Growth Disorders And Acromegaly

Author : Constantine A. Stratakis
Publisher : Academic Press
Page : 312 pages
File Size : 41,9 Mb
Release : 2021-06-01
Category : Medical
ISBN : 9780128145388

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Gigantism and Acromegaly by Constantine A. Stratakis Pdf

Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism

Author : Ahmed R.G.,Ahmet Uçar
Publisher : BoD – Books on Demand
Page : 179 pages
File Size : 50,7 Mb
Release : 2020-04-29
Category : Medical
ISBN : 9781838805838

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Growth Disorders and Acromegaly by Ahmed R.G.,Ahmet Uçar Pdf

The first two years of life represent a transition period when growth changes from predominantly growth hormone (GH) independent to GH dependent. This book, Growth Disorders and Acromegaly, includes two parts. The first part consists of five chapters that illustrate the nature, causes, types, signs, and symptoms of GH deficiency (GHD) and fetal growth restriction. It describes the impact of GH and its deficiency on different biological systems in children and adults. Also, this book assesses the role of human GH (hGH) and insulin-growth factor1 (IGF-1) gene families during pregnancy. This book offers several novel insights of GH in male reproductive health. The second part consists of three chapters that show the pegvisomant, colorectal neoplasms in acromegaly, epidemiology and underlying mechanisms, and the surgical managements of acromegaly. Finally, this book will be of interest to scientists, embryologists, neuroendocrinologists, neurotoxicologists, and physicians who follow recent developments in the field of growth disorders.

Author : Enrico de Divitiis,Paolo Cappabianca
Publisher : Springer Science & Business Media
Page : 203 pages
File Size : 55,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783709160848

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Endoscopic Endonasal Transsphenoidal Surgery by Enrico de Divitiis,Paolo Cappabianca Pdf

Currently, surgical management provides the definitive treatment of choice for most pituitary adenomas, craniopharyngiomas and meningiomas of the sellar region. The elegant minimally invasive transnasal endoscopic approach to the sella turcica and the anterior skull base has added a new dimension of versatility to pituitary surgery and can be adapted to many lesions in the region. In this multi-author book with numerous color illustrations the main aspects of the endonasal endoscopic approach to the skull base are presented, starting with a clear description of the endoscopic anatomy, the panoramic view afforded by the endoscope and the development of effective instruments and adjuncts. After the diagnostic studies, the strictly surgical features are considered in detail. The standard technique is described and particular aspects are treated, including the new extended approaches to the cavernous sinus, spheno-ethmoid planum and clival regions.

Author : Jens O. L. Jørgensen,Jens Sandahl Christiansen
Publisher : Karger Medical and Scientific Publishers
Page : 241 pages
File Size : 46,5 Mb
Release : 2005-01-01
Category : Science
ISBN : 9783805579926

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Growth Hormone Deficiency in Adults by Jens O. L. Jørgensen,Jens Sandahl Christiansen Pdf

It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

Author : Ken Ho
Publisher : Springer Science & Business Media
Page : 413 pages
File Size : 55,8 Mb
Release : 2011-08-12
Category : Medical
ISBN : 9781607613176

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Growth Hormone Related Diseases and Therapy by Ken Ho Pdf

The molecular era ushered in the cloning of the growth hormone (GH) gene and the production of unlimited amounts of GH through recombinant technology. The continuing momentum of research from basic science to clinical evaluation has brought unprecedented advances to the understanding of GH biology for the clinical endocrinologist. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician distills all the new information of relevance to the endocrinologist over the last 20 years by offering five sections: physiology, molecular genetics, GH deficiency, acromegaly and pharmacotherapy. The first section on physiology focuses on GH action. A review on the structure and function of the GH receptor is followed by a perspective on the regulatory role of ghrelin on GH secretion. The second section on genetics covers pituitary function and adenomas, including new and fascinating information on familial pituitary adenomas, their genotype and phenotype. The adult GH deficiency section spans the epidemiology and diagnosis of GH deficiency with a strong reminder for the clinician that the transition period represents a critical time of somatic maturation, which continues for years after cessation of liner growth. The section on acromegaly focuses on management, giving practical guides to the value of GH and IGF-1 measurements, the place of somatostatin analogues and of radiotherapy while reminding the reader as to why evaluating quality of life is an important part of management. Finally, the section on GH pharmacology takes the reader through innovative developments of long-acting GH formulations with some products on the threshold of clinical use. This section provides a balanced evidence based review of the effects of GH supplementation in aging and in sports where recent data indicates an enhancing effect on a selective aspect of performance. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician integrates a wealth of information and will prove an invaluable reference for pediatric endocrinologists, adult endocrinologists, endocrine scientists and internists interested in the human biology of GH.

Author : Dieter K. Lüdecke,George Tolis
Publisher : Unknown
Page : 312 pages
File Size : 40,6 Mb
Release : 1987
Category : Acromegaly
ISBN : UCSC:32106007835215

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Growth Hormone, Growth Factors, and Acromegaly by Dieter K. Lüdecke,George Tolis Pdf

Author : Luciano Cavallo,Jean-Claude Job,Maria I. New
Publisher : Unknown
Page : 400 pages
File Size : 40,8 Mb
Release : 1991
Category : Children
ISBN : UOM:39015024931092

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Growth Disorders by Luciano Cavallo,Jean-Claude Job,Maria I. New Pdf

Author : Richard J. Robbins
Publisher : Springer Science & Business Media
Page : 281 pages
File Size : 40,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461319139

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Acromegaly by Richard J. Robbins Pdf

The manuscripts in this volume were contributed by the speakers invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The meeting was organized to commemorate the description of acromegaly by the French physician Pierre Marie, in 1886. The members of the Scientific Committee spent many hours assisting us in ensuring an outstanding meeting. The support of Serono Symposia, USA in all phases of the planning and execution of the meeting was sincerely appreciated and was highly professional. Special recognition roust be extended to Professor Roger Guillemin of the Salk Institute, whosp interest in medical history led him to devote a great deal of time and personal expense in obtaining information about the life of Pierre Marie. Dr. GuilIemin's presentation on the life and times of Marie was an extraordinary overview of the cultural, social, and scientific backgrounds in which Marie came to describe the disease, acromegaly. Dr. Guillemin' s findings, which were presented at the main banquet in a splendid audiovisual presentation, were clearly the highlight of the meeting and will long be remembered by the attendees. We were also honored by the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her address at the banquet, Dr. Granier provided several delightful and intimate vignettes concerning Pierre Marie, using old family records and photographs. The Scientific Committee wishes to extend its gratitude to Dr. Granier for adding immeasurably to the historical atmosphere of the meeting.

Author : Maximilian Sternberg
Publisher : Legare Street Press
Page : 0 pages
File Size : 40,7 Mb
Release : 2023-07-18
Category : Electronic
ISBN : 1022678132

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Acromegaly by Maximilian Sternberg Pdf

This groundbreaking study of acromegaly, a rare and debilitating disease caused by overproduction of growth hormone, offers a comprehensive overview of the latest research on diagnosis, treatment, and management of symptoms. With case studies, diagrams, and practical advice, the book is a crucial resource for patients, caregivers, and medical professionals. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Author : Alan G. Harris,Adrian F. Daly
Publisher : Lippincott Williams & Wilkins
Page : 104 pages
File Size : 49,5 Mb
Release : 1996
Category : Medical
ISBN : NWU:35558004320723

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Acromegaly and Its Management by Alan G. Harris,Adrian F. Daly Pdf

Author : Michael B. Ranke,R. Abs
Publisher : Unknown
Page : 0 pages
File Size : 43,8 Mb
Release : 2005
Category : Acromegaly
ISBN : 3805578377

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The Role of IGF Parameters in the Management of Growth Disorders and Acromegaly by Michael B. Ranke,R. Abs Pdf

Author : Mary E. Williams
Publisher : Greenhaven Publishing LLC
Page : 168 pages
File Size : 41,5 Mb
Release : 2011-12-01
Category : Young Adult Nonfiction
ISBN : 9780737764901

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Growth Disorders by Mary E. Williams Pdf

Growth disorders prevent children from developing normal height, weight, sexual maturity or other features, at decreased or accelerated rates. Provide your readers with essential information on growth disorders. This book also serves as a historical survey, by providing information on the controversies surrounding its causes. Compelling first-person narratives by people coping with growth disorders give readers a first-hand experience. Patients, family members, or caregivers explain the condition from their own experience. The symptoms, causes, treatments, and potential cures are explained in detail. Essential to anyone trying to learn about diseases and conditions, the alternative treatments are explored. Each essay is carefully edited and presented with an introduction, so that they are accessible for student researchers and readers.

Author : Shlomo Melmed
Publisher : Academic Press
Page : 744 pages
File Size : 53,9 Mb
Release : 2010-12-09
Category : Medical
ISBN : 0123809274

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The Pituitary by Shlomo Melmed Pdf

The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary. The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing. The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy. Presents a comprehensive, translational source of information about the pituitary in one reference work Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches

Author : Lewis S. Blevins Jr.,Manish K. Aghi
Publisher : Springer Nature
Page : 300 pages
File Size : 53,9 Mb
Release : 2022-11-12
Category : Medical
ISBN : 9783031162589

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Acromegaly by Lewis S. Blevins Jr.,Manish K. Aghi Pdf

Reviewing the most current literature, this text is a guide to medical decision-making regarding the diagnosis and treatment of patients with acromegaly. The scope of the book is comprehensive, covering all relevant facets of acromegaly, beginning with a history of the disorder and a review of the somatotrophic axis. Etiology is then discussed, including growth hormone secreting pituitary adenomas and other neuroendocrine tumors. Subsequent chapters present imaging modalities and diagnosis via radiology and clinical findings, as well as comorbid symptoms such as sleep apnea, musculoskeletal considerations, cardiovascular disorders, cancer and diabetes. Both medical and surgical management chapters describe each in detail, including radiotherapy, transsphenoidal surgery, somatostatin analogues and dopamine agonists. Concluding chapters present long-term follow-up as well as an extended selected patient story detailing life with the disease. Bringing together the latest in endocrinologic and neurosurgical evidence and practice, Acromegaly will be the go-to resource for this challenging condition for years to come.

Author : Edward C.C. Wong,Dennis J. Dietzen,Michael J. Bennett,Shannon Haymond
Publisher : Academic Press
Page : 1172 pages
File Size : 40,9 Mb
Release : 2021-05-13
Category : Science
ISBN : 9780128179635

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Biochemical and Molecular Basis of Pediatric Disease by Edward C.C. Wong,Dennis J. Dietzen,Michael J. Bennett,Shannon Haymond Pdf

Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases. Provides a fully-updated resource with more color illustrations Focuses on the biochemical and molecular basis of disease as well as the analytical techniques Defines important differences in the pathophysiology of diseases, comparing childhood with adult