Genomic Surveillance And Pandemic Preparedness

Author : Rajesh Pandey
Publisher : Elsevier
Page : 428 pages
File Size : 43,5 Mb
Release : 2023-06-29
Category : Science
ISBN : 9780443187681

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Genomic Surveillance and Pandemic Preparedness by Rajesh Pandey Pdf

Genomic Surveillance and Pandemic Preparedness offers practical, in-depth instruction in where, how, and why genomic surveillance may be applied. Drawing heavily from the learnings during the COVID-19 pandemic, this book covers different aspects of microbes with a focus on viral genome sequencing and analysis, implementation and inference of genomic surveillance, and global data sharing best practices for future pandemic preparedness. Here, more than a dozen international authors consider host and pathogen genome interaction, population-level prevalence, individual disease susceptibility and gene protection, pathogen mutation evolutionary dynamics, RNA modulation of infection, pathogen diversity, and the role of coinfections and comorbidities in disease severity. A wide range of examples, from bacterial pathogens to fungal and viral infections, with an emphasis on recent COVID-19 analysis, are discussed. Finally, the authors provide step-by-step instruction in experimental and computational approaches for genomic surveillance, including nucleic acid isolation, sequencing library preparation, functional sequencing analysis, and bioinformatics pipelines. Throughout this book, importance is placed on inference—moving from genomic sequencing to meaningful genomic surveillance that bolsters pandemic preparedness. Highlights different aspects of genomic surveillance, from theory to implementation to inferences Covers a broad range of infectious diseases, with emphasis on recent COVID-19 studies Shares methods and approaches for sequencing-based pathogen detection, diagnostics, and surveillance Facilitates international collaboration in drug and vaccine development

Author : Anonim
Publisher : World Health Organization
Page : 32 pages
File Size : 42,5 Mb
Release : 2022-03-23
Category : Medical
ISBN : 9789240046979

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Global genomic surveillance strategy for pathogens with pandemic and epidemic potential, 2022-2032 by Anonim Pdf

The Global Genomic Surveillance Strategy for Pathogens with Pandemic and Epidemic Potential 2022-2032 provides a high-level unifying framework to leverage existing capacities, address barriers and strengthen the use of genomic surveillance in the detection, monitoring and response to public health threats. Genomic surveillance is part of the broader surveillance and laboratory system, and its implementation should reinforce end-to-end capacities including sample collection, diagnostics, data sharing and analysis. The strategy aims to facilitate the connectivity between different disease control programs and surveillance networks. This interoperability will strengthen the cross-cutting essential public health laboratory functions underpinning genomics holistically. The strategy articulates the overarching goal, objectives and strategic actions needed. These are dependent on commitments from countries, partners and WHO for their implementation.

Author : World Health Organization
Publisher : World Health Organization
Page : 26 pages
File Size : 53,8 Mb
Release : 2023-05-01
Category : Medical
ISBN : 9789240057401

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Global genomic surveillance strategy for pathogens with pandemic and epidemic potential 2022-2032 by World Health Organization Pdf

The Global Genomic Surveillance Strategy for Pathogens with Pandemic and Epidemic Potential 2022-2032 provides a high-level unifying framework to leverage existing capacities, address barriers and strengthen the use of genomic surveillance in the detection, monitoring and response to public health threats. Genomic surveillance is part of the broader surveillance and laboratory system, and its implementation should reinforce end-to-end capacities including sample collection, diagnostics, data sharing and analysis. The strategy aims to facilitate the connectivity between different disease control programs and surveillance networks. This interoperability will strengthen the cross-cutting essential public health laboratory functions underpinning genomics holistically. The strategy articulates the overarching goal, objectives and strategic actions needed. These are dependent on commitments from countries, partners and WHO for their implementation.

Author : Bernd Salzberger,Alexander Mellmann,Anna Bludau,Sandra Ciesek,Victor Max Corman,Alexander Dilthey,Tjibbe Donker,Tim Eckmanns,Richard Egelkamp,Sören Gatermann,Hajo Grundmann,Georg Häcker,Martin Kaase,Berit Lange,Martin Mielke,Mathias Pletz,Torsten Semmler,Andrea Thürmer,Lothar H. Wieler,Thorsten Wolff,Andreas Widmer,Simone Scheithauer
Publisher : Unknown
Page : 0 pages
File Size : 50,8 Mb
Release : 2023
Category : Electronic
ISBN : OCLC:1393160092

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An Appeal for Strengthening Genomic Pathogen Surveillance to Improve Pandemic Preparedness and Infection Prevention: the German Perspective by Bernd Salzberger,Alexander Mellmann,Anna Bludau,Sandra Ciesek,Victor Max Corman,Alexander Dilthey,Tjibbe Donker,Tim Eckmanns,Richard Egelkamp,Sören Gatermann,Hajo Grundmann,Georg Häcker,Martin Kaase,Berit Lange,Martin Mielke,Mathias Pletz,Torsten Semmler,Andrea Thürmer,Lothar H. Wieler,Thorsten Wolff,Andreas Widmer,Simone Scheithauer Pdf

Abstract: The SARS-CoV-2 pandemic has highlighted the importance of viable infection surveillance and the relevant infrastructure. From a German perspective, an integral part of this infrastructure, genomic pathogen sequencing, was at best fragmentary and stretched to its limits due to the lack or inefficient use of equipment, human resources, data management and coordination. The experience in other countries has shown that the rate of sequenced positive samples and linkage of genomic and epidemiological data (person, place, time) represent important factors for a successful application of genomic pathogen surveillance. Planning, establishing and consistently supporting adequate structures for genomic pathogen surveillance will be crucial to identify and combat future pandemics as well as other challenges in infectious diseases such as multi-drug resistant bacteria and healthcare-associated infections. Therefore, the authors propose a multifaceted and coordinated process for the definition of procedural, legal and technical standards for comprehensive genomic pathogen surveillance in Germany, covering the areas of genomic sequencing, data collection and data linkage, as well as target pathogens. A comparative analysis of the structures established in Germany and in other countries is applied. This proposal aims to better tackle epi- and pandemics to come and take action from the "lessons learned" from the SARS-CoV-2 pandemic

Author : World Health Organization
Publisher : World Health Organization
Page : 58 pages
File Size : 43,7 Mb
Release : 2023-12-04
Category : Medical
ISBN : 9789240084773

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Global genomic surveillance strategy for pathogens with pandemic and epidemic potential 2022–2032 by World Health Organization Pdf

Author : World Health Organization
Publisher : World Health Organization
Page : 28 pages
File Size : 54,6 Mb
Release : 2023-08-18
Category : Medical
ISBN : 9789240076563

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Considerations for developing a national genomic surveillance strategy or action plan for pathogens with pandemic and epidemic potential by World Health Organization Pdf

Policy considerations to strengthen genomic surveillance for pathogens with pandemic and epidemic potential is a support tool that provides key consideration and a proposed stepwise approach for countries to develop a national genomic surveillance strategy or action plan for pathogens with pandemic and epidemic potential. This document is intended for use by all stakeholders at the national and subnational level relevant to the development and implementation of the strategy or action plan, including health authorities, One Health partners, donors, public health officers, academia, the private sector and laboratory specialists.

Author : National Research Council,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology
Publisher : National Academies Press
Page : 164 pages
File Size : 40,5 Mb
Release : 2004-03-02
Category : Technology & Engineering
ISBN : 9780309089777

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Biotechnology Research in an Age of Terrorism by National Research Council,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology Pdf

In recent years much has happened to justify an examination of biological research in light of national security concerns. The destructive application of biotechnology research includes activities such as spreading common pathogens or transforming them into even more lethal forms. Policymakers and the scientific community at large must put forth a vigorous and immediate response to this challenge. This new book by the National Research Council recommends that the government expand existing regulations and rely on self-governance by scientists rather than adopt intrusive new policies. One key recommendation of the report is that the government should not attempt to regulate scientific publishing but should trust scientists and journals to screen their papers for security risks, a task some journals have already taken up. With biological information and tools widely distributed, regulating only U.S. researchers would have little effect. A new International Forum on Biosecurity should encourage the adoption of similar measures around the world. Seven types of risky studies would require approval by the Institutional Biosafety Committees that already oversee recombinant DNA research at some 400 U.S. institutions. These "experiments of concern" include making an infectious agent more lethal and rendering vaccines powerless.

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 431 pages
File Size : 54,8 Mb
Release : 2005-04-09
Category : Medical
ISBN : 9780309095044

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The Threat of Pandemic Influenza by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.

Author : Joseph R. Biden, Jr.
Publisher : Simon and Schuster
Page : 329 pages
File Size : 44,6 Mb
Release : 2021-05-04
Category : Political Science
ISBN : 9781510767614

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National Strategy for the COVID-19 Response and Pandemic Preparedness by Joseph R. Biden, Jr. Pdf

The ultimate guide for anyone wondering how President Joe Biden will respond to the COVID-19 pandemic—all his plans, goals, and executive orders in response to the coronavirus crisis. Shortly after being inaugurated as the 46th President of the United States, Joe Biden and his administration released this 200 page guide detailing his plans to respond to the coronavirus pandemic. The National Strategy for the COVID-19 Response and Pandemic Preparedness breaks down seven crucial goals of President Joe Biden's administration with regards to the coronavirus pandemic: 1. Restore trust with the American people. 2. Mount a safe, effective, and comprehensive vaccination campaign. 3. Mitigate spread through expanding masking, testing, data, treatments, health care workforce, and clear public health standards. 4. Immediately expand emergency relief and exercise the Defense Production Act. 5. Safely reopen schools, businesses, and travel while protecting workers. 6. Protect those most at risk and advance equity, including across racial, ethnic and rural/urban lines. 7. Restore U.S. leadership globally and build better preparedness for future threats. Each of these goals are explained and detailed in the book, with evidence about the current circumstances and how we got here, as well as plans and concrete steps to achieve each goal. Also included is the full text of the many Executive Orders that will be issued by President Biden to achieve each of these goals. The National Strategy for the COVID-19 Response and Pandemic Preparedness is required reading for anyone interested in or concerned about the COVID-19 pandemic and its effects on American society.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 231 pages
File Size : 48,8 Mb
Release : 2019-06-05
Category : Medical
ISBN : 9780309490351

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Exploring Lessons Learned from a Century of Outbreaks by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats Pdf

In November 2018, an ad hoc planning committee at the National Academies of Sciences, Engineering, and Medicine planned two sister workshops held in Washington, DC, to examine the lessons from influenza pandemics and other major outbreaks, understand the extent to which the lessons have been learned, and discuss how they could be applied further to ensure that countries are sufficiently ready for future pandemics. This publication summarizes the presentations and discussions from both workshops.

Author : World Health Organization
Publisher : World Health Organization
Page : 56 pages
File Size : 45,8 Mb
Release : 2023-12-07
Category : Medical
ISBN : 9789240084513

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A checklist for respiratory pathogen pandemic preparedness planning by World Health Organization Pdf

Author : Gregory J. Tsongalis
Publisher : Elsevier Health Sciences
Page : 273 pages
File Size : 45,6 Mb
Release : 2021-10-13
Category : Medical
ISBN : 9780323813365

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Advances in Molecular Pathology, E-Book 2021 by Gregory J. Tsongalis Pdf

Advances in Molecular Pathology is an annual review publication that covers the current practices and latest developments in the field of Molecular Pathology. Each issue is divided into sections for comprehensive coverage of all subspecialty areas within molecular pathology, including, Genetics, Hematopathology, Infectious Disease, Pharmacogenomics, Informatics, Solid Tumors, and special topics on COVID-19. The Editor-in-Chief of the publication is Dr. Gregory Tsongalis, a leading expert in the field. Topics covered this year include but are not limited to: Phenotype Association and Variant Pathogenicity Prediction Tools in Genomic Analysis; The application of noninvasive prenatal screening to detect copy number variations; Next generation cytogenomics using optical mapping; Review of molecular in APL; NGS for MRD in acute leukemia; Review of emerging technologies as they pertain to infectious disease testing; Germline genetic variants that predict drug response; Nutrigenomics; PGx of hypertension; Genomic data for blood typing, specifically both through NGS and arrays; Preanalytic Variables and Tissue Stewardship for Reliable Next-Generation Sequencing (NGS) Clinical Analysis; and Cell-free nucleic acids in cancer: Current approaches, challenges, and future directions.

Author : Frédéric Keck
Publisher : Duke University Press
Page : 162 pages
File Size : 44,8 Mb
Release : 2020-01-17
Category : Social Science
ISBN : 9781478007555

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Avian Reservoirs by Frédéric Keck Pdf

After experiencing the SARS outbreak in 2003, Hong Kong, Singapore, and Taiwan all invested in various techniques to mitigate future pandemics involving myriad cross-species interactions between humans and birds. In some locations microbiologists allied with veterinarians and birdwatchers to follow the mutations of flu viruses in birds and humans and create preparedness strategies, while in others, public health officials worked toward preventing pandemics by killing thousands of birds. In Avian Reservoirs Frédéric Keck offers a comparative analysis of these responses, tracing how the anticipation of bird flu pandemics has changed relations between birds and humans in China. Drawing on anthropological theory and ethnographic fieldwork, Keck demonstrates that varied strategies dealing with the threat of pandemics—stockpiling vaccines and samples in Taiwan, simulating pandemics in Singapore, and monitoring viruses and disease vectors in Hong Kong—reflect local geopolitical relations to mainland China. In outlining how interactions among pathogens, birds, and humans shape the way people imagine future pandemics, Keck illuminates how interspecies relations are crucial for protecting against such threats.

Author : World Health Organization
Publisher : World Health Organization
Page : 59 pages
File Size : 49,8 Mb
Release : 2023-12-11
Category : Medical
ISBN : 9789240080959

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Future surveillance for epidemic and pandemic diseases by World Health Organization Pdf

Surveillance is a pillar of the public health response to epidemics and pandemics. Yet, gaps in surveillance, from the local to the global, continue to leave the world vulnerable to infectious hazards. To address these vulnerabilities, the health emergency preparedness, response, and resilience (HEPR) architecture calls for a new approach to future surveillance - collaborative surveillance - that aligns traditional tactics with new initiatives to safeguard health for all. This report reflects the input and advice on future surveillance of leading experts with different skills, worldviews and experiences who share a commitment to better prepare for future infectious hazards. It charts a course towards future surveillance and collaborative action.

Author : Homeland Security Council (U.S.)
Publisher : International Medical Publishing
Page : 0 pages
File Size : 52,8 Mb
Release : 2006
Category : Medical
ISBN : 1588088898

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National Strategy for Pandemic Influenza by Homeland Security Council (U.S.) Pdf

This Implementation Plan clarifies the roles and responsibilities of governmental and non-governmental entities, including Federal, State, local, and tribal authorities and regional, national, and international stakeholders, and provides preparedness guidance for all segments of society.--Preface.