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Author : Richard M. Kostrzewa
Publisher : Unknown
Page : 128 pages
File Size : 43,5 Mb
Release : 2021
Category : Neurotoxicology
ISBN : 3030715191
Author : Richard M. Kostrzewa
Publisher : Springer Nature
Page : 2551 pages
File Size : 40,5 Mb
Release : 2023-01-02
Category : Medical
ISBN : 9783031150807
This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin’ is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction – akin to a neurotoxin’s effect. This new edition significantly expands on the information provided in the first edition, providing the latest research in neurotoxicity and highlighting the relationship between specific neurotoxins and the neurodegenerative disorders they can cause. It also includes new sections on the neurotoxicity of heavy metals, fungi, and snake venom. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.
Author : Edward J. Massaro
Publisher : Springer Science & Business Media
Page : 658 pages
File Size : 51,6 Mb
Release : 2001-11-12
Category : Medical
ISBN : 9781592591329
Neurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, lead, mercury, and the polytypic bypro ducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins of broadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentally by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor tunately, the environmental accumulation of some neurotoxic ants of anthropogenic ori gin, especially pesticides and metals, has resulted in incidents of human poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the result of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxic ants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.
Author : Edward J. Massaro
Publisher : Springer Science & Business Media
Page : 599 pages
File Size : 50,8 Mb
Release : 2002-03-20
Category : Medical
ISBN : 9781592591657
N eurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, 1ead, mercury, and the polytypic byproducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins ofbroadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentalIy by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor of some neurotoxicants of anthropogenic ori tunately, the environmental accumulation gin, expecialIy pesticides and metals, has resulted in incidents ofhuman poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the re suit of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxicants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.
Author : William Slikker, Jr.,Merle G. Paule,Cheng Wang
Publisher : Academic Press
Page : 616 pages
File Size : 51,8 Mb
Release : 2018-01-04
Category : Science
ISBN : 9780128093948
Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts
Author : Andreas Moser
Publisher : Springer Science & Business Media
Page : 437 pages
File Size : 54,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461220008
It is a great pleasure to write the foreword to this important volume for several reasons. First: As far as we know, already primitive societies had to cope with environmental toxins of many kinds and set up regulations to limit their effects on food and drug use. Modem science, synthesizing tens of millions of new compounds has incredibly magnified this challenge. Today, xenobiotic metabolism has become a crucial task for humans and many other species alike. Second: When reading this book, one is impressed by the extraordinary speed at which neurotoxicology has advanced. Obviously, processing (and endogenous formation) oftox ins has become an extremely relevant topic. When I had the chance, almost three decades ago, to work in chemical pharmacology with Bernard B. Brodie at NIH, the drug metabo lizing system of the liver had just been recognized and characterized. We had just started to work on the biogenic amines, newly discovered cyclic nucleotides in rat brain, human cere brospinal fluid, and on the effects of toxic drugs like amphetamines. Today, biochemical neuropharmacology is a mature field of neuroscience.
Author : Edward J. Massaro
Publisher : Humana Press
Page : 668 pages
File Size : 45,9 Mb
Release : 2012-11-05
Category : Medical
ISBN : 146849659X
Neurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, lead, mercury, and the polytypic bypro ducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins of broadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentally by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor tunately, the environmental accumulation of some neurotoxic ants of anthropogenic ori gin, especially pesticides and metals, has resulted in incidents of human poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the result of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxic ants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.
Author : Edward J. Massaro
Publisher : Unknown
Page : 128 pages
File Size : 47,8 Mb
Release : 2002
Category : Electronic
ISBN : OCLC:748539253
Neurotoxins-whether natural products that can provide valuable therapeutic agents and research reagents or human-generated pollutants-have recently attracted great scientific interest. In the Handbook of Neurotoxicology, Volumes I and II, many leading researchers and clinicians-all acknowledged experts-review in depth the status of research in key areas of current neurotoxicologic interest and examine the latest methodologies for in vivo assessment of a wide spectrum of agents exhibiting neurotoxicologic properties. This second volume of the Handbook focuses on the biologic effects of human-made toxins on the developing organism, and of drugs of abuse. Here are discussed the interpretation of neurotoxicity data, the art of risk assessment, and the manifestation of CNS insult during development. The drugs of abuse surveyed include cocaine, marijuana, the cannabinoids, and amphetamines. Also provided are state-of-the-art methods for the evaluation of neurotoxicant effects by both imaging and neurobehavioral assessment. Volume I concentrates on the biological effects of both human-made neurotoxins (pesticides, mercury, lead, zinc, and polytypic by-products of combustion and manufacture) and those of natural origin (microbial and animal toxins). Up-to-date and timely, the Handbook of Neurotoxicology, Volumes I and II, not only affords today's biomedical and clinical investigators a full panoply of knowledge in all the critical areas of current neurotoxicologic interest, but also illuminates the latest methodologies for assessing the effects of a broad spectrum of significant neurotoxicological agents.
Author : Louis W. Chang,William Slikker Jr.
Publisher : Elsevier
Page : 875 pages
File Size : 45,6 Mb
Release : 1995-04-20
Category : Science
ISBN : 9780080537474
Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity. Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market. Discusses neurobehavioral testing methods for assessment of neural dysfunctions Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity Presents step-by-step procedures for many methods Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation
Author : Anonim
Publisher : Elsevier
Page : 544 pages
File Size : 49,8 Mb
Release : 2015-11-09
Category : Medical
ISBN : 9780444626288
Occupational Neurology a volume in the Handbook of Clinical Neurology Series, provides a comprehensive overview of the science, clinical diagnosis, and treatment for neurotoxin related neurological and psychiatric disorders. This timely collection provides not only a complete scientific reference on the chemical origin of this class of neurological and psychiatric disorders, but also a practical guide to diagnosis and treatment challenges and best practices. Handbook of Clinical Neurology Series The first volume of the Handbook of Clinical Neurology under the editorship of George Bruyn and Pierre Vinken was published in 1968. In 1982, the series was brought to an interim conclusion with the publication of the cumulative index volume (Volume 44). By that stage, the Handbook had come to represent one of the largest scientific works ever published. It enjoys a high reputation in specialist media circles throughout the world. After the series was concluded in 1982, it was realized that an update of the material was imperative. Accordingly, a revised series was planned and published over the following years, concluding with the publication of another cumulative index to both series (Volume 76-78) in 2002. Since then, George Bruyn has passed away and Pierre Vinken has retired, but the need for a further new series, incorporating advances in the field, again become necessary. Professors Michael J. Aminoff, François Boller and Dick F. Swaab have with enthusiasm taken on the responsibility of supervising the preparation of a third series, the first volumes of which were published in 2003. Now, more than 130 volumes after the first published, the Handbook of Clinical Neurology series continues to have an unparalleled reputation for providing the latest foundational research, diagnosis, and treatment protocols essential for both basic neuroscience research and clinical neurology. Provides comprehensive coverage of neurotoxins, especially in the workplace Details the latest science as the foundation for neurotoxicity diagnosis and treatment Presents coverage of the diagnosis and treatment essential for clinical neurologists and occupational medicine specialists
Author : Edward J. Massaro
Publisher : Unknown
Page : 668 pages
File Size : 48,9 Mb
Release : 2002
Category : Neurotoxicology
ISBN : OCLC:648273756
Neurotoxins-whether human-generated pollutants or natural products-have recently attracted growing scientific interest. In the Handbook of Neurotoxicology, Volumes I and II, many leading researchers and clinicians-all acknowledged experts-review in depth the status of research in key areas of current neurotoxicologic interest and examine the latest methodologies for in vivo assessment of a wide spectrum of agents exhibiting neurotoxicologic properties. This first volume of the Handbook focuses on the biological effects of human-made neurotoxins, as well as those of natural origin, which so often provide valuable therapeutics and research reagents. Topics range from anticholinesterase insecticides and pesticides that target ion channels, to such metals as mercury, lead, zinc, and to the polytypic byproducts of combustion and industrial manufacture. The natural toxins discussed include those of microbial origin (microbial, marine, clostridial, and botulilinal neurotoxins), as well as those of animal origin (snake, spider, and scorpion venoms). Volume II concentrates on the biological effects of human-made toxins on the developing nervous system, reviews the neuronal impact of drugs of abuse, and provides state-of-the-art methods for the evaluation of the biological effects of neurotoxicants by both imaging and neurobehavioral assessment. Up-to-date and timely, the Handbook of Neurotoxicology, Volumes I and II, not only affords today's biomedical and clinical investigators a full panoply of knowledge in all the critical areas of current neurotoxicologic interest, but also illuminates the latest methodologies for assessing the effects of a broad spectrum of significant neurotoxicological agents.
Author : Swaran Jeet Singh Flora
Publisher : Academic Press
Page : 988 pages
File Size : 51,6 Mb
Release : 2023-02-21
Category : Medical
ISBN : 9780323984713
Handbook of Arsenic Toxicology, Second Edition presents the latest findings on arsenic, including its chemistry, sources and effects on the environment and human health. The book discusses both acute and chronic effects, discussing many aspects of arsenic, from physical and chemical properties, exposure, epidemiology, organ toxicity, diagnosis, prevention and treatment. Fully updated and revised, this new edition includes new topics on risk assessment, molecular mechanisms of arsenic, advances in the integrated approach to testing, assessment and development, evaluation and application of high content predictive models, and new alternative methods (NAMS) in the context of Adverse Outcome Pathways (AOPs) to assess toxicology. This comprehensive resource allows readers to effectively assess the risks related to arsenic, providing them with all they need to know on arsenic exposure, toxicity and toxicity prevention. Brings together current findings on the effects of arsenic on the environment and human health Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms Provides all the information needed for effective risk assessment, prevention and countermeasures
Author : Nicolaus Kröger,John Gribben,Christian Chabannon,Ibrahim Yakoub-Agha,Hermann Einsele
Publisher : Springer Nature
Page : 221 pages
File Size : 53,6 Mb
Release : 2022-02-07
Category : Medical
ISBN : 9783030943530
This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills.
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Page : 492 pages
File Size : 46,8 Mb
Release : 2010-02-06
Category : Medical
ISBN : 9781607616856
Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.
Author : Michael J. Derelanko,Mannfred A. Hollinger
Publisher : CRC Press
Page : 1381 pages
File Size : 51,5 Mb
Release : 2001-08-29
Category : Medical
ISBN : 9781420042078
LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLY Working in the laboratory or office, you use a diverse assortment of basic information to design, conduct, and interpret toxicology studies and to perform risk assessments. The Second Edition of the best-selling Handbook of Toxicology gives you the information you need in a single referen
