Hepatobiliary Transport From Bench To Bedside

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Hepatobiliary Transport: From Bench to Bedside

S. Matern,J.L. Boyer,D. Keppler,P.J. Meier-Abt
Hepatobiliary Transport From Bench to Bedside Book PDF

Author : S. Matern,J.L. Boyer,D. Keppler,P.J. Meier-Abt
Publisher : Springer Science & Business Media
Page : 196 pages
File Size : 45,6 Mb
Release : 2001-12-31
Category : Medical
ISBN : 0792387716

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Hepatobiliary Transport: From Bench to Bedside by S. Matern,J.L. Boyer,D. Keppler,P.J. Meier-Abt Pdf

There has been a tremendous amount of scientific progress in our understanding of the molecular mechanisms of transport processes in the liver within the last few years. Cloning of various members of organic anion and cation transporters has provided the necessary tools to study their regulation under physiological and pathophysiological conditions and has advanced our knowledge about bile formation. Mutations of various hepatic organic anion transporters have been identified in humans as hereditary defects leading to the heterogenous syndrome of progressive familial intrahepatic cholestasis (PFIC). Various mouse models including knockout animals have given us the opportunity to gain insight into lipid transport by the liver and the genetics of cholesterol gallstone formation. The physiology of bile duct cells and the molecular mechanisms leading to various cholangiopathies have been a main scientific focus in hepatology in recent years. Drug targeting to the liver by hepatic organic anion transporters represents an attractive way of selective delivery of pharmaceutical agents in humans. Ursodeoxycholic acid is successfully used in the treatment of patients with chronic cholestatic liver disease and major advances have been made in understanding its mode of action in liver and bile duct cells. This book, the proceedings of the Falk Workshop held in Aachen, Germany, on 25-26 January 2001, contains chapters on all important aspects of biliary transport by well-known experts in this field. It is an essential resource for new developments in the field of biliary transport, both in basic science and clinical medicine.

Hepatobiliary Transport in Health and Disease

Dieter Häussinger,Verena Keitel,Ralf Kubitz
Hepatobiliary Transport in Health and Disease Book PDF

Author : Dieter Häussinger,Verena Keitel,Ralf Kubitz
Publisher : Walter de Gruyter
Page : 312 pages
File Size : 44,6 Mb
Release : 2012-05-29
Category : Science
ISBN : 9783110279344

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Hepatobiliary Transport in Health and Disease by Dieter Häussinger,Verena Keitel,Ralf Kubitz Pdf

One major function of the liver is the uptake of endo- and xenobiotics from the bloodstream and their excretion into bile. The transport systems involved in hepatobiliary transport have been recently cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. Furthermore, new research has shown that bile acids, whose function in digestion is long known, also behave as signal molecules in a variety of organs, including the intestinal and biliary epithelia, sinusoidal endothelial and immune cells. This book provides indepth surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease, the mechanisms of bile salt-induced apoptosis and hepatocyte protection, and the role of transporter mutations as causes and modifiers of liver diseases. The book will be of interest not only for biochemists, structural chemists and biologists, but also for clinicians.

Pediatric Gastrointestinal Disease

W. Allan Walker
Pediatric Gastrointestinal Disease Book PDF

Author : W. Allan Walker
Publisher : PMPH-USA
Page : 1158 pages
File Size : 55,7 Mb
Release : 2004
Category : CD-ROMs
ISBN : 1550092405

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Pediatric Gastrointestinal Disease by W. Allan Walker Pdf

This new edition of Pediatric Gastrointestinal Disease is dedicated to the maintenance of a comprehensive approach to the practice of Pediatric Gastroenterology. Considered to be the definitive reference work, this fourth edition has been extensively reviewed. As a result, the size and content of various sections have been modified and new ......

Drug Transporters

Martin F. Fromm,Richard B. Kim
Drug Transporters Book PDF

Author : Martin F. Fromm,Richard B. Kim
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 50,9 Mb
Release : 2010-11-19
Category : Medical
ISBN : 9783642145414

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Drug Transporters by Martin F. Fromm,Richard B. Kim Pdf

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Molecular Pathogenesis of Cholestasis

Michael Trauner,Peter L. M. Jansen
Molecular Pathogenesis of Cholestasis Book PDF

Author : Michael Trauner,Peter L. M. Jansen
Publisher : Springer Science & Business Media
Page : 388 pages
File Size : 47,9 Mb
Release : 2004
Category : Medical
ISBN : 0306482401

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Molecular Pathogenesis of Cholestasis by Michael Trauner,Peter L. M. Jansen Pdf

Knowledge of hepatobiliary transport is increasing rapidly. This book provides a cutting-edge overview of hepatobiliary transport and the molecular pathogenesis of cholestasis. Topics range from basic mechanisms of transport and regulation to general molecular and cellular concepts of cholestatic liver injury to specific molecular mechanisms of hereditary and acquired cholestatic liver injury, their complications and treatment. Basic researchers, academic physicians and students in hepatology, genetics, molecular and cell biology, pharmacology, pathology, gastroenterology and endocrinology will find this book instructive and stimulating.

Marine Physiology Down East: The Story of the Mt. Desert Island Biological Laboratory

David H. Evans
Marine Physiology Down East The Story of the Mt Desert Island Biological Laboratory Book PDF

Author : David H. Evans
Publisher : Springer
Page : 1094 pages
File Size : 51,5 Mb
Release : 2015-08-13
Category : Medical
ISBN : 9781493929603

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Marine Physiology Down East: The Story of the Mt. Desert Island Biological Laboratory by David H. Evans Pdf

This volume offers a comprehensive history of the Mount Desert Island Biological Laboratory (MDIBL), one of the major marine laboratories in the United States and a leader in using marine organisms to study fundamental physiological concepts. Beginning with its founding as the Harpswell Laboratory of Tufts University in 1898, David H. Evans follows its evolution from a teaching facility to a research center for distinguished renal and epithelial physiologists. He also describes how it became the site of major advances in cytokinesis, regeneration, cardiac and vascular physiology, hepatic physiology, endocrinology and toxicology, as well as studies of the comparative physiology of marine organisms. Fundamental physiological concepts in the context of the discoveries made at the MDIBL are explained and the social and administrative history of this renowned facility is described.

Pathogenesis and Clinical Practice in Gastroenterology

I. Ferkolj,Peter R. Galle,Alfred Gangl,B. Vucelic
Pathogenesis and Clinical Practice in Gastroenterology Book PDF

Author : I. Ferkolj,Peter R. Galle,Alfred Gangl,B. Vucelic
Publisher : Springer Science & Business Media
Page : 289 pages
File Size : 45,6 Mb
Release : 2011-04-28
Category : Medical
ISBN : 9781402087677

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Pathogenesis and Clinical Practice in Gastroenterology by I. Ferkolj,Peter R. Galle,Alfred Gangl,B. Vucelic Pdf

The translation of new molecular understanding of disease into clinical practice in gastroenterology is a special challenge. The Falk Symposium No. 160, entitled ‘Pathogenesis and Clinical Practice in Gastroenterology’, held 15-16 June 2007 in Portorož, Slovenia, provided a stimulating framework to bridge discussions from bench to bedside. The proceedings of the symposium are contained in this book, and the unifying theme is the growing understanding of inflammation as a driving force in chronic disease leading to disability and malignancy. Aspects of early detection - endoscopically or via molecular markers - are covered as well as in-depth discussions of the validation of new findings in clinical practice. Whilst on a molecular basis gastroenterologists and hepatologists try to shed light on the same intracellular pathways, clinical implications such as surveillance of cancer in IBD or chronic hepatitis with cirrhosis have to be tailored to specific needs. New therapeutic agents - approved or on the horizon of early clinical studies - will dramatically change the options of patients with chronic disease such as Crohn’s disease, viral hepatitis or hepatocellular carcinoma.

Malignant Liver Tumours: Basic Concepts and Clinical Management

F. Berr,J. Bruix,J. Hauss,Ch. Wittekind,J. Wands
Malignant Liver Tumours Basic Concepts and Clinical Management Book PDF

Author : F. Berr,J. Bruix,J. Hauss,Ch. Wittekind,J. Wands
Publisher : Springer Science & Business Media
Page : 242 pages
File Size : 53,5 Mb
Release : 2002-11-30
Category : Medical
ISBN : 0792387791

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Malignant Liver Tumours: Basic Concepts and Clinical Management by F. Berr,J. Bruix,J. Hauss,Ch. Wittekind,J. Wands Pdf

Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic strategies. The current concepts on risk profiling, surveillance of risk groups and therapeutic strategies are evidence-based for HCC and less detailed for CC. Surveillance of risk groups improves detection of liver tumours in curable stages. Best strategies for curative treatment of HCC use neoadjuvant antitumour therapies before liver transplantation and a role is emerging for living donor-related liver transplantation. New palliative therapies for HCC are in the experimental stage with biological response modifiers, including angiogenesis inhibitors, and entering phase II clinical trials with the alpha-fetoprotein derived vaccines.

Hepatocyte Transplantation

S. Gupta,Peter L.M. Jansen,J. Klempnauer,M.P. Manns
Hepatocyte Transplantation Book PDF

Author : S. Gupta,Peter L.M. Jansen,J. Klempnauer,M.P. Manns
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 51,6 Mb
Release : 2002-09-30
Category : Medical
ISBN : 0792387767

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Hepatocyte Transplantation by S. Gupta,Peter L.M. Jansen,J. Klempnauer,M.P. Manns Pdf

In recent years there has been an increasing need for transplantation, but the number of donor livers available has increased only slightly, despite intensive public relations activities. New concepts in the field of transplantation, for instance the transplantation of living donor organs or the splitting of organs, are urgently required, to safeguard the treatment of patients with severe liver disease. The development and clinical application of cell therapy for patients with liver disease could soon present a significant enhancement of the therapeutic options. The aim of such cell therapy is to repair or improve the biological function of the chronically and acutely damaged liver. Even though systematic trials are not available, individual case reports and small series already show promising clinical results. Present concepts of cell therapy for liver diseases based on the use of primary hepatocytes have recently been considerably extended through new data on the biology of stem cells. The adult haematopoetic stem cell as a pool for hepatocyte grafts - what would be the perspectives for the clinical application? This book is the proceedings of the Falk Symposium No. 126 on `Hepatocyte Transplantation' (Progress in Gastroenterology and Hepatology Part III) held in Hannover, Germany, October 2-3, 2001, and is a forum for basic research, but also for questions concerning clinical applications in the field of hepatocyte transplantation.

State of the Art of Hepatology

H.E. Blum,M.P. Manns,Marianne Manns
State of the Art of Hepatology Book PDF

Author : H.E. Blum,M.P. Manns,Marianne Manns
Publisher : Springer Science & Business Media
Page : 266 pages
File Size : 52,6 Mb
Release : 2004-06-30
Category : Medical
ISBN : 0792387953

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State of the Art of Hepatology by H.E. Blum,M.P. Manns,Marianne Manns Pdf

In honour of Hans Popper's 100th birthday

Future Perspectives in Gastroenterology

Martin C. Carey,J. Mossner,Petr Dite,A. Gabryelewicz,V. Keim
Future Perspectives in Gastroenterology Book PDF

Author : Martin C. Carey,J. Mossner,Petr Dite,A. Gabryelewicz,V. Keim
Publisher : Springer Science & Business Media
Page : 310 pages
File Size : 54,8 Mb
Release : 2008-08-21
Category : Medical
ISBN : 1402088329

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Future Perspectives in Gastroenterology by Martin C. Carey,J. Mossner,Petr Dite,A. Gabryelewicz,V. Keim Pdf

In 1996, an international symposium entitled "Future Perspectives in Gastroenterology" was held in the city of Leipzig, State of Saxony, Germany. Leading scientists in diverse fields of gastroenterology presented their recent findings and undertook the propitious risk of speculating about future directions. Thanks once again to the generous support of the Falk Foundation, it was possible to revisit a symposium with the same title, but held this time in the beautiful, rebuilt city of Dresden in Saxony. This book contains the proceedings of the Falk Symposium No. 161 on "Future Perspectives in Gastroenterology", held October 11–12, 2007. It presents many innovative themes as well as "new faces" and offers a rich opportunity to learn firsthand about the latest scientific discoveries in the broad field of gastroenterology. Several of these novel developments are probably well on their way to being implemented in clinical practice.

Trends and Controversies in IBD: Evidence-Based Approach Or Individual Management?

A. Dignass,H. Lochs,E.-F. Stange
Trends and Controversies in IBD Evidence Based Approach Or Individual Management Book PDF

Author : A. Dignass,H. Lochs,E.-F. Stange
Publisher : Springer Science & Business Media
Page : 268 pages
File Size : 47,8 Mb
Release : 2004-04-30
Category : Medical
ISBN : 0792387880

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Trends and Controversies in IBD: Evidence-Based Approach Or Individual Management? by A. Dignass,H. Lochs,E.-F. Stange Pdf

In spite of significant scientific progress in recent years, the aetiopathogenesis of chronic inflammatory bowel diseases (IBD) remains elusive. With a prevalence of 1:700 to 1:500 in central Europe, both diseases are not rare. However, most physicians will generally treat only a few patients with IBD in their clinical practice. Because of this limited experience and the variety of clinical IBD manifestations, IBD patients are frequently treated in specialized tertiary care centres. Nevertheless, IBD patients will also consult less specialized general practitioners, who will not be able to focus extensively on the management of IBD patients due to time constraints. Physicians who take care of IBD patients have to select among an ever-increasing amount of new scientific information in order to provide optimal and up-to-date care to their patients. In the era of evidence-based medicine it is often under debate whether evidence-based medicine may really improve the management of IBD patients or whether the diversity and complexity of IBD needs an individual and patient-oriented approach. This book, the proceedings of the Falk Symposium 134 on `Trends and Controversies in IBD - Evidence-Based Approach or Individual Management', held in Berlin, Germany, on 12-13 June 2003, critically discusses established and emerging new concepts in the field of IBD. It critically analyzes evidence-based and individual approaches in the management of IBD and discusses these approaches with the help of selected case reports.

Topical Steroids in Gastroenterology and Hepatology

A. Dignass,V. Gross,H.J. Buhr,O.F.W. James
Topical Steroids in Gastroenterology and Hepatology Book PDF

Author : A. Dignass,V. Gross,H.J. Buhr,O.F.W. James
Publisher : Springer Science & Business Media
Page : 150 pages
File Size : 45,9 Mb
Release : 2004-02-29
Category : Medical
ISBN : 0792387899

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Topical Steroids in Gastroenterology and Hepatology by A. Dignass,V. Gross,H.J. Buhr,O.F.W. James Pdf

This book, the proceedings of a Falk Workshop on `Topical Steroids in Gastroenterology and Hepatology', held in Berlin, Germany, on 14 June 2003, critically discusses the current role of budesonide in gastroenterology, hepatology, surgery and oncology and focuses especially on potential new indications for the use of budesonide. A number of smaller clinical studies and anecdotal case reports with impressive clinical effects are reported in patients with gastrointestinal, hepatic, oncological and surgical problems. In addition, the use of budesonide for the treatment of distal ulcerative colitis and ileocolonic Crohn's disease is evaluated with respect to its role in an evidence-based management of IBD. Finally, as clinical experience with the use of budesonide is increasing, safety issues and the side-effect profile of budesonide is addressed.

Bile Acid Biology and its Therapeutic Implications

G. Paumgartner,D. Keppler,U. Leuschner,A. Stiehl
Bile Acid Biology and its Therapeutic Implications Book PDF

Author : G. Paumgartner,D. Keppler,U. Leuschner,A. Stiehl
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 40,5 Mb
Release : 2005-03-02
Category : Medical
ISBN : 1402028938

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Bile Acid Biology and its Therapeutic Implications by G. Paumgartner,D. Keppler,U. Leuschner,A. Stiehl Pdf

This book is the proceedings of the 18th International Bile Acid Meeting, held as the Falk Symposium 141 in Stockholm, Sweden, on June 18–19, 2004. The International Bile Acid Meetings have become some of the most important meetings in the bile acid field worldwide since Herbert Falk decided to sponsor these Symposia in biannual sequence in 1970. The 17 International Bile Acid Meetings in the past have been a great stimulus for new ideas and methods as well as the development of therapeutic applications of bile acids. They have always been a forum where basic scientists and clinicians interact. Many novel results of bile acid research were first presented at these meetings. The meeting in Stockholm again attracted a large number of basic and clinical scientists interested in bile acid and biliary research from all over the world. Knowledge about the regulation of bile acid synthesis, bile acid transport and enterohepatic circulation in health and in disease has increased considerably during recent years. Accordingly, bile acid research is alive as ever. A new chapter of bile acid research was opened by the finding that bile acids are ligands of nuclear receptors which regulate synthesis, metabolism and transport of bile acids and steroids. A large part of the book is devoted to these topics. The 18th International Bile Acid Meeting was again a truly interdisciplinary symposium at the highest scientific level. Its participants enjoyed hearing the latest reports on bile acid research in the city where so many seminal studies on bile acids were performed. It is hoped that the readers of this book will share the enjoyment.

Mechanisms of Intestinal Inflammation

R. Duchmann
Mechanisms of Intestinal Inflammation Book PDF

Author : R. Duchmann
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 42,8 Mb
Release : 2004-04-30
Category : Medical
ISBN : 0792387872

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Mechanisms of Intestinal Inflammation by R. Duchmann Pdf

In recent years considerable progress has been achieved in regard to our understanding of the induction and modulation of the immune response in the intestinal mucosa. It is clear that this mucosal immune reaction is predominantly steered by certain T-cell populations, which are characterized by their cytokine secretion profile. Less well known are the conditions under which the uptake and processing of a specific antigen leads to a certain immune response, whether it be protective, tolerant or inflammatory. However, here again distinct progress has been made in our understanding. Equally significant for immune regulation in the gut appears to be so-called innate immunity. Every shift of equilibrium in the highly regulated mucosal immune reaction is accompanied by an inflammatory reaction and destruction of the mucosa. In nearly all cases, this inflammatory response is dependent on the presence of bacterial intestinal flora. This book, the proceedings of Falk Symposium 133 on Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD', held in Berlin, Germany, on 10-11 June 2003, summarizes present knowledge in the area of unspecific and specific immune reactions in the gut, recording the gaps in our knowledge and, in particular, presenting the possibilities of targeted intervention. The link to inflammatory bowel diseases - Crohn's disease and ulcerative colitis - is always in focus. Chapters by an international panel of basic scientists, clinical researchers and clinicians also record the problems which can originate through today's possible modulation of the immune reaction, setting the basis for review of clinical problems. This book is valuable readings for all scientists and physicians, who, from different perspectives, have an interest in research on IBD and in the clinical management of these diseases.