Understanding Breast Cancer Genetics

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Understanding Breast Cancer Genetics

Author : Barbara T. Zimmerman
Publisher : Univ. Press of Mississippi
Page : 128 pages
File Size : 41,9 Mb
Release : 2009-09-18
Category : Health & Fitness
ISBN : 9781604730449

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Understanding Breast Cancer Genetics by Barbara T. Zimmerman Pdf

This book by a scientist whose background is in cellular and molecular biology examines the fearsome disease that strikes one in eight women in the United States. Although women are more likely to die of heart disease or of lung cancer, a diagnosis of breast cancer is the medical pronouncement that a woman is most likely to fear. It kills more than 40,000 Americans annually. Why are some women more vulnerable than others? The interplay between genetics and environment is suspected. Thus this book for general readers will help them understand the genetic basis of both sporadic and inherited breast cancers. Although only five to ten percent of breast cancer patients have inherited mutations in these genes, all women need to understand the genetic implications of the disease. In clear, concise language Barbara T. Zimmerman guides the reader through the complexities, discussing in detail the genes that are known to increase susceptibility and the ways they are passed on. Examining the general biology of breast cancer, Zimmerman describes how sporadic and inherited forms of the disease arise and how the location of the tumors can affect the body. She discusses genetic mutations and their roles in the development of tumors and tells how these potentially cancer-inducing genes were discovered. Covered too are the issues of risk, prevention, screening, diagnosis, therapy, and genetic testing and counseling. Zimmerman concludes with a comprehensive analysis of current research and with an emphasis on how a woman's understanding of inherited breast cancer can help doctors seeking to design better methods for prevention and therapy. A useful list of resources for further information about the genetic causes of breast cancer is included.

Saving Women's Lives

Author : National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Publisher : National Academies Press
Page : 384 pages
File Size : 43,9 Mb
Release : 2005-03-18
Category : Medical
ISBN : 9780309165945

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Saving Women's Lives by National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer Pdf

The outlook for women with breast cancer has improved in recent years. Due to the combination of improved treatments and the benefits of mammography screening, breast cancer mortality has decreased steadily since 1989. Yet breast cancer remains a major problem, second only to lung cancer as a leading cause of death from cancer for women. To date, no means to prevent breast cancer has been discovered and experience has shown that treatments are most effective when a cancer is detected early, before it has spread to other tissues. These two facts suggest that the most effective way to continue reducing the death toll from breast cancer is improved early detection and diagnosis. Building on the 2001 report Mammography and Beyond, this new book not only examines ways to improve implementation and use of new and current breast cancer detection technologies but also evaluates the need to develop tools that identify women who would benefit most from early detection screening. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis encourages more research that integrates the development, validation, and analysis of the types of technologies in clinical practice that promote improved risk identification techniques. In this way, methods and technologies that improve detection and diagnosis can be more effectively developed and implemented.

The Genetics of Cancer

Author : B.A. Ponder,M.J. Waring
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401106771

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The Genetics of Cancer by B.A. Ponder,M.J. Waring Pdf

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

The Role of Genetics in Breast and Reproductive Cancers

Author : Piri Welcsh
Publisher : Springer Science & Business Media
Page : 346 pages
File Size : 42,6 Mb
Release : 2009-10-03
Category : Medical
ISBN : 9781441904775

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The Role of Genetics in Breast and Reproductive Cancers by Piri Welcsh Pdf

This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.

Genetics and Breast Cancer

Author : Henry T. Lynch
Publisher : Unknown
Page : 280 pages
File Size : 43,6 Mb
Release : 1981
Category : Medical
ISBN : UCAL:B4978289

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Genetics and Breast Cancer by Henry T. Lynch Pdf

Mammography and Beyond

Author : National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer
Publisher : National Academies Press
Page : 34 pages
File Size : 46,6 Mb
Release : 2001-06-04
Category : Medical
ISBN : 9780309075503

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Mammography and Beyond by National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer Pdf

X-ray mammography screening is the current mainstay for early breast cancer detection. It has been proven to detect breast cancer at an earlier stage and to reduce the number of women dying from the disease. However, it has a number of limitations. These current limitations in early breast cancer detection technology are driving a surge of new technological developments, from modifications of x-ray mammography such as computer programs that can indicate suspicious areas, to newer methods of detection such as magnetic resonance imaging (MRI) or biochemical tests on breast fluids. To explore the merits and drawbacks of these new breast cancer detection techniques, the Institute of Medicine of the National Academy of Sciences convened a committee of experts. During its year of operation, the committee examined the peer-reviewed literature, consulted with other experts in the field, and held two public workshops. In addition to identifying promising new technologies for early detection, the committee explored potential barriers that might prevent the development of new detection methods and their common usage. Such barriers could include lack of funding from agencies that support research and lack of investment in the commercial sector; complicated, inconsistent, or unpredictable federal regulations; inadequate insurance reimbursement; and limited access to or unacceptability of breast cancer detection technology for women and their doctors. Based on the findings of their study, the committee prepared a report entitled Mammography and Beyond: Developing Technology for Early Detection of Breast Cancer, which was published in the spring of 2001. This is a non-technical summary of that report.

Understanding BRCA

Author : Clarissa Foster
Publisher : Unknown
Page : 0 pages
File Size : 44,9 Mb
Release : 2017
Category : BRCA genes
ISBN : 1781611203

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Understanding BRCA by Clarissa Foster Pdf

"Do you have a close relative who has died from, or is experiencing, aggressive breast, ovarian or prostate cancer? Have they been tested for the BRCA gene mutation? Have you? At the age of 35 and following the death of her mother from ovarian cancer, Clarissa Foster was found to carry a harmful mutation in the BRCA2 gene which drastically increased her risk of developing breast and ovarian cancer. She searched for a book that would help her to understand the full extent of what it meant to carry a harmful mutation, the options available to her to lower her risk and, most importantly, how it would feel to undergo risk-reducing surgery. Finding nothing that answered her needs, she set about reading all the available medical literature and liaising with relevant medical professionals to answer her questions. This book is the result of that research and of the decision she took based on it – to have a bilateral mastectomy and salpingo-oophorectomy. Within the context of her own painful experience of family cancer and of elective surgery, Clarissa explains what the BRCA mutation is, what it signifies, what the individual’s choices are and what the fall out can be in terms of a woman’s body image, identity and sexual functioning."--Publisher's description.

A Review of the Department of Defense's Program for Breast Cancer Research

Author : Institute of Medicine,Committee to Review the Department of Defense's Breast Cancer Research Program
Publisher : National Academies Press
Page : 150 pages
File Size : 44,7 Mb
Release : 1997-07-31
Category : Medical
ISBN : 9780309174565

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A Review of the Department of Defense's Program for Breast Cancer Research by Institute of Medicine,Committee to Review the Department of Defense's Breast Cancer Research Program Pdf

According to current statistical data, one in eight women will be diagnosed with breast cancer. The five-year survival rate for breast cancer patients has improved in recent years, but the overall mortality rates have changed little. In 1993 Congress allocated $210 million for breast cancer research as part of the Department of Defense budget. An Institute of Medicine (IOM) committee was convened at that time to advise the U.S. Army Medical Research and Development Command on strategies for managing a breast cancer research program. This book evaluates the program's management and achievements to date. Although it is too early to evaluate the program in terms of breakthrough results and new insights produced by the funded projects or investigators, this book documents the process used to select research proposals for funding and analyzes the portfolio of funded projects in terms of their responsiveness to the recommendations and fundamental questions articulated in the 1993 IOM report.

Breast Cancer

Author : Anne M. Bowcock
Publisher : Springer Science & Business Media
Page : 593 pages
File Size : 54,9 Mb
Release : 1999-01-11
Category : Medical
ISBN : 9781592594566

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Breast Cancer by Anne M. Bowcock Pdf

A comprehensive state-of-the-art summary of breast cancer research and treatment by leading authorities. The book's many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis. In addition, the authors describe current and future methods of breast cancer treatment in depth, and discuss environment and diet as risk factors for the disease. Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics constitutes an excellent reference and resource for all those clinical and experimental oncologists, as well as genetic counselors nurses, who need to understand the latest developments in breast cancer biology, risk, and treatment.

Accomplishments, Collaborative Projects and Future Initiatives in Breast Cancer Genetic Predisposition

Author : Paolo Peterlongo,Nandita Mitra,Luis G. Carvajal-Carmona
Publisher : Frontiers Media SA
Page : 141 pages
File Size : 49,8 Mb
Release : 2019-10-16
Category : Electronic
ISBN : 9782889631322

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Accomplishments, Collaborative Projects and Future Initiatives in Breast Cancer Genetic Predisposition by Paolo Peterlongo,Nandita Mitra,Luis G. Carvajal-Carmona Pdf

In this eBook, we described the accomplishments, collaborative projects and future initiatives in the field of breast cancer genetic predisposition. More specifically, the articles included focused on aspects such as mutation screening in unexplored populations, identification and characterization of novel predisposing genes and mutations, and population screening.

Genetics for Health Professionals in Cancer Care

Author : Chris Jacobs,Lorraine Robinson,Patricia Webb
Publisher : OUP Oxford
Page : 384 pages
File Size : 50,8 Mb
Release : 2014-08-14
Category : Medical
ISBN : 9780191653483

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Genetics for Health Professionals in Cancer Care by Chris Jacobs,Lorraine Robinson,Patricia Webb Pdf

The role of genetics is becoming increasingly important in all aspects of healthcare and particularly in the field of cancer care. Genetics for Health Professionals in Cancer Care: From Principles to Practice equips health professionals with the knowledge and skills required for all aspects of managing cancer family history. This includes taking an accurate cancer family history and drawing a family tree; understanding cancer biology, basic cancer genetics and the genes involved in hereditary breast, ovarian, prostate, colorectal, gastric and related gynaecological cancers and rare cancer predisposing syndromes; assessing cancer risk and communicating risk information; early detection and risk reducing measures available for those at increased risk and managing individuals with hereditary cancer. Drawing on experiences of health professionals, Genetics for Health Professionals in Cancer Care discusses the challenges raised and provides practical advice and insight into what happens when a patient is referred for genetic counselling and genetic testing, including the psychological, social and ethical issues faced by individuals and families with and at risk of hereditary cancer. The book also provides practical guidance on setting up a cancer family history clinic in primary and secondary care. Genetics for Health Professionals in Cancer Care is essential reading for healthcare professionals working with cancer patients and their families, and is an ideal reference text for non-specialists working in cancer genetics.

Confronting Hereditary Breast and Ovarian Cancer

Author : Sue Friedman,Rebecca Sutphen,Kathy Steligo
Publisher : JHU Press
Page : 320 pages
File Size : 54,6 Mb
Release : 2012-03-01
Category : Health & Fitness
ISBN : 9781421404455

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Confronting Hereditary Breast and Ovarian Cancer by Sue Friedman,Rebecca Sutphen,Kathy Steligo Pdf

"Be informed. Be empowered. Be well." If you are concerned that the cancer in your family is hereditary, you face difficult choices. Should you have a blood test that may reveal whether you have a high likelihood of disease? Do you preemptively treat a disease that may never develop? How do you make decisions now that will affect the rest of your life? This helpful, informative guide answers your questions as you confront hereditary breast and ovarian cancer. Developed by Facing Our Risk of Cancer Empowered (FORCE), the nation’s only nonprofit organization dedicated to supporting families affected by hereditary breast and ovarian cancer, this book stands alone among breast and ovarian cancer resources. Equal parts health guide and memoir, it defines complex issues facing previvors and survivors and provides solutions with a fresh, authoritative voice. Written by three passionate advocates for the hereditary cancer community who are themselves breast cancer survivors, Confronting Hereditary Breast and Ovarian Cancer dispels myths and misinformation and presents practical risk-reducing alternatives and decision-making tools. Including information about genetic counseling and testing, preventive surgery, and fertility and family planning, as well as explanations of health insurance coverage and laws protecting genetic privacy, this resource tackles head-on the challenges of living in a high-risk body. Confronting hereditary cancer is a complex, confusing, and highly individual journey. With its unique combination of the latest research, expert advice, and compelling personal stories, this book gives previvors, survivors, and their family members the guidance they need to face the unique challenges of hereditary cancer.

The Role of Genetics in Breast and Reproductive Cancers

Author : Piri Welcsh
Publisher : Springer
Page : 344 pages
File Size : 44,6 Mb
Release : 2009-11-05
Category : Medical
ISBN : 144190476X

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The Role of Genetics in Breast and Reproductive Cancers by Piri Welcsh Pdf

This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.

Cancer and the Environment

Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine
Publisher : National Academies Press
Page : 160 pages
File Size : 52,8 Mb
Release : 2002-08-01
Category : Science
ISBN : 9780309169240

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Cancer and the Environment by Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine Pdf

The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

The Breast Cancer Book

Author : Kenneth D. Miller,Melissa Camp
Publisher : JHU Press
Page : 457 pages
File Size : 55,8 Mb
Release : 2021-09-28
Category : Health & Fitness
ISBN : 9781421441900

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The Breast Cancer Book by Kenneth D. Miller,Melissa Camp Pdf

"Providing comprehensive, current, and reliable information on breast cancer, this book, written by an experienced oncologist, a surgeon, and a breast cancer survivor, informs and inspires readers, wherever they are in the breast cancer experience. Patient stories, essays from medical specialists, and illustrations add clarity and insight"--