Good Genes Gone Bad

Author : Narendra Chirmule
Publisher : Ebury Press
Page : 304 pages
File Size : 44,7 Mb
Release : 2022-03
Category : Medical
ISBN : 0670096032

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Good Genes Gone Bad by Narendra Chirmule Pdf

The field of biotechnology has evolved over the past four decades, developing medicines which are curing diseases. But this journey of success has been tough and arduous, built upon the shoulders of major failures. Good Genes Gone Bad highlights seven such colossal failures in drug development-all of which culminated in the development of novel drugs-weaving together various analogies through the stories and thus allowing the reader to understand complex biological phenomena. These stories include treatment of medical conditions such as genetic clotting disorder (haemophilia), childhood-diarrhoea (rotavirus vaccine), preventing HIV infection, activation of the immune systems to treat cancer, gene therapy for treatment of diseases caused by gene-defects/mutations, cell therapy for treatment of leukaemias, and finally the success of Biocon's approval of the first biologic drug for breast cancer. Written by the former R&D head of Biocon, India's largest pharmaceutical company, Good Genes Gone Bad is a fascinating look at the complex world of medicine and drug development, providing the readers with a sense of magnitude of challenges and the extent of difficulty that it takes to make novel medicines.

Author : Narendra Chirmule
Publisher : Penguin Random House India Private Limited
Page : 304 pages
File Size : 42,5 Mb
Release : 2021-09-20
Category : Medical
ISBN : 9789354922237

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Good Genes Gone Bad by Narendra Chirmule Pdf

The field of biotechnology has evolved over the past four decades, developing medicines which are curing diseases. But this journey of success has been tough and arduous, built upon the shoulders of major failures. Good Genes Gone Bad highlights seven such colossal failures in drug development-all of which culminated in the development of novel drugs-weaving together various analogies through the stories and thus allowing the reader to understand complex biological phenomena. These stories include treatment of medical conditions such as genetic clotting disorder (haemophilia), childhood-diarrhoea (rotavirus vaccine), preventing HIV infection, activation of the immune systems to treat cancer, gene therapy for treatment of diseases caused by gene-defects/mutations, cell therapy for treatment of leukaemias, and finally the success of Biocon's approval of the first biologic drug for breast cancer. Written by the former R&D head of Biocon, India's largest pharmaceutical company, Good Genes Gone Bad is a fascinating look at the complex world of medicine and drug development, providing the readers with a sense of magnitude of challenges and the extent of difficulty that it takes to make novel medicines.

Author : Robin Constance
Publisher : iUniverse
Page : 185 pages
File Size : 48,7 Mb
Release : 2005-09
Category : Electronic
ISBN : 9780595339365

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Universal Mighty Mind by Robin Constance Pdf

You probably take yourself for granted, seldom stopping to consider your own singular magnificence; and you yearn to be happy-the pervasive quality of being content, of feeling calm and relaxed, sometimes even joyful . what you would call a state of mind. Yet you already have all the necessary gear: you are a three-in-one package of a mind to choose, a body to do and a natural desire to have. Everything in your life is a fluent and clear expression of your mind, for your mental energies are the sole authority, working ceaselessly to bring into form-to embody or materialize-that which you have accepted as the truth at the very deepest levels. There can be nothing outside your mind, for you experience the whole caboodle as your mind. As such, you are a potent force, for your universe is the universe. The grand aim of Universal Mighty Mind is to entice you to ponder and reflect so as to create an attitude of appreciation and awe for that unique system of dynamic energies you will proudly call I. Bolstered by newfound practical understanding and valuable insight, your life must inevitably become ever richer.

Author : V. Boulyjenkov,K. Berg,Y. Christen
Publisher : Springer Science & Business Media
Page : 180 pages
File Size : 41,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642569470

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Genes and Resistance to Disease by V. Boulyjenkov,K. Berg,Y. Christen Pdf

The advances in human genetics that have ocurred during the past 20 years have revolutionized our knowledge of the role played by inheritance in health and disase. It is clear that our DNA determines not only the emergence of catastrophic single-gene disorders, which affect millions of persons worldwide, but also interacts with environments to predispose individuals to cancer, allergy, hypertension, heart disease, diabetes, psychiatric disorders and even to some infectious diseases. Overall, the study of longevity and the demonstration of genes favouring a long lifespan suggest that such protective systems exist. In recent years, the study of genetic polymorphisms has made clear that some alleles have beneficial effects. These discoveries can substantially improve our understanding of the interactions between genetics and the environment, between pathogenetic mechanisms and new treatments.

Author : David Raup
Publisher : W. W. Norton & Company
Page : 236 pages
File Size : 51,8 Mb
Release : 1992-11-03
Category : Science
ISBN : 0393309274

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Extinction Bad Genes Or Bad Luck by David Raup Pdf

The science of extinction is a lively and moveable feast of scientific speculation and research. Scientist/author David Raup takes the subject of nature's disappearing act to task, covering everything from the Ice Age Blitzkreig to the fate of the marshes on Martha's Vineyard, the extinction of flying reptiles to mankind's impact on tropical reefs. Graphs.

Author : Siddhartha Mukherjee
Publisher : Simon and Schuster
Page : 624 pages
File Size : 55,8 Mb
Release : 2016-05-17
Category : Medical
ISBN : 9781476733531

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The Gene by Siddhartha Mukherjee Pdf

The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

Author : S. S. Baig
Publisher : IOS Press
Page : 170 pages
File Size : 54,5 Mb
Release : 1995
Category : Brussels, Belgium
ISBN : 9051992157

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Cancer Research at the European Level by S. S. Baig Pdf

This text describes the activities of current cancer research projects as well as the strengths and weaknesses within the specific domains of basic research, clinical research and screening, chemoprevention and epidemiological research. These reflections therefore bring together the experiences from different scientific and biomedical research teams and from most of the national cancer research organizations of the European Union who are also involved in the BIOMED programme.

Author : University of California, San Francisco
Publisher : Unknown
Page : 428 pages
File Size : 54,6 Mb
Release : 1992
Category : Hospitals
ISBN : UCSF:31378005946077

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UCSF News by University of California, San Francisco Pdf

Author : Michael Fortun,E. Mendelsohn
Publisher : Springer Science & Business Media
Page : 236 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401147187

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The Practices of Human Genetics by Michael Fortun,E. Mendelsohn Pdf

That concern about human genetics is at the top of many lists of issues requiring intense discussion from scientific, political, social, and ethical points of view is today no surprise. It was in the spirit of attempting to establish the basis for intelligent discussion of the issues involved that a group of us gathered at a meeting of the International Society for the History, Philosophy, and Social Studies of Biology in the Summer of 1995 at Brandeis University and began an exploration of these questions in earlier versions of the papers presented here. Our aim was to cross disciplines and jump national boundaries, to be catholic in the methods and approaches taken, and to bring before readers interested in the emerging issues of human genetics well-reasoned, informative, and provocative papers. The initial conference and elements of the editorial work which have followed were generously supported by the Stifterverband fUr die Deutsche Wissenschaft. We thank Professor Peter Weingart of Bielefeld University for his assistance in gaining this support. As Editors, we thank the anonymous readers who commented upon and critiqued many of the papers and in tum made each paper a more valuable contribution. We also thank the authors for their understanding and patience. Michael Fortnn Everett Mendelsohn Cambridge, MA September 1998 vii INTRODUCTION In 1986, the annual symposium at the venerable Cold Spring Harbor laboratories was devoted to the "Molecular Biology of Homo sapiens.

Author : Mark C. Glassy
Publisher : McFarland
Page : 304 pages
File Size : 44,8 Mb
Release : 2015-09-11
Category : Performing Arts
ISBN : 9781476608228

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The Biology of Science Fiction Cinema by Mark C. Glassy Pdf

Science fiction films of the 1930s and 1940s were often set in dark laboratories that had strange looking glass containers with bubbling fluids and mad scientists conducting glandular and hormonal experiments. In the 1950s, films were more focused on radiation induced mutations. The 1960s and 1970s brought more sophisticated biological sciences to the movies and focused on such relatively new concepts as immunology, cyrobiology, and biochemistry. In the 1980s and 1990s, the focus of science fiction films has been DNA. This work of film criticism relates 71 science fiction films to the biological sciences. The author covers cell biology, pharmacology, endocrinology, hematology, and entomology, to name just a few topics. An analysis of each film includes a brief plot synopsis, the author’s favorite quotations, the biological principles involved, the accuracy of the laboratory, and correct and incorrect biological information. In his analyses, the author sets out what would be required to achieve in real life the results seen in the movies and whether these experiments or events could actually happen.

Author : William Ayers,Therese M. Quinn,David Stovall
Publisher : Routledge
Page : 1095 pages
File Size : 41,5 Mb
Release : 2009-06-02
Category : Education
ISBN : 9781135596132

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Handbook of Social Justice in Education by William Ayers,Therese M. Quinn,David Stovall Pdf

The Handbook of Social Justice in Education, a comprehensive and up-to-date review of the field, addresses, from multiple perspectives, education theory, research, and practice in historical and ideological context, with an emphasis on social movements for justice. Each of the nine sections explores a primary theme of social justice and education: Historical and Theoretical Perspectives International Perspectives on Social Justice in Education Race and Ethnicity, Language and Identity: Seeking Social Justice in Education Gender, Sexuality and Social Justice in Education Bodies, Disability and the Fight for Social Justice in Education Youth and Social Justice in Education Globalization: Local and World Issues in Education The Politics of Social Justice Meets Practice: Teacher Education and School Change Classrooms, Pedagogy, and Practicing Justice. Timely and essential, this is a must-have volume for researchers, professionals, and students across the fields of educational foundations, multicultural/diversity education, educational policy, and curriculum and instruction.

Author : Susan Krauss Whitbourne,Stacey B. Whitbourne
Publisher : John Wiley & Sons
Page : 417 pages
File Size : 46,9 Mb
Release : 2010-10-18
Category : Psychology
ISBN : 9780470646977

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Adult Development and Aging by Susan Krauss Whitbourne,Stacey B. Whitbourne Pdf

The fourth edition continues to provide psychologists with a fresh and engaging approach to the field of psychology of adult development and aging. It focuses on three themes: a multidisciplinary approach, positive images of aging, and the newest and most relevant research. Recent articles and updates to the information on demography, economics, and public policy are presented. The Aging in the News feature includes a story of a remarkable achievement by a middle-aged or older adult. The Assess Yourself boxes are also updated with new questions. Psychologists appreciate this mix of examples and discussions that make the material come to life.

Author : Sheri Amsel,Sheryl Racine,Tom Robinson,Joseph Snedeker,Kathi Wagner
Publisher : Simon and Schuster
Page : 847 pages
File Size : 50,5 Mb
Release : 2017-11-14
Category : Juvenile Nonfiction
ISBN : 9781507206720

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The Everything Kids' Science Bundle by Sheri Amsel,Sheryl Racine,Tom Robinson,Joseph Snedeker,Kathi Wagner Pdf

With The Everything® Kids’ Science Collection learning has never been so easy—or fun! Inside, you’ll find: The Everything® Kids’ Astronomy Book The Everything® Kids’ Human Body Book The Everything® Kids’ Science Experiments Book The Everything® Kids’ Weather Book You’ll have so much fun conducting experiments and completing activities, you’ll forget that you’re actually learning about science!

Author : Susan K. Whitbourne,Stacey B. Whitbourne
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 42,6 Mb
Release : 2020-04-14
Category : Psychology
ISBN : 9781119607878

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Adult Development and Aging by Susan K. Whitbourne,Stacey B. Whitbourne Pdf

The new edition of the leading textbook on the biopsychosocial processes of aging in adults, fully revised and updated. Adult Development and Aging helps student readers understand the aging process both in themselves and in those around them. Approaching the subject from the biopsychosocial perspective — an innovative model of adult development that takes into account the influences and interactions of complex biological, psychological, and social processes — authors Susan Krauss Whitbourne and Stacey B. Whitbourne explore the latest concepts and applications in this exciting academic discipline. Based on Susan's classroom experience teaching her Psychology of Aging course, this engaging textbook integrates current research, real-world data, detailed explanations, and relatable examples to provide a balanced and accessible examination of the subject. This fully updated and revised seventh edition offers inclusive coverage of recent advances in neuroscience and genetics, cognitive functions, vocational development, sociocultural influences, mental health issues, health and prevention, and much more. "AgeFeeds" provide key information for each chapter, while new graphics, charts, tables, and figures enhance the text's visual appeal and strengthen student comprehension and retention. Acclaimed for its depth, currency, and student-friendly presentation, this popular textbook: Uses a multidisciplinary approach for understanding adult aging and development Offers positive images of aging and the newest and most relevant research in the field Provides new and updated illustrations, references, quizzes, examples, and research Offers practical self-help tips and up-to-date links to online resources Includes extensive supplementary teaching and learning material including a test bank, PowerPoint slides, and an instructor’s manual Adult Development and Aging: Biopsychosocial Perspectives, 7th Editionis an invaluable source of topically relevant information for traditional college-age learners and mature returning students alike, as well as for instructors and academic researchers in areas of adult aging and lifespan development.

Author : Nancy Langston
Publisher : Yale University Press
Page : 253 pages
File Size : 42,5 Mb
Release : 2010-03-02
Category : Science
ISBN : 9780300162998

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Toxic Bodies by Nancy Langston Pdf

In 1941 the Food and Drug Administration approved the use of diethylstilbestrol (DES), the first synthetic chemical to be marketed as an estrogen and one of the first to be identified as a hormone disruptor—a chemical that mimics hormones. Although researchers knew that DES caused cancer and disrupted sexual development, doctors prescribed it for millions of women, initially for menopause and then for miscarriage, while farmers gave cattle the hormone to promote rapid weight gain. Its residues, and those of other chemicals, in the American food supply are changing the internal ecosystems of human, livestock, and wildlife bodies in increasingly troubling ways. In this gripping exploration, Nancy Langston shows how these chemicals have penetrated into every aspect of our bodies and ecosystems, yet the U.S. government has largely failed to regulate them and has skillfully manipulated scientific uncertainty to delay regulation. Personally affected by endocrine disruptors, Langston argues that the FDA needs to institute proper regulation of these commonly produced synthetic chemicals.