Genomics Enabled Learning Health Care Systems

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Genomics-Enabled Learning Health Care Systems

Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
Genomics Enabled Learning Health Care Systems Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
Publisher : National Academies Press
Page : 116 pages
File Size : 45,7 Mb
Release : 2015-07-08
Category : Medical
ISBN : 9780309371155

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Genomics-Enabled Learning Health Care Systems by Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health Pdf

The inclusion of genomic data in a knowledge-generating health care system infrastructure is one promising way to harness the full potential of that information to provide better patient care. In such a system, clinical practice and research influence each other with the goal of improving the efficiency and effectiveness of disease prevention, diagnosis, and treatment. To examine pragmatic approaches to incorporating genomics in learning health care systems, the Institute of Medicine Roundtable on Translating Genomic-Based Research for Health hosted a workshop which convened a variety of stakeholder groups, including commercial developers, health information technology professionals, clinical providers, academic researchers, patient groups, and government and health system representatives, to present their perspectives and participate in discussions on maximizing the value that can be obtained from genomic information. The workshop examined how a variety of systems are capturing and making use of genomic data to generate knowledge for advancing health care in the 21st century. It also sought to evaluate the challenges, opportunities, and best practices for capturing or using genomic information in knowledge-generating health care systems. Genomics-Enabled Learning Health Care Systems summarizes the presentations and discussion of the workshop.

Genomics-enabled Learning Health Care Systems

Anonim
Genomics enabled Learning Health Care Systems Book PDF

Author : Anonim
Publisher : Unknown
Page : 95 pages
File Size : 42,5 Mb
Release : 2015
Category : Electronic
ISBN : OCLC:930014392

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Genomics-enabled Learning Health Care Systems by Anonim Pdf

The inclusion of genomic data in a knowledge-generating health care system infrastructure is one promising way to harness the full potential of that information to provide better patient care. In such a system, clinical practice and research influence each other with the goal of improving the efficiency and effectiveness of disease prevention, diagnosis, and treatment. To examine pragmatic approaches to incorporating genomics in learning health care systems, the Institute of Medicine Roundtable on Translating Genomic-Based Research for Health hosted a workshop which convened a variety of stakeholder groups, including commercial developers, health information technology professionals, clinical providers, academic researchers, patient groups, and government and health system representatives, to present their perspectives and participate in discussions on maximizing the value that can be obtained from genomic information. The workshop examined how a variety of systems are capturing and making use of genomic data to generate knowledge for advancing health care in the 21st century. It also sought to evaluate the challenges, opportunities, and best practices for capturing or using genomic information in knowledge-generating health care systems. Genomics-Enabled Learning Health Care Systems summarizes the presentations and discussion of the workshop.

Implementing and Evaluating Genomic Screening Programs in Health Care Systems

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health
Implementing and Evaluating Genomic Screening Programs in Health Care Systems Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health
Publisher : National Academies Press
Page : 151 pages
File Size : 42,6 Mb
Release : 2018-05-16
Category : Medical
ISBN : 9780309473446

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Implementing and Evaluating Genomic Screening Programs in Health Care Systems by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health Pdf

Genomic applications are being integrated into a broad range of clinical and research activities at health care systems across the United States. This trend can be attributed to a variety of factors, including the declining cost of genome sequencing and the potential for improving health outcomes and cutting the costs of care. The goals of these genomics-based programs may be to identify individuals with clinically actionable variants as a way of preventing disease, providing diagnoses for patients with rare diseases, and advancing research on genetic contributions to health and disease. Of particular interest are genomics- based screening programs, which will, in this publication, be clinical screening programs that examine genes or variants in unselected populations in order to identify individuals who are at an increased risk for a particular health concern (e.g., diseases, adverse drug outcomes) and who might benefit from clinical interventions. On November 1, 2017, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop to explore the challenges and opportunities associated with integrating genomics-based screening programs into health care systems. This workshop was developed as a way to explore the challenges and opportunities associated with integrating genomics-based programs in health care systems in the areas of evidence collection, sustainability, data sharing, infrastructure, and equity of access. This publication summarizes the presentations and discussions from the workshop.

Best Care at Lower Cost

Institute of Medicine,Committee on the Learning Health Care System in America
Best Care at Lower Cost Book PDF

Author : Institute of Medicine,Committee on the Learning Health Care System in America
Publisher : National Academies Press
Page : 437 pages
File Size : 40,5 Mb
Release : 2013-05-10
Category : Medical
ISBN : 9780309282819

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Best Care at Lower Cost by Institute of Medicine,Committee on the Learning Health Care System in America Pdf

America's health care system has become too complex and costly to continue business as usual. Best Care at Lower Cost explains that inefficiencies, an overwhelming amount of data, and other economic and quality barriers hinder progress in improving health and threaten the nation's economic stability and global competitiveness. According to this report, the knowledge and tools exist to put the health system on the right course to achieve continuous improvement and better quality care at a lower cost. The costs of the system's current inefficiency underscore the urgent need for a systemwide transformation. About 30 percent of health spending in 2009-roughly $750 billion-was wasted on unnecessary services, excessive administrative costs, fraud, and other problems. Moreover, inefficiencies cause needless suffering. By one estimate, roughly 75,000 deaths might have been averted in 2005 if every state had delivered care at the quality level of the best performing state. This report states that the way health care providers currently train, practice, and learn new information cannot keep pace with the flood of research discoveries and technological advances. About 75 million Americans have more than one chronic condition, requiring coordination among multiple specialists and therapies, which can increase the potential for miscommunication, misdiagnosis, potentially conflicting interventions, and dangerous drug interactions. Best Care at Lower Cost emphasizes that a better use of data is a critical element of a continuously improving health system, such as mobile technologies and electronic health records that offer significant potential to capture and share health data better. In order for this to occur, the National Coordinator for Health Information Technology, IT developers, and standard-setting organizations should ensure that these systems are robust and interoperable. Clinicians and care organizations should fully adopt these technologies, and patients should be encouraged to use tools, such as personal health information portals, to actively engage in their care. This book is a call to action that will guide health care providers; administrators; caregivers; policy makers; health professionals; federal, state, and local government agencies; private and public health organizations; and educational institutions.

Implementing and Evaluating Genomic Screening Programs in Health Care Systems

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health
Implementing and Evaluating Genomic Screening Programs in Health Care Systems Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health
Publisher : National Academies Press
Page : 151 pages
File Size : 52,5 Mb
Release : 2018-06-16
Category : Medical
ISBN : 9780309473415

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Implementing and Evaluating Genomic Screening Programs in Health Care Systems by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health Pdf

Genomic applications are being integrated into a broad range of clinical and research activities at health care systems across the United States. This trend can be attributed to a variety of factors, including the declining cost of genome sequencing and the potential for improving health outcomes and cutting the costs of care. The goals of these genomics-based programs may be to identify individuals with clinically actionable variants as a way of preventing disease, providing diagnoses for patients with rare diseases, and advancing research on genetic contributions to health and disease. Of particular interest are genomics- based screening programs, which will, in this publication, be clinical screening programs that examine genes or variants in unselected populations in order to identify individuals who are at an increased risk for a particular health concern (e.g., diseases, adverse drug outcomes) and who might benefit from clinical interventions. On November 1, 2017, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop to explore the challenges and opportunities associated with integrating genomics-based screening programs into health care systems. This workshop was developed as a way to explore the challenges and opportunities associated with integrating genomics-based programs in health care systems in the areas of evidence collection, sustainability, data sharing, infrastructure, and equity of access. This publication summarizes the presentations and discussions from the workshop.

The Learning Healthcare System

Institute of Medicine,Roundtable on Evidence-Based Medicine
The Learning Healthcare System Book PDF

Author : Institute of Medicine,Roundtable on Evidence-Based Medicine
Publisher : National Academies Press
Page : 374 pages
File Size : 53,8 Mb
Release : 2007-06-01
Category : Medical
ISBN : 9780309133937

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The Learning Healthcare System by Institute of Medicine,Roundtable on Evidence-Based Medicine Pdf

As our nation enters a new era of medical science that offers the real prospect of personalized health care, we will be confronted by an increasingly complex array of health care options and decisions. The Learning Healthcare System considers how health care is structured to develop and to apply evidence-from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement-and highlights opportunities for the creation of a sustainable learning health care system that gets the right care to people when they need it and then captures the results for improvement. This book will be of primary interest to hospital and insurance industry administrators, health care providers, those who train and educate health workers, researchers, and policymakers. The Learning Healthcare System is the first in a series that will focus on issues important to improving the development and application of evidence in health care decision making. The Roundtable on Evidence-Based Medicine serves as a neutral venue for cooperative work among key stakeholders on several dimensions: to help transform the availability and use of the best evidence for the collaborative health care choices of each patient and provider; to drive the process of discovery as a natural outgrowth of patient care; and, ultimately, to ensure innovation, quality, safety, and value in health care.

The Value of Genetic and Genomic Technologies

Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
The Value of Genetic and Genomic Technologies Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
Publisher : National Academies Press
Page : 109 pages
File Size : 50,9 Mb
Release : 2010-11-29
Category : Medical
ISBN : 9780309184991

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The Value of Genetic and Genomic Technologies by Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health Pdf

Knowing one's genetic disposition to a variety of diseases, including common chronic diseases, can benefit both the individual and society at large. The IOM's Roundtable on Translating Genomic-Based Research for Health held a workshop on March 22, 2010, to bring together diverse perspectives on the value of genetic testing, and to discuss its use in clinical practice.

Genomics

Hans C. Andersson, MD,Whitney Stewart
Genomics Book PDF

Author : Hans C. Andersson, MD,Whitney Stewart
Publisher : Millbrook Press
Page : 139 pages
File Size : 46,7 Mb
Release : 2020-09-01
Category : Young Adult Nonfiction
ISBN : 9781728411583

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Genomics by Hans C. Andersson, MD,Whitney Stewart Pdf

Over the past 50 years, scientists have made incredible progress in the application of genetic research to human health care and disease treatment. Innovative tools and techniques, including gene therapy and CRISPR-Cas9 editing, can treat inherited disorders that were previously untreatable, or prevent them from happening in the first place. You can take a DNA test to learn where your ancestors are from. Police officers can use genetic evidence to identify criminals—or innocents. And some doctors are using new medical techniques for unprecedented procedures. Genomics: A Revolution in Health and Disease Discovery delves into the history, science, and ethics behind recent breakthroughs in genetic research. Authors Whitney Stewart and Hans Andersson, MD, present fascinating case studies that show how real people have benefitted from genetic research. Though the genome remains full of mysteries, researchers and doctors are working hard to uncover its secrets and find the best ways to treat patients and cure diseases. The discoveries to come will inform how we target disease treatment, how we understand our health, and how we define our very identities.

Genomic and Precision Medicine

Geoffrey S. Ginsburg,Huntington F Willard
Genomic and Precision Medicine Book PDF

Author : Geoffrey S. Ginsburg,Huntington F Willard
Publisher : Academic Press
Page : 398 pages
File Size : 45,6 Mb
Release : 2016-11-22
Category : Science
ISBN : 9780128006566

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Genomic and Precision Medicine by Geoffrey S. Ginsburg,Huntington F Willard Pdf

Genomic and Precision Medicine: Translation and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care. The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care. Provides a comprehensive volume on the translation and implementation of biology into health care provision Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation Includes an up-to-date overview on major ‘translational events’ in genomic and personalized medicine, along with lessons learned

Educating Health Professionals in Genomic Medicine: Evidence-Based Strategies and Approaches

Sylvia Ann Metcalfe,Clara Gaff,Michael Dougherty
Educating Health Professionals in Genomic Medicine Evidence Based Strategies and Approaches Book PDF

Author : Sylvia Ann Metcalfe,Clara Gaff,Michael Dougherty
Publisher : Frontiers Media SA
Page : 129 pages
File Size : 46,7 Mb
Release : 2020-10-09
Category : Medical
ISBN : 9782889660599

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Educating Health Professionals in Genomic Medicine: Evidence-Based Strategies and Approaches by Sylvia Ann Metcalfe,Clara Gaff,Michael Dougherty Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics

Reed E. Pyeritz,Bruce R. Korf,Wayne W. Grody
Emery and Rimoin s Principles and Practice of Medical Genetics and Genomics Book PDF

Author : Reed E. Pyeritz,Bruce R. Korf,Wayne W. Grody
Publisher : Academic Press
Page : 412 pages
File Size : 48,8 Mb
Release : 2018-11-20
Category : Science
ISBN : 9780128126844

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Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics by Reed E. Pyeritz,Bruce R. Korf,Wayne W. Grody Pdf

For decades, Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics into medical practice. With detailed coverage in contributions from over 250 of the world’s most trusted authorities in medical genetics and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for medical students, residents, physicians, and researchers involved in the care of patients with genetic conditions. This comprehensive yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly. Clinical Principles and Applications thoroughly addresses general methods and approaches to genetic counseling, genetic diagnostics, treatment pathways, and drug discovery. Additionally, new and updated chapters explore the clinical implementation of genomic technologies, analytics, and therapeutics, with special attention paid to developing technologies, common challenges, patient care, and ethical and legal aspects. With regular advances in genomic technologies propelling precision medicine into the clinic, the seventh edition of Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for the health professionals and researchers. Fully revised and up-to-date, this new edition introduces genetic researchers, students, and health professionals to general principles of genetic counseling, genetic and genomic diagnostics, treatment pathways, drug discovery, and the application of genomic technologies, analytics, and therapeutics in clinical practice Examines key topics and developing areas within clinical genomics, including genetic evaluation of patients, clinical trials and drug discovery, genetic health records, cytogenetic analysis, diagnostic molecular genetics, small molecule genetic therapeutics, gene product replacement, clinical teratology, transplantation genetics, and ethical and legal aspects of genomic medicine Includes color images supporting identification, concept illustration, and method processing Features contributions by leading international researchers and practitioners of medical genetics

Clinical Decision Support and Beyond

Robert Greenes,Guilherme Del Fiol
Clinical Decision Support and Beyond Book PDF

Author : Robert Greenes,Guilherme Del Fiol
Publisher : Academic Press
Page : 880 pages
File Size : 53,8 Mb
Release : 2023-02-10
Category : Computers
ISBN : 9780323995771

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Clinical Decision Support and Beyond by Robert Greenes,Guilherme Del Fiol Pdf

Clinical Decision Support and Beyond: Progress and Opportunities in Knowledge-Enhanced Health and Healthcare, now in its third edition, discusses the underpinnings of effective, reliable, and easy-to-use clinical decision support systems at the point of care as a productive way of managing the flood of data, knowledge, and misinformation when providing patient care. Incorporating CDS into electronic health record systems has been underway for decades; however its complexities, costs, and user resistance have lagged its potential. Thus it is of utmost importance to understand the process in detail, to take full advantage of its capabilities. The book expands and updates the content of the previous edition, and discusses topics such as integration of CDS into workflow, context-driven anticipation of needs for CDS, new forms of CDS derived from data analytics, precision medicine, population health, integration of personal monitoring, and patient-facing CDS. In addition, it discusses population health management, public health CDS and CDS to help reduce health disparities. It is a valuable resource for clinicians, practitioners, students and members of medical and biomedical fields who are interested to learn more about the potential of clinical decision support to improve health and wellness and the quality of health care. Presents an overview and details of the current state of the art and usefulness of clinical decision support, and how to utilize these capabilities Explores the technological underpinnings for developing, managing, and sharing knowledge resources and deploying them as CDS or for other uses Discusses the current drivers and opportunities that are expanding the prospects for use of knowledge to enhance health and healthcare

The Thinking Healthcare System

Dominique J Monlezun
The Thinking Healthcare System Book PDF

Author : Dominique J Monlezun
Publisher : Elsevier
Page : 324 pages
File Size : 47,6 Mb
Release : 2023-02-17
Category : Medical
ISBN : 9780443189074

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The Thinking Healthcare System by Dominique J Monlezun Pdf

The Thinking Healthcare System: Artificial Intelligence and Human Equity is the first comprehensive book detailing the historical, global, and technical trends shaping the evolution of the modern healthcare system into its final form—an AI-driven thinking healthcare system, structured and functioning as a global digital health ecosystem. Written by the world’s first triple doctorate trained physician-data scientist and ethicist, and author of three AI textbooks and over 350 scientific and ethics papers, this indispensable resource makes sense of how technology, economics, and ethics are already producing the future’s health system—and how to ensure it works for every patient, community, and culture in our globalized, digitalized, and divided world. Providing clear descriptions and concrete examples, this book brings together AI-accelerated digital health ecosystems, data architecture, cloud and edge computing, precision medicine, public health, telemedicine, patient safety, health political economics, multicultural global ethics, blockchain, and quantum health computing, among other topics. Healthcare and business executives, clinicians, researchers, government leaders, policymakers, and students in the fields of healthcare management, data science, medicine, public health, informatics, health and public policy, political economics, and bioethics will find this book to be a groundbreaking resource on how to create, nourish, and lead AI-driven health systems for the future that can think, adapt, and so care in a manner worthy of the world’s patients. Details the first comprehensive, global, and multidisciplinary analysis of the AI-driven transformation of modern healthcare systems into their definitive digitalized form that will dominate the future Provides clear descriptions and concrete examples of AI-informed value-based healthcare, digital health ecosystems, data architecture, cloud and edge computing, precision medicine, public health, telemedicine, patient safety, health political economics, multicultural and embedded global ethics, blockchain, AI security, health security, digital twins, and quantum health computing Serves as a practical blueprint, roadmap, and system DNA for creating the future’s healthcare system that integrates efficiency and equity to accelerate the treatment (and in some cases even cures) for some of our world’s most urgent, immediate, and impending global health challenges and crises

Biomarker Tests for Molecularly Targeted Therapies

National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,Committee on Policy Issues in the Clinical Development and Use of Biomarkers for Molecularly Targeted Therapies
Biomarker Tests for Molecularly Targeted Therapies Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,Committee on Policy Issues in the Clinical Development and Use of Biomarkers for Molecularly Targeted Therapies
Publisher : National Academies Press
Page : 293 pages
File Size : 44,9 Mb
Release : 2016-07-30
Category : Medical
ISBN : 9780309381345

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Biomarker Tests for Molecularly Targeted Therapies by National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,Committee on Policy Issues in the Clinical Development and Use of Biomarkers for Molecularly Targeted Therapies Pdf

Every patient is unique, and the evolving field of precision medicine aims to ensure the delivery of the right treatment to the right patient at the right time. In an era of rapid advances in biomedicine and enhanced understanding of the genetic basis of disease, health care providers increasingly have access to advanced technologies that may identify molecular variations specific to an individual patient, which subsequently can be targeted for treatment. Known as biomarker tests for molecularly targeted therapies, these complex tests have the potential to enable the selection of the most beneficial treatment (and also to identify treatments that may be harmful or ineffective) for the molecular underpinnings of an individual patient's disease. Such tests are key to unlocking the promise of precision medicine. Biomarker tests for molecularly targeted therapies represent a crucial area of focus for developing methods that could later be applicable to other areas of precision medicine. The appropriate regulatory oversight of these tests is required to ensure that they are accurate, reliable, properly validated, and appropriately implemented in clinical practice. Moreover, common evidentiary standards for assessing the beneficial impact of biomarker-guided therapy selection on patient outcomes, as well as the effective collection and sharing of information related to those outcomes, are urgently needed to better inform clinical decision making. Biomarker Tests of Molecularly Targeted Therapies examines opportunities for and challenges to the use of biomarker tests to select optimal therapy and offers recommendations to accelerate progress in this field. This report explores regulatory issues, reimbursement issues, and clinical practice issues related to the clinical development and use of biomarker tests for targeting therapies to patients. Properly validated, appropriately implemented biomarker tests hold the potential to enhance patient care and improve outcomes, and therefore addressing the challenges facing such tests is critical.

Applied Genomics and Public Health

George P. Patrinos
Applied Genomics and Public Health Book PDF

Author : George P. Patrinos
Publisher : Academic Press
Page : 406 pages
File Size : 50,7 Mb
Release : 2019-11-13
Category : Science
ISBN : 9780128136966

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Applied Genomics and Public Health by George P. Patrinos Pdf

Applied Genomics and Public Health examines the interdisciplinary and growing area of how evidence-based genomic knowledge can be applied to public health, population health, healthcare and health policies. The book gathers experts from a variety of disciplines, including life sciences, social sciences, and health care to develop a comprehensive overview of the field. In addition, the book delves into subjects such as pharmacogenomics, genethics, big data, data translation and analysis, economic evaluation, genomic awareness and education, sociology, pricing and reimbursement, policy measures and economic evaluation in genomic medicine. This book is essential reading for researchers and students exploring applications of genomics to population and public health. In addition, it is ideal for those in the biomedical sciences, medical sociologists, healthcare professionals, nurses, regulatory bodies and health economists interested in learning more about this growing field. Explores the growing application of genomics to population and public health Features internationally renowned contributors from a variety of related fields Contains chapters on important topics such as genomic data sharing, genethics and public health genomics, genomics and sociology, and regulatory aspects of genomic medicine and pharmacogenomics