Growth Factors And Their Receptors In Cancer Metastasis

Author : Wen G. Jiang,K. Matsumoto,T. Nakamura
Publisher : Springer Science & Business Media
Page : 310 pages
File Size : 41,9 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306483998

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Growth Factors and their Receptors in Cancer Metastasis by Wen G. Jiang,K. Matsumoto,T. Nakamura Pdf

about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).

Author : G V Sherbet
Publisher : Elsevier
Page : 368 pages
File Size : 48,8 Mb
Release : 2011-07-12
Category : Science
ISBN : 9780123878205

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Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy by G V Sherbet Pdf

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research

Author : G. V. Sherbet
Publisher : Elsevier
Page : 368 pages
File Size : 44,9 Mb
Release : 2011-07
Category : Science
ISBN : 0323165311

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Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy by G. V. Sherbet Pdf

Author : David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
Publisher : Oxford University Press
Page : 832 pages
File Size : 51,8 Mb
Release : 2016-01-28
Category : Medical
ISBN : 9780191065118

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Oxford Textbook of Oncology by David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann Pdf

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Author : Steven A. Stacker,Marc G. Achen
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 44,6 Mb
Release : 2009-09-30
Category : Medical
ISBN : 9789048122479

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Lymphangiogenesis in Cancer Metastasis by Steven A. Stacker,Marc G. Achen Pdf

Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells. The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi’s sarcoma, and approaches for imaging lymphatics in cancer. The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer. The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis. Key Features: Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process Provides a comprehensive summary of current research in this ground breaking area Provides a book which links progress in basic tumor and developmental biology with current and future oncology practise Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area.

Author : Gajanan V. Sherbet,M. S. Lakshmi
Publisher : Academic Press
Page : 338 pages
File Size : 54,8 Mb
Release : 1997-06-22
Category : Medical
ISBN : 0080542484

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The Genetics of Cancer by Gajanan V. Sherbet,M. S. Lakshmi Pdf

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Clonal evolution of the metastasis phenotype Cell Cycle regulation Apoptosis in tumour growth and metastasis Angiogenesis in cancer Cell surface glycoproteins and their receptors Proteinases and their inhibitors in cancer invasion Oncogenes and cancer metastasis Developmental genes Tumour suppressor genes Metastasis suppressor genes Dominant metastasis-associated genes

Author : Mels Sluyser
Publisher : John Wiley & Sons
Page : 218 pages
File Size : 40,6 Mb
Release : 1987
Category : Breast
ISBN : UCAL:B4978280

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Growth Factors and Oncogenes in Breast Cancer by Mels Sluyser Pdf

Author : Itzhak D. Goldberg,Eliot M. Rosen
Publisher : Birkhäuser
Page : 304 pages
File Size : 50,9 Mb
Release : 2013-03-07
Category : Science
ISBN : 9783034890700

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Epithelial—Mesenchymal Interactions in Cancer by Itzhak D. Goldberg,Eliot M. Rosen Pdf

The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.

Author : Amy M. Fulton
Publisher : Springer Science & Business Media
Page : 181 pages
File Size : 48,9 Mb
Release : 2009-06-12
Category : Medical
ISBN : 9781603272674

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Chemokine Receptors in Cancer by Amy M. Fulton Pdf

Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells. Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.

Author : Derek LeRoith
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 43,9 Mb
Release : 2011-09-18
Category : Medical
ISBN : 9781461405986

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Insulin-like Growth Factors and Cancer by Derek LeRoith Pdf

The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.

Author : Padma V. Devarajan,Prajakta Dandekar,Anisha A. D'Souza
Publisher : Springer Nature
Page : 560 pages
File Size : 54,6 Mb
Release : 2019-11-09
Category : Medical
ISBN : 9783030291686

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Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis by Padma V. Devarajan,Prajakta Dandekar,Anisha A. D'Souza Pdf

This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.

Author : Abdel-Majid Khatib
Publisher : Biota Publishing
Page : 88 pages
File Size : 48,5 Mb
Release : 2013-02-01
Category : Science
ISBN : 9781615045372

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The Proprotein Convertases by Abdel-Majid Khatib Pdf

Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are involved in the maturation of many precursor proteins involved in the process of tumorigenesis and metastasis. Since their discovery, PCs were suggested as potential targets for anti-cancer therapy, and their activity was found to directly affect tumor cell proliferation, migration invasion, and the malignant phenotypes of tumor cells. Here, we discuss a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells, and their clinical relevance in cancer patients. Among the substrates of the proprotein convertases, various growth factors, their receptors, adhesion molecules, and proteases were identified. The PCs are inhibited by endogenous and exogenous inhibitors. To date, only pro7B2, a specific chaperone of PC2, and the granine-like precursor of neuroendocrine protein proSAAS, a selective ligand of PC1, have been identified as endogenous inhibitors of the PCs found in the regulated pathway. However, only PCs prosegments, several bioengineered inhibitors, peptides, and non-peptide compounds were found to inhibit the activity of the PCs found in the secretory pathway.

Author : Ralph A. Bradshaw,Steve Prentis
Publisher : Elsevier Science & Technology
Page : 334 pages
File Size : 50,6 Mb
Release : 1987
Category : Medical
ISBN : 0444808272

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Oncogenes and Growth Factors by Ralph A. Bradshaw,Steve Prentis Pdf

Author : M. Bolla,E. M. Chambaz,C. Vrousos
Publisher : Inserm
Page : 244 pages
File Size : 43,6 Mb
Release : 1989
Category : Medical
ISBN : CHI:33963430

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Growth Factors and Oncogenes by M. Bolla,E. M. Chambaz,C. Vrousos Pdf

Author : Rosemarie B. Lichtner,Richard N. Harkins
Publisher : Unknown
Page : 280 pages
File Size : 47,9 Mb
Release : 1997
Category : Medical
ISBN : NWU:35558003879745

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EGF Receptor in Tumor Growth and Progression by Rosemarie B. Lichtner,Richard N. Harkins Pdf

Members of the tyrosine kinase family are frequently implicated in experimental as well as in human cancer. The best studied receptor signaling system from this family is the EGF receptor. Experts in this area report on the involvement of the receptor in a variety of human tumors, outline underlying molecular mechanisms for aberrant receptor signaling in experimental systems and present the status of current therapies directed against the receptor. A detailed analysis of EGF receptor signal transduction via expression of receptor, ligands, phosphatases and presence of other members of the receptor family will provide new information for the design of therapeutic modalities targeting this receptor system.