Heat Shock Proteins In Signaling Pathways

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Heat Shock Proteins in Signaling Pathways

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins in Signaling Pathways Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer
Page : 482 pages
File Size : 43,8 Mb
Release : 2019-07-09
Category : Science
ISBN : 9783030039523

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Heat Shock Proteins in Signaling Pathways by Alexzander A. A. Asea,Punit Kaur Pdf

Signaling pathways is a comprehensive mechanism by which all cellular organisms communicate internally and externally with their microenvironment. This is a highly complex and exact process. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. Knowledge gained from the better understanding of signaling pathways will help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Heat shock proteins (HSP) are uniquely involved in a number of critical signaling pathways. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Proteins in Signaling Pathways

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins in Signaling Pathways Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Unknown
Page : 482 pages
File Size : 42,6 Mb
Release : 2019
Category : Biochemistry
ISBN : 3030039536

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Heat Shock Proteins in Signaling Pathways by Alexzander A. A. Asea,Punit Kaur Pdf

This edited volume offers an insightful overview of contemporary research on signaling pathways. These signaling processes are the comprehensive mechanisms by which all cellular organisms communicate internally and externally with their microenvironment. The volume is focused on heat shock proteins (HSP), which are uniquely involved in a number of critical signaling pathways. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. The knowledge gained from better understanding these mechanisms can help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Proteins in Neuroscience

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins in Neuroscience Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 307 pages
File Size : 44,7 Mb
Release : 2019-10-30
Category : Science
ISBN : 9783030242855

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Heat Shock Proteins in Neuroscience by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Proteins in Cancer

Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Heat Shock Proteins in Cancer Book PDF

Author : Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 47,7 Mb
Release : 2007-09-09
Category : Medical
ISBN : 9781402064012

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Heat Shock Proteins in Cancer by Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca Pdf

Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Identification of a Small Heat-shock Protein Associated with a Ras-mediated Signaling Pathway in Ectomycorrhizal Symbiosis

Shiv Hiremath
Identification of a Small Heat shock Protein Associated with a Ras mediated Signaling Pathway in Ectomycorrhizal Symbiosis Book PDF

Author : Shiv Hiremath
Publisher : Unknown
Page : 12 pages
File Size : 44,7 Mb
Release : 2009
Category : Ectomycorrhizal fungi
ISBN : UOM:39015089330636

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Identification of a Small Heat-shock Protein Associated with a Ras-mediated Signaling Pathway in Ectomycorrhizal Symbiosis by Shiv Hiremath Pdf

Initiation, development, and establishment of a functional ectomycorrhiza involve a series of biochemical events mediated by a number of genes from the fungus as well as the host plant. We have identified a heat shock protein gene from Laccaria bicolor (Lbhsp) that appears to play a role in these events. The size and characteristics of Lbhsp suggest that it belongs to the family of small heat-shock proteins described in the literature. Nucleotide sequencing of an almost full length cDNA indicated that the Lbhsp mRNA is about 611 nucleotides long and codes for a single protein of ~ 17 kDa. Isolation and characterization of the Lbhsp gene showed that it was made up of three exons separated by two small introns. Southern analysis suggested that the L. bicolor genome contains at least two copies of the Lbhsp gene. Temporal expression analyses revealed that the gene is expressed within 4 to 12 hours after interaction with red pine roots. The yeast two-hybrid studies showed that the Lbhsp was closely associated with the ras gene (Lbras) described earlier. The data suggest that Lbhsp may play a supporting role in ras-mediated mycorrhizal signaling pathways during various stages of ectomycorrhizal development.

Stress Proteins

David S. Latchman
Stress Proteins Book PDF

Author : David S. Latchman
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 52,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642582592

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Stress Proteins by David S. Latchman Pdf

This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

Heat Shock Protein 90 in Human Diseases and Disorders

Alexzander A. A. Asea,Punit Kaur
Heat Shock Protein 90 in Human Diseases and Disorders Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 607 pages
File Size : 55,9 Mb
Release : 2019-11-04
Category : Science
ISBN : 9783030231583

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Heat Shock Protein 90 in Human Diseases and Disorders by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Chaperokine Activity of Heat Shock Proteins

Alexzander A. A. Asea,Punit Kaur
Chaperokine Activity of Heat Shock Proteins Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer
Page : 320 pages
File Size : 52,5 Mb
Release : 2019-02-01
Category : Science
ISBN : 9783030022549

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Chaperokine Activity of Heat Shock Proteins by Alexzander A. A. Asea,Punit Kaur Pdf

Chaperokine, is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators like cytokines, chemokines, nitric oxide, apotogenic mediator, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity. The book Chaperokine Activity of Heat Shock Proteins provides the most comprehensive review on contemporary knowledge on the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide a synopsis of novel mechanisms, signal transduction pathways and how the principles of the chaperokine activity of HSP has been harnessed for therapeutic gain. To enhance the ease of reading and comprehension this book has been subdivided into various section, including; Section I, reviews current progress on our understanding of Immunological and Inflammatory Responses; Section II, evaluates the role of Physiological Responses and Section III, focuses the reader on the Therapeutic Approach. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts, Pathologists, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Proteins and Stress

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins and Stress Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer
Page : 315 pages
File Size : 47,7 Mb
Release : 2018-10-24
Category : Science
ISBN : 9783319907253

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Heat Shock Proteins and Stress by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Proteins and Stress provides the most comprehensive review on contemporary knowledge on the role of HSP in Stress. Using an integrative approach to understanding the regulation of HSP responses, the contributors provide a synopsis of novel mechanisms by which HSP responses are regulated under normal physiological and pathophysiological conditions. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts and Pathologists.

Plant Signaling Molecules

M. Iqbal R. Khan,Palakolanu Sudhakar Reddy,Antonio Ferrante,Nafees A. Khan
Plant Signaling Molecules Book PDF

Author : M. Iqbal R. Khan,Palakolanu Sudhakar Reddy,Antonio Ferrante,Nafees A. Khan
Publisher : Woodhead Publishing
Page : 596 pages
File Size : 50,6 Mb
Release : 2019-03-15
Category : Science
ISBN : 9780128164525

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Plant Signaling Molecules by M. Iqbal R. Khan,Palakolanu Sudhakar Reddy,Antonio Ferrante,Nafees A. Khan Pdf

Plant Signaling Molecule: Role and Regulation under Stressful Environments explores tolerance mechanisms mediated by signaling molecules in plants for achieving sustainability under changing environmental conditions. Including a wide range of potential molecules, from primary to secondary metabolites, the book presents the status and future prospects of the role and regulation of signaling molecules at physiological, biochemical, molecular and structural level under abiotic stress tolerance. This book is designed to enhance the mechanistic understanding of signaling molecules and will be an important resource for plant biologists in developing stress tolerant crops to achieve sustainability under changing environmental conditions. Focuses on plant biology under stress conditions Provides a compendium of knowledge related to plant adaptation, physiology, biochemistry and molecular responses Identifies treatments that enhance plant tolerance to abiotic stresses Illustrates specific physiological pathways that are considered key points for plant adaptation or tolerance to abiotic stresses

Heat Shock Protein 60 in Human Diseases and Disorders

Alexzander A. A. Asea,Punit Kaur
Heat Shock Protein 60 in Human Diseases and Disorders Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 363 pages
File Size : 53,6 Mb
Release : 2019-10-31
Category : Science
ISBN : 9783030231545

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Heat Shock Protein 60 in Human Diseases and Disorders by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Regulation of Heat Shock Protein Responses

Alexzander A A Asea,Punit Kaur
Regulation of Heat Shock Protein Responses Book PDF

Author : Alexzander A A Asea,Punit Kaur
Publisher : Springer
Page : 472 pages
File Size : 46,7 Mb
Release : 2018-05-01
Category : Medical
ISBN : 9783319747156

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Regulation of Heat Shock Protein Responses by Alexzander A A Asea,Punit Kaur Pdf

This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.

Heat Shock Proteins in Human Diseases

Alexzander A. A. Asea,Punit Kaur
Heat Shock Proteins in Human Diseases Book PDF

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 297 pages
File Size : 47,6 Mb
Release : 2021-03-23
Category : Science
ISBN : 9783030622893

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Heat Shock Proteins in Human Diseases by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Proteins in Cancer Therapeutics provides the most comprehensive review on contemporary knowledge on the role of HSP in various types of cancer therapeutics. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in cancer therapeutics. The heat shock response pathway is a highly conserved cellular process. Heat shock factors are a master transcriptional regulator responsible for expression of several important heat shock proteins, which can effectively protect critical client proteins from misfolding and degradation, thus maintaining intracellular integrity under stressed conditions. Recent studies have demonstrated the direct connections between heat shock response players and tumor cell survival, validating heat shock response players as novel molecular targets in anticancer treatment. Although many hurdles in clinical application still need to be effectively addressed, such as undesirable drug toxicity and off target effects; narrow therapeutic window; poor PK/PD profiles, etc. Recent reports on synergistic drug combination, advanced prodrug design, smart nanoparticle packaging, and RNA aptamer selection offer promising solutions to overcome these challenges. Future advancements in this fast-growing area can potentially lead to the next generation of cancer therapeutics. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Heat Shock Proteins and Plants

Alexzander A. A. Asea,Stuart K. Calderwood,Punit Kaur
Heat Shock Proteins and Plants Book PDF

Author : Alexzander A. A. Asea,Stuart K. Calderwood,Punit Kaur
Publisher : Springer
Page : 344 pages
File Size : 51,7 Mb
Release : 2016-11-23
Category : Science
ISBN : 9783319463407

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Heat Shock Proteins and Plants by Alexzander A. A. Asea,Stuart K. Calderwood,Punit Kaur Pdf

Heat Shock Proteins and Plants provides the most up-to-date and concise reviews and progress on the role of heat shock proteins in plant biology, structure and function and is subdivided into chapters focused on Small Plant HSPs (Part I), Larger Plant HSPs (Part II) and HSPs for Therapeutic Gain (Part III). This book is written by eminent leaders and experts from around the world and is an important reference book and a must-read for undergraduate, postgraduate students and researchers in the fields of Agriculture, Botany, Crop Research, Plant Genetics and Biochemistry, Biotechnology, Drug Development and Pharmaceutical Sciences.

Heat Shock Proteins in the Immune System

Robert J. Binder,Pramod K. Srivastava
Heat Shock Proteins in the Immune System Book PDF

Author : Robert J. Binder,Pramod K. Srivastava
Publisher : Springer
Page : 185 pages
File Size : 54,9 Mb
Release : 2018-04-09
Category : Medical
ISBN : 9783319690421

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Heat Shock Proteins in the Immune System by Robert J. Binder,Pramod K. Srivastava Pdf

Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.