Genetics And Breast Cancer

Author : B.A. Ponder,M.J. Waring
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 45,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401106771

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The Genetics of Cancer by B.A. Ponder,M.J. Waring Pdf

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

Author : Barbara T. Zimmerman
Publisher : Univ. Press of Mississippi
Page : 128 pages
File Size : 43,5 Mb
Release : 2009-09-18
Category : Health & Fitness
ISBN : 9781604730449

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Understanding Breast Cancer Genetics by Barbara T. Zimmerman Pdf

This book by a scientist whose background is in cellular and molecular biology examines the fearsome disease that strikes one in eight women in the United States. Although women are more likely to die of heart disease or of lung cancer, a diagnosis of breast cancer is the medical pronouncement that a woman is most likely to fear. It kills more than 40,000 Americans annually. Why are some women more vulnerable than others? The interplay between genetics and environment is suspected. Thus this book for general readers will help them understand the genetic basis of both sporadic and inherited breast cancers. Although only five to ten percent of breast cancer patients have inherited mutations in these genes, all women need to understand the genetic implications of the disease. In clear, concise language Barbara T. Zimmerman guides the reader through the complexities, discussing in detail the genes that are known to increase susceptibility and the ways they are passed on. Examining the general biology of breast cancer, Zimmerman describes how sporadic and inherited forms of the disease arise and how the location of the tumors can affect the body. She discusses genetic mutations and their roles in the development of tumors and tells how these potentially cancer-inducing genes were discovered. Covered too are the issues of risk, prevention, screening, diagnosis, therapy, and genetic testing and counseling. Zimmerman concludes with a comprehensive analysis of current research and with an emphasis on how a woman's understanding of inherited breast cancer can help doctors seeking to design better methods for prevention and therapy. A useful list of resources for further information about the genetic causes of breast cancer is included.

Author : National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer
Publisher : National Academies Press
Page : 34 pages
File Size : 54,6 Mb
Release : 2001-06-04
Category : Medical
ISBN : 9780309075503

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Mammography and Beyond by National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer Pdf

X-ray mammography screening is the current mainstay for early breast cancer detection. It has been proven to detect breast cancer at an earlier stage and to reduce the number of women dying from the disease. However, it has a number of limitations. These current limitations in early breast cancer detection technology are driving a surge of new technological developments, from modifications of x-ray mammography such as computer programs that can indicate suspicious areas, to newer methods of detection such as magnetic resonance imaging (MRI) or biochemical tests on breast fluids. To explore the merits and drawbacks of these new breast cancer detection techniques, the Institute of Medicine of the National Academy of Sciences convened a committee of experts. During its year of operation, the committee examined the peer-reviewed literature, consulted with other experts in the field, and held two public workshops. In addition to identifying promising new technologies for early detection, the committee explored potential barriers that might prevent the development of new detection methods and their common usage. Such barriers could include lack of funding from agencies that support research and lack of investment in the commercial sector; complicated, inconsistent, or unpredictable federal regulations; inadequate insurance reimbursement; and limited access to or unacceptability of breast cancer detection technology for women and their doctors. Based on the findings of their study, the committee prepared a report entitled Mammography and Beyond: Developing Technology for Early Detection of Breast Cancer, which was published in the spring of 2001. This is a non-technical summary of that report.

Author : Henry T. Lynch
Publisher : Unknown
Page : 280 pages
File Size : 43,6 Mb
Release : 1981
Category : Medical
ISBN : UCAL:B4978289

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Genetics and Breast Cancer by Henry T. Lynch Pdf

Author : Paolo Peterlongo,Nandita Mitra,Luis G. Carvajal-Carmona
Publisher : Frontiers Media SA
Page : 141 pages
File Size : 49,6 Mb
Release : 2019-10-16
Category : Electronic
ISBN : 9782889631322

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Accomplishments, Collaborative Projects and Future Initiatives in Breast Cancer Genetic Predisposition by Paolo Peterlongo,Nandita Mitra,Luis G. Carvajal-Carmona Pdf

In this eBook, we described the accomplishments, collaborative projects and future initiatives in the field of breast cancer genetic predisposition. More specifically, the articles included focused on aspects such as mutation screening in unexplored populations, identification and characterization of novel predisposing genes and mutations, and population screening.

Author : Piri Welcsh
Publisher : Springer Science & Business Media
Page : 346 pages
File Size : 52,5 Mb
Release : 2009-10-03
Category : Medical
ISBN : 9781441904775

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The Role of Genetics in Breast and Reproductive Cancers by Piri Welcsh Pdf

This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.

Author : Jessica Mozersky
Publisher : Routledge
Page : 178 pages
File Size : 52,8 Mb
Release : 2013
Category : Health & Fitness
ISBN : 9780415502283

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Risky Genes by Jessica Mozersky Pdf

What does it mean to be told you have an increased risk of genetic breast cancer because you are of Ashkenazi Jewish origin? In a time of ever increasing knowledge about variations in genetic disease risk among different populations, there is a pressing need for research regarding the implications of such information for members of high-risk populations. With first hand, intimate descriptions of women's experiences of being Jewish and of being at increased risk of genetic breast cancer, this book offers new insight into the ongoing debates regarding the implications of genetic research for populations, and of new genetic knowledge for individual and collective identity.

Author : Sahra Gibbon,Galen Joseph,Jessica Mozersky,Andrea zur Nieden,Sonja Palfner
Publisher : Routledge
Page : 248 pages
File Size : 46,8 Mb
Release : 2014-03-05
Category : Social Science
ISBN : 9781135925451

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Breast Cancer Gene Research and Medical Practices by Sahra Gibbon,Galen Joseph,Jessica Mozersky,Andrea zur Nieden,Sonja Palfner Pdf

The discovery of the two inherited susceptibility genes BRCA1 and BRCA2 in the mid-1990s created the possibility of predictive genetic testing and led to the establishment of specific medical programmes for those at high risk of developing breast cancer in the UK, US and Europe. In the intervening fifteen years, the medical institutionalisation of these knowledge-practices and accompanying medical techniques for assessing and managing risk have advanced at a rapid pace across multiple national and transnational arenas, whilst also themselves constituting a highly mobile and shifting terrain. This unique edited collection brings together cross-disciplinary social science research to present a broad global comparative understanding of the implications of BRCA gene research and medical practices. With a focus on time-economies that unfold locally, nationally and transnationally (including in Brazil, Canada, France, Germany, India, Italy, the UK and the USA), the essays in this volume facilitate a re-reading of concepts such as prevention, kinship and heredity, and together offer a unique, timely and comparative perspective on these developments. The book provides a coherent structure for examining the diversity of practices and discourses that surround developments linked to BRCA genetics, and to the evolving field of genetics more broadly. It will be of interest to students and scholars of anthropology, sociology, history of science, STS, public health and bioethics. Chapter 8 of this book is freely available as a downloadable Open Access PDF at www.tandfebooks.com/openaccess. It has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license.

Author : Piri Welcsh
Publisher : Springer
Page : 344 pages
File Size : 54,7 Mb
Release : 2009-11-05
Category : Medical
ISBN : 144190476X

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The Role of Genetics in Breast and Reproductive Cancers by Piri Welcsh Pdf

This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.

Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine
Publisher : National Academies Press
Page : 160 pages
File Size : 41,5 Mb
Release : 2002-08-01
Category : Science
ISBN : 9780309169240

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Cancer and the Environment by Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine Pdf

The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Author : Anne M. Bowcock
Publisher : Springer Science & Business Media
Page : 593 pages
File Size : 53,6 Mb
Release : 1999-01-11
Category : Medical
ISBN : 9781592594566

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Breast Cancer by Anne M. Bowcock Pdf

A comprehensive state-of-the-art summary of breast cancer research and treatment by leading authorities. The book's many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis. In addition, the authors describe current and future methods of breast cancer treatment in depth, and discuss environment and diet as risk factors for the disease. Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics constitutes an excellent reference and resource for all those clinical and experimental oncologists, as well as genetic counselors nurses, who need to understand the latest developments in breast cancer biology, risk, and treatment.

Author : Kevin Davies,Michael White
Publisher : Unknown
Page : 328 pages
File Size : 46,5 Mb
Release : 1996-01-26
Category : Science
ISBN : UOM:39015038112275

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Breakthrough by Kevin Davies,Michael White Pdf

The race began in October 1990, when Dr. Mary-Claire King startled the American society of Human Genetics with the news that after fifteen years, her research group had found irrefutable evidence of a gene linking heredity and the risk of breast cancer. From that moment on, the quest to isolate the gene became the focus of worldwide attention, eventually reaching fever pitch. In a race against time and one another, "researchers relentlessly zeroed in on a piece of DNA too small to see, for a prize too enormous to contemplate."

Author : National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Publisher : National Academies Press
Page : 384 pages
File Size : 54,7 Mb
Release : 2005-03-18
Category : Medical
ISBN : 9780309165945

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Saving Women's Lives by National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer Pdf

The outlook for women with breast cancer has improved in recent years. Due to the combination of improved treatments and the benefits of mammography screening, breast cancer mortality has decreased steadily since 1989. Yet breast cancer remains a major problem, second only to lung cancer as a leading cause of death from cancer for women. To date, no means to prevent breast cancer has been discovered and experience has shown that treatments are most effective when a cancer is detected early, before it has spread to other tissues. These two facts suggest that the most effective way to continue reducing the death toll from breast cancer is improved early detection and diagnosis. Building on the 2001 report Mammography and Beyond, this new book not only examines ways to improve implementation and use of new and current breast cancer detection technologies but also evaluates the need to develop tools that identify women who would benefit most from early detection screening. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis encourages more research that integrates the development, validation, and analysis of the types of technologies in clinical practice that promote improved risk identification techniques. In this way, methods and technologies that improve detection and diagnosis can be more effectively developed and implemented.

Author : Seigo Nakamura,Daisuke Aoki,Yoshio Miki
Publisher : Springer Nature
Page : 324 pages
File Size : 48,7 Mb
Release : 2021-10-20
Category : Medical
ISBN : 9789811645211

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Hereditary Breast and Ovarian Cancer by Seigo Nakamura,Daisuke Aoki,Yoshio Miki Pdf

This highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.

Author : Chris Jacobs,Lorraine Robinson,Patricia Webb
Publisher : OUP Oxford
Page : 384 pages
File Size : 51,8 Mb
Release : 2014-08-14
Category : Medical
ISBN : 9780191653490

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Genetics for Health Professionals in Cancer Care by Chris Jacobs,Lorraine Robinson,Patricia Webb Pdf

The role of genetics is becoming increasingly important in all aspects of healthcare and particularly in the field of cancer care. Genetics for Health Professionals in Cancer Care: From Principles to Practice equips health professionals with the knowledge and skills required for all aspects of managing cancer family history. This includes taking an accurate cancer family history and drawing a family tree; understanding cancer biology, basic cancer genetics and the genes involved in hereditary breast, ovarian, prostate, colorectal, gastric and related gynaecological cancers and rare cancer predisposing syndromes; assessing cancer risk and communicating risk information; early detection and risk reducing measures available for those at increased risk and managing individuals with hereditary cancer. Drawing on experiences of health professionals, Genetics for Health Professionals in Cancer Care discusses the challenges raised and provides practical advice and insight into what happens when a patient is referred for genetic counselling and genetic testing, including the psychological, social and ethical issues faced by individuals and families with and at risk of hereditary cancer. The book also provides practical guidance on setting up a cancer family history clinic in primary and secondary care. Genetics for Health Professionals in Cancer Care is essential reading for healthcare professionals working with cancer patients and their families, and is an ideal reference text for non-specialists working in cancer genetics.