Genomics Of Bacterial Metal Resistance

Author : Alessio Mengoni,Carlo Viti,Raymond J. Turner,Li-Nan Huang
Publisher : MDPI
Page : 238 pages
File Size : 51,8 Mb
Release : 2021-03-03
Category : Science
ISBN : 9783036503905

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Genomics of Bacterial Metal Resistance by Alessio Mengoni,Carlo Viti,Raymond J. Turner,Li-Nan Huang Pdf

The importance of understanding metal–microbe interactions underlies a number of social–economic issues in the world. The antimicrobial resistance era has created a need for novel antimicrobials and within this fieldm metal and metalloid ions are promising solutions. Pollution sites, either co-contaminated with metals or with metals as the sole pollutant, contain microbes that are present as key participants, with both of these issues habing links to agriculture. Microbes also play key roles in the global geochemical cycle of many elements. Such statements solidify the need to understand metal–microbe interactions. Given that genomics has arguably become the most useful tool in biology, the application of this technology within the field of understanding metal resistance comes as no surprise. Whilst by no means comprehensive, this book provides examples of the applications of genomic approaches in the study of metal–microbe interactions. Here, we present a collection of manuscripts that highlights some present directions in the field. The book starts with a collection of three papers evaluating aspects of the genomics of the archetype metal resistant bacteria, Cuprividus metallidurans. This is followed by four studies that evaluate the mechanisms of metal resistance. The next two papers assess metal resistance in agricultural related situations, including a review on metal resistance in Listeria. The book concludes with a review on metal phytoremediation via Rhizobia and two subsequent studies of metal biotechnology relevance.

Author : Raymond J. Turner,Alessio Mengoni,Carlo Viti,Li-Nan Huang
Publisher : Unknown
Page : 238 pages
File Size : 50,5 Mb
Release : 2021
Category : Electronic
ISBN : 3036503919

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Genomics of Bacterial Metal Resistance by Raymond J. Turner,Alessio Mengoni,Carlo Viti,Li-Nan Huang Pdf

The importance of understanding metal-microbe interactions underlies a number of social-economic issues in the world. The antimicrobial resistance era has created a need for novel antimicrobials and within this fieldm metal and metalloid ions are promising solutions. Pollution sites, either co-contaminated with metals or with metals as the sole pollutant, contain microbes that are present as key participants, with both of these issues habing links to agriculture. Microbes also play key roles in the global geochemical cycle of many elements. Such statements solidify the need to understand metal-microbe interactions. Given that genomics has arguably become the most useful tool in biology, the application of this technology within the field of understanding metal resistance comes as no surprise. Whilst by no means comprehensive, this book provides examples of the applications of genomic approaches in the study of metal-microbe interactions. Here, we present a collection of manuscripts that highlights some present directions in the field. The book starts with a collection of three papers evaluating aspects of the genomics of the archetype metal resistant bacteria, Cuprividus metallidurans. This is followed by four studies that evaluate the mechanisms of metal resistance. The next two papers assess metal resistance in agricultural related situations, including a review on metal resistance in Listeria. The book concludes with a review on metal phytoremediation via Rhizobia and two subsequent studies of metal biotechnology relevance.

Author : Max Mergeay,Rob Van Houdt
Publisher : Springer
Page : 89 pages
File Size : 46,8 Mb
Release : 2015-07-09
Category : Science
ISBN : 9783319205946

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Metal Response in Cupriavidus metallidurans by Max Mergeay,Rob Van Houdt Pdf

This book is the first volume of a two-volume set summarizing 40 years of key research findings directly related to metal-resistant Cupriavidus/Ralstonia (Betaproteobacteria). In this first volume, the historical and geographical context of these bacteria, which are mostly found in industrial and polluted environments linked to zinc and other non-ferrous metallurgy, is sketched to illustrate the interactions between bacteria and human activities and the possible evolutionary consequences on bacterial genomes especially as far as the association of metal resistance genes with mobile genetic elements is concerned. A detailed description of the response and underlying genetic determinants of type strain Cupriavidus metallidurans CH34 to a variety of metals is provided. With high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification carried by its megaplasmids pMOL28 and pMOL30. This description is complemented with the genomic context of the metal response genes in C. metallidurans CH34 with a focus on its mobilome including insertion sequence elements, transposons, integrative and conjugative elements and genomic islands. In addition, in the second volume, structural and catalytic data from bacterial primary and secondary transporters (P-ATPases, tripartite chemiosmotic cation/proton efflux systems, cation diffusion facilitators, Major Facilitator Superfamily and some minor categories) are outlined and detailed for the corresponding C. metallidurans proteins. The available three-dimensional structures of C. metallidurans proteins are reviewed in detail, including RND and membrane fusion proteins (from tripartite chemiosmotic cation/proton efflux systems), sigma and anti-sigma regulatory proteins of the cnr efflux system (resistance to cobalt and nickel) and various periplasmic proteins mainly involved in the response to copper and mercury.

Author : Wolfgang Banzhaf,Betty H.C. Cheng,Kalyanmoy Deb,Kay E. Holekamp,Richard E. Lenski,Charles Ofria,Robert T. Pennock,William F. Punch,Danielle J. Whittaker
Publisher : Springer Nature
Page : 607 pages
File Size : 41,6 Mb
Release : 2020-07-08
Category : Computers
ISBN : 9783030398316

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Evolution in Action: Past, Present and Future by Wolfgang Banzhaf,Betty H.C. Cheng,Kalyanmoy Deb,Kay E. Holekamp,Richard E. Lenski,Charles Ofria,Robert T. Pennock,William F. Punch,Danielle J. Whittaker Pdf

This edited research monograph brings together contributions from computer scientists, biologists, and engineers who are engaged with the study of evolution and how it may be applied to solve real-world problems. It also serves as a Festschrift dedicated to Erik D. Goodman, the founding director of the BEACON Center for the Study of Evolution in Action, a pioneering NSF Science and Technology Center headquartered at Michigan State University. The contributing authors are leading experts associated with the center, and they serve in top research and industrial establishments across the US and worldwide. Part I summarizes the history of the BEACON Center, with refreshingly personal chapters that describe Erik's working and leadership style, and others that discuss the development and successes of the center in the context of research funding, projects, and careers. The chapters in Part II deal with the evolution of genomes and evolvability. The contributions in Part III discuss the evolution of behavior and intelligence. Those in Part IV concentrate on the evolution of communities and collective dynamics. The chapters in Part V discuss selected evolutionary computing applications in domains such as arts and science, automated program repair, cybersecurity, mechatronics, and genomic prediction. Part VI deals with evolution in the classroom, using creativity in research, and responsible conduct in research training. The book concludes with a special chapter from Erik Goodman, a short biography that concentrates on his personal positive influences and experiences throughout his long career in academia and industry.

Author : Janice P. L. Kenney,Harish Veeramani,Daniel S. Alessi
Publisher : Cambridge University Press
Page : 429 pages
File Size : 45,7 Mb
Release : 2019-07-18
Category : Nature
ISBN : 9781107070332

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Analytical Geomicrobiology by Janice P. L. Kenney,Harish Veeramani,Daniel S. Alessi Pdf

A comprehensive handbook outlining state-of-the-art analytical techniques used in geomicrobiology, for advanced students, researchers and professional scientists.

Author : Daad Saffarini
Publisher : Springer
Page : 92 pages
File Size : 46,5 Mb
Release : 2015-05-20
Category : Science
ISBN : 9783319185705

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Bacteria-Metal Interactions by Daad Saffarini Pdf

This book provides a detailed description and analysis of the reduction and metabolism of metals and metalloids by sulfate reducing bacteria. The molecular mechanisms of bacterial resistance to copper are examined as well as extracellular electron transfer and bacterial metal oxide respiration. Furthermore, in this book enrichment, isolation, and physiology of magnetotactic bacteria are discussed. The interactions of bacteria with metals in natural environments and their role in metal cycling have been studied for decades. Advances in studies of bacteria-metal interactions identified numerous important aspects of these interactions, such as bioremediation of metal-contaminated environments, the role of metals in redox reactions and other cellular functions, as well as the role of metals in toxicity and infection. Microbiologists, environmental scientists, and students interested in microbe interactions with metals and their effect on the environment and their application in biotechnology will be interested in the topics discussed in the book.

Author : Rob Van Houdt,Jon L. Hobman,Raymond J. Turner,Jean-Yves Matroule
Publisher : Frontiers Media SA
Page : 168 pages
File Size : 54,6 Mb
Release : 2022-05-03
Category : Science
ISBN : 9782889760596

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Metal Resistance in Microorganisms by Rob Van Houdt,Jon L. Hobman,Raymond J. Turner,Jean-Yves Matroule Pdf

Author : Adam P. Roberts,Peter Mullany
Publisher : CRC Press
Page : 456 pages
File Size : 42,8 Mb
Release : 2022-03-07
Category : Science
ISBN : 9781000724707

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Bacterial Integrative Mobile Genetic Elements by Adam P. Roberts,Peter Mullany Pdf

As our understanding of mobile genetic elements continues to grow we are gaining a deeper appreciation of their importance in shaping the bacterial genome and in the properties they confer to their bacterial hosts. These include, but are by no means limited to, resistance to antibiotics, and heavy metals, toxin production and increased virulence, production of antibiotics and the ability to utilize a diverse range of metabolic substrates. We are also gaining an understanding of diversity of these elements and their interactions with each other; a property which continually complicates any attempt to classify them. We are learning more about the molecular mechanisms by which they translocate to new genomic sites both within genomes and between different bacteria. This book provides a timely, state of the art update on the properties of an important selection of different bacterial integrative mobile genetic elements and the myriad of different ways in which they move and influence the biology of the host bacterium. The chapters are all written by authors who have undertaken pioneering work in their respective fields, making this book vital reading for all who are interested in the biology of bacteria and the mobile elements they carry.

Author : Guy Vandenbussche,Max Mergeay,Rob Van Houdt
Publisher : Springer
Page : 70 pages
File Size : 44,9 Mb
Release : 2015-07-10
Category : Science
ISBN : 3319206230

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Metal Response in Cupriavidus metallidurans by Guy Vandenbussche,Max Mergeay,Rob Van Houdt Pdf

This book is the second volume of a two-volume set summarizing 40 years of key research findings directly related to metal-resistant Cupriavidus/Ralstonia (Betaproteobacteria). In this second volume, the structural and catalytic data from bacterial primary and secondary transporters (P-ATPases, tripartite chemiosmotic cation/proton efflux systems, cation diffusion facilitators, Major Facilitator Superfamily and some minor categories) are outlined and detailed for the corresponding C. metallidurans proteins. The available three-dimensional structures are reviewed in detail, including RND and membrane fusion proteins (from tripartite chemiosmotic cation/proton efflux systems), sigma and anti-sigma regulatory proteins of the cnr efflux system (resistance to cobalt and nickel) and various periplasmic proteins mainly involved in the response to copper and mercury. In addition, the first volume sketches the historical and geographical context of these bacteria, which are mostly found in industrial and polluted environments linked to zinc and other non-ferrous metallurgy, to illustrate the interactions between bacteria and human activities and the possible evolutionary consequences on bacterial genomes especially as far as the association of metal resistance genes with mobile genetic elements is concerned. It provides a detailed description of the response and underlying genetic determinants of type strain Cupriavidus metallidurans CH34 to a variety of metals. With high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification carried by its megaplasmids pMOL28 and pMOL30. This description is complemented with the genomic context of the metal response genes in C. metallidurans CH34 with a focus on its mobilome including insertion sequence elements, transposons, integrative and conjugative elements and genomic islands.

Author : Dietrich H. Nies,Simon Silver
Publisher : Springer Science & Business Media
Page : 455 pages
File Size : 54,5 Mb
Release : 2007-03-24
Category : Science
ISBN : 9783540697718

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Molecular Microbiology of Heavy Metals by Dietrich H. Nies,Simon Silver Pdf

This book covers allocation of metals in cells, metal transporter, storage and metalloregulatory proteins, cellular responses to metal ion stress, transcription of genes involved in metal ion homeostasis, uptake of essential metals, metal efflux and other detoxification mechanisms. The book also discusses metal bioreporters for the nanomolar range of concentration and tools to address the metallome. In addition, coverage details specific metals.

Author : Edward Schwartz
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 45,9 Mb
Release : 2009-01-29
Category : Science
ISBN : 9783540854678

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Microbial Megaplasmids by Edward Schwartz Pdf

Megaplasmids are extrachromosomal genetic elements in the size range of 100 kb and larger. They are found in physiologically and phylogenetically diverse groups of bacteria and archaea. By definition, megaplasmids are not essential for the viability of their hosts under all growth conditions, but paradoxically many megaplasmids carry the genetic information for the defining and characteristic traits of the organism in which they reside. Microbial Megaplasmids reviews our knowledge of the extensively studied representatives, such as the catabolic plasmids of the pseudomonads, the rhizobial Sym plasmids, the Ti plasmids of the genus Agrobacterium and the giant enterobacterial virulence plasmids. It also presents snapshots of more recently discovered megaplasmids. The contribution of megaplasmids to the biology of their hosts is described, highlighting the interactions between megaplasmid and chromosomal genes.

Author : Indra Mani,Vijai Singh,Khalid J. Alzahrani,Dinh-Toi Chu
Publisher : Springer Nature
Page : 369 pages
File Size : 52,6 Mb
Release : 2023-03-31
Category : Science
ISBN : 9789811993428

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Microbial Genomic Islands in Adaptation and Pathogenicity by Indra Mani,Vijai Singh,Khalid J. Alzahrani,Dinh-Toi Chu Pdf

This book elucidates the role of microbial genomic islands (GEIs) in genome stability, plasticity, evolutionary adaptation, and pathogenicity in the bacterial population. The initial chapters of the book present tools, including bioinformatics, artificial intelligence, machine learning, next-generation sequencing, and molecular biology techniques, for the analysis of the genomic islands. The book also discusses the importance of genomic islands in bacterial speciation, acquisition of genes related to resistome, nitrogen fixation, mobilomes, and nutritional fitness and adaptation. It provides recent advances in understanding microbial genomic islands' distribution, evolution, and mechanistic modes of behavior in pathogenic, non-pathogenic, and environmental species. This book is a valuable source for beginners in molecular microbiology, students, researchers, clinicians, stakeholders, and policymakers interested in understanding the role of GEIs in the adaptive evolution of microorganisms. ​

Author : Vijay Tripathi,Pradeep Kumar,Pooja Tripathi,Amit Kishore,Madhu Kamle
Publisher : Springer Nature
Page : 377 pages
File Size : 49,9 Mb
Release : 2019-11-23
Category : Science
ISBN : 9789813298606

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Microbial Genomics in Sustainable Agroecosystems by Vijay Tripathi,Pradeep Kumar,Pooja Tripathi,Amit Kishore,Madhu Kamle Pdf

Today, microbiology is a rapidly growing discipline in the life sciences, and the technologies are evolving on a virtually daily basis. Next-generation sequencing technologies have revolutionized microbial analysis, and can help us understand the biology and genomic diversity of various bacterial species with significant impacts on agro-ecosystems. In addition, advances in molecular biology and microbiology techniques hold the potential to improve the productivity and sustainability of agriculture and forestry. This new volume addresses the role of microbial genomics in understanding the living systems that exist in the soil and their interactions with plants, an aspect that is also important for crop improvement. The topics covered focus on a deeper and clearer understanding of how microbes cause diseases, the genome-based development of novel antibacterial agents and vaccines, and the role of microbial genomics in crop improvement and agroforestry. Given its scope, the book offers a valuable resource for researchers and students of agriculture and infectious biology.

Author : Stefan Schwarz,Lina Maria Cavaco,Jianzhong Shen
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 43,6 Mb
Release : 2020-07-02
Category : Medical
ISBN : 9781555819804

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Antimicrobial Resistance in Bacteria from Livestock and Companion Animals by Stefan Schwarz,Lina Maria Cavaco,Jianzhong Shen Pdf

The global spread of antimicrobial-resistant pathogenic bacteria is a continuing challenge to the health care of humans and domesticated animals. With no new agents on the horizon, it is imperative to use antimicrobial agents wisely to preserve their future efficacy. Led by Editors Stefan Schwarz, Lina Maria Cavaco, and Jianzhong Shen with Frank Møller Aarestrup, an international team of experts in antimicrobial resistance of livestock and companion animals has created this valuable reference for veterinary students and practitioners as well as researchers and decision makers interested in understanding and preventing antimicrobial resistance.

Author : Jerome O. Nriagu,Eric P. Skaar
Publisher : MIT Press
Page : 501 pages
File Size : 49,7 Mb
Release : 2024-06-11
Category : Medical
ISBN : 9780262552486

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Trace Metals and Infectious Diseases by Jerome O. Nriagu,Eric P. Skaar Pdf

Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang