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Author : Isadore Michael Lerner
Publisher : Unknown
Page : 134 pages
File Size : 43,7 Mb
Release : 1954
Category : Genetics
ISBN : LCCN:50006930
Author : I. Michael Lerner
Publisher : Unknown
Page : 128 pages
File Size : 47,5 Mb
Release : 1984-06-01
Category : Electronic
ISBN : 084460772X
Author : I. Michael Lerner
Publisher : Forgotten Books
Page : 152 pages
File Size : 45,9 Mb
Release : 2018-10-04
Category : Science
ISBN : 1391652630
Excerpt from Genetic Homeostasis Other types Of evidence, which contribute to the problem but which will be considered here in less detail include. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
Author : Barton Childs
Publisher : JHU Press
Page : 352 pages
File Size : 42,8 Mb
Release : 2003-09-15
Category : Medical
ISBN : 0801874424
Childs thus provides a conceptual framework within which to teach and practice a humane medicine.
Author : Angel L. Pey
Publisher : Academic Press
Page : 450 pages
File Size : 48,7 Mb
Release : 2020-02-13
Category : Science
ISBN : 9780128191330
Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance
Author : Kelly Anne Hyndman,Thomas L. Pannabecker
Publisher : Springer
Page : 325 pages
File Size : 52,5 Mb
Release : 2015-11-02
Category : Science
ISBN : 9781493932139
This book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecular, cellular and whole animal studies that involve multiple physiological systems and shows how the internal milieu is regulated by multifactorial gene regulation, molecular signaling, and cell and organ architecture. Topics covered include: water channels, the urinary concentrating mechanism, angiotensin, the endothelin system, miRNAs and MicroRNA in osmoregulation, desert-adapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The book highlights how different approaches to explaining the same physiological processes greatly increase our understanding of these fundamental processes. Greater integration of comparative, evolutionary and genetic animal models in basic science and medical science will improve our overall grasp of the mechanisms of sodium and water balance.
Author : Jen-Tsan Ashley Chi
Publisher : Springer
Page : 158 pages
File Size : 51,6 Mb
Release : 2014-10-20
Category : Medical
ISBN : 9781493916832
Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological functional at every level, including protein folding, enzymatic activities and proliferation and cell death. Therefore, maintain the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in the scientific literature and medical textbooks. However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases, including cancer, stroke, myocardial infarction and diabetes, renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanism and cellular responses to pH alterations in both physiological (taste, pain) and pathological settings (ischemia and cancers). Furthermore, these authors present a broad spectrum of investigative approaches to cellular response to acidosis in a in wide variety of human diseases.
Author : Joel B. Hagen
Publisher : University Alabama Press
Page : 356 pages
File Size : 52,7 Mb
Release : 2021-04-13
Category : Science
ISBN : 9780817320898
Traces historical developments in scientific conceptions of physiology, ecology, behavior, and evolutionary biology during the mid-twentieth century Life Out of Balance focuses on a period in history when new ideas of self-regulation, adaptation, and fitness became central to a variety of biological disciplines. During the decades surrounding World War II, these ideas developed in several quite different contexts and led to greater debates about the merits of such models as applied to larger systems, including society at large. Particularly in its later cybernetic form, homeostasis seemed to provide new ways of discussing balance and regulation that avoided discredited approaches of earlier champions of vitalism and mechanism. It provided a common perspective and terminology for discussing self-regulating “systems,” whether biological, mechanical, or social. Although enormously fruitful and influential, homeostatic perspectives also generated numerous controversies when critics questioned the degree to which biological systems are characterized by balance and self-regulation. Resolving these controversies continues to be a challenge in modern biology. If natural selection constitutes the first law of biology, scientists who champion homeostasis as a theoretical model claim that it is a second law, equally important and closely related to the first. Such claims notwithstanding, homeostasis has generated a series of controversies since it was formalized by Walter Cannon in the late 1920s. Critics contended that Cannon took a too-optimistic view of life, not only ignoring pathological deviations from normality but also failing to adequately explain the ability of living things to respond adaptively to environmental challenges. Underlying these controversies was the unresolved problem of integrating physiology and other areas of functional biology with the emerging evolutionary synthesis of Mendelian genetics and Darwinian natural selection. The physiological idea of homeostasis as the adaptive “fit” between the organism and its environment and the Darwinian idea of adaptation and fitness in terms of reproductive success might seem to be complementary in an unproblematic way, but historically they have had an uneasy relationship.
Author : Samantha Fowler,Rebecca Roush,James Wise
Publisher : Unknown
Page : 618 pages
File Size : 55,6 Mb
Release : 2018-01-07
Category : Science
ISBN : 9888407457
Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.
Author : Anonim
Publisher : Academic Press
Page : 182 pages
File Size : 42,9 Mb
Release : 2021-07-07
Category : Science
ISBN : 9780323854269
Advances in Insect Physiology Volume 60 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including The Steroid, Ecdysis Triggering Hormone, Juvenile Hormone Signaling Triad in Development and Reproduction, A Decade of Teasing Apart the Juvenile Hormone Receptor, Evolutionary Physiology of Peptidergic Signaling, Recent Advances in Neuroendocrine Regulation of Insect Excretory Systems, Recent Advances in Ecdysteroid Research in Insects, and Regulation and Mechanisms of Sleep in Drosophila. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Insect Physiology series
Author : C.H. Waddington
Publisher : Routledge
Page : 231 pages
File Size : 48,5 Mb
Release : 2014-04-29
Category : History
ISBN : 9781317657545
First published in 1957, this essential classic work bridged the gap between analytical and theoretical biology, thus setting the insights of the former in a context which more sensitively reflects the ambiguities surrounding many of its core concepts and objectives. Specifically, these five essays are concerned with some of the major problems of classical biology: the precise character of biological organisation, the processes which generate it, and the specifics of evolution. With regard to these issues, some thinkers suggest that biological organisms are not merely distinguishable from inanimate ‘things’ in terms of complexity, but are in fact radically different qualitatively: they exemplify some constitutive principle which is not elsewhere manifested. It is the desire to bring such ideas into conformity with our understanding of analytical biology which unifies these essays. They explore the contours of a conceptual framework sufficiently wide to embrace all aspects of living systems.
Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Publisher : Academic Press
Page : 878 pages
File Size : 54,8 Mb
Release : 2017-10-31
Category : Medical
ISBN : 9780128041987
Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 42,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Joy Alcedo,Thomas Flatt,Elena G. Pasyukova
Publisher : Frontiers
Page : 136 pages
File Size : 44,7 Mb
Release : 2013-08-23
Category : Electronic
ISBN : 9782889191604
An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environments. This is achieved through intercellular communication not only within a single tissue but also among different tissues and organ systems. Thus, alterations in tissue-to-tissue or organ-to-organ communications, which are under genetic regulation, can affect organismal homeostasis, and consequently impact the aging process. One of the organ systems that play a major role in maintaining homeostasis is the nervous system. Considering that the nervous system includes the sensory system, which perceives the complexity of an animal’s environment, it should be no surprise that there would be a sensory influence on homeostasis and aging. To promote homeostasis, any given sensory information is transmitted through short-range signals via neural circuits and/or through long-range endocrine signals to target tissues, which may in turn be neuronal or non-neuronal in nature. At the same time, since homeostasis involves a number of feedback mechanisms, non-neuronal tissues can also modulate sensory and other neuronal functions. Several genes that regulate signaling pathways known to affect homeostasis and aging have been shown to act in neurons, in tissues that are likely downstream targets of the nervous system, or through feedback regulation of neuronal activities. These genes can have different temporal requirements: some might function early, e.g., by affecting neural development, while others may only be required later in adulthood. Some well-known examples of genes involved in the neuronal regulation of homeostasis and longevity encode components of the evolutionarily conserved nutrient-sensing insulin/insulin-like signaling pathway, the stress-sensing internal repair system, and the mitochondrial electron transport chain. Indeed, the genetic perturbation of these pathways has been found to lead to numerous diseases, many of which are age-related and involve the nervous system, such as neurodegeneration and the metabolic syndrome. Despite much progress, however, many aspects of the neuronal inputs and outputs that affect aging and longevity are poorly understood to date. For example, the precise neuronal and non-neuronal circuitries and the details of the molecular mechanisms through which genes/signaling pathways maintain homeostasis and affect aging in response to the environment remain to be elucidated. Similarly, it is presently unclear whether genes that regulate the early development of the nervous system and its consequent circuitry influence homeostasis and longevity during adulthood. At the same time, although many genes affecting aging are conserved, both the nervous system and the aging process are highly variable within populations and among taxa. Accordingly, the role of natural genetic variation in shaping the neurobiology of aging is also presently unknown. The aim of this Research Topic is therefore to highlight the genetic, developmental, and physiological aspects of the signaling networks that mediate the neuronal inputs and outputs that are required to maintain organismal homeostasis. The elucidation of the effects of these neuronal activities on homeostasis may thus provide much-needed insight into mechanisms that affect aging and longevity.
Author : Edward J. Massaro,John M. Rogers
Publisher : Springer Science & Business Media
Page : 812 pages
File Size : 50,5 Mb
Release : 2004-02-16
Category : Medical
ISBN : 9781592597369
A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.