Glutathione System And Oxidative Stress In Health And Disease

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Glutathione System and Oxidative Stress in Health and Disease

Anonim
Glutathione System and Oxidative Stress in Health and Disease Book PDF

Author : Anonim
Publisher : BoD – Books on Demand
Page : 140 pages
File Size : 49,9 Mb
Release : 2020-08-26
Category : Science
ISBN : 9781838801250

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Glutathione System and Oxidative Stress in Health and Disease by Anonim Pdf

The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.

Glutathione in Health and Disease

Pinar Erkekoglu,Belma Kocer-Gumusel
Glutathione in Health and Disease Book PDF

Author : Pinar Erkekoglu,Belma Kocer-Gumusel
Publisher : BoD – Books on Demand
Page : 94 pages
File Size : 48,8 Mb
Release : 2018-10-31
Category : Science
ISBN : 9781789842753

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Glutathione in Health and Disease by Pinar Erkekoglu,Belma Kocer-Gumusel Pdf

Reduced glutathione (GSH) is the most important thiol in living organisms. It is the key component of antioxidant system and serves as a free radical scavenger. There is a cycle of GSH in biological systems and this cycle provides higher intracellular levels of GSH. GSH depletion and apparent oxidative stress may cause toxicity and can affect the general well-being of the organism. GSH was shown to be preventive against aging, cancer, heart disease, infections and dementia. This book is mainly focused on GSH in health and disease. The readers will gain qualified scientific knowledge on the diverse functions of GSH, the importance of GSH status against oxidative stress and the interaction between GSH and nervous system-related infections from this book.

Glutathione in Health and Disease

Belma Kocer-Gumusel,Pinar Erkekoglu
Glutathione in Health and Disease Book PDF

Author : Belma Kocer-Gumusel,Pinar Erkekoglu
Publisher : Unknown
Page : 92 pages
File Size : 55,5 Mb
Release : 2018
Category : Biology (General)
ISBN : 178984276X

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Glutathione in Health and Disease by Belma Kocer-Gumusel,Pinar Erkekoglu Pdf

Reduced glutathione (GSH) is the most important thiol in living organisms. It is the key component of antioxidant system and serves as a free radical scavenger. There is a cycle of GSH in biological systems and this cycle provides higher intracellular levels of GSH. GSH depletion and apparent oxidative stress may cause toxicity and can affect the general well-being of the organism. GSH was shown to be preventive against aging, cancer, heart disease, infections and dementia. This book is mainly focused on GSH in health and disease. The readers will gain qualified scientific knowledge on the diverse functions of GSH, the importance of GSH status against oxidative stress and the interaction between GSH and nervous system-related infections from this book.

Oxidative Stress and Oxygen Radicals

Michael Breitenbach,Peter Eckl
Oxidative Stress and Oxygen Radicals Book PDF

Author : Michael Breitenbach,Peter Eckl
Publisher : MDPI
Page : 542 pages
File Size : 53,6 Mb
Release : 2018-09-27
Category : Electronic book
ISBN : 9783038421733

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Oxidative Stress and Oxygen Radicals by Michael Breitenbach,Peter Eckl Pdf

This book is a printed edition of the Special Issue "Oxidative Stress and Oxygen Radicals" that was published in Biomolecules

Glutathione and Sulfur Amino Acids in Human Health and Disease

Roberta Masella,Giuseppe Mazza
Glutathione and Sulfur Amino Acids in Human Health and Disease Book PDF

Author : Roberta Masella,Giuseppe Mazza
Publisher : John Wiley & Sons
Page : 626 pages
File Size : 51,8 Mb
Release : 2009-08-06
Category : Technology & Engineering
ISBN : 9780470475966

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Glutathione and Sulfur Amino Acids in Human Health and Disease by Roberta Masella,Giuseppe Mazza Pdf

The complex roles of glutathione and sulfur amino acids in human health Glutathione (γ-L-glutamyl-L-cysteinylglycine, GSH) is a major antioxidant acting as a free radical scavenger that protects the cell from reactive oxygen species (ROS). Sulfur amino acids (SAAs), such as methionine and cysteine, play a critical role in the maintenance of health. GSH depletion as well as alterations of SAA metabolism are linked to a host of disease states including liver cirrhosis, various pulmonary diseases, myocardial ischemia and reperfusion injury, aging, Parkinson's disease, Alzheimer's disease, sepsis, and others. This book provides researchers with a comprehensive review of the biochemistry, absorption, metabolism, biological activities, disease prevention, and health promotion of glutathione and sulfur amino acids. The twenty-two chapters explore such topics as: Chemistry, absorption, transport, and metabolism of GSH and sulfur amino acids Antioxidant and detoxification properties of GSH and sulfur amino acids, highlighting the enzymatic systems involved in antioxidant defenses Biological activities of GSH and sulfur amino acids and their role in modulating cell processes Role of GSH and sulfur amino acid deficiency and alteration in the onset of diseases and in aging Protective effects exerted by GSH and sulfur amino acids when used as drugs, functional foods, and nutraceuticals in humans and animals Special attention is paid to the molecular mechanisms for the modulation of transcription factors and enzyme activities, as well as the nutritional and therapeutic significance of dietary sulfur amino acids as shown in human and animal models. With more than 2,000 scientific references, this book provides food scientists, nutritionists, biochemists, food technologists, chemists, molecular biologists, and public health professionals with a comprehensive and up-to-date examination of glutathione and sulfur amino acids in human health and disease.

Oxidative Stress, Inflammation, and Health

Young-Joon Surh
Oxidative Stress Inflammation and Health Book PDF

Author : Young-Joon Surh
Publisher : CRC Press
Page : 660 pages
File Size : 49,7 Mb
Release : 2005-05-24
Category : Science
ISBN : 9781420028256

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Oxidative Stress, Inflammation, and Health by Young-Joon Surh Pdf

Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-analyzing the implications of oxidative stress and inflammatory damage in the pathogenesis of human disorders such as cancer, neurodegenerative disease, and diabetes.

The Glutathione Revolution

Nayan Patel
The Glutathione Revolution Book PDF

Author : Nayan Patel
Publisher : Hachette Go
Page : 288 pages
File Size : 40,8 Mb
Release : 2020-09-08
Category : Health & Fitness
ISBN : 9780306873959

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The Glutathione Revolution by Nayan Patel Pdf

Ward off life-threatening disease and symptoms of aging with this guide to boosting your levels of glutathione (GSH), the "master antioxidant." The body has a remarkable ability to ward off disease and heal itself--and it does it with the help of the most important antioxidant you've never heard of: glutathione (GSH), the "master antioxidant." This indispensable molecule--which we make ourselves--holds the key to immunity, vitality, and lifelong health, helping to flush out toxins, fight DNA-damaging free radicals, and rebuild other essential antioxidants like Vitamins C and E. It's been linked to longevity in centenarians, and it protects against diseases like cancer, diabetes, and Alzheimer's. It plays a role in lesser ailments too: low glutathione levels could be the culprit behind your fatigue, aches, and pains. At the forefront of the latest GSH research, Dr. Nayan Patel shares all the information you need to boost your glutathione levels, revitalize your body, and transform your life with this naturally-occurring super antioxidant. In The Glutathione Revolution, he addresses the most important questions about GSH: What exactly is glutathione? What happens when your GSH levels are low? What diseases does GSH ward off? How can you naturally increase the amount of GSH your cells produce? What foods should you eat--and not eat? What are the safest and most effective GSH supplements? With a wealth of practical information and three easy, accessible action plans that you can tailor to your own life and health concerns, you too can harness the power of glutathione.

Role of Oxidative Stress in Pathophysiology of Diseases

Pawan K. Maurya,Kamal Dua
Role of Oxidative Stress in Pathophysiology of Diseases Book PDF

Author : Pawan K. Maurya,Kamal Dua
Publisher : Springer Nature
Page : 297 pages
File Size : 52,9 Mb
Release : 2020-06-15
Category : Science
ISBN : 9789811515682

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Role of Oxidative Stress in Pathophysiology of Diseases by Pawan K. Maurya,Kamal Dua Pdf

This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.

Antioxidants in Health and Disease

Antonis Zampelas,Renata Micha
Antioxidants in Health and Disease Book PDF

Author : Antonis Zampelas,Renata Micha
Publisher : CRC Press
Page : 340 pages
File Size : 55,6 Mb
Release : 2015-06-09
Category : Medical
ISBN : 9781466580114

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Antioxidants in Health and Disease by Antonis Zampelas,Renata Micha Pdf

Antioxidant use in health promotion and disease prevention either through dietary intake or supplementation is controversial. This book reviews the latest evidence-based research in the area, principally through prospective cohort studies and randomized controlled trials. It assesses major dietary antioxidants and discusses their use in diseases such as cancer, diabetes, stroke, coronary heart disease, HIV/AIDS, and neurodegenerative and immune diseases. The use of antioxidants in health is also discussed along with common adverse effects associated with antioxidant use.

Importance of Oxidative Stress and Antioxidant System in Health and Disease

Anonim
Importance of Oxidative Stress and Antioxidant System in Health and Disease Book PDF

Author : Anonim
Publisher : BoD – Books on Demand
Page : 232 pages
File Size : 45,6 Mb
Release : 2023-05-31
Category : Science
ISBN : 9781803563299

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Importance of Oxidative Stress and Antioxidant System in Health and Disease by Anonim Pdf

Oxidative stress is a major contributor to the etiology of chronic disorders like cancer, diabetes, neurodegenerative diseases, and cardiovascular diseases. Long-term exposure to elevated levels of pro-oxidant substances can lead to structural damage in mitochondrial DNA as well as functional changes in a number of enzymes and cellular components, which can lead to abnormalities in gene expression. Modern lifestyles, which include eating processed food, exposure to a variety of chemicals, and not exercising, are significant factors in the development of oxidative stress. However, the ability of medicinal plants with antioxidant capabilities to cure or prevent a number of human illnesses in which oxidative stress appears to be a contributing factor has been demonstrated. A growing body of research links free radicals to the etiology of many diseases, supporting the use of antioxidants as a promising therapeutic strategy for the management of pathologies caused by free radicals. Despite these remarkable advances, there is still much to learn about the relationship between free radicals and antioxidants. Understanding the principles behind pathological and physiological disorders caused by free radicals is crucial. Importance of Oxidative Stress and Antioxidant System in Health and Disease contributes to understanding the fundamental principles of oxidative stress and the effects of antioxidants on disease and health.

Oxidative Stress in Aging

Satomi Miwa,Kenneth Bruce Beckman,Florian Muller
Oxidative Stress in Aging Book PDF

Author : Satomi Miwa,Kenneth Bruce Beckman,Florian Muller
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 48,8 Mb
Release : 2008-06-17
Category : Medical
ISBN : 9781597454209

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Oxidative Stress in Aging by Satomi Miwa,Kenneth Bruce Beckman,Florian Muller Pdf

Human aging is a complex phenomenon. This state-of-the-art book discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in humans (following an introduction section of the basics and theory of free radicals). In addition, the major interventions trials of antioxidant supplements in age-related disease, cancer and so forth are reviewed and discussed.

Glutathione In The Nervous System

Christopher Ari Shaw
Glutathione In The Nervous System Book PDF

Author : Christopher Ari Shaw
Publisher : CRC Press
Page : 410 pages
File Size : 49,9 Mb
Release : 1998-02-27
Category : Science
ISBN : 1560326433

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Glutathione In The Nervous System by Christopher Ari Shaw Pdf

The goal of this text is to focus readers attention on three major areas; the origin and localization of GSH in the nervous system; the multiple effects of GSH on neural health activity; and the potential for alterations on GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease and other neurological disorders. The text also touches upon the additional roles of the antoxidant GSH, including possible neurotransmitter action, redox modulation of ionotropic receptor function, and neuroprotection against exicitoxic actions of glutamate.

Environmental Stressors in Health and Disease

Jürgen Fuchs
Environmental Stressors in Health and Disease Book PDF

Author : Jürgen Fuchs
Publisher : CRC Press
Page : 571 pages
File Size : 40,6 Mb
Release : 2001-07-20
Category : Science
ISBN : 9780824746001

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Environmental Stressors in Health and Disease by Jürgen Fuchs Pdf

This volume illustrates the impact of environmental oxidants on the tissues of the eyes, lungs and skin, as well as on the immune system - highlighting common illnesses, injuries and pathologies induced by pro-oxidant environmental xenobiotics such as inflammation, immune response, signal transduction, regulation of gene expression, and carcinogenesis. It provides clinical presentations and discusses the effects of environmental oxidants on target organs.

Oxidative Stress and Vascular Disease

John F. Keaney Jr.
Oxidative Stress and Vascular Disease Book PDF

Author : John F. Keaney Jr.
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461546498

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Oxidative Stress and Vascular Disease by John F. Keaney Jr. Pdf

One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.

Oxidative Stress and Chronic Degenerative Diseases

Jose Antonio Morales-Gonzalez
Oxidative Stress and Chronic Degenerative Diseases Book PDF

Author : Jose Antonio Morales-Gonzalez
Publisher : BoD – Books on Demand
Page : 516 pages
File Size : 49,8 Mb
Release : 2013-05-22
Category : Science
ISBN : 9789535111238

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Oxidative Stress and Chronic Degenerative Diseases by Jose Antonio Morales-Gonzalez Pdf

This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.