Heat Shock Protein 90 In Human Diseases And Disorders

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Heat Shock Protein 90 in Human Diseases and Disorders

Alexzander A. A. Asea,Punit Kaur
Heat Shock Protein 90 in Human Diseases and Disorders Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 607 pages
File Size : 48,9 Mb
Release : 2019-11-04
Category : Science
ISBN : 9783030231583

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Heat Shock Protein 90 in Human Diseases and Disorders by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Protein 90 in Human Diseases and Disorders

Anonim
Heat Shock Protein 90 in Human Diseases and Disorders Book PDF

Author : Anonim
Publisher : Unknown
Page : 599 pages
File Size : 49,7 Mb
Release : 2019
Category : Electronic books
ISBN : 3030231593

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Heat Shock Protein 90 in Human Diseases and Disorders by Anonim Pdf

The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Proteins in Cancer

Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Heat Shock Proteins in Cancer Book PDF

Author : Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 45,9 Mb
Release : 2007-09-09
Category : Medical
ISBN : 9781402064012

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Heat Shock Proteins in Cancer by Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca Pdf

Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Heat Shock Proteins in Signaling Pathways

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins in Signaling Pathways Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer
Page : 482 pages
File Size : 49,8 Mb
Release : 2019-07-09
Category : Science
ISBN : 9783030039523

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Heat Shock Proteins in Signaling Pathways by Alexzander A. A. Asea,Punit Kaur Pdf

Signaling pathways is a comprehensive mechanism by which all cellular organisms communicate internally and externally with their microenvironment. This is a highly complex and exact process. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. Knowledge gained from the better understanding of signaling pathways will help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Heat shock proteins (HSP) are uniquely involved in a number of critical signaling pathways. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Protein-Based Therapies

Alexzander A.A. Asea,Naif N. Almasoud,Sunil Krishnan,Punit Kaur
Heat Shock Protein Based Therapies Book PDF

Author : Alexzander A.A. Asea,Naif N. Almasoud,Sunil Krishnan,Punit Kaur
Publisher : Springer
Page : 385 pages
File Size : 41,7 Mb
Release : 2015-07-22
Category : Medical
ISBN : 9783319172118

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Heat Shock Protein-Based Therapies by Alexzander A.A. Asea,Naif N. Almasoud,Sunil Krishnan,Punit Kaur Pdf

The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

Heat Shock Proteins and Whole Body Physiology

Alexzander A. A. Asea,Bente K. Pedersen
Heat Shock Proteins and Whole Body Physiology Book PDF

Author : Alexzander A. A. Asea,Bente K. Pedersen
Publisher : Springer Science & Business Media
Page : 431 pages
File Size : 44,5 Mb
Release : 2009-12-10
Category : Medical
ISBN : 9789048133819

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Heat Shock Proteins and Whole Body Physiology by Alexzander A. A. Asea,Bente K. Pedersen Pdf

Heat Shock Proteins and Whole Body Physiology is an exciting new book in the Heat Shock Proteins series which provides the most up-to-date review on novel mechanisms insights into the important role played by heat shock proteins in human physiology. Written by leaders in the field of heat shock protein exercise physiology, neuroscience and aging, the chapters systematically and in a step wise fashion takes the reader through the fascinating mechanisms by which heat shock proteins modulate human disease and pathophysiology and provides answers as to its biological significance to the host. Section I, introduces the readers to the role played by heat shock proteins in various diseases and disorders (Heat Shock Proteins and Disease). Section II, addresses the role heat shock proteins play in psychological disorders including post traumatic stress disorders and learning (Heat Shock Proteins and Psychological Stress). Section III, present a detailed review of the role played by heat shock proteins in exercise physiology (Heat Shock Proteins and Exercise Physiology). This book is a must read for heat shock protein researchers, graduate and postgraduate fellows in the field of Medicine in general and specialities in Excersie Physiology, Neuroscience, Immunology, Aging and Pathology.

Hsp90 in Cancer: Beyond the Usual Suspects

Anonim
Hsp90 in Cancer Beyond the Usual Suspects Book PDF

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 42,5 Mb
Release : 2016-02-23
Category : Science
ISBN : 9780128024836

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Hsp90 in Cancer: Beyond the Usual Suspects by Anonim Pdf

Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression. Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression

Stress Proteins

David S. Latchman
Stress Proteins Book PDF

Author : David S. Latchman
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642582592

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Stress Proteins by David S. Latchman Pdf

This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

Heat Shock Proteins in the Immune System

Robert J. Binder,Pramod K. Srivastava
Heat Shock Proteins in the Immune System Book PDF

Author : Robert J. Binder,Pramod K. Srivastava
Publisher : Springer
Page : 185 pages
File Size : 49,7 Mb
Release : 2018-04-09
Category : Medical
ISBN : 9783319690421

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Heat Shock Proteins in the Immune System by Robert J. Binder,Pramod K. Srivastava Pdf

Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.

Regulation of Heat Shock Protein Responses

Alexzander A A Asea,Punit Kaur
Regulation of Heat Shock Protein Responses Book PDF

Author : Alexzander A A Asea,Punit Kaur
Publisher : Springer
Page : 0 pages
File Size : 52,8 Mb
Release : 2019-01-08
Category : Medical
ISBN : 3030090620

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Regulation of Heat Shock Protein Responses by Alexzander A A Asea,Punit Kaur Pdf

This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.

Heat Shock Proteins in Neuroscience

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins in Neuroscience Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 307 pages
File Size : 43,7 Mb
Release : 2019-10-30
Category : Science
ISBN : 9783030242855

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Heat Shock Proteins in Neuroscience by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Proteins in Inflammatory Diseases

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins in Inflammatory Diseases Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 520 pages
File Size : 49,6 Mb
Release : 2021-10-13
Category : Science
ISBN : 9783030851682

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Heat Shock Proteins in Inflammatory Diseases by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Proteins in Inflammatory Diseases provides the most comprehensive highlight and insight of the expression, function and therapeutic activity of Heat Shock Proteins in inflammatory diseases including sepsis, psoriasis, neurodegenerative diseases, cancers, viral infection and autoimmune rheumatic diseases. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in inflammatory diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Chaperokine Activity of Heat Shock Proteins

Alexzander A. A. Asea,Punit Kaur
Chaperokine Activity of Heat Shock Proteins Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer
Page : 320 pages
File Size : 48,7 Mb
Release : 2019-02-01
Category : Science
ISBN : 9783030022549

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Chaperokine Activity of Heat Shock Proteins by Alexzander A. A. Asea,Punit Kaur Pdf

Chaperokine, is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators like cytokines, chemokines, nitric oxide, apotogenic mediator, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity. The book Chaperokine Activity of Heat Shock Proteins provides the most comprehensive review on contemporary knowledge on the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide a synopsis of novel mechanisms, signal transduction pathways and how the principles of the chaperokine activity of HSP has been harnessed for therapeutic gain. To enhance the ease of reading and comprehension this book has been subdivided into various section, including; Section I, reviews current progress on our understanding of Immunological and Inflammatory Responses; Section II, evaluates the role of Physiological Responses and Section III, focuses the reader on the Therapeutic Approach. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts, Pathologists, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Protein 60 in Human Diseases and Disorders

Alexzander A. A. Asea,Punit Kaur
Heat Shock Protein 60 in Human Diseases and Disorders Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 363 pages
File Size : 53,9 Mb
Release : 2019-10-31
Category : Science
ISBN : 9783030231545

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Heat Shock Protein 60 in Human Diseases and Disorders by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

The Big Book on Small Heat Shock Proteins

Robert M. Tanguay,Lawrence E. Hightower
The Big Book on Small Heat Shock Proteins Book PDF

Author : Robert M. Tanguay,Lawrence E. Hightower
Publisher : Springer
Page : 610 pages
File Size : 40,9 Mb
Release : 2015-06-15
Category : Medical
ISBN : 9783319160771

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The Big Book on Small Heat Shock Proteins by Robert M. Tanguay,Lawrence E. Hightower Pdf

Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field. These colleagues include Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the structure of small heat shock proteins, moving to their functions and finishing with their involvement in diseases. Although this is quite broad, the structural aspect will be the unifying theme of the book.