Heterocyclic Chemistry In Drug Discovery

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Heterocyclic Chemistry in Drug Discovery

Jie Jack Li
Heterocyclic Chemistry in Drug Discovery Book PDF

Author : Jie Jack Li
Publisher : John Wiley & Sons
Page : 688 pages
File Size : 46,9 Mb
Release : 2013-04-26
Category : Science
ISBN : 9781118354438

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Heterocyclic Chemistry in Drug Discovery by Jie Jack Li Pdf

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Applications of Heterocycles in the Design of Drugs and Agricultural Products

Anonim
Applications of Heterocycles in the Design of Drugs and Agricultural Products Book PDF

Author : Anonim
Publisher : Academic Press
Page : 332 pages
File Size : 53,8 Mb
Release : 2021-06-09
Category : Science
ISBN : 9780128201824

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Applications of Heterocycles in the Design of Drugs and Agricultural Products by Anonim Pdf

Applications of Heterocycles in the Design of Drugs and Agricultural Products, Volume 134 in the Advances in Heterocyclic Chemistry series represents the most definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Chapters in this updated volume cover Hydroxy azoles as carboxylic acid bioisosteres, Cyclic sulfoxides and sulfones in drug design, Thiazoles and topological control in drug design, Applications of fused pyrrolidine [3.3.0] heterocycles in drug design, 1,4 Disubstituted and 1,4,5 trisubstituted-1,2,3-triazoles in drug discovery and development: from the flask to the clinic, and Conformationally restricted [3.2.2]- and [3.2.1]-3-azabicyclic diamines. Because biology and organic chemistry increasingly intersect, the associated nomenclature is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and biological scientists Provides the latest, comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Piperidine-Based Drug Discovery

Ruben Vardanyan
Piperidine Based Drug Discovery Book PDF

Author : Ruben Vardanyan
Publisher : Elsevier
Page : 358 pages
File Size : 42,6 Mb
Release : 2017-06-12
Category : Science
ISBN : 9780128134283

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Piperidine-Based Drug Discovery by Ruben Vardanyan Pdf

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. Explores this extremely important heterocycle to a high level of detail Describes synthesis methods for 70 current drugs based on Piperidine scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Modern Green Chemistry and Heterocyclic Compounds

Ravindra S. Shinde,A. K. Haghi
Modern Green Chemistry and Heterocyclic Compounds Book PDF

Author : Ravindra S. Shinde,A. K. Haghi
Publisher : CRC Press
Page : 302 pages
File Size : 50,9 Mb
Release : 2020-03-31
Category : Medical
ISBN : 9781000029178

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Modern Green Chemistry and Heterocyclic Compounds by Ravindra S. Shinde,A. K. Haghi Pdf

This book covers the general properties of heterocyclic compounds and methods for their preparation to use in applications of green chemistry. Heterocyclic compounds are an important class of molecules in organic chemistry due to their presence in natural products and their use in pharmaceuticals and new materials. They also play a vital role in the metabolism of living cells. Heterocyclic compounds have a wide range of applications in agrochemicals, pharmaceuticals, veterinary products, etc. This research-oriented volume is ideal for readers who want to fully realize the almost limitless potential of heterocyclic compounds and to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features several case studies and step-by-step descriptions of synthetic methods and practical techniques. It also serves as a guide for chemists, offering them new insights and new paths to explore for effective drug discovery.

Fundamentals of Heterocyclic Chemistry

Louis D. Quin,John A. Tyrell
Fundamentals of Heterocyclic Chemistry Book PDF

Author : Louis D. Quin,John A. Tyrell
Publisher : Wiley
Page : 344 pages
File Size : 44,6 Mb
Release : 2010-08-09
Category : Science
ISBN : 0470566698

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Fundamentals of Heterocyclic Chemistry by Louis D. Quin,John A. Tyrell Pdf

Heterocyclic chemistry is of prime importance as a sub-discipline of Organic Chemistry, as millions of heterocyclic compounds are known with more being synthesized regularly Introduces students to heterocyclic chemistry and synthesis with practical examples of applied methodology Emphasizes natural product and pharmaceutical applications Provides graduate students and researchers in the pharmaceutical and related sciences with a background in the field Includes problem sets with several chapters

Heterocycles in Life and Society

Alexander F. Pozharskii,Anatoly T. Soldatenkov,Alan R. Katritzky
Heterocycles in Life and Society Book PDF

Author : Alexander F. Pozharskii,Anatoly T. Soldatenkov,Alan R. Katritzky
Publisher : John Wiley & Sons
Page : 404 pages
File Size : 52,5 Mb
Release : 2011-03-31
Category : Science
ISBN : 9781119970132

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Heterocycles in Life and Society by Alexander F. Pozharskii,Anatoly T. Soldatenkov,Alan R. Katritzky Pdf

Heterocycles in Life and Society is an introduction to the chemistry of heterocyclic compounds, focusing on their origin and occurrence in nature, biochemical significance and wide range of applications. Written in a readable and accessible style, the book takes a multidisciplinary approach to this extremely important area of organic chemistry. Topics covered include an introduction to the structure and properties of heterocycles; the key role of heterocycles in important life processes such as the transfer of hereditary information, how enzymes function, the storage and transport of bioenergy, and photosynthesis; applications of heterocycles in medicine, agriculture and industry; heterocycles in supramolecular chemistry; the origin of heterocycles on primordial Earth; and how heterocycles can help us solve 21st century challenges. For this second edition, Heterocycles in Life and Society has been completely revised and expanded, drawing on a decade of innovation in heterocyclic chemistry. The new edition includes discussions of the role of heterocycles in nanochemistry, green chemistry, combinatorial chemistry, molecular devices and sensors, and supramolecular chemistry. Impressive achievements include the creation of various molecular devices, the recording and storage of information, the preparation of new organic conductors, and new effective drugs and pesticides with heterocyclic structures. Much new light has been thrown on various life processes, while the chemistry of heterocycles has expanded to include new types of heterocyclic structures and reactions, and the use of heterocyclic molecules as ionic liquids and proton sponges. Heterocycles in Life and Society is an essential guide to this important field for students and researchers in chemistry, biochemistry, and drug discovery, and scientists at all levels wishing to expand their scientific horizon.

Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective

Ravi Varala
Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective Book PDF

Author : Ravi Varala
Publisher : BoD – Books on Demand
Page : 169 pages
File Size : 51,7 Mb
Release : 2016-06-30
Category : Science
ISBN : 9789535125037

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Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective by Ravi Varala Pdf

Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective is a compilation of bioactive-chosen heterocyclic scaffolds intended for postgraduates, research scholars, pharmaceutical scientists, and others interested in an appreciation of the title subject. It is an edited book and is not comprehensive as well in the mentioned field. Few synthetic strategies along with bioactivity are presented, and some limitations were raised in order to arouse curiosity of the reader.

Key Heterocycle Cores for Designing Multitargeting Molecules

Om Silakari
Key Heterocycle Cores for Designing Multitargeting Molecules Book PDF

Author : Om Silakari
Publisher : Elsevier
Page : 436 pages
File Size : 44,5 Mb
Release : 2018-06-11
Category : Science
ISBN : 9780081021057

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Key Heterocycle Cores for Designing Multitargeting Molecules by Om Silakari Pdf

Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research. Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases

Flow Chemistry for the Synthesis of Heterocycles

Upendra K. Sharma,Erik V. Van der Eycken
Flow Chemistry for the Synthesis of Heterocycles Book PDF

Author : Upendra K. Sharma,Erik V. Van der Eycken
Publisher : Springer
Page : 397 pages
File Size : 47,8 Mb
Release : 2018-06-20
Category : Science
ISBN : 9783319943282

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Flow Chemistry for the Synthesis of Heterocycles by Upendra K. Sharma,Erik V. Van der Eycken Pdf

This volume provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis. The heterocyclic ring is the most prominent structural motif in the vast majority of natural products as well as pharmaceutical compounds since this facilitates tuneable interactions with the biological target besides conferring a degree of structural and metabolic stability. In recent times, flow chemistry has heralded a paradigm shift in organic synthesis as it offers several unique advantages over conventional methods like drastic acceleration of sluggish transformations, enhanced yields, cleaner reactions etc and is gradually gaining a lot of attention among organic chemist worldwide. Given the importance of heterocycles in natural products, medicinal chemistry and pharmaceuticals, this is a well warranted volume and complements the previous volume of Topics in Organometallic Chemistry ‘Organometallic Flow Chemistry’. This volume offers a versatile overview of the topic, besides discussing the recent progress in the flourishing area of flow chemistry in relevance to heterocyclic chemistry; it will also help researchers to better understand the chemistry behind these reactions. This in turn provides a platform for future innovations towards the designing of novel transformations under continuous flow. Thus, this volume will appeal to both the novices in this field as well as to experts in academia and industry.

Heterocyclic Chemistry in the 21st Century: A Tribute to Alan Katritzky

Anonim
Heterocyclic Chemistry in the 21st Century A Tribute to Alan Katritzky Book PDF

Author : Anonim
Publisher : Academic Press
Page : 314 pages
File Size : 53,9 Mb
Release : 2017-01-03
Category : Science
ISBN : 9780128120705

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Heterocyclic Chemistry in the 21st Century: A Tribute to Alan Katritzky by Anonim Pdf

Advances in Heterocyclic Chemistry: Heterocyclic Chemistry in the 21st Century: A Tribute to Alan Katritzky is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature is used more frequently in explanations. Written by established, global authorities in the field, this comprehensive review combines descriptive synthetic chemistry and mechanistic insights to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists, and many biological scientists Provides the latest comprehensive reviews as written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds

Synthesis of Heterocycles via Multicomponent Reactions II

Romano V. A. Orru,Eelco Ruijter
Synthesis of Heterocycles via Multicomponent Reactions II Book PDF

Author : Romano V. A. Orru,Eelco Ruijter
Publisher : Springer
Page : 292 pages
File Size : 46,9 Mb
Release : 2010-07-26
Category : Science
ISBN : 9783642154553

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Synthesis of Heterocycles via Multicomponent Reactions II by Romano V. A. Orru,Eelco Ruijter Pdf

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery

Handbook of Heterocyclic Chemistry

Alan R. Katritzky
Handbook of Heterocyclic Chemistry Book PDF

Author : Alan R. Katritzky
Publisher : Elsevier
Page : 568 pages
File Size : 41,8 Mb
Release : 2017-01-31
Category : Science
ISBN : 9781483293424

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Handbook of Heterocyclic Chemistry by Alan R. Katritzky Pdf

Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.

Multicomponent Reactions towards Heterocycles

Erik Van der Eycken,Upendra K. Sharma
Multicomponent Reactions towards Heterocycles Book PDF

Author : Erik Van der Eycken,Upendra K. Sharma
Publisher : John Wiley & Sons
Page : 626 pages
File Size : 45,7 Mb
Release : 2022-03-21
Category : Science
ISBN : 9783527349081

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Multicomponent Reactions towards Heterocycles by Erik Van der Eycken,Upendra K. Sharma Pdf

Presents a wide-ranging overview of essential topics and recent advances in MCR chemistry Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs. Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and C–H functionalization and multicomponent reactions. Provides a thorough overview of heterocycles as input in multicomponent reactions Discusses recent advances in the field of MCR chemistry and progress in the synthesis and functionalization of heterocycles Demonstrates the use of MCRs to simplify synthetic design and achieve complexity and diversity in novel bioactive molecules Highlights examples of multicomponent polymerizations, target-oriented synthesis, and applications of MCR in medicinal chemistry Explains the methodology of using on-resin MCRs to produce heterocycle compounds Illustrating the key role of MCRs towards heterocycles in natural product synthesis, drug discovery, organic synthesis, and other applications, Multicomponent Reactions towards Heterocycles is required reading for synthetic chemists in academia and industry alike.

Advances in Heterocyclic Chemistry

Anonim
Advances in Heterocyclic Chemistry Book PDF

Author : Anonim
Publisher : Academic Press
Page : 434 pages
File Size : 47,9 Mb
Release : 2021-06-12
Category : Science
ISBN : 9780323851039

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Advances in Heterocyclic Chemistry by Anonim Pdf

Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Synthetic Methods in Drug Discovery

David C. Blakemore,Paul M. Doyle,Yvette M. Fobian
Synthetic Methods in Drug Discovery Book PDF

Author : David C. Blakemore,Paul M. Doyle,Yvette M. Fobian
Publisher : Royal Society of Chemistry
Page : 474 pages
File Size : 45,8 Mb
Release : 2016
Category : Drug development
ISBN : 9781849738033

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Synthetic Methods in Drug Discovery by David C. Blakemore,Paul M. Doyle,Yvette M. Fobian Pdf

The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact in drug discovery and facilitate delivery of drug molecules. Synthetic Methods in Drug Discovery Volume 1 focuses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.