Harrison S Cardiovascular Medicine

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Harrison's Cardiovascular Medicine

Author : Joseph Loscalzo
Publisher : McGraw Hill Professional
Page : 641 pages
File Size : 45,6 Mb
Release : 2010-06-04
Category : Medical
ISBN : 9780071702928

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Harrison's Cardiovascular Medicine by Joseph Loscalzo Pdf

Market: cardiologists and fellows (26,000), second year medical students (18,000/year), internal medicine residents (23,000); internists (75,000), family practice clinicians and residents (55,000); nurse practitioners (50,000), physician assistants (40,000)

Harrison's Cardiovascular Medicine 3/E

Author : Joseph Loscalzo
Publisher : McGraw Hill Professional
Page : 762 pages
File Size : 46,7 Mb
Release : 2016-09-22
Category : Medical
ISBN : 9781259835759

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Harrison's Cardiovascular Medicine 3/E by Joseph Loscalzo Pdf

Cardiovascular Medicine – with all the authority of Harrison’s A Doody's Core Title for 2019! Featuring a superb compilation of chapters related to cardiovascular medicine derived from Harrison’s Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison’s DVD), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find 53 chapters from 58 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features: • Current, complete coverage of essential cardiovascular medicine topics, including Diagnosis of Cardiovascular Disorders, Heart Rhythm Disturbances, Disorders of the Heart, and Disorders of the Vasculature • An important opening section “Introduction to Cardiovascular Disorders” provides a systems overview, beginning with the basic biology of the cardiovascular system, followed by epidemiology of cardiovascular systems, and approach to the patient • Integration of pathophysiology with clinical management • High-yield board review questions make this text ideal for keeping current and preparing for the boards • Helpful appendix of laboratory values of clinical importance

Harrison's Cardiovascular Medicine 2/E

Author : Joseph Loscalzo
Publisher : McGraw Hill Professional
Page : 657 pages
File Size : 48,8 Mb
Release : 2013-03-22
Category : Medical
ISBN : 9780071814997

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Harrison's Cardiovascular Medicine 2/E by Joseph Loscalzo Pdf

Cardiovascular Medicine – as only Harrison’s can cover it Featuring a superb compilation of chapters related to cardiovascular disorders that appear in Harrison’s Principles of Internal Medicine, Eighteenth Edition, this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find content from renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features Current, complete coverage of essential cardiovascular medicine topics, including Diagnosis of Cardiovascular Disorders, Heart Rhythm Disturbances, Disorders of the Heart, and Disorders of the Vasculature An important opening section “Introduction to Cardiovascular Disorders” that provides a systems overview, beginning with the basic biology of the cardiovascular system, followed by epidemiology of cardiovascular diseases, and approach to the patient Integration of pathophysiology with clinical management 108 high-yield questions and answers drawn from Harrison’s Principles of Internal Medicine Self-Assessment and Board Review, 18e Content updates and new developments since the publication of Harrison’s Principles of Internal Medicine, 18e 44 chapters written by physicians who are recognized experts in the field of cardiovascular medicine Helpful appendix of laboratory values of clinical importance

Harrison's Advances in Cardiology

Author : Eugene Braunwald
Publisher : McGraw Hill Professional
Page : 712 pages
File Size : 48,8 Mb
Release : 2003
Category : Medical
ISBN : 0071370889

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Harrison's Advances in Cardiology by Eugene Braunwald Pdf

This timely new resource brings you the complete collection of cardiology reviews from the popular Harrison’s Online website. Here prominent clinician/investigators present commissioned summaries of current topics in cardiology, reporting on the clinical significance of a particular problem or discovery relating to cardiac arrhythmias, congestive heart failure, hypertension, atherosclerosis and more. Contributors have reviewed their chapter for currency, incorporating new references, tables and figures where applicable. * Includes the newest clinical guidelines for therapy * Summarizes current clinical issues and field trials. * References the newest cardiovascular therapeutics

Tinsley Harrison, M.D.

Author : James Pittman
Publisher : NewSouth Books
Page : 400 pages
File Size : 53,7 Mb
Release : 2014-11-26
Category : Biography & Autobiography
ISBN : 9781588382269

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Tinsley Harrison, M.D. by James Pittman Pdf

Tinsley Harrison -- doctor, teacher, researcher, medical school leader -- is one of the most important medical figures of the 20th century. He edited the first five editions of Harrison’s Principles of Internal Medicine, regarded as a quintessential medical text and perhaps the best-selling medical textbook of all time. He traveled the world in his capacity as a teaching doctor, made significant contributions to scholarship, and served as the dean/medical chairman at four medical schools. He is a titan of the field, an enormous presence central to the narrative of American medicine. Author Dr. James Pittman knew Harrison well, studying and teaching with him from the 1950s until Harrison’s death. Pittman spent six years interviewing Harrison near the end of Harrison’s life, and these lengthy interviews, as well as interviews with his colleagues, family and friends, form the bulk of the scholarship of this compulsively readable book. Pittman brings his own medical knowledge to the fore, as well as his personal friendship with the subject, in this beautifully written character study of one of science’s great but not well-known men. Harrison lived a long, exciting life, and in these pages, readers will get a glimpse of the historical forces that shaped and in turn were shaped by this legendary doctor.

Harrisons Manual of Medicine, 20th Edition

Author : Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Page : 1248 pages
File Size : 47,5 Mb
Release : 2019-10-22
Category : Medical
ISBN : 9781260455359

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Harrisons Manual of Medicine, 20th Edition by Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo Pdf

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. All the authority of the most trusted brand in medical content in a convenient, portable guide Derived from most clinically salient content featured in Harrison's Principles of Internal Medicine, 20th Edition, this full color, portable guide covers all diseases and conditions commonly seen in general medical practice. This edition has been updated to reflect the latest clinical developments in medicine. Designed for quick access and employing an effective blend of concise text, bulleted key points, decision trees, and summary tables, the Manual makes it easy to find what you need at the point of care. The easy-to-navigate chapters use a standard repeating template and cover: •Etiology and Epidemiology •Clinically Relevant Pathophysiology •Signs and Symptoms •Differential Diagnosis •Physical and Laboratory Findings •Therapeutics •Practice Guidelines, and more

Cardiology: An Integrated Approach

Author : Adel Elmoselhi
Publisher : McGraw Hill Professional
Page : 317 pages
File Size : 40,5 Mb
Release : 2017-12-29
Category : Medical
ISBN : 9780071791557

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Cardiology: An Integrated Approach by Adel Elmoselhi Pdf

An innovative, cardiology-specific text that blends basic science with the fundamentals of clinical medicine A Doody’s Core Title for 2022! Cardiology: An Integrated Approach to Disease skillfully bridges the gap between the science and practice of medicine. This beautifully illustrated book seamlessly integrates the core elements of cell biology, anatomy, physiology, pharmacology, and pathology with clinical medicine. It is the perfect companion for medical students transitioning to their clinical years, as well as for practicing physicians who need a user-friendly update on the basic science underlying the practice of clinical medicine. Full-color design includes approximately 340 images and 40 tables Cases teach students how to apply principles to real-world patient situations The latest developments in the field are incorporated throughout the text End-of-chapter case-based questions with detailed explanations reinforce important concepts and assess understanding of the material

Harrison's Principles of Internal Medicine Self-Assessment and Board Review, 20th Edition

Author : Charles Wiener,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Dennis L. Kasper,Joseph Loscalzo
Publisher : McGraw Hill Professional
Page : 768 pages
File Size : 40,7 Mb
Release : 2021-06-12
Category : Medical
ISBN : 9781260463057

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Harrison's Principles of Internal Medicine Self-Assessment and Board Review, 20th Edition by Charles Wiener,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Dennis L. Kasper,Joseph Loscalzo Pdf

The book that serves as the basis for the popular “Harrison’s Podclass” podcast series! This outstanding collection of internal medicine Q&A is perfect for prepping for board or shelf exams, getting in multiple “reps” of self directed learning, and increasing your understanding of clinical reasoning. It’s packed with 1,000+ high-quality clinical vignettes, with expert, on-point explanations for correct and incorrect answers. Harrison’s Principles of Internal Medicine Self-Assessment and Board Review reflects all the specialties of internal medicine, and has been exhaustively revised and updated to reflect hundreds of never-before published Q&A in board-style format. This great resource will bolster your understanding of pathophysiology, epidemiology, differential diagnosis, clinical decision making, and therapeutics. Illustrations, radiographs, and pathology slides are included throughout. Each question is accompanied by a complete answer and explanation, and cross-referenced to Harrison’s Principles of Internal Medicine for deeper-dive understanding. 325 full-color photos and illustrations Clinical vignettes and Q&A presented in board-style format Content consistent with board exam blueprint in internal medicine Aligned with Harrison’s Principles of Internal Medicine, the global authority in medicine Explanations for correct and incorrect answer choices

Pulmonary Hypertension

Author : Nicholas S. Hill,Harrison W. Farber
Publisher : Springer Science & Business Media
Page : 448 pages
File Size : 54,8 Mb
Release : 2008-05-05
Category : Medical
ISBN : 9781603270755

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Pulmonary Hypertension by Nicholas S. Hill,Harrison W. Farber Pdf

This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the past decade. The discoveries of endothelin overexpression as well as prostacyclin and nitric oxide deficiency in association with pulmonary hypertension have led to important therapeutic insights. The new therapies have led to significant improvements in patient function, quality of life and survival. In this book, expert authors describe these new therapies. It will be of interest not only to cardiologists, pulmonary specialists and rheumatologists, but also many nurses and pharmacotherapists.

Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)

Author : J. Larry Jameson,Anthony S. Fauci,Dennis L. Kasper,Stephen L. Hauser,Dan L. Longo,Joseph Loscalzo
Publisher : McGraw-Hill Education / Medical
Page : 4048 pages
File Size : 45,6 Mb
Release : 2018-08-13
Category : Medical
ISBN : 1259644030

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Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2) by J. Larry Jameson,Anthony S. Fauci,Dennis L. Kasper,Stephen L. Hauser,Dan L. Longo,Joseph Loscalzo Pdf

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms A Doody's Core Title for 2019! Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patien

Harrison's Principles of Internal Medicine 19/E (Vol.1 & Vol.2) (ebook)

Author : Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Page : 3000 pages
File Size : 46,9 Mb
Release : 2015-04-17
Category : Medical
ISBN : 9780071802161

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Harrison's Principles of Internal Medicine 19/E (Vol.1 & Vol.2) (ebook) by Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo Pdf

The landmark guide to internal medicine— updated and streamlined for today’s students and clinicians The only place you can get ALL the great content found in the two print volumes AND the acclaimed DVD in one convenient resource! Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of Harrison’s Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the new 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods. Here are just a few of the outstanding features of the new Nineteenth Edition: Content is practically organized around two basic themes: education and clinical practice The teaching and learning sections cover foundational principles, cardinal manifestations of disease and approach to differential diagnosis; the content devoted to clinical practice focuses on disease pathogenesis and treatment NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more. Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever Outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, are available for easy download Supporting the renowned coverage are supplemental resources that reflect and assist modern medical practice: more than 1,000 full-color photographs to aid visual recognition skills, hundreds of state-of-the-art radiographs, from plain film to 3D CT to PET Scans; beautiful illustrations that bring applied anatomy and processes to life; the renowned Harrison’s patient-care algorithms, essential summary tables, and practical demonstrative videos. In addition, several digital atlases highlight noninvasive imaging, percutaneous revascularization, gastrointestinal endoscopy, diagnosis and management of vasculitis, and numerous other issues commonly encountered in clinical practice. Acclaim for Harrison’s: “Covering nearly every possible topic in the field of medicine, the book begins with a phenomenal overview of clinical medicine, discussing important topics such as global medicine, decision-making in clinical practice, the concepts of disease screening and prevention, as well as the importance of medical disorders in specific groups (e.g. women, surgical patients, end of life). The extensive chapters that follow focus on a symptom-based presentation of disease and then illness organized by organ system. Numerous tables, graphs, and figures add further clarity to the text." ...Written by experts in the field, this book is updated with the latest advances in pathophysiology and treatment. It is organized in a way that makes reading from beginning to end a logical journey, yet each chapter can stand alone as a quick reference on a particular topic. “ Doody’s Review Service reviewing the previous edition of Harrison’s

Oxford Textbook of Heart Failure

Author : Andrew L. Clark,Roy S. Gardner,Theresa A. McDonagh
Publisher : Oxford University Press
Page : 897 pages
File Size : 55,8 Mb
Release : 2022
Category : Medical
ISBN : 9780198766223

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Oxford Textbook of Heart Failure by Andrew L. Clark,Roy S. Gardner,Theresa A. McDonagh Pdf

Taking the reader from an understanding of the basic mechanisms of heart failure through to an appreciation of the complexities of heart failure management and the remarkable improvements possible with good treatment, the Oxford Textbook of Heart Failure 2e covers all aspects necessary to manage a patient with heart failure. In full colour throughout, containing over 300 illustrations, and supported by detailed referencing from the huge evidence base that has developed over the last two decades, the textbook also includes extensive chapters on common co-morbidities. The new edition has been completely updated in line with new British and European Guidelines and contains new chapters on; Natriuretic Peptides and Novel Biomarkers in Heart Failure, The Future of Heart Failure, and Regenerative Therapies. Essential reading for consultant cardiologists and those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses.

Landmark Papers in Cardiovascular Medicine

Author : Aung Myat,Tony Gershlick
Publisher : OUP Oxford
Page : 520 pages
File Size : 55,6 Mb
Release : 2012-09-27
Category : Medical
ISBN : 9780191637865

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Landmark Papers in Cardiovascular Medicine by Aung Myat,Tony Gershlick Pdf

Landmark Papers in Cardiovascular Medicine provides a thorough and wide-ranging analysis of core examples of novel research, clinical trials and seminal papers published in the medical literature that have paved the way for breakthroughs in the management of the entire spectrum of cardiovascular disease. These papers may have produced positive, negative or equivocal findings but are regarded by the experts as having either stimulated a paradigm shift in therapeutic strategy or been the catalyst for new and improved methods of research, diagnosis or drug development. Our aim is to provide both a benchmark and inspiration for future work in the field of cardiovascular medicine and also to give the reader an insight into the mechanics and infrastructure of how high-quality evidence-based medicine has been produced. Each trial summary is punctuated by sections on 'strengths and limitations', 'impact on the field', 'learning points' and 'further reading' suggestions that allow for a completely holistic analysis of the data. The experts also give their views on what research is currently underway, their hopes for the future and what advances they predict will occur in each subspecialty field of cardiovascular medicine, making this book essential reading for all those individuals with an interest in the field.

Harrisons Manual of Medicine, 19th Edition

Author : Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo
Publisher : McGraw Hill Professional
Page : 1244 pages
File Size : 48,6 Mb
Release : 2016-05-22
Category : Medical
ISBN : 9780071828543

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Harrisons Manual of Medicine, 19th Edition by Dennis L. Kasper,Anthony S. Fauci,Stephen L. Hauser,Dan L. Longo,J. Larry Jameson,Joseph Loscalzo Pdf

Essential Clinical Information Drawn From Harrison’s Harrison’s Manual of Medicine is a concise, bedside resource derived from content found in Harrison’s Principles of Internal Medicine, Nineteenth Edition. Perfect for use at the point of care, the Manual presents clinical information covering key aspects of the diagnosis, clinical manifestations, and treatment of the major diseases that are likely to be encountered in medical practice. Presented in full color and incorporating an efficient blend of succinct text, bullet points, algorithms, and tables Harrison’s Manual of Medicine, Nineteenth Edition covers every area of clinical medicine, including: · Etiology and Epidemiology · Clinically Relevant Pathophysiology · Signs and Symptoms · Differential Diagnosis · Physical and Laboratory Findings · Therapeutics · Practice Guidelines

Harrison's Principles of Internal Medicine, Twenty-First Edition (Vol.1 & Vol.2)

Author : Joseph Loscalzo,Anthony S. Fauci,Dennis L. Kasper,Stephen Hauser,Dan Longo,J. Larry Jameson
Publisher : McGraw Hill Professional
Page : 4132 pages
File Size : 52,8 Mb
Release : 2022-04-05
Category : Medical
ISBN : 9781264268511

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Harrison's Principles of Internal Medicine, Twenty-First Edition (Vol.1 & Vol.2) by Joseph Loscalzo,Anthony S. Fauci,Dennis L. Kasper,Stephen Hauser,Dan Longo,J. Larry Jameson Pdf

The Voice of Clinical ReasonHarrison’s Principles of Internal Medicine is the world's most trusted clinical medicine text—and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine. Harrison's Principles of Internal Medicine stands as the benchmark for authoritative, practical information on patient care and the pathogenesis and clinical management of symptoms and signs and specific diseases. Written and edited by the world’s top experts in their respective fields, this landmark guide provides the comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. Harrison’s is world-renowned as the most authoritative source for: • Descriptions of disease mechanisms and how the clinician can apply that knowledge for the best patient care and optimal diagnosis and treatment of specific diseases • Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases • The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow • Updated clinical trial results and recommended guidelines • Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings • Coverage of both therapeutic approaches and specific treatment regimens • Practical clinical decision trees and algorithms • Organ-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, general and specific approaches to therapy Harrison’s remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world’s top experts are featured in the 21st edition: • Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer • Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries • More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes • More than a dozen atlases featuring curated collections of visual aspects of diagnosis and management • Complete, updated curation and synthesis of primary medical literature which incorporates current data from major studies and clinical trials • Clinical reasoning resources and helpful disease/presentation schemas • Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms