Gpcr Signalling Complexes Synthesis Assembly Trafficking And Specificity

Author : Denis J. Dupré,Terence E. Hébert,Ralf Jockers
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 48,7 Mb
Release : 2012-11-19
Category : Medical
ISBN : 9789400747654

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GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity by Denis J. Dupré,Terence E. Hébert,Ralf Jockers Pdf

Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.

Author : Yu Cao
Publisher : Springer Nature
Page : 130 pages
File Size : 43,6 Mb
Release : 2019-09-30
Category : Science
ISBN : 9789811390777

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Advances in Membrane Proteins by Yu Cao Pdf

This book reviews recent advances regarding the biochemical and biophysical properties of membrane proteins and their applications in biomedicine. Divided into two thematic parts, this second volume addresses proteins’ formation, signaling and malfunctions. It covers a number of important membrane proteins including receptors, cell adhesion molecules, single-transmembrane proteins and viral membrane proteins, and discusses their structures, functions, related diseases, and roles in drug discovery in detail. In turn, the book elucidates the lifecycle of membrane proteins, including their synthesis and facilitated folding process, as well as QC procedures for their production. Additional topics include fundamental concepts, the latest findings, and critical puzzles yet to be solved. Given its scope, the book will appeal to a broad readership in the field of membrane structural and functional biology. Junior scientists can use it as an introduction to the field, while advanced scientists will find a broader view of the field beyond their area of specialization.

Author : Anonim
Publisher : Academic Press
Page : 560 pages
File Size : 53,9 Mb
Release : 2017-07-24
Category : Medical
ISBN : 9780128121573

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Cannabinoids and Their Receptors by Anonim Pdf

Cannabinoids and Their Receptors, Volume 593, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This updated volume includes comprehensive chapters on a variety of topics, including Real time cAMP signaling in response to CB1 activation, CB1 signaling in mitochondria, Lipidomics of cannabinoid systems, Studying endocannabinoid transport, Metabolic profiling of CB1 neutral antagonists, Approaches to assess biased signaling at the CB1 receptor, and the Development of CB1 allosteric modulators. Continues the legacy of this premier serial with a new and updated release Covers research cannabinoids and their receptors

Author : Yoji Kato
Publisher : Springer Science & Business Media
Page : 202 pages
File Size : 52,5 Mb
Release : 2013-12-28
Category : Medical
ISBN : 9789400779204

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Lipid Hydroperoxide-Derived Modification of Biomolecules by Yoji Kato Pdf

Lipid peroxidation is an important cellular process which can lead to detrimental effects if it is not regulated efficiently. Lipid hydroperoxide is formed in an initial step of lipid peroxidation. Lipid hydroperoxide is also known as a potential source of singlet oxygen. Harmful aldehydes are formed when the lipid hydroperoxide is degraded. The formed aldehyde has high reactivity against thiol or amine moieties. Therefore, it could act as a signaling molecule, which might induce the changing of gears inside a cell. Recent studies have shown that lipid hydroperoxide or a slightly modified product of the lipid hydroperoxide reacts with biomolecules such as proteins and aminophospholipids, which leads to formation of amide-type adducts. Amide-type adducts could be one of markers for oxidative stress and could also be an important player in some diseases. In this book, the chemistry and biochemistry of lipid hydroperoxide along with their conjugates with biomolecules are described.

Author : Aparajita Dey
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 53,7 Mb
Release : 2013-02-12
Category : Medical
ISBN : 9789400758810

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Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism by Aparajita Dey Pdf

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

Author : Beata Jastrzebska,Paul S.-H. Park
Publisher : Academic Press
Page : 500 pages
File Size : 53,6 Mb
Release : 2019-09-11
Category : Science
ISBN : 9780128167281

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GPCRs by Beata Jastrzebska,Paul S.-H. Park Pdf

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer’s disease, Parkinson’s disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth. Addresses our current understanding and novel advances in the GPCR field, directing readers towards recent finding of key significance for translational medicine Combines a thorough discussion of structure and function of GPCRs with disease association and drug discovery Features chapter contributions from international experts in GPCR structure, signaling, physiology and pharmacology

Author : Anonim
Publisher : Academic Press
Page : 4225 pages
File Size : 54,8 Mb
Release : 2018-09-12
Category : Medical
ISBN : 9780128122006

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Encyclopedia of Endocrine Diseases by Anonim Pdf

Encyclopedia of Endocrine Diseases, Second Edition, Five Volume Set comprehensively reviews the extensive spectrum of diseases and disorders that can occur within the endocrine system. It serves as a useful and comprehensive source of information spanning the many and varied aspects of the endocrine end metabolic system. Students will find a concise description of the physiology and pathophysiology of endocrine and metabolic functions, as well as their diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers, from advanced undergraduate students, to research professionals. Chapters explore the latest advances and hot topics that have emerged in recent years, such as the molecular basis of endocrine and metabolic diseases (mutations, epigenetics, signaling), the pathogenesis and therapy of common endocrine diseases (e.g. diabetes and endocrine malignancies), new technologies in endocrine research, new methods of treatment, and endocrine toxicology/disruptors. Covers all aspects of endocrinology and metabolism Incorporates perspectives from experts working within the domains of biomedicine (e.g. physiology, pharmacology and toxicology, immunology, genetics) and clinical sciences to provide readers with reputable, multi-disciplinary content from domain experts Provides a ‘one-stop’ resource for access to information as written by world-leading scholars in the field, with easy cross-referencing of related articles to promote understanding and further research

Author : Nava Segev
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 45,6 Mb
Release : 2010-05-30
Category : Science
ISBN : 9780387938776

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Trafficking Inside Cells by Nava Segev Pdf

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Author : Jeffrey L. Benovic
Publisher : Unknown
Page : 330 pages
File Size : 40,6 Mb
Release : 2000
Category : Medical
ISBN : UOM:39015047851277

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Regulation of G Protein-coupled Receptor Function and Expression by Jeffrey L. Benovic Pdf

This comprehensive text describes many techniques that are used to define the molecular mechanisms involved in receptor regulation. It covers a broad range of important concepts and methodologies in the study of G protein-coupled receptors.

Author : Vsevolod V. Gurevich
Publisher : Springer Science & Business Media
Page : 447 pages
File Size : 50,9 Mb
Release : 2013-11-29
Category : Medical
ISBN : 9783642411991

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Arrestins - Pharmacology and Therapeutic Potential by Vsevolod V. Gurevich Pdf

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

Author : Jose C. Jimenez-Lopez
Publisher : BoD – Books on Demand
Page : 344 pages
File Size : 50,7 Mb
Release : 2017-05-17
Category : Science
ISBN : 9789535131694

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Cytoskeleton by Jose C. Jimenez-Lopez Pdf

The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.

Author : Anonim
Publisher : Academic Press
Page : 480 pages
File Size : 47,7 Mb
Release : 2013-01-24
Category : Science
ISBN : 9780123918734

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G Protein Coupled Receptors by Anonim Pdf

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high throughput assays for identification of pharmacoperone drugs. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high-throughput assays for identifying pharmacoperone drugs

Author : Mario Tiberi
Publisher : Humana Press
Page : 406 pages
File Size : 43,8 Mb
Release : 2019-03-01
Category : Science
ISBN : 1493991205

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G Protein-Coupled Receptor Signaling by Mario Tiberi Pdf

This detailed volume assembles comprehensive protocols to assist with the study of structural, molecular, cell biological, and in vivo facets of GPCRs, and to enable the development of experimental tools for screening novel GPCR drugs. Sections explore the tweaking of ligands, bioluminescence and FRET approaches, specific GPCR signaling properties, as well as visualization of subcellular compartmentalization. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, G Protein-Coupled Receptor Signaling: Methods and Protocols serves as an ideal reference for life scientists working in a variety of research fields including molecular pharmacology, cell and developmental biology, brain behavior and physiology, drug development and screening. Chapter 4 is available open access under a CC BY 4.0 license via link.springer.com.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 46,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 40,9 Mb
Release : 19??
Category : Electronic
ISBN : 1461464382

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Encyclopedia of Signaling Molecules by Anonim Pdf