Histamine In Inflammation

Author : Robin Thurmond
Publisher : Springer Science & Business Media
Page : 153 pages
File Size : 42,9 Mb
Release : 2011-06-29
Category : Medical
ISBN : 9781441980564

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Histamine in Inflammation by Robin Thurmond Pdf

The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

Author : András Falus
Publisher : R. G. Landes
Page : 166 pages
File Size : 49,7 Mb
Release : 1994
Category : Histamine
ISBN : UCLA:L0072515851

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Histamine and Inflammation by András Falus Pdf

Histamine is released in allergic, inflammatory reactions. This comprehensive text fully examines the physiological, biochemical and clinical significance of this mediator with a central role in allergic reaction.

Author : Carlo Riccardi,Francesca Levi-Schaffer,Ekaterini Tiligada
Publisher : Springer
Page : 331 pages
File Size : 43,9 Mb
Release : 2018-06-09
Category : Medical
ISBN : 9783319776583

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Immunopharmacology and Inflammation by Carlo Riccardi,Francesca Levi-Schaffer,Ekaterini Tiligada Pdf

A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.

Author : Ross Elliot Rocklin
Publisher : Marcel Dekker
Page : 374 pages
File Size : 44,9 Mb
Release : 1990
Category : Medical
ISBN : UOM:39015018455785

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Histamine and H2 Antagonists in Inflammation and Immunodeficiency by Ross Elliot Rocklin Pdf

Author : Anonim
Publisher : Springer Science & Business Media
Page : 808 pages
File Size : 50,8 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9783642668883

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Inflammation by Anonim Pdf

Throughout the centuries, inflammation has been considered as a disease in itself. This misconception arose from the inability to distinguish between inflammatory changes and the insults which induce them. The understanding of the distinction between the genesis of inflammation and the tissue reactions that follow is attributed to JOHN HUNTER, who, at the end of the 18th century, substantially contributed to the analysis of inflammation in objective terms. Today, however, we are still trying to find explanations for Celsus' Signs in terms of structural and functional changes occurring in the inflamed tissue. There are drugs which modulate these signs but, without a detailed knowledge of the basic physiopathological events, it is impossible to understand their mechanism of action. Notwithstanding, the effects of anti inflammatory drugs provided new knowledge of the relevance of the signs and symptoms to the sequence of biochemical and morphological changes occurring in inflammation. When we accepted the invitation to edit a Handbook on Inflammation and Anti Inflammatory Drugs, we were aware of the magnitude of the task. We knew the impossibility of covering the whole field in detail, especially taking into account the rapid accumulation of experimental knowledge which would, in all likelihood, overtake the process of publication.

Author : Leslie Langevin
Publisher : Union Square + ORM
Page : 570 pages
File Size : 49,9 Mb
Release : 2019-02-05
Category : Cooking
ISBN : 9781454931393

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The Anti-Inflammatory Kitchen Cookbook by Leslie Langevin Pdf

Delicious, therapeutic recipes for a properly calibrated diet rich in anti-inflammatory ingredients—includes photos. If you suffer from fatigue, migraines, eczema, allergic reactions, mast cell activation, celiac disease, IBS, chronic hives, or an inflammatory condition such as arthritis, these delicious low-histamine, anti-inflammatory, and gluten-free dishes will help you embrace the healing power of food. Enjoy a Cornmeal Scallion Waffle Egg Sandwich for breakfast, a Quinoa Dill Summer Salad or Roasted Carrot Hummus Wrap for lunch, a Fajita Chicken Rice Bowl or Lemon & Dill Salmon Cakes for dinner, and then Maple Shortbread Cookies or a Mascarpone Fruit Tart for dessert. This must-have cookbook also features helpful lists of foods and supplements to eat and to avoid, cooking tips, kitchen hacks, recommendations for eating out, a month-long meal plan, and a selection of 15-minute meal ideas. Eating healthy never tasted—or felt—so good! “A resource for [people] with histamine intolerance and inflammation-related conditions such as asthma, interstitial cystitis, irritable bowel syndrome, and rheumatoid arthritis . . . showcases beautifully photographed recipes such as Soft Oatmeal Bread; Quinoa, Beet & Corn Salad; Butternut Squash with Brown Butter & Sage; and Blueberry Bars.” —Today’s Dietitian

Author : Gerald Weissmann
Publisher : Springer Science & Business Media
Page : 214 pages
File Size : 43,7 Mb
Release : 2013-03-13
Category : Medical
ISBN : 9781468407457

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Mediators of Inflammation by Gerald Weissmann Pdf

Lewis Thomas has suggested that "Perhaps the inflammatory reaction should be regarded as a defense of an individual against all the rest of nature, symbolizing his individuality and announcing his existence as an entity. " Provision of these symbols and announcements is the task of various mediators of inflammation and this volume has been designed to present our current understanding of their biochemistry, cellular origins, pharmacology, and role in pathology. Unlike other volumes of collected papers, this book did not result from a specific conference or symposium at which each contributor presented his own, narrowly framed research experience. Rather, each of the chapters represents, in the form of a general review, a summary of our knowledge of the mediators and the mecha nisms by which they are released to launch the inflammatory response. Much effort has been taken to insure that the often conflicting terminology in this field is defmed in detail: many synonyms (e. g. , of the properdin system or the alternate pathway of complement activation) have been repeatedly presented, in order to avoid confusion. Although each of the contributors is actively engaged in the field of inflammation, few text figures or tables of ongoing research have been included; the overall aim was to provide a volume readily accessible to workers in other areas as well as to the general reader.

Author : Yuichi Hattori,Roland Seifert
Publisher : Springer
Page : 363 pages
File Size : 48,5 Mb
Release : 2017-05-22
Category : Medical
ISBN : 9783319581941

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Histamine and Histamine Receptors in Health and Disease by Yuichi Hattori,Roland Seifert Pdf

This ​book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field completely within the constraints of a single HEP volume, nonetheless, all important aspects will be covered in one way or the other. An overarching introductory chapter will link the individual chapters and provide an overview on the field. This chapter will also link the book to the previous HEP volume on histamine receptors and the recent HEP volume on the pharmacology of itch. Great attention will be paid to complementation of existing literature while avoiding undue duplication. The book will cover new methods for analysis of histamine and histamine metabolites, development of methods for histamine receptor analysis, signal transduction, histamine release, regulation of immune cells by histamine, histamine metabolism and associated diseases, regulation of major organ systems by histamine and development of new drugs and experimental tools for the study of histamine receptors.

Author : Nancy Khardori,Rahat Ali Khan,Trivendra Tripathi
Publisher : Springer Science & Business Media
Page : 441 pages
File Size : 55,6 Mb
Release : 2010-09-30
Category : Medical
ISBN : 9789048193493

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Biomedical Aspects of Histamine by Nancy Khardori,Rahat Ali Khan,Trivendra Tripathi Pdf

Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.

Author : Holger Stark
Publisher : Walter de Gruyter
Page : 368 pages
File Size : 55,5 Mb
Release : 2013-11-20
Category : Science
ISBN : 9788376560564

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Histamine H4 receptor by Holger Stark Pdf

H4 R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4 R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4 R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4 R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed.

Author : M. Rocha E Silva,J. Garcia Leme
Publisher : Elsevier
Page : 276 pages
File Size : 41,5 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483150512

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Chemical Mediators of the Acute Inflammatory Reaction by M. Rocha E Silva,J. Garcia Leme Pdf

International Series of Monographs in Pure and Applied Biology, Modern Trends in Physiological Sciences, Volume 37: Chemical Mediators of the Acute Inflammatory Reaction traces the history of investigation into the acute inflammatory reaction from the early observations in invertebrates to the experiments of therapeutic significance for humans. This book focuses on mediators that are accepted as being commonly involved in the inflammatory reaction, such as histamine, kinins, serotonin, prostaglandins, and permeability factors. The topics discussed include the phagocytic system and antibody production; factors which influence phagocytosis; measurement of the acute inflammatory reaction; and combined actions of mediators. The reaction to injury and manifestation of inflammation and biochemical aspects of anti-inflammatory drug reaction are also covered. This volume is beneficial to anatomists, biochemists, physiologists, immunologists, pathologists, pharmacologists, and clinicians interested in acute inflammatory reaction.

Author : Jian-Sheng Lin,Pertti Panula,Maria Beatrice Passani
Publisher : Frontiers Media SA
Page : 100 pages
File Size : 42,8 Mb
Release : 2015-03-18
Category : Brain
ISBN : 9782889194346

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Histamine in the brain by Jian-Sheng Lin,Pertti Panula,Maria Beatrice Passani Pdf

Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.

Author : Gianni Marone,Lawrence M. Lichtenstein,Federica J. Galli
Publisher : Academic Press
Page : 707 pages
File Size : 48,8 Mb
Release : 2000-05-25
Category : Medical
ISBN : 9780080535852

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Mast Cells and Basophils by Gianni Marone,Lawrence M. Lichtenstein,Federica J. Galli Pdf

Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

Author : Patrizio Blandina,Maria Beatrice Passani
Publisher : Springer
Page : 378 pages
File Size : 49,6 Mb
Release : 2016-11-07
Category : Medical
ISBN : 9783319403083

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Histamine Receptors by Patrizio Blandina,Maria Beatrice Passani Pdf

A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.

Author : András Falus,N. Grosman,Zsuzsanna Darvas
Publisher : S. Karger AG (Switzerland)
Page : 368 pages
File Size : 48,6 Mb
Release : 2004
Category : Histamine
ISBN : UOM:39015061151554

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Histamine by András Falus,N. Grosman,Zsuzsanna Darvas Pdf

Histamine, discovered in 1910 by the British physiologist Sir Henry H. Dale, has become one of the most important biogenic amines in medicine and biology. In addition to the three well-known functions such as the contraction of smooth muscles, the increase in vascular permeability, and the stimulation of gastric acid secretion, histamine has been known to play various roles in neurotransmission, immunomodulation, the regulation of cell proliferation, etc. This book provides a comprehensive overview of histamine biology including structure, anabolic and catabolic enzymes, receptors and their ligands. It outlines the details of histamine physiology such as its role in the immune response, nutrition and neuro/psychobiology, and covers medical fields like allergy, gastroenterology, oncology, sepsis, posttraumatic stress, embryonic development and hematopoiesis. Also considered is the structural and functional genomics of histamine. Presenting the most recent advances in histamine research from basic science to clinical medicine, this book is a valuable source for students, graduates and postgraduates in medicine and the life sciences, and to anyone interested in this multifaceted molecule.