Genetic Epidemiology Of Cancer

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Genetic Epidemiology of Cancer

Henry T. Lynch,Takeshi Hirayama
Genetic Epidemiology of Cancer Book PDF

Author : Henry T. Lynch,Takeshi Hirayama
Publisher : CRC Press
Page : 376 pages
File Size : 55,8 Mb
Release : 1989-06-30
Category : Medical
ISBN : 0849367565

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Genetic Epidemiology of Cancer by Henry T. Lynch,Takeshi Hirayama Pdf

This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapters are devoted to tumor biomarkers and their applicability to cancer of multiple anatomic sites. Clinical correlation will involve surveillance/management programsand focus on high-risk groups-such as those involving primary genetic or environmental factors and/or their interaction. The development of registries involving families with differing hereditary cancer syndromes are considered. Also, many chapters are devoted to environmental protective measures, as well as the need for more responsibility for coverage of patients at inordinately high risk for cancer by third party carriers. Other chapters address segregation and linkage analysis, oncogenes, cytogenetics, and other biomarkers. This book will be of interest to general clinicians, oncologists, surgeons, geneticists, and carcinogenesis investigators.

Recent Progress in the Genetic Epidemiology of Cancer

Henry T. Lynch,Petre Tautu
Recent Progress in the Genetic Epidemiology of Cancer Book PDF

Author : Henry T. Lynch,Petre Tautu
Publisher : Springer Science & Business Media
Page : 162 pages
File Size : 51,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642759932

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Recent Progress in the Genetic Epidemiology of Cancer by Henry T. Lynch,Petre Tautu Pdf

The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C. King et al. in 1984. 1t pinpoints the fundamental genetic hypothesis, namely, the existence of an inherited condition that predisposes an individual to a specific disease, and the corresponding subject ofinvestigation, the family. Thus, the genetic epidemiological situation consists of three basic elements: (l) the genealogical structure, (2) the mode of inherit ance (i. e. , the "genetic model") for the trait of interest, and (3) the observable phenotypes of susceptibility. It is clear that genetic epidemiology is a research field posi tioned at the intersection of molecular genetics, population gen etics, and clinical genetics. Perhaps the genealogical tree should be its central element: it evidences something forgotten in mole cular genetics, namely the relationships, and associations with probabilistic and statistical concepts from population genetics. It offers a structure and a "history" for those clinicians studying familial diseases who are searching for genetic determinants of susceptibility. The genetic epidemiologist begins his analysis with a point on this genealogical tree, namely the proband, and attempts to carry out (nonrandom) "ascertainment sampling" by using a strategy that depends on the form and dimension (extended pedigrees versus nuclear families) of the tree.

Division of Cancer Epidemiology and Genetics Annual Research Directory

National Cancer Institute (U.S.). Division of Cancer Epidemiology and Genetics
Division of Cancer Epidemiology and Genetics Annual Research Directory Book PDF

Author : National Cancer Institute (U.S.). Division of Cancer Epidemiology and Genetics
Publisher : Unknown
Page : 204 pages
File Size : 45,6 Mb
Release : 1997
Category : Cancer
ISBN : UCR:31210012726194

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Division of Cancer Epidemiology and Genetics Annual Research Directory by National Cancer Institute (U.S.). Division of Cancer Epidemiology and Genetics Pdf

DCEG Linkage

National Cancer Institute (U.S.). Division of Cancer Epidemiology and Genetics
DCEG Linkage Book PDF

Author : National Cancer Institute (U.S.). Division of Cancer Epidemiology and Genetics
Publisher : Unknown
Page : 20 pages
File Size : 49,9 Mb
Release : 1998
Category : Cancer
ISBN : STANFORD:36105223071171

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DCEG Linkage by National Cancer Institute (U.S.). Division of Cancer Epidemiology and Genetics Pdf

Statistical Methods in Genetic Epidemiology

Duncan C. Thomas
Statistical Methods in Genetic Epidemiology Book PDF

Author : Duncan C. Thomas
Publisher : Oxford University Press
Page : 458 pages
File Size : 49,8 Mb
Release : 2004-01-29
Category : Medical
ISBN : 9780199748051

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Statistical Methods in Genetic Epidemiology by Duncan C. Thomas Pdf

This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.

The Genetics of Cancer

B.A. Ponder,M.J. Waring
The Genetics of Cancer Book PDF

Author : B.A. Ponder,M.J. Waring
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401106771

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The Genetics of Cancer by B.A. Ponder,M.J. Waring Pdf

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

An Introduction to Genetic Epidemiology

Palmer, Lyle J.,Burton, Paul R.,George Davey Smith
An Introduction to Genetic Epidemiology Book PDF

Author : Palmer, Lyle J.,Burton, Paul R.,George Davey Smith
Publisher : Policy Press
Page : 240 pages
File Size : 48,8 Mb
Release : 2011-05-31
Category : Medical
ISBN : 9781861348975

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An Introduction to Genetic Epidemiology by Palmer, Lyle J.,Burton, Paul R.,George Davey Smith Pdf

This book brings together leading experts to provide an introduction to genetic epidemiology that begins with a primer in human molecular genetics through all the standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field.

Cancer Epidemiology

Mukesh Verma
Cancer Epidemiology Book PDF

Author : Mukesh Verma
Publisher : Humana
Page : 0 pages
File Size : 41,8 Mb
Release : 2010-11-19
Category : Medical
ISBN : 1617378682

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Cancer Epidemiology by Mukesh Verma Pdf

Population studies and epidemiology facilitate the discovery of genetic and environmental determinants of cancer and the development of new approaches to cancer control and prevention, therefore they play a central role in the creation of health policies. Cancer Epidemiology compiles areas of research which cover etiological factors or determinants that contribute to the development of cancer and describe the latest technologies in cancer epidemiology. In Volume 1, Host Susceptibility Factors, leading experts provide chapters on cancer incidence, prevalence, mortality and surveillance, methods, technologies and study design in cancer epidemiology as well as host susceptibility factors in cancer epidemiology. Although a non-standard volume of the highly successful Methods in Molecular BiologyTM series, this comprehensive text retains the commitment of the series to collecting the kind of detailed, up-to-date information and implementation advice that is crucial for getting optimal results. Cutting-edge and essential, Cancer Epidemiology allows readers to get the maximum advantage of the methods involved in this exciting and important field.

Male Reproductive Cancers

William D. Foulkes,Kathleen A. Cooney
Male Reproductive Cancers Book PDF

Author : William D. Foulkes,Kathleen A. Cooney
Publisher : Springer Science & Business Media
Page : 346 pages
File Size : 53,6 Mb
Release : 2009-12-17
Category : Medical
ISBN : 9781441904492

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Male Reproductive Cancers by William D. Foulkes,Kathleen A. Cooney Pdf

Knowledge about cancer genetics is rapidly expanding, and has implications for all aspects of cancer research and treatment, including molecular causation, diagnosis, prevention, screening, and treatment. Additionally, while cancer genetics has traditionally focused on mutational events that have their primary effect within the cancer cell, recently the focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range of individual susceptibility within the population is increasingly recognized, and is now being widely addressed using information from the Human Genome Project. These new research directions will highlight determinants of cancer that lie outside the cancer cell, suggest new targets for intervention, and inform the design of strategies for prevention in groups at increased risk. Today, the NCI is putting more and more money into research into the genetics of cancer. The very first of the NCI’s stated research priorities is a project called The Cancer Genome Atlas. The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing. The NCI and the NHGRI (National Human Genome Research Institute, where the series editor is employed) have each committed $50 million over three years to the TCGA Pilot Project. This book proposes cover the latest findings in the genetics of male reproductive cancers; specifically cancers of the prostate and testes. The volume will cover the epidemiology of these cancers; model systems, pathology, molecular genetics, and inherited susceptibility.

Pediatric Cancer Genetics

Nathaniel H. Robin,Meagan Farmer
Pediatric Cancer Genetics Book PDF

Author : Nathaniel H. Robin,Meagan Farmer
Publisher : Elsevier Health Sciences
Page : 350 pages
File Size : 47,5 Mb
Release : 2017-08-22
Category : Medical
ISBN : 9780323495967

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Pediatric Cancer Genetics by Nathaniel H. Robin,Meagan Farmer Pdf

Get a quick, expert overview of the many key facets of pediatric cancer genetics with this concise, practical resource by Dr. Nathaniel H. Robin and Meagan Farmer, MS, CGC, MBA. Ideal for pediatric oncologists and all providers who care for children, this easy-to-read reference addresses the remarkable potential of genetic testing as well as the complexities of choosing the correct test, understanding the results, and counseling the family. Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counselors. Highlights examples of syndromes that present in childhood and increase susceptibility to cancer. Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer. Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples. Consolidates today’s available information and guidance in this timely area into one convenient resource.

Familial Cancer and Prevention

Joji Utsunomiya,John J. Mulvihill,Walter Weber
Familial Cancer and Prevention Book PDF

Author : Joji Utsunomiya,John J. Mulvihill,Walter Weber
Publisher : John Wiley & Sons
Page : 592 pages
File Size : 50,5 Mb
Release : 1999-04-27
Category : Medical
ISBN : 0471249378

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Familial Cancer and Prevention by Joji Utsunomiya,John J. Mulvihill,Walter Weber Pdf

A New Strategy Toward Cancer Control. Still in its infancy, the familial/hereditary approach to cancer control is proving to be one of the most potent strategies in the war on cancer. Over the past few years the human genome project has generated an abundance of valuable information on the genetic origins of a range of cancers. Tests now exist for several hereditary, tumor-promoting genetic mutations-including those found in BRCA genes associated with breast cancer as well as mutations of HNPCC genes which have been linked to colon cancers-and many more are anticipated in the near future. Armed with the information yielded by these tests, physicians have already saved countless lives through preventative counseling, early detection, and more highly-focused intervention strategies. Inspired by the proceedings of the UICC 1997 Symposium on Familial Cancer and Prevention held in Kobe, Japan, this volume provides clinicians and researchers with a detailed review of the latest developments at the front lines of the familial cancer prevention movement. In a series of edited contributions, leading researchers and clinicians from around the globe summarize their experiences and analyze current and emerging trends in: * Information gathering and history taking. * Risk assessment. * Genetic testing for colorectal, endocrine, breast, and other familial cancers. * Diagnosis, prognosis, and management of an array of familial cancers. * Genetic counseling for familial cancers. Up-to-date, authoritative, and comprehensive, Familial Cancer and Prevention is an important working resource for clinicians, cancer researchers, and epidemiologists.