supposed to do and kept following the leads. However, organizations like WHO dismissed him immediately. Those powerful organizations either knew what he knew, that aluminum vaccine adjuvants were harmful, or they simply didn’t care. In either case, two possible reasons for the lack of response became clear to Shaw and his colleagues: dogma and money. The first had served to convince most of the world’s medical professionals that Shaw had to be wrong because, after all, “the science was settled.” And, behind much of this was the naked fact of how much money vaccines brought in to cover the pharmaceutical industry’s profit margin. The combination of those two have the finger prints of various Big Pharma companies smudged all over the question of vaccine safety, which included the demonization of both scientists and lay scholars who raised even the tamest questions about safety and the push for vaccine mandates around the world. After these events, Shaw decided to dig deeper. Dispatches from the Vaccine Wars is a comprehensive look at the origin of vaccination and the oversight of vaccines by various regulatory bodies in the United States and in Canada. The book provides not only the official view on vaccines safety and efficacy, but also provides a critical analysis on which such views are based. Aluminum and other compounds that may contribute to autism spectrum disorder are discussed at length. Professor Shaw also analyzes the corporate influences driving vaccine uptake worldwide and provides an in depth look at the push for mandatory vaccination. Dispatches from the Vaccine Wars evaluates the extent to which vaccinology has become a cult religion driving attempts to suppress divergent scientific opinions. Finally, the book delves into the COVID-19 pandemic and what it means for the future of us all.

Author : Alberto Giubilini
Publisher : Springer
Page : 126 pages
File Size : 40,6 Mb
Release : 2018-12-28
Category : Philosophy
ISBN : 9783030020682

Get Book

The Ethics of Vaccination by Alberto Giubilini Pdf

This open access book discusses individual, collective, and institutional responsibilities with regard to vaccination from the perspective of philosophy and public health ethics. It addresses the issue of what it means for a collective to be morally responsible for the realisation of herd immunity and what the implications of collective responsibility are for individual and institutional responsibilities. The first chapter introduces some key concepts in the vaccination debate, such as ‘herd immunity’, ‘public goods’, and ‘vaccine refusal’; and explains why failure to vaccinate raises certain ethical issues. The second chapter analyses, from a philosophical perspective, the relationship between individual, collective, and institutional responsibilities with regard to the realisation of herd immunity. The third chapter is about the principle of least restrictive alternative in public health ethics and its implications for vaccination policies. Finally, the fourth chapter presents an ethical argument for unqualified compulsory vaccination, i.e. for compulsory vaccination that does not allow for any conscientious objection. The book will appeal to philosophers interested in public health ethics and the general public interested in the philosophical underpinning of different arguments about our moral obligations with regard to vaccination.

Author : Ciro A. de Quadros,Pan American Health Organization
Publisher : Pan American Health Org
Page : 410 pages
File Size : 45,9 Mb
Release : 2004
Category : Medical
ISBN : 9789275115961

Get Book

Vaccines by Ciro A. de Quadros,Pan American Health Organization Pdf

This publication contains a number of papers which consider the public health role of vaccines in improving the health of the world's populations, and looks at the challenges of using immunisation to combat emerging and re-emerging diseases. Issues discussed include the innovative use of vaccines against diseases such as meningococcal infection in Africa, Haemophilus influenza type b, varicella, and hepatitis, efforts to develop a new generation of vaccines against cholera and typhoid, shigella and Helicobacter pylori, as well as developments in the quest for vaccines against tuberculosis, HIV/AIDS, dengue, malaria, and hookworm. It also deals with the use of vaccines to fight bioterrorism attacks; regulatory and safety issues; financing issues, impact of health sector reform and the sustainability of immunisation programmes.

Author : Evanson Chege Kamau,Gerd Winter
Publisher : Routledge
Page : 433 pages
File Size : 53,6 Mb
Release : 2013-07-18
Category : Business & Economics
ISBN : 9781135069698

Get Book

Common Pools of Genetic Resources by Evanson Chege Kamau,Gerd Winter Pdf

The Convention on Biological Diversity (CBD) strives for the sustainable and equitable utilization of genetic resources, with the ultimate goal of conserving biodiversity. The CBD and the Nagoya Protocol which has since been elaborated suggest a bilateral model for access to genetic resources and the sharing of benefits from their utilization. There is concern that the bilateral exchange "genetic resource for benefit sharing" could have disappointing results because providers are left out of the process of research and development, benefits are difficult to be traced to sources, and providers owning the same resource may complain of being excluded from benefit sharing. Thus, the CBD objective of full utilization and equitability may become flawed. Common Pools of Genetic Resources: Equity and Innovation in International Biodiversity Law suggests common pools as a complementary approach to bilateralism. This is one of the first books to reply to a number of complex legal questions related to the interpretation and implementation of the Nagoya Protocol. Taking an inductive approach, it describes existing pools and analyzes how they are organized and how they perform in terms of joint R&D and benefit sharing. It presents case studies of the most characteristic types of common pools, provides suggestions for further developing existing pools to cope with the requirements of the CBD and NP and, at the same time uses the clauses these conventions contain to open up for commons approaches. Written by a team of expert academics and practitioners in the field, this innovative book makes a timely and valuable contribution to academic and policy debates in international environmental law, international biodiversity law, intellectual property law, climate law and the law of indigenous populations.

Author : Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee to Study Priorities for Vaccine Development
Publisher : National Academies Press
Page : 472 pages
File Size : 54,6 Mb
Release : 2001-02-21
Category : Medical
ISBN : 9780309174985

Get Book

Vaccines for the 21st Century by Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee to Study Priorities for Vaccine Development Pdf

Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.

Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Assessment of Studies of Health Outcomes Related to the Recommended Childhood Immunization Schedule
Publisher : National Academies Press
Page : 237 pages
File Size : 41,7 Mb
Release : 2013-04-27
Category : Medical
ISBN : 9780309267021

Get Book

The Childhood Immunization Schedule and Safety by Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Assessment of Studies of Health Outcomes Related to the Recommended Childhood Immunization Schedule Pdf

Vaccines are among the most safe and effective public health interventions to prevent serious disease and death. Because of the success of vaccines, most Americans today have no firsthand experience with such devastating illnesses as polio or diphtheria. Health care providers who vaccinate young children follow a schedule prepared by the U.S. Advisory Committee on Immunization Practices. Under the current schedule, children younger than six may receive as many as 24 immunizations by their second birthday. New vaccines undergo rigorous testing prior to receiving FDA approval; however, like all medicines and medical interventions, vaccines carry some risk. Driven largely by concerns about potential side effects, there has been a shift in some parents' attitudes toward the child immunization schedule. The Childhood Immunization Schedule and Safety identifies research approaches, methodologies, and study designs that could address questions about the safety of the current schedule. This report is the most comprehensive examination of the immunization schedule to date. The IOM authoring committee uncovered no evidence of major safety concerns associated with adherence to the childhood immunization schedule. Should signals arise that there may be need for investigation, however, the report offers a framework for conducting safety research using existing or new data collection systems.

Author : Institute of Medicine,Board on Health Promotion and Disease Prevention
Publisher : National Academies Press
Page : 43 pages
File Size : 45,7 Mb
Release : 1997-08-10
Category : Medical
ISBN : 9780309057905

Get Book

Risk Communication and Vaccination by Institute of Medicine,Board on Health Promotion and Disease Prevention Pdf

Author : Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee
Publisher : National Academies Press
Page : 118 pages
File Size : 52,7 Mb
Release : 2003-11-26
Category : Medical
ISBN : 9780309168915

Get Book

Immunization Safety Review by Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee Pdf

The Immunization Safety Review Committee was established by the Institute of Medicine (IOM) to evaluate the evidence on possible causal associations between immunizations and certain adverse outcomes, and to then present conclusions and recommendations. The committee's mandate also includes assessing the broader societal significance of these immunization safety issues. While all the committee members share the view that immunization is generally beneficial, none of them has a vested interest in the specific immunization safety issues that come before the group. The committee reviews three immunization safety review topics each year, addressing each one at a time. In this fifth report in a series, the committee examines the hypothesis that exposure to polio vaccine contaminated with simian virus 40 (SV40), a virus that causes inapparent infection in some monkeys, can cause certain types of cancer.