Genomic Regulatory Systems

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Genomic Regulatory Systems

Eric H. Davidson
Genomic Regulatory Systems Book PDF

Author : Eric H. Davidson
Publisher : Elsevier
Page : 261 pages
File Size : 45,5 Mb
Release : 2001-01-24
Category : Science
ISBN : 0080525598

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Genomic Regulatory Systems by Eric H. Davidson Pdf

The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest. The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist. * Contents Include * Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression * Regulation of Direct Cell-Type Specification in Early Development * The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts * Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans

The Regulatory Genome

Eric H. Davidson
The Regulatory Genome Book PDF

Author : Eric H. Davidson
Publisher : Elsevier
Page : 304 pages
File Size : 49,7 Mb
Release : 2010-07-19
Category : Science
ISBN : 0080455573

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The Regulatory Genome by Eric H. Davidson Pdf

Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. The only book in the market that is solely devoted to the genomic regulatory code for animal development Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding Presents a comprehensive treatment of molecular control elements that determine the function of genes Provides a comparative treatment of development, based on principles rather than description of developmental processes Considers the evolutionary processes in terms of the structural properties of gene regulatory networks Includes 42 full-color descriptive figures and diagrams

Genomic Control Process

Isabelle Peter,Eric H. Davidson
Genomic Control Process Book PDF

Author : Isabelle Peter,Eric H. Davidson
Publisher : Academic Press
Page : 460 pages
File Size : 43,8 Mb
Release : 2015-01-21
Category : Science
ISBN : 9780124047464

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Genomic Control Process by Isabelle Peter,Eric H. Davidson Pdf

Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type Demonstrates the causal power of system-level understanding of genomic control process Conceptually organizes a constellation of complex and diverse biological phenomena Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome

Bioinformatics of Genome Regulation and Systems Biology

Yuriy L. Orlov,Ancha Baranova
Bioinformatics of Genome Regulation and Systems Biology Book PDF

Author : Yuriy L. Orlov,Ancha Baranova
Publisher : Frontiers Media SA
Page : 258 pages
File Size : 48,5 Mb
Release : 2020-09-17
Category : Medical
ISBN : 9782889660148

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Bioinformatics of Genome Regulation and Systems Biology by Yuriy L. Orlov,Ancha Baranova Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Systems Biology and Regulatory Genomics

Eleazar Eskin,Trey Ideker,Ben Raphael,Christopher Workman
Systems Biology and Regulatory Genomics Book PDF

Author : Eleazar Eskin,Trey Ideker,Ben Raphael,Christopher Workman
Publisher : Springer
Page : 261 pages
File Size : 46,6 Mb
Release : 2007-05-16
Category : Science
ISBN : 9783540485407

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Systems Biology and Regulatory Genomics by Eleazar Eskin,Trey Ideker,Ben Raphael,Christopher Workman Pdf

This book constitutes the thoroughly refereed post-proceedings of two joint RECOMB 2005 satellite events: the First Annual Workshop on Systems Biology, RSB 2005 and the Second Annual Workshop on Regulatory Genomics, RRG 2005, held in San Diego, CA, USA in December 2005. It contains 21 revised full papers that address a broad variety of topics in systems biology and regulatory genomics.

RNA-Based Regulation in Human Health and Disease

Anonim
RNA Based Regulation in Human Health and Disease Book PDF

Author : Anonim
Publisher : Academic Press
Page : 444 pages
File Size : 41,5 Mb
Release : 2020-08-19
Category : Medical
ISBN : 9780128171943

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RNA-Based Regulation in Human Health and Disease by Anonim Pdf

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Genomic Signal Processing and Statistics

Edward R. Dougherty
Genomic Signal Processing and Statistics Book PDF

Author : Edward R. Dougherty
Publisher : Hindawi Publishing Corporation
Page : 456 pages
File Size : 49,9 Mb
Release : 2005
Category : DNA microarrays
ISBN : 9789775945075

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Genomic Signal Processing and Statistics by Edward R. Dougherty Pdf

Recent advances in genomic studies have stimulated synergetic research and development in many cross-disciplinary areas. Processing the vast genomic data, especially the recent large-scale microarray gene expression data, to reveal the complex biological functionality, represents enormous challenges to signal processing and statistics. This perspective naturally leads to a new field, genomic signal processing (GSP), which studies the processing of genomic signals by integrating the theory of signal processing and statistics. Written by an international, interdisciplinary team of authors, this invaluable edited volume is accessible to students just entering this emergent field, and to researchers, both in academia and in industry, in the fields of molecular biology, engineering, statistics, and signal processing. The book provides tutorial-level overviews and addresses the specific needs of genomic signal processing students and researchers as a reference book. The book aims to address current genomic challenges by exploiting potential synergies between genomics, signal processing, and statistics, with special emphasis on signal processing and statistical tools for structural and functional understanding of genomic data. The first part of this book provides a brief history of genomic research and a background introduction from both biological and signal-processing/statistical perspectives, so that readers can easily follow the material presented in the rest of the book. In what follows, overviews of state-of-the-art techniques are provided. We start with a chapter on sequence analysis, and follow with chapters on feature selection, classification, and clustering of microarray data. We then discuss the modeling, analysis, and simulation of biological regulatory networks, especially gene regulatory networks based on Boolean and Bayesian approaches. Visualization and compression of gene data, and supercomputer implementation of genomic signal processing systems are also treated. Finally, we discuss systems biology and medical applications of genomic research as well as the future trends in genomic signal processing and statistics research.

Next Steps for Functional Genomics

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences
Next Steps for Functional Genomics Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences
Publisher : National Academies Press
Page : 201 pages
File Size : 50,9 Mb
Release : 2020-12-18
Category : Science
ISBN : 9780309676731

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Next Steps for Functional Genomics by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences Pdf

One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.

Emerging Research in the Analysis and Modeling of Gene Regulatory Networks

Ivanov, Ivan V.,Qian, Xiaoning,Pal, Ranadip
Emerging Research in the Analysis and Modeling of Gene Regulatory Networks Book PDF

Author : Ivanov, Ivan V.,Qian, Xiaoning,Pal, Ranadip
Publisher : IGI Global
Page : 418 pages
File Size : 44,7 Mb
Release : 2016-06-06
Category : Medical
ISBN : 9781522503545

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Emerging Research in the Analysis and Modeling of Gene Regulatory Networks by Ivanov, Ivan V.,Qian, Xiaoning,Pal, Ranadip Pdf

While technological advancements have been critical in allowing researchers to obtain more and better quality data about cellular processes and signals, the design and practical application of computational models of genomic regulation continues to be a challenge. Emerging Research in the Analysis and Modeling of Gene Regulatory Networks presents a compilation of recent and emerging research topics addressing the design and use of technology in the study and simulation of genomic regulation. Exploring both theoretical and practical topics, this publication is an essential reference source for students, professionals, and researchers working in the fields of genomics, molecular biology, bioinformatics, and drug development.

Gene Regulation and Metabolism

Julio Collado-Vides,Ralf Hofestädt
Gene Regulation and Metabolism Book PDF

Author : Julio Collado-Vides,Ralf Hofestädt
Publisher : MIT Press
Page : 326 pages
File Size : 44,7 Mb
Release : 2002
Category : Computers
ISBN : 0262532689

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Gene Regulation and Metabolism by Julio Collado-Vides,Ralf Hofestädt Pdf

An overview of current computational approaches to metabolism and gene regulation.

Preparing for Future Products of Biotechnology

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Board on Agriculture and Natural Resources,Board on Life Sciences,Committee on Future Biotechnology Products and Opportunities to Enhance Capabilities of the Biotechnology Regulatory System
Preparing for Future Products of Biotechnology Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Board on Agriculture and Natural Resources,Board on Life Sciences,Committee on Future Biotechnology Products and Opportunities to Enhance Capabilities of the Biotechnology Regulatory System
Publisher : National Academies Press
Page : 231 pages
File Size : 48,5 Mb
Release : 2017-07-28
Category : Science
ISBN : 9780309452052

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Preparing for Future Products of Biotechnology by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Board on Agriculture and Natural Resources,Board on Life Sciences,Committee on Future Biotechnology Products and Opportunities to Enhance Capabilities of the Biotechnology Regulatory System Pdf

Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.

Practical Systems Biology

Alistair Hetherington,Claire Grierson
Practical Systems Biology Book PDF

Author : Alistair Hetherington,Claire Grierson
Publisher : Taylor & Francis
Page : 237 pages
File Size : 40,7 Mb
Release : 2008-11-19
Category : Science
ISBN : 9781134133048

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Practical Systems Biology by Alistair Hetherington,Claire Grierson Pdf

Practical Systems Biology provides a detailed overview of the different approaches used in this relatively new discipline, integrating bioinformatics, genomics, proteomics and metabolomics. Various areas of research are also discussed, including the use of computational models of biological processes, and post-genomic research.

Heritable Human Genome Editing

The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Heritable Human Genome Editing Book PDF

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 55,7 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

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Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Gene Regulatory Mechanisms in Development and Evolution: Insights from Echinoderms

Anonim
Gene Regulatory Mechanisms in Development and Evolution Insights from Echinoderms Book PDF

Author : Anonim
Publisher : Academic Press
Page : 252 pages
File Size : 51,7 Mb
Release : 2022-02-10
Category : Science
ISBN : 9780128171882

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Gene Regulatory Mechanisms in Development and Evolution: Insights from Echinoderms by Anonim Pdf

Sea urchins and other echinoderms, which have been studied intensively by developmental biologists for more than a century, are currently among the most prominent models for elucidating the genomic regulatory processes that control embryogenesis and the evolution of those processes. This volume contains reviews from the world’s leading researchers who are using echinoderms to address these questions. Chapters focus on gene regulatory networks that drive the differentiation and morphogenesis of major embryonic tissues such as the skeleton, muscle, nervous system, immune system, pigment cells, and germ line, and on evolutionary insights from comparative studies of these networks across echinoderms and other taxa. Other chapters comprehensively review the architecture and evolution of the cell signaling pathways that establish the early embryonic axes and on recent evolutionary changes in gene networks that have led to dramatic changes in the life history modes of echinoderms. This volume provides a comprehensive, current picture of exciting research at the interface between developmental genomics and evolution from one of the research communities leading this work. Contributions from leading investigators who use echinoderms as model organisms Up-to-date reviews of developmental gene regulatory networks Current work at the interface between developmental genomics and evolution

Bioinformatics of Genome Regulation and Structure II

Nikolay Kolchanov,Ralf Hofestaedt,Luciano Milanesi
Bioinformatics of Genome Regulation and Structure II Book PDF

Author : Nikolay Kolchanov,Ralf Hofestaedt,Luciano Milanesi
Publisher : Springer Science & Business Media
Page : 545 pages
File Size : 42,9 Mb
Release : 2006-06-15
Category : Science
ISBN : 9780387294551

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Bioinformatics of Genome Regulation and Structure II by Nikolay Kolchanov,Ralf Hofestaedt,Luciano Milanesi Pdf

The last 15 years in development of biology were marked with accumulation of unprecedentedly huge arrays of experimental data. The information was amassed with exclusively high rates due to the advent of highly efficient experimental technologies that provided for high throughput genomic sequencing; of functional genomics technologies allowing investigation of expression dynamics of large groups of genes using expression DNA chips; of proteomics methods giving the possibility to analyze protein compositions of cells, tissues, and organs, assess the dynamics of the cell proteome, and reconstruct the networks of protein-protein interactions; and of metabolomics, in particular, high resolution mass spectrometry study of cell metabolites, and distribution of metabolic fluxes in the cells with a concurrent investigation of the dynamics of thousands metabolites in an individual cell. Analysis, comprehension, and use of the tremendous volumes of experimental data reflecting the intricate processes underlying the functioning of molecular genetic systems are unfeasible in principle without the systems approach and involvement of the state-of-the-art information and computer technologies and efficient mathematical methods for data analysis and simulation of biological systems and processes. The need in solving these problems initiated the birth of a new science— postgenomic bioinformatics or systems biology in silico.