Key Heterocycle Cores For Designing Multitargeting Molecules

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Key Heterocycle Cores for Designing Multitargeting Molecules

Om Silakari
Key Heterocycle Cores for Designing Multitargeting Molecules Book PDF

Author : Om Silakari
Publisher : Elsevier
Page : 436 pages
File Size : 49,5 Mb
Release : 2018-06-11
Category : Science
ISBN : 9780081021057

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Key Heterocycle Cores for Designing Multitargeting Molecules by Om Silakari Pdf

Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research. Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases

Advances in Heterocyclic Chemistry

Anonim
Advances in Heterocyclic Chemistry Book PDF

Author : Anonim
Publisher : Academic Press
Page : 492 pages
File Size : 42,5 Mb
Release : 2020-05-08
Category : Science
ISBN : 9780128211687

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Advances in Heterocyclic Chemistry by Anonim Pdf

Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Surfactants from Renewable Raw Materials

Divya Bajpai Tripathy,Anjali Gupta,Arvind Kumar Jain,Anuradha Mishra
Surfactants from Renewable Raw Materials Book PDF

Author : Divya Bajpai Tripathy,Anjali Gupta,Arvind Kumar Jain,Anuradha Mishra
Publisher : CRC Press
Page : 357 pages
File Size : 45,9 Mb
Release : 2021-12-22
Category : Science
ISBN : 9781000511895

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Surfactants from Renewable Raw Materials by Divya Bajpai Tripathy,Anjali Gupta,Arvind Kumar Jain,Anuradha Mishra Pdf

Surfactants are often completely invisible to us and yet they are present in almost every chemical that we use in our daily life. They are found in toothpastes, cosmetics, sunscreens, mayonnaise, detergents, and an array of cleaning products. Traditional surfactants are known to have adverse environmental impacts spurring research into eco-friendly and cost-effective surfactants from renewable resources. Surfactants from Renewable Raw Materials examines the class of surfactants synthesized using plant-based raw materials detailing their properties, applications, bioavailability, and biodegradability. The concluding chapter reviews patent activity over the last decade. Additional features include: Addresses the tremendous variation found in the raw materials used to synthesize commercially available surfactants. Explores the selection of raw materials based upon the desired hydrophobic group or hydrophilic group to be incorporated into the product. Examines the characteristics and medicinal applications of pulmonary surfactants in preterm babies as well as their probable contribution in COVID-19 Discusses the biodegradability of surfactants to assist with the determination of truly green surfactants. This comprehensive reference will prove indispensable for professional and academic researchers creating or working with bio-based surfactants.

Essential Oils

Gulzar Ahmad Nayik,Mohammad Javed Ansari
Essential Oils Book PDF

Author : Gulzar Ahmad Nayik,Mohammad Javed Ansari
Publisher : Academic Press
Page : 524 pages
File Size : 48,5 Mb
Release : 2023-02-06
Category : Science
ISBN : 9780323972352

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Essential Oils by Gulzar Ahmad Nayik,Mohammad Javed Ansari Pdf

Essential Oils: Extraction, Characterization and Applications covers sixteen essential oils from different herbal and aromatic plants, including production, composition and extraction techniques such as distillation, chemistry and properties, characterization and applications. The book also presents their safety, toxicity and regulation, alongside trade, storage, stability and transport concepts. Essential oils in plants, extraction and analysis, and current trends in the use of essential oils, like aroma therapy, agro-food and non-food usage are thoroughly explored. Remaining chapters are dedicated to different essential oils, including lavender, peppermint, sandalwood, citrus, eucalyptus, tea tree, clove, ginger, cinnamon, nutmeg, rosewood, juniper and pine, patchouli, clary, and more. Edited by a global team of experts in essential oils, this book is designed to be a practical tool for the many diverse professionals who develop and market essential oils. Thoroughly explores the extraction and characterization of essential oils Contains comprehensive information on major, popular essential oils Provides an exceptional range of information on properties, applications, safety, toxicity and regulations

A Review on Diverse Neurological Disorders

Rameshwar Nath Chaurasia,Sunny Ohia,Debasis Bagchi
A Review on Diverse Neurological Disorders Book PDF

Author : Rameshwar Nath Chaurasia,Sunny Ohia,Debasis Bagchi
Publisher : Elsevier
Page : 732 pages
File Size : 53,9 Mb
Release : 2024-06-14
Category : Medical
ISBN : 9780323957366

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A Review on Diverse Neurological Disorders by Rameshwar Nath Chaurasia,Sunny Ohia,Debasis Bagchi Pdf

According to World Health Organization (WHO) one billion people worldwide are affected by one of the thousands of neurological disorders, including epilepsy, Alzheimer disease, strokes, and headaches. Neurological disorders also include brain injuries, neuroinfections, multiple sclerosis and Parkinson disease. A Review on Neurological Disorders: Pathophysiology, Molecular Mechanisms, and Therapeutics covers the major topics related to neurological disorders, current challenges in diagnosis and intervention. This book is organized into four distinct sections, starting with an introduction, providing a general overview of the epidemiology of neurological disorders, pathogenesis and management. The second section presents the aspects of brain diseases due to infection of bacteria, parasite, fungus and viruses. The third section discusses neurodegenerative disorders due to comorbid factors like diabetes, hypertension, hyperlipidemia and post traumatic brain injuries. The last section covers prevention through application of bioactive compounds and neuroprotective agents. Epidemiology of neurological disorders and pathogenesis. Explores neuroinflammation, ligand-receptors binding, and neurodegeneration. Discusses aging and associated disorders in the onset of neurological disorders. Neuropharmacology and the protective role of bioactive compounds in neuroprotection.

Greener Synthesis of Organic Compounds

Ahindra Nag
Greener Synthesis of Organic Compounds Book PDF

Author : Ahindra Nag
Publisher : CRC Press
Page : 791 pages
File Size : 55,9 Mb
Release : 2022-05-30
Category : Science
ISBN : 9781000545128

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Greener Synthesis of Organic Compounds by Ahindra Nag Pdf

This book provides an interdisciplinary, integrative overview of environmental problem-solving using mild reaction conditions, green reagents, waste free and energy efficient synthesis in both industry and academic world. Discussions include a broad, integrated perspective on sustainability, integrated risk, multi-scale changes and impacts taking place within ecosystems worldwide. Features: This book serves as a reference book for scientific investigators who need to do greener synthesis of organic compounds, drugs and natural products under mild reaction condition using green reagents, eco-friendly catalysts and benign reaction mediums over traditional synthetic processes which is a key driving force of scientists. Greener synthesis of multiple value-added heterocycles opens up a new horizon towards the organic catalysis and for this purpose, development of natural resources acts as an effective catalyst. Using environmentally friendly reaction medium e.g. ACC, WETSA, WEBSA have been used for the synthesis of some crucial heterocyclic scaffolds such as bisenols and 2-amino-4H-pyrans, tetraketones, pyrans, and biaryls. This book can also be used as a textbook for graduate and post graduate level courses for students. Furthermore, the problems with answers in book will add better understanding for students.

Pharmacognosy

Simone Badal McCreath,Yuri N. Clement
Pharmacognosy Book PDF

Author : Simone Badal McCreath,Yuri N. Clement
Publisher : Elsevier
Page : 847 pages
File Size : 54,8 Mb
Release : 2023-10-13
Category : Medical
ISBN : 9780443186585

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Pharmacognosy by Simone Badal McCreath,Yuri N. Clement Pdf

Pharmacognosy: Fundamentals, Applications and Strategies, Second Edition represents a comprehensive compilation of the philosophical, scientific and technological aspects of contemporary pharmacognosy. The book examines the impact of the advanced techniques of pharmacognosy on improving the quality, safety and effectiveness of traditional medicines, and how pharmacokinetics and pharmacodynamics have a crucial role to play in discerning the relationships of active metabolites to bioavailability and function at the active sites, as well as the metabolism of plant constituents. Structured in seven parts, the book covers the foundational aspects of Pharmacognosy, the chemistry of plant metabolites, their effects, other sources of metabolites, crude drugs from animals, basic animal anatomy and physiology, technological applications and biotechnology, and the current trends in research. New to this edition is a chapter on plant metabolites and SARS-Cov-2, extensive updates on existing chapters and the development of a Laboratory Guide to support instructors execute practical activities on the laboratory setting. Covers the main sources of natural bioactive substances Contains practice questions and laboratory exercises at the end of every chapter to test learning and retention Describes how pharmacokinetics and pharmacodynamics play a crucial role in discerning the relationships of active metabolites to bioavailability and function at active sites Includes a dedicated chapter on the effect of plant metabolites on SARS-CoV-2

Science of Synthesis: Click Chemistry

Floris P. J. T. Rutjes
Science of Synthesis Click Chemistry Book PDF

Author : Floris P. J. T. Rutjes
Publisher : Thieme
Page : 750 pages
File Size : 50,5 Mb
Release : 2021-11-24
Category : Science
ISBN : 9783132442153

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Science of Synthesis: Click Chemistry by Floris P. J. T. Rutjes Pdf

This reference work presents the state-of-the-art in the field of click chemistry, collecting the most useful, practical, and reliable methods. Click chemistry is a discipline that has grown rapidly since the introduction of this term by Barry Sharpless and Huisgen approximately two decades ago. Initially, click reactions mostly involved copper-catalyzed azide-alkyne cycloadditions and their applications to connect molecules, but gradually new types of click reactions were developed which also allowed a much wider range of applications throughout the chemical, biological, and materials sciences. This volume provides an overview of the most widely used click reactions and their scope and limitations. Written by pioneers and leaders in the field and including representative applications and experimental procedures. Newcomers to the field are enabled to instantly apply these reactions in synthesis.

Key Heterocyclic Cores for Smart Anticancer Drug–Design Part II

Rajesh Kumar Singh
Key Heterocyclic Cores for Smart Anticancer Drug Design Part II Book PDF

Author : Rajesh Kumar Singh
Publisher : Bentham Science Publishers
Page : 231 pages
File Size : 42,7 Mb
Release : 2022-09-02
Category : Medical
ISBN : 9789815040050

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Key Heterocyclic Cores for Smart Anticancer Drug–Design Part II by Rajesh Kumar Singh Pdf

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 2 of the book set covers these topics: - Anticancer targets for heterocyclic lead compounds - Coumarin hybrids for cancer treatments - Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity - Imidazole as an anticancer heterocyclic ring - Morpholine for profiling anticancer lead compounds - Natural products as anticancer agents

Advances in Polymer Chemistry and Methods Reported in Recent US Patents

Thomas F. DeRosa
Advances in Polymer Chemistry and Methods Reported in Recent US Patents Book PDF

Author : Thomas F. DeRosa
Publisher : Wiley
Page : 0 pages
File Size : 51,9 Mb
Release : 2008-10-06
Category : Science
ISBN : 0470312866

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Advances in Polymer Chemistry and Methods Reported in Recent US Patents by Thomas F. DeRosa Pdf

The objective of this book is to convey to academic and industrial researchers and students advances in synthetic and characterization methods in 9 selected areas of polymer chemistry reported in 2007-2008 US Patents. It reviews the impact of newer bulk anionic, cationic, and free radical polymerization methods within selected industrial applications. Bulk and surface crosslinking agents using selected bi- and tri-functional reagents, photochemical methods, or free radical agents are also reviewed. Finally, there is a separate section on cationic and cationic ring opening polymerization reactions describing di- and tri-heterocyclic monomers and their use in medical devices.

Comprehensive Natural Products III

Anonim
Comprehensive Natural Products III Book PDF

Author : Anonim
Publisher : Elsevier
Page : 4266 pages
File Size : 54,7 Mb
Release : 2020-07-22
Category : Science
ISBN : 9780081026915

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Comprehensive Natural Products III by Anonim Pdf

Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Bimal Krishna Banik
Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book PDF

Author : Bimal Krishna Banik
Publisher : Elsevier
Page : 699 pages
File Size : 45,8 Mb
Release : 2024-05-31
Category : Science
ISBN : 9780443161674

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design by Bimal Krishna Banik Pdf

Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods. Highlights the need for adoption of sustainable and green chemistry pathways in drug development Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability

Green Synthetic Approaches for Biologically Relevant Heterocycles

Goutam Brahmachari
Green Synthetic Approaches for Biologically Relevant Heterocycles Book PDF

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 642 pages
File Size : 51,5 Mb
Release : 2021-02-26
Category : Science
ISBN : 9780128205860

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Green Synthetic Approaches for Biologically Relevant Heterocycles by Goutam Brahmachari Pdf

Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability

Handbook of Heterocyclic Chemistry

Alan R. Katritzky
Handbook of Heterocyclic Chemistry Book PDF

Author : Alan R. Katritzky
Publisher : Elsevier
Page : 568 pages
File Size : 50,6 Mb
Release : 2017-01-31
Category : Science
ISBN : 9781483293424

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Handbook of Heterocyclic Chemistry by Alan R. Katritzky Pdf

Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.

Contemporary Drug Synthesis

Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Contemporary Drug Synthesis Book PDF

Author : Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Publisher : John Wiley & Sons
Page : 238 pages
File Size : 49,9 Mb
Release : 2004-12-27
Category : Science
ISBN : 9780471686736

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Contemporary Drug Synthesis by Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth Pdf

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.