Germinal Centers In Immune Responses

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Germinal Centers in Immune Responses

Author : Universität Bern. Pathologisches Institut
Publisher : Springer
Page : 524 pages
File Size : 45,5 Mb
Release : 1967
Category : Medical
ISBN : UCAL:B3721973

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Germinal Centers in Immune Responses by Universität Bern. Pathologisches Institut Pdf

In the last few years the study of germinal centers of the lymphoid tissue has progressed at an accelerated pace. Questions about their role and their significance in immune responses that could not be answered, mainly because of tedmicallimitations, are presently approached experimentally from many different directions. Hypotheses, some more than half a century old, receive renewed attention. At this time, members of the Biology Division, Oak Ridge National Laboratory, U.S.A., and of the Institute of Pathology, University of Bern, Switzerland, decided to bring together workers interested in the field. The Conference was held in Bern, June 22-24, 1966, and included fifty-seven contributions which were discussed at length. The range of interest extended from phylogenesis and anatomy to studies on cell proliferation, immunohistochemistry, cancer research and radiobiology. The aim of this broad coverage was to combine all available information on the role of germinal centers in immune responses in a single package, instead of leaving it scattered around in reports dealing with divergent immunological problems. This attempt is reflected in the present book. A rather large space has been devoted to the lively discussions which followed the reports, the volume of most of which had been voluntarily limited. The discussions are not reported verbatim but care has been taken to insure neutrality and objectivity in the necessary adaptation of the shortened transcription. We have been very fortunate indeed, to have Drs.

Germinal Centers in Immune Responses

Author : Hans Cottier,N. Odartchenko,R. Schindler,C.C. Gongdon
Publisher : Springer Science & Business Media
Page : 514 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642868375

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Germinal Centers in Immune Responses by Hans Cottier,N. Odartchenko,R. Schindler,C.C. Gongdon Pdf

In the last few years the study of germinal centers of the lymphoid tissue has progressed at an accelerated pace. Questions about their role and their significance in immune responses that could not be answered, mainly because of tedmicallimitations, are presently approached experimentally from many different directions. Hypotheses, some more than half a century old, receive renewed attention. At this time, members of the Biology Division, Oak Ridge National Laboratory, U.S.A., and of the Institute of Pathology, University of Bern, Switzerland, decided to bring together workers interested in the field. The Conference was held in Bern, June 22-24, 1966, and included fifty-seven contributions which were discussed at length. The range of interest extended from phylogenesis and anatomy to studies on cell proliferation, immunohistochemistry, cancer research and radiobiology. The aim of this broad coverage was to combine all available information on the role of germinal centers in immune responses in a single package, instead of leaving it scattered around in reports dealing with divergent immunological problems. This attempt is reflected in the present book. A rather large space has been devoted to the lively discussions which followed the reports, the volume of most of which had been voluntarily limited. The discussions are not reported verbatim but care has been taken to insure neutrality and objectivity in the necessary adaptation of the shortened transcription. We have been very fortunate indeed, to have Drs.

Janeway's Immunobiology

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 41,5 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Lymphatic Tissue and Germinal Centers in Immune Response

Author : L. Fiore-Donati
Publisher : Springer Science & Business Media
Page : 529 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468431926

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Lymphatic Tissue and Germinal Centers in Immune Response by L. Fiore-Donati Pdf

The Biology of Germinal Centers in Lymphoid Tissue

Author : G. Jeanette Thorbecke,Vincent K. Tsiagbe
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 43,9 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662131411

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The Biology of Germinal Centers in Lymphoid Tissue by G. Jeanette Thorbecke,Vincent K. Tsiagbe Pdf

This book meets the demand of a recent surge of interest in germinal centers, the foci of antigen-induced, rapidly proliferating B lymphocytes, representing sites in mammalian lymphoid tissue where memory B cells are generated. Various aspects of the generation of germinal centers, the somatic hypermutation process and the cellular interactions involved in the selection process are discussed in detail. A chapter on germinal center-derived lymphomas completes the treatment.

Morphological and Functional Aspects of Immunity

Author : K. Lindahl-Kiessling
Publisher : Springer Science & Business Media
Page : 684 pages
File Size : 44,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461590118

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Morphological and Functional Aspects of Immunity by K. Lindahl-Kiessling Pdf

The Third International Conference on Lymphatic Tissue and Germinal Centers in Immune Reactions was held at the University of Uppsala in Sweden, September 1-4, 1970. The conference is obliged to Professor K. E. Fichtelius for his initiative in establishing the meeting, as well as for the assistance of his staff at the Department of Histology in organizing the meetings. At the University of Uppsala inquiries into the lymphatic system go back to the 17th century and are marked by milestones, such as Olof Rudbeck's discovery of the thoracic duct in 1651 and August Hammar's fundamental work on the thymus in the beginning of this century. So one is justified to s~ that the conference gathered on historical ground. The organizing committee, naturally, hopes that the achievements presented at the conference will contribute to and provide significant advances in the history of lymphatic research. The material presented in this volume displ~s a great diversity of methods and the ingenuity of different investigators in their experimental designs. It is also apparent that contemporary research on lymphatic tissues or cells no longer recognizes the artificial borderline of morphologic ve~8U8 functional. It has become a multi disciplinary affair in which an increasing number of different specialists are working closely together. Apparently this is one reason why so many new and important discoveries have been made recently.

B Cell Receptor Signaling

Author : Tomohiro Kurosaki,Jürgen Wienands
Publisher : Springer
Page : 231 pages
File Size : 40,5 Mb
Release : 2015-12-26
Category : Medical
ISBN : 9783319261331

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B Cell Receptor Signaling by Tomohiro Kurosaki,Jürgen Wienands Pdf

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

Encyclopedic Reference of Immunotoxicology

Author : Hans-Werner Vohr
Publisher : Springer
Page : 0 pages
File Size : 44,7 Mb
Release : 2005-06-01
Category : Medical
ISBN : 3540441727

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Encyclopedic Reference of Immunotoxicology by Hans-Werner Vohr Pdf

This work provides rapid access to focused information on topics of Immunotoxicology not only for scientists and those dealing with laboratory aspects but also for lecturers and advanced students. Over 200 contributing authors – including many of the world’s top specialists – have contributed full essays on all relevant topics, supplemented by keyword definitions of related terms. Full essays are structured uniformly to provide reader-friendly information on all aspects of Immunotoxicology, including methods of testing and analysis, characteristics of substances, the regulatory environment and the relevance of these to humans. The single A–Z format of both types of entry makes this reference book very easy to use. The Encyclopedic Reference of Immunotoxicology is intended to be a comprehensive work of reference which will provide easy access to relevant information in the fast-growing field of Immunotoxicology.

Microenvironmental Aspects of Immunity

Author : B. Jankovic
Publisher : Springer Science & Business Media
Page : 710 pages
File Size : 46,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461590170

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Microenvironmental Aspects of Immunity by B. Jankovic Pdf

Immune Reactivity of Lymphocytes

Author : Michael Feldman
Publisher : Springer Science & Business Media
Page : 698 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461343554

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Immune Reactivity of Lymphocytes by Michael Feldman Pdf

The area of the Lake of Galilee, which is the site of the Fifth Confer ence on Lymphatic Tissues and Germinal Centers, has been a germinal center of dramatic events in human history. Thus, some two million years ago, it seems to have harbored an important phase of human evolu tion, when the descendants of the African Australopithecus migrated north wards, attempting to become Homo sapiens. Two thousand years ago, this very place was a germinal center for a new religion which determined some of the most important components of the history of western civilization. This may have been the first significant contribution of the people of the Lake of Galilee area to the world of ideas and values. More recently, some 70 years ago, this very place was a germinal center for a great ex periment aimed at the translation into actual reality of ethical and social values, by the establishment of the first kibbutz in Israel on this shore. We, therefore, hoped that by selecting this place for the Fifth Germinal Centers Meeting we could expect the inspiration of the site to generate new concepts and views.

Histophysiology of the Immune System

Author : Sigbjørn Fossum,Bent Rolstad
Publisher : Springer Science & Business Media
Page : 860 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468455359

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Histophysiology of the Immune System by Sigbjørn Fossum,Bent Rolstad Pdf

The 9th International Conference on Lymphatic Tissues and Germinal Centres in Immune Reactions was held in Oslo, 9-14 August, 1987. These conferen ces, by the regular devotees just referred to as the germinal centre con ferences or GCC, have been held regularly at roughly three-year intervals since 1966. The credo of these conferences is "in vivo veritas", signifying that investigating components, like molecules and cells, only gives partial truth. The components must ultimately be explored in their natural con text, to see how they interact with other parts and are integrated to a whole. To the biologist it is obvious that the world must be investigated at many different levels of organization. At each level the patterns observed represent just some of many possible ways of putting together the elements of the lower levels. These patterns are not predetermined, but the results of evolution, i.e. of a history in which stochastic processes play a major role. The organic world can therefore not be torn apart and then reconstructed from basic principles alone. This realization is often expressed as the whole being more than the sum of its parts.

Function and Structure of the Immune System

Author : Wolfgang Muller-Ruchholtz
Publisher : Springer Science & Business Media
Page : 802 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461591016

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Function and Structure of the Immune System by Wolfgang Muller-Ruchholtz Pdf

This volume represents the Proceedings of the VI. International Conference on Lymphatic Tissues and Germinal Centers in Immune Reactions. The Meeting took place in Damp, a small resort with great facilities on the shores of the Baltic Sea near Kiel on June 11 - 16, 1978. Both, the Genius loci and the God of Weathers were charming enough to stimulate the many participants from all continents and also to facilitate the establishment and/or maintenance of close contacts outside the sessions. The organizers of this Conference have tried to remind the scientific community of the necessity to (re-) consider sufficiently the role of morphological studies for a thorough understanding of immune reactions. Furthermore, they have been anxious to emphasize a closer connection between analytical work and biological relevance of the phenomena observed. Thus, three main trends were formulated: (1) connections and correlations between function and structure, (2) in-vivo relevance of in-vitro models and (3) clinical relevance of experimental models. The programme, induced by these outlines and reflected by the contents of this volume, covers a remarkably broad field of interests and activities. It is set in order under nine session chapters. Each of them may allow the reader to answer for himself the question how far the above trends have been recognized, especially when considering the variety of new methodological approaches reported.

In Vivo Immunology

Author : Paul Nieuwenhuis
Publisher : Springer Science & Business Media
Page : 812 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468490664

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In Vivo Immunology by Paul Nieuwenhuis Pdf

In 1966, the first Germinal Centre Conference was held in Bern, Switzerland, as a result of an initiative from C. C. Longdon of Oak Ridge, Tennessee and H. Cottier of Bern. Fifteen years later, in June of 1981, the 7th conference in this series was held in Groningen, the Netherlands. At this "International Conference on Lymphatic Tissues and Germinal Centers in Immune Reactions," instead of focusing on germinal centres only, the intricate relationships between various constituents of the lympho-myeloid complex consti tuted the theme of the meeting. As Yoffee stated in 1966, "Perhaps we should consider not only the germinal centre itself but the surrounding tissue as well. " Over the years, these conferences have brought together a small but dedicated group of scientists, sharing (1) a fundamental interest in the physiology of the lymphoid system proper, and (2) the recognition that, only in the in vivo situation can the final answers be obtained, however ingeniously in vitro experiments may mimic reality. In 1966, the conference lasted three days and included 57 contributions "which were discussed at length. " The present conference accomodated 62 free papers and 64 poster presentations as well as some 24 additional abstracts selected from more than 200 submissions. Prominent among the selection criteria was the adage "in vivo veritas. " This volume represents the presentations from the 1981 Germinal Centre Conference.