Hepatocellular Carcinoma

Author : Brian I. Carr
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 54,7 Mb
Release : 2009-10-03
Category : Medical
ISBN : 9781603273763

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Hepatocellular Carcinoma by Brian I. Carr Pdf

Hepatocellular cancer is the fifth most common cancer, with 600,000 new cases reported each year worldwide. Additionally, exciting changes in the science of HCC in the last four years have turned the practice of diagnosing and treating the disease upside down. In Hepatocellular Carcinoma: Diagnosis and Treatment, Second Edition, the leading experts in the field of HCC thoroughly update and expand upon the critically acclaimed first edition with all the latest developments in the diagnosis and treatment of primary liver cancer. The book details for physicians the diagnostic and therapeutic decision making process for dealing with such problems as incidental tumors in the liver transplant, the role of neo-adjuvant chemotherapy, intra-arterial vs intravenous therapy, the uses of embolization, and the significance of portal vein thrombus. New chapters discuss the introduction into clinical practice of cell cycle growth inhibitors, an expanded knowledge of Genomics and Proteomics, and novel ways of delivering intra-hepatic chemotherapy. This cutting-edge text is a vital resource and must have for today’s hepatologists and medical and surgical oncologists.

Author : Yujin Hoshida
Publisher : Springer
Page : 366 pages
File Size : 51,7 Mb
Release : 2019-08-05
Category : Medical
ISBN : 9783030215408

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Hepatocellular Carcinoma by Yujin Hoshida Pdf

This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Author : W. Y. Lau
Publisher : World Scientific
Page : 864 pages
File Size : 50,7 Mb
Release : 2008
Category : Medical
ISBN : 9789812707994

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Hepatocellular Carcinoma by W. Y. Lau Pdf

This essential book is a compendium of papers written by an international team of world-renowned experts, who cover topics in their respective areas of expertise. Presenting the most up-to-date knowledge of hepatocellular carcinoma, it covers all topics ? including those more controversial ones ? in this rapidly advancing field, from epidemiology to prevention, from molecular biology to gross pathology, from screening to atypical presentation, from diagnosis to treatment, and from assessment to choice of appropriate treatment. This volume is therefore an important contribution to the field of hepatocellular carcinoma.

Author : World Health Organization
Publisher : World Health Organization
Page : 0 pages
File Size : 55,9 Mb
Release : 2017
Category : Medical
ISBN : 924154998X

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Guidelines on Hepatitis B and C Testing by World Health Organization Pdf

Testing and diagnosis of hepatitis B (HBV) and C (HCV) infection is the gateway for access to both prevention and treatment services, and is a crucial component of an effective response to the hepatitis epidemic. Early identification of persons with chronic HBV or HCV infection enables them to receive the necessary care and treatment to prevent or delay progression of liver disease. Testing also provides an opportunity to link people to interventions to reduce transmission, through counselling on risk behaviors and provision of prevention commodities (such as sterile needles and syringes) and hepatitis B vaccination. These are the first WHO guidelines on testing for chronic HBV and HCV infection and complement published guidance by WHO on the prevention, care and treatment of chronic hepatitis C and hepatitis B infection. These guidelines outline the public health approach to strengthening and expanding current testing practices for HBV and HCV, and are intended for use across age groups and populations.

Author : Haeryoung Kim,Wei-Qiang Leow,Regina Lo,Paulo Giovanni L. Mendoza,Anthony Wing-Hung Chan
Publisher : Springer Nature
Page : 193 pages
File Size : 48,5 Mb
Release : 2022-01-31
Category : Medical
ISBN : 9789811685002

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Atlas of Hepatocellular Carcinoma Pathology by Haeryoung Kim,Wei-Qiang Leow,Regina Lo,Paulo Giovanni L. Mendoza,Anthony Wing-Hung Chan Pdf

This atlas is designed to be a user-friendly bench-side reference for pathology trainees and general pathologists in handling and interpreting specimens of hepatocellular carcinoma. It provides over 550 high-quality gross and microscopic photos focusing on hepatocellular carcinoma and its mimickers, and demonstrating a full range of various histological variants of hepatocellular carcinoma. Introductory text in each chapter summarises salient clinical associations, pathological features, and molecular alterations of different variants of hepatocellular carcinoma. Differentiation between hepatocellular carcinoma and its mimickers is illustrated through various case studies. The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high.The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high.The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high.The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high.The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high./divThe authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high./divThe authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high./div

Author : Tim F. Greten
Publisher : Springer
Page : 167 pages
File Size : 51,9 Mb
Release : 2017-10-04
Category : Medical
ISBN : 9783319649580

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Immunotherapy of Hepatocellular Carcinoma by Tim F. Greten Pdf

In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Author : Toshiro Nakashima,Masamichi Kojiro
Publisher : Springer Science & Business Media
Page : 267 pages
File Size : 49,8 Mb
Release : 2013-11-09
Category : Medical
ISBN : 9784431683346

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Hepatocellular Carcinoma by Toshiro Nakashima,Masamichi Kojiro Pdf

Hepatocellular carcinoma is one of the most common fatal malignan cies of mankind. Up to a few decades ago it was looked upon as a cancer which aroused mainly academic concern but relatively little clinical interest, because its therapy and prognosis had a most un favorable outlook. Indeed, it was mostly recognized only at autopsy. Recently this pessimism has radically changed and is disappearing to a rapidly accelerating degree. Many of the scientific contributions at this change in outlook are the result of research in the Far East, first, Japan and then gradually extending to its neighbors. The introduction of experimental hepatocarcinogens by Yoshida more than 50 years ago may have been one of the first important steps. Hepatocellular car cinoma shows a characteristic geographical distribution. With the highest incidence in China, Taiwan, Southeast Asia and sub-Saharan Africa, followed by southern and eastern Europe, while generally the incidence is rather low in western and northern Europe and North and South America.

Author : Catherine Frenette
Publisher : Elsevier Health Sciences
Page : 273 pages
File Size : 43,5 Mb
Release : 2020-10-22
Category : Medical
ISBN : 9780323711418

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Hepatocellular Carcinoma: Moving into the 21st Century , An Issue of Clinics in Liver Disease E-Book by Catherine Frenette Pdf

In collaboration with Consulting Editor, Dr. Norman Gitlin, Guest Editor Dr. Catherine Frenette has assembled expert authors to provide current updates on Hepatocellular Carcinoma (HCC). This issue asks important questions and provides answers and current thoughts on the staging and treatment of HCC. Clinical review articles are specifically dedicated to the following topics: The Changing Global Epidemiology of Hepatocellular Carcinoma; Prevention Strategies for HCC; Biomarkers or Biopsy for Diagnosis of HCC; Screening and Surveillance Strategies to Improve the Chance of Success; Imaging Diagnosis of HCC; Surgical Resection: Old dog--Any new tricks; Hepatocellular Carcinoma and Liver Transplant: How Will Organ Allocation Changes Affect the HCC Patient Within Transplant Criteria; Downstaging to Liver Transplant: Success Involves Choosing the Right Patient; Locoregional Therapies for Hepatocellular Carcinoma: What has Changed in the Past Ten Years; External Beam Radiotherapy: Is There a Place for This in HCC Treatment; Tyrosine Kinase Inhibitors and Hepatocellular Carcinoma; Immuno-oncology for Hepatocellular Carcinoma: The Present and the Future; Management of Side Effects of Systemic Therapies for HCC: Guide for the Hepatologist; and Why a Multi-disciplinary Tumor Board is Critical for Success with Hepatocellular Carcinoma. Readers will come away with the information they need to improve patient outcomes in the patient with HCC.

Author : Jean-Nicolas` Vauthey,Antoine Brouquet
Publisher : Springer Science & Business Media
Page : 266 pages
File Size : 45,7 Mb
Release : 2012-08-31
Category : Medical
ISBN : 9783642160370

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Multidisciplinary Treatment of Hepatocellular Carcinoma by Jean-Nicolas` Vauthey,Antoine Brouquet Pdf

It is now widely accepted that multidisciplinary collaboration and multimodality treatment approaches are important in improving the survival of patients with hepatocellular carcinoma. In this comprehensive textbook, internationally renowned experts in the field present and discuss the various strategies employed in the treatment of the disease. Up-to-date information is provided on the indications for and outcome of a range of treatment options, including surgical resection, liver transplantation, radiofrequency ablation, transarterial chemoembolization, yttrium-90 transarterial radioembolization, and systemic therapy. In addition, important background information is included on biology, pathology, staging, and imaging. This book will be particularly helpful to all professionals and trainees worldwide who have an interest in the diagnosis and treatment of hepatocellular carcinoma.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 50,8 Mb
Release : 2024-06-11
Category : Electronic
ISBN : 9789814474948

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Hepatocellular Carcinoma by Anonim Pdf

Author : Jiangsheng Huang,Xianling Liu,Jixiong Hu
Publisher : Springer
Page : 329 pages
File Size : 41,7 Mb
Release : 2018-10-12
Category : Medical
ISBN : 9789811306686

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Atlas of Anatomic Hepatic Resection for Hepatocellular Carcinoma by Jiangsheng Huang,Xianling Liu,Jixiong Hu Pdf

This book comprehensibly describes the clinical details of anatomic hepatic resection using the Glissonean pedicle approach for hepatocellular carcinoma. It includes all aspects of the surgical anatomy of the liver, preoperative management of patients, surgical techniques, and intraoperative key points to prevent postoperative complications. The first three chapters provide a general introduction to the clinical anatomy of the liver, preoperative management of patients with hepatocellular carcinoma, basic techniques for hepatic resection using the Glissonean approach, and the application of dye staining in anatomic hepatic resection. Subsequent chapters present the technical details of anatomical segmentectomy (Couinaud’s classification), sectionectomy and hemi-hepatectomy for hepatocellular carcinoma using the modified suprahilar Glissonean approach. All of these hepatectomies can be performed using simple and easily available surgical instruments. In addition, it discusses precise transection of the deepest hepatic parenchyma guided by methylene blue staining. It is a useful and timely reference for hepatobiliary surgeons, clinical staff, and medical students.

Author : Costin Teodor Streba,Cristin Constantin Vere,Ion Rogoveanu
Publisher : BoD – Books on Demand
Page : 201 pages
File Size : 45,6 Mb
Release : 2018-11-28
Category : Medical
ISBN : 9781789842739

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Hepatocellular Carcinoma by Costin Teodor Streba,Cristin Constantin Vere,Ion Rogoveanu Pdf

Hepatocellular carcinoma (HCC) currently ranks as the third most common cause of death. As the primary malignancy of the liver is directly related to an underlying liver condition, its incidence and profile are expected to change soon. While effective prevention programs and antiviral therapies for hepatitis B and C will lower the incidence of HCC, emerging socioeconomic issues will deliver new at-risk populations. Moreover, diagnostic techniques and protocols have undergone significant advancements. Reliance on contrast enhanced ultrasound has been re-evaluated, imaging methods being considered as sufficient diagnostic tools. Molecular characterization remains desirable, since chemotherapeutic agents still have limited applicability. In light of recent diagnostic advancements and novel therapeutic solutions, it is our belief that a comprehensive update on recent paradigm shifts and interesting upcoming developments is highly needed.

Author : Nagy A. Habib
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 47,8 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592590797

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Hepatocellular Carcinoma by Nagy A. Habib Pdf

Advances in molecular characterization and novel gene-isolation techniques have vigorously expanded our understanding of hepatocellular carcinoma (HCC), a form of liver cancer that affects one million people annually, and generated many new therapeutic possibilities. In Hepatocellular Carcinoma: Methods and Protocols, Nagy Habib and a team of basic and clinical researchers describe the wide variety of powerful new laboratory-based molecular methods currently being used for investigating and treating this disease. The book focuses on gene therapy approaches, including the use of such vectors as lipids, adenovirus, and baculovirus, and virus detection assessment using electron microscopy. It also provides preclinical and clinical data on the killing of cancer cells using tumor-suppressor genes, antisense compounds to growth factors, immunotherapy (remove gene), and virus-directed enzyme prodrug therapy. A perspective on future treatment of the failing liver is given, along with a clinical protocol for p53 gene therapy. Hepatocellular Carcinoma: Methods and Protocols offers experimental and clinical investigators a rich source of both basic science and clinical information on today's optimal use of gene therapy to treat and manage patients suffering from hepatocellular carcinoma.

Author : Tim Cross,Daniel H. Palmer
Publisher : Springer
Page : 312 pages
File Size : 53,8 Mb
Release : 2018-12-12
Category : Medical
ISBN : 9783319922164

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Liver Cancers by Tim Cross,Daniel H. Palmer Pdf

This book explores in detail the primary liver cancers of hepatocellular carcinoma and cholangiocarcinoma examining the pathogenesis of disease along with diagnosis and current management options together with exploration of future treatment strategies and areas of controversy. Furthermore, the book highlights management of the common secondary malignancies and touches on benign liver tumours and how to best manage these. Written in a clear and didactic style, this volume includes summaries of the key learning points and questions so that the reader can gauge their knowledge and understanding. This book is aimed to broaden the knowledge base of primary care physicians, general physicians along with specialists in hepatology, oncology and hepato-biliary surgery

Author : Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 43,5 Mb
Release : 2012-08-28
Category : Medical
ISBN : 9783642256042

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Stereotactic Body Radiation Therapy by Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter Pdf

Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.